Purpose:To assess the effect of praziquantel(PZQ)treatment on liver echotexture and diameters of the portal and splenic veins.Materials and methods:This was a prospective study involving 86 known cases of schistosomia...Purpose:To assess the effect of praziquantel(PZQ)treatment on liver echotexture and diameters of the portal and splenic veins.Materials and methods:This was a prospective study involving 86 known cases of schistosomiasis;these cases were examined via gray-scale sonography in 3-month intervals for a period of 6 months.The patients were categorized into two groups based on whether or not they were treated with PZQ.The liver,spleen,main portal vein(PV),and splenic vein(SV)were evaluated sonographically using 3.5-curvilinear transducers,according to a standard abdominal ultrasound protocol.Results:The liver echotexture and size were significantly recovered in patients who received PZQ therapy compared to those who did not use the drug(p-values<0.001).PZQ caused significant reduction in diameters of the PV and SV(p-value<0.001).Conclusion:Liver size and echotexture and diameters of PV and SV improved well as a result of Praziquantel therapy in patients with chronic Schistosoma infection.Treatment of Schistosomiasis is necessary to prevent liver cirrhosis and portal hypertension.展开更多
The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was inv...The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.展开更多
文摘Purpose:To assess the effect of praziquantel(PZQ)treatment on liver echotexture and diameters of the portal and splenic veins.Materials and methods:This was a prospective study involving 86 known cases of schistosomiasis;these cases were examined via gray-scale sonography in 3-month intervals for a period of 6 months.The patients were categorized into two groups based on whether or not they were treated with PZQ.The liver,spleen,main portal vein(PV),and splenic vein(SV)were evaluated sonographically using 3.5-curvilinear transducers,according to a standard abdominal ultrasound protocol.Results:The liver echotexture and size were significantly recovered in patients who received PZQ therapy compared to those who did not use the drug(p-values<0.001).PZQ caused significant reduction in diameters of the PV and SV(p-value<0.001).Conclusion:Liver size and echotexture and diameters of PV and SV improved well as a result of Praziquantel therapy in patients with chronic Schistosoma infection.Treatment of Schistosomiasis is necessary to prevent liver cirrhosis and portal hypertension.
基金supported by the Bill & Melinda Gates Foundation(Grant No.1024516)
文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % （37 ℃, 5 min） to 0 （49℃, 10 min） with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy （P 〈 0.05）. Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45-49℃ for 5 min within 8 h of infection, worm reduction rate （WRR） reached 74 %-83 % （P 〈 0.01）. The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia （thermal dosages 42-43℃, 20 min）. The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel （PZQ）-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.
