The application of vibrational spectroscopy in the pharmaceutical industry is widely investigated, from the quality assurance of the product during the production process control to the final products’ quality contro...The application of vibrational spectroscopy in the pharmaceutical industry is widely investigated, from the quality assurance of the product during the production process control to the final products’ quality control and the authentication of products on the markets. This study focuses on non-contact and noninvasive detection and identification of pain-relievers at 1-5 meters standoff distances. The specimens analyzed include standard laboratory-grade active ingredients and commercially available pain relievers in powder, solid and liquid forms. All the remote measurements captured revealed the Raman signatures of the specimens, with varying peak intensities. To correlate the band intensities captured with the standoff distances between the laser source and the specimens, the intensity ratios of the two prominent peaks of the laboratory grade reference active ingredient (1607 and 1319 cm<sup>-1</sup>) normalized with 1319 cm<sup>-1</sup> are used. The results of the study suggest the viability of standoff Raman spectroscopy for routine monitoring and identification of pharma-ceuticals, including counterfeit pain relievers.展开更多
Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through m...Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through methods such as changing positions and manual pressing,but the efficacy is limited.Hence alternative therapies for sedation and analgesia in unsedated colonoscopy warrant further study.Electroacupuncture(EA)can simplify the procedure of anesthesia and analgesia,while the efficacy of EA on unsedated colonoscopy remains unclear.Therefore,a well-designed randomized controlled trial is needed to demonstrate the potential efficacy of acupuncture in unsedated colonoscopy,particularly for pain relief.Methods In this prospective randomized sham-controlled trial,105 eligible participants will be recruited and randomly assigned to either EA group(n=35),sham EA group(n=35),or control group(n=35)in a 1:1:1 ratio.The EA group will receive acupuncture intervention on bilateral Hegu(LI4),Neiguan(PC6),Zusanli(ST36),and Shenmen(HT7),with LI4 and PC6 on both sides connected to the EA device.The sham EA group will received non transdermal needling on points of no meridian,and deliberately connect the needle to the incorrect output socket of EA device to block the stimulation.The needling will conducted from 30 min before the unsedated colonoscopy to the end of the colonoscopy,the whole retention time would be approximately 40 min.The participants in the control group will not receive any acupuncture intervention.All participants of the three groups will not receive any other treatment.Primary outcomes:Numerical Rating Scale(NRS)reported by participants and Face Pain Scale Revised(FPS-R)evaluated by observers of four areas of the participants during the unsedated colonoscopy.Secondary outcomes:tolerance reported by endoscopists,tolerance reported by participants,satisfaction reported by endoscopists,satisfaction reported by participants,adverse events during the unsedated colonoscopy,postoperative discomfort,unsedated colonoscopy smoothness(cecal insertion time,unwinding time,success rate of one-time intubation).Both intention-to-treat(ITT)and per-protocol(PP)analyses will be performed to assess the efficacy of EA.Discussion The trial will explore the efficacy of relieving pain,improving tolerability,and reducing undesirable adverse events of EA for unsedated colonoscopy.The results of this trial will provide sound evidence for promoting the clinical application of EA for unsedated colonoscopy.Trial registration ClinicalTrials.gov Identifier:ChiCTR2300069903,retrospectively registered on March 16,2023.展开更多
Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine ...Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.展开更多
Objective: to analyze the related factors that affect the postoperative pain symptoms of patients undergoing general surgery and explore targeted therapeutic interventions. Methods: 112 surgical patients admitted in o...Objective: to analyze the related factors that affect the postoperative pain symptoms of patients undergoing general surgery and explore targeted therapeutic interventions. Methods: 112 surgical patients admitted in our hospital from August 2020 to September 2021 were selected as the research object, and divided into observation group (targeted treatment intervention) and control group (routine treatment intervention) with 56 cases in each group. The therapeutic effects of the two groups were compared. Results: among 112 patients undergoing general surgery, there was no significant difference in the severity of postoperative pain between male and female patients, patients with or without chronic pain history (p > 0.05). the severity of pain symptoms of patients aged ≥60 years old was higher than that of patients aged < 60 years old (p < 0.05), and the severity of pain symptoms of patients receiving targeted pain intervention was lower than that of patients receiving conventional pain intervention (p < 0.05). The satisfaction degree of the patients in the observation group (96.43% > 82.14%, χ2=5.973) was higher than that of the control group (p < 0.05). the pain VAS score of the patients in the observation group after the intervention was [(1.98±0.43) point < (2.91±0.67) point, t=8.742], and the score of pittsburgh sleep quality index scale (PSQI) [(8.31±1.57) point < (9.44±1.62) point. t = 3.748, SAS score [(36.87±2.97) point < (46.05±3.51) point, t=14.941], SDS score [(37.91±3.98) point < (45.02±4.19) point, t=9.207] was lower than that of the control group (p < 0.05). Conclusion: in the postoperative rehabilitation treatment of general surgery patients, attention should be paid to the postoperative pain symptoms of patients. Considering the related factors that cause the onset of pain symptoms and aggravate the pain, targeted pain intervention should be implemented to effectively reduce the postoperative pain of patients and reduce the adverse effects of pain symptoms on daily life.展开更多
1 Objective: to explore the practicality and potential of classical therapy for hypochondriac pain caused by hepatobiliary diseases in modern clinical application. 2 Methods: through the collation of "Compendium ...1 Objective: to explore the practicality and potential of classical therapy for hypochondriac pain caused by hepatobiliary diseases in modern clinical application. 2 Methods: through the collation of "Compendium of Acupuncture and Moxibustion" and modern literature, a conclusion is drawn after comparative analysis. 3 Result: of the 44 acupoints involved in the treatment of hypochondriac pain caused by liver and gallbladder diseases in “Compendium of Acupuncture and Moxibustion”, there are mainly 16 acupoints in modern clinical application, among which "Yanglingquan", "Qimen" and "Zhigou" have a higher frequency of application, the other 13 acupoints have a lower frequency, and the remaining 28 acupoints are unused. 4 Conclusion: “Compendium of Acupuncture and Moxibustion” has higher practicability on "Yanglingquan", "Qimen" and "Zhigou" of the acupoints involved in the hypochondriac pain therapy for hepatobiliary diseases;The application of the other 13 acupoints "the benevolent see the benevolence, the wise see the wisdom";The remaining 28 acupoints have great potential and are worthy of later generations to explore, study and put into practice.展开更多
Objective:The objective of this study is to investigate the inhibitory effect of peony and licorice decoction and its compatibility components on the Nav1.4 voltage-gated sodium channels(VGSCs).Materials and Methods:W...Objective:The objective of this study is to investigate the inhibitory effect of peony and licorice decoction and its compatibility components on the Nav1.4 voltage-gated sodium channels(VGSCs).Materials and Methods:Writhing test was carried out with ICR mice.Paeonia lactiflora and Glycyrrhiza uralensis group were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 2.94 mg/ml,1.47 mg/ml,and 0.74 mg/ml using intragastric administration,respectively.Peony and licorice decoction groups were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 5.89 mg/ml,2.94 mg/ml,and 1.47 mg/ml using intragastric administration,respectively.For electrophysiology studies,each freeze-dried powder was dissolved in DMSO to make 10 mg/ml and 50 mg/ml stock solutions.The electrophysiological recordings were obtained under visual control of a microscope.For UPLC analysis,the freeze-dried powder was dissolved in methanol and then determines the contents of the nine marker compounds.Results:The effect of G.uralensis on incubation period and writhing frequency was significantly better than that of peony and licorice decoction group and P.lactiflora group.The inhibition rate of 50 mg/ml water extracts of the three samples was significantly higher than that of the 10 mg/ml group.Moreover,the water extract of G.uralensis at 50 mg/ml had the strongest inhibitory effect on I_(Nav) 1.4 of the three.Conclusion:The possible mechanism of peony and licorice decoction in relieving spasm and pain is most likely by inhibiting Voltage-Gated Sodium Channel Subtype 1.4.展开更多
文摘The application of vibrational spectroscopy in the pharmaceutical industry is widely investigated, from the quality assurance of the product during the production process control to the final products’ quality control and the authentication of products on the markets. This study focuses on non-contact and noninvasive detection and identification of pain-relievers at 1-5 meters standoff distances. The specimens analyzed include standard laboratory-grade active ingredients and commercially available pain relievers in powder, solid and liquid forms. All the remote measurements captured revealed the Raman signatures of the specimens, with varying peak intensities. To correlate the band intensities captured with the standoff distances between the laser source and the specimens, the intensity ratios of the two prominent peaks of the laboratory grade reference active ingredient (1607 and 1319 cm<sup>-1</sup>) normalized with 1319 cm<sup>-1</sup> are used. The results of the study suggest the viability of standoff Raman spectroscopy for routine monitoring and identification of pharma-ceuticals, including counterfeit pain relievers.
基金Supported by National Basic Evidence-based Capacity Building Project of Traditional Chinese Medicine([2019]130)Natural Science Foundation of Liaoning Province:2024-MS-042+1 种基金Xingliao Talent Program Medical Master Project:YXMJ-QNMZY-10Liaoning University of Traditional Chinese Medicine Key Laboratory of Traditional Chinese Medicine Theory and Application of Ministry of Education open fund project:zyzx2302.
文摘Background Unsedated colonoscopy is an important method used for diagnosing colorectal cancer,but it can cause discomfort such as pain and bloating,as well as anxiety.At present,the relief is mainly achieved through methods such as changing positions and manual pressing,but the efficacy is limited.Hence alternative therapies for sedation and analgesia in unsedated colonoscopy warrant further study.Electroacupuncture(EA)can simplify the procedure of anesthesia and analgesia,while the efficacy of EA on unsedated colonoscopy remains unclear.Therefore,a well-designed randomized controlled trial is needed to demonstrate the potential efficacy of acupuncture in unsedated colonoscopy,particularly for pain relief.Methods In this prospective randomized sham-controlled trial,105 eligible participants will be recruited and randomly assigned to either EA group(n=35),sham EA group(n=35),or control group(n=35)in a 1:1:1 ratio.The EA group will receive acupuncture intervention on bilateral Hegu(LI4),Neiguan(PC6),Zusanli(ST36),and Shenmen(HT7),with LI4 and PC6 on both sides connected to the EA device.The sham EA group will received non transdermal needling on points of no meridian,and deliberately connect the needle to the incorrect output socket of EA device to block the stimulation.The needling will conducted from 30 min before the unsedated colonoscopy to the end of the colonoscopy,the whole retention time would be approximately 40 min.The participants in the control group will not receive any acupuncture intervention.All participants of the three groups will not receive any other treatment.Primary outcomes:Numerical Rating Scale(NRS)reported by participants and Face Pain Scale Revised(FPS-R)evaluated by observers of four areas of the participants during the unsedated colonoscopy.Secondary outcomes:tolerance reported by endoscopists,tolerance reported by participants,satisfaction reported by endoscopists,satisfaction reported by participants,adverse events during the unsedated colonoscopy,postoperative discomfort,unsedated colonoscopy smoothness(cecal insertion time,unwinding time,success rate of one-time intubation).Both intention-to-treat(ITT)and per-protocol(PP)analyses will be performed to assess the efficacy of EA.Discussion The trial will explore the efficacy of relieving pain,improving tolerability,and reducing undesirable adverse events of EA for unsedated colonoscopy.The results of this trial will provide sound evidence for promoting the clinical application of EA for unsedated colonoscopy.Trial registration ClinicalTrials.gov Identifier:ChiCTR2300069903,retrospectively registered on March 16,2023.
基金supported by the National Natural Science Foundation of China General Program(82174377)National Traditional Chinese Medicine Advantageous Specialty Construction Project(GZY-ZY[2024]90).
文摘Objective To explore the medication patterns of Professor Zulong Wang in treating sleep-related painful erection(SRPE)through data mining,aiming to discover new therapeutic strategies for traditional Chinese medicine in managing this condition.Methods Medical records of SRPE patients treated by Professor Zulong Wang at the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to December 2024 were collected to establish a database.Frequency analysis,association rule analysis,and cluster analysis were employed to examine the frequency of herb use,four properties and five flavors,channel tropisms,and herb combinations.Results A total of 59 prescriptions meeting the criteria were included,involving 81 Chinese herbs,among which 27 herbs were used 10 or more times.The primary herb properties were cold,warm,and neutral,with bitter,sweet,and pungent flavors being most common.The herbs predominantly entered the liver,heart,spleen,and kidney channels.Forty-three commonly used herb combinations were identified,and cluster analysis revealed six core herb groups.Conclusion Professor Zulong Wang primarily treats SRPE with modified Huoluo Xiaoling Dan,focusing on unblocking collaterals and relieving pain,supplemented by soothing the liver and regulating qi,resolving stasis and phlegm,nourishing yin and reducing fire,and tonifying the kidney and activating blood circulation.
文摘Objective: to analyze the related factors that affect the postoperative pain symptoms of patients undergoing general surgery and explore targeted therapeutic interventions. Methods: 112 surgical patients admitted in our hospital from August 2020 to September 2021 were selected as the research object, and divided into observation group (targeted treatment intervention) and control group (routine treatment intervention) with 56 cases in each group. The therapeutic effects of the two groups were compared. Results: among 112 patients undergoing general surgery, there was no significant difference in the severity of postoperative pain between male and female patients, patients with or without chronic pain history (p > 0.05). the severity of pain symptoms of patients aged ≥60 years old was higher than that of patients aged < 60 years old (p < 0.05), and the severity of pain symptoms of patients receiving targeted pain intervention was lower than that of patients receiving conventional pain intervention (p < 0.05). The satisfaction degree of the patients in the observation group (96.43% > 82.14%, χ2=5.973) was higher than that of the control group (p < 0.05). the pain VAS score of the patients in the observation group after the intervention was [(1.98±0.43) point < (2.91±0.67) point, t=8.742], and the score of pittsburgh sleep quality index scale (PSQI) [(8.31±1.57) point < (9.44±1.62) point. t = 3.748, SAS score [(36.87±2.97) point < (46.05±3.51) point, t=14.941], SDS score [(37.91±3.98) point < (45.02±4.19) point, t=9.207] was lower than that of the control group (p < 0.05). Conclusion: in the postoperative rehabilitation treatment of general surgery patients, attention should be paid to the postoperative pain symptoms of patients. Considering the related factors that cause the onset of pain symptoms and aggravate the pain, targeted pain intervention should be implemented to effectively reduce the postoperative pain of patients and reduce the adverse effects of pain symptoms on daily life.
文摘1 Objective: to explore the practicality and potential of classical therapy for hypochondriac pain caused by hepatobiliary diseases in modern clinical application. 2 Methods: through the collation of "Compendium of Acupuncture and Moxibustion" and modern literature, a conclusion is drawn after comparative analysis. 3 Result: of the 44 acupoints involved in the treatment of hypochondriac pain caused by liver and gallbladder diseases in “Compendium of Acupuncture and Moxibustion”, there are mainly 16 acupoints in modern clinical application, among which "Yanglingquan", "Qimen" and "Zhigou" have a higher frequency of application, the other 13 acupoints have a lower frequency, and the remaining 28 acupoints are unused. 4 Conclusion: “Compendium of Acupuncture and Moxibustion” has higher practicability on "Yanglingquan", "Qimen" and "Zhigou" of the acupoints involved in the hypochondriac pain therapy for hepatobiliary diseases;The application of the other 13 acupoints "the benevolent see the benevolence, the wise see the wisdom";The remaining 28 acupoints have great potential and are worthy of later generations to explore, study and put into practice.
基金financial supports from "Study on the Development of Classical Prescriptions of Peony and Liquorice Decoction"(NO:H2016072-03)"Study on the Standard Decoction of Traditional Chinese Medicinal Slices"(NO:H2016021-06)
文摘Objective:The objective of this study is to investigate the inhibitory effect of peony and licorice decoction and its compatibility components on the Nav1.4 voltage-gated sodium channels(VGSCs).Materials and Methods:Writhing test was carried out with ICR mice.Paeonia lactiflora and Glycyrrhiza uralensis group were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 2.94 mg/ml,1.47 mg/ml,and 0.74 mg/ml using intragastric administration,respectively.Peony and licorice decoction groups were administrated 0.2 ml of solution of freeze-dried powder dissolved in normal saline with the concentration of 5.89 mg/ml,2.94 mg/ml,and 1.47 mg/ml using intragastric administration,respectively.For electrophysiology studies,each freeze-dried powder was dissolved in DMSO to make 10 mg/ml and 50 mg/ml stock solutions.The electrophysiological recordings were obtained under visual control of a microscope.For UPLC analysis,the freeze-dried powder was dissolved in methanol and then determines the contents of the nine marker compounds.Results:The effect of G.uralensis on incubation period and writhing frequency was significantly better than that of peony and licorice decoction group and P.lactiflora group.The inhibition rate of 50 mg/ml water extracts of the three samples was significantly higher than that of the 10 mg/ml group.Moreover,the water extract of G.uralensis at 50 mg/ml had the strongest inhibitory effect on I_(Nav) 1.4 of the three.Conclusion:The possible mechanism of peony and licorice decoction in relieving spasm and pain is most likely by inhibiting Voltage-Gated Sodium Channel Subtype 1.4.
