Objective:To observe the clinical efficacy and safety of butylphthalide joint human albumin in the treatment of the progress of type in acute cerebral infarction(PTCI).Methods:120 patients with PTCI in Department of N...Objective:To observe the clinical efficacy and safety of butylphthalide joint human albumin in the treatment of the progress of type in acute cerebral infarction(PTCI).Methods:120 patients with PTCI in Department of Neurology of Shuyang People's Hospital were used to observe the efficacy.These patients were all treated by routine medicine including anti-platelet,statins,edaravone,ginkgo leaf extract and dipyridamole after admission.According to whether used butylphthalide and(or)human albumin in the treatment of PTCI,the patients were divided into A group 30 cases,B group 45 cases,and C group 45 cases.Patients of group C were given conventional treatment.Group B were given conventional treatment and human albumin injection(5 g,ivgtt,qd,3 days in a course);Group A were treated with butylphthalide(first,with butylphthalide and sodium chloride injection 100 ml,ivgtt,for 7 d,then with butylphthalide soft capsules 0.2 g,tid,for 21 d),human albumin(5 g,ivgtt,qd,for 3 d)and routine medicine.The change of NIHSS score,Barthel Index,and mRS of three groups respectively during progress,1 week,2 weeks and 90 days after progress were observed and analyzed.Results:NIHSS score,Barthel Index,and mRS of group A,group B and group C all showed no statistically significant(all p>0.05)on 1 week after treatment;NIHSS score and mRS of group A were both lower than group B and group C on 2 weeks and 90 days after treatment,and both of them showed statistically significant(p<0.05);Barthel Index of group A was higher than group B and group C on 90 days after treatment,it showed statistically significant(p<0.05);The total effective rate of group A(96.7%)>group B(88.9%)>group C(77.8%),showed statistically significant(p<0.05).Conclusions:Butylphthalide joint human albumin treatment of PTCI has good therapeutic effect and safety,it is useful to clinical promotion and further research.展开更多
目的研究创伤性颅脑损伤术后脑梗死(posttraumatic cerebral infarction, PTCI)患者血浆中D-二聚体和血清超敏 C 反应蛋白(high-sensitivity C reaction protein, hs-CRP)表达水平及临床意义。方法以2011年至2017年在我院接受治疗的53例...目的研究创伤性颅脑损伤术后脑梗死(posttraumatic cerebral infarction, PTCI)患者血浆中D-二聚体和血清超敏 C 反应蛋白(high-sensitivity C reaction protein, hs-CRP)表达水平及临床意义。方法以2011年至2017年在我院接受治疗的53例PTCI患者为研究对象,格拉斯哥昏迷评分(Glasgow coma scale,GCS)评估病情,检测患者血浆D-二聚体浓度及血清hs-CRP表达情况,分析其与病情进展的相关性,以同期77例无PTCI患者作为对照。结果 PTCI患者血浆D-二聚体和血清hs-CRP水平随着缺血病变的严重程度增加明显升高,术后第7天分别达到(7015.3±402.6)μg/L和(505.3±10.7)μg/L,而非梗死组的测量值为(3866.7±201.2)μg/L和(278.7±17.4)μg/L,差异均具有统计学意义(P<0.05)。Logistic回归分析显示,术后D-二聚体及hs-CRP与继发性脑梗死之间具有相关性(OR=1.061和1.019)。结论 D-二聚体和hs-CRP水平是评价PTCI的重要指标,检测患者D-二聚体和hs-CRP的表达有助于预测和诊断PTCI。展开更多
文摘Objective:To observe the clinical efficacy and safety of butylphthalide joint human albumin in the treatment of the progress of type in acute cerebral infarction(PTCI).Methods:120 patients with PTCI in Department of Neurology of Shuyang People's Hospital were used to observe the efficacy.These patients were all treated by routine medicine including anti-platelet,statins,edaravone,ginkgo leaf extract and dipyridamole after admission.According to whether used butylphthalide and(or)human albumin in the treatment of PTCI,the patients were divided into A group 30 cases,B group 45 cases,and C group 45 cases.Patients of group C were given conventional treatment.Group B were given conventional treatment and human albumin injection(5 g,ivgtt,qd,3 days in a course);Group A were treated with butylphthalide(first,with butylphthalide and sodium chloride injection 100 ml,ivgtt,for 7 d,then with butylphthalide soft capsules 0.2 g,tid,for 21 d),human albumin(5 g,ivgtt,qd,for 3 d)and routine medicine.The change of NIHSS score,Barthel Index,and mRS of three groups respectively during progress,1 week,2 weeks and 90 days after progress were observed and analyzed.Results:NIHSS score,Barthel Index,and mRS of group A,group B and group C all showed no statistically significant(all p>0.05)on 1 week after treatment;NIHSS score and mRS of group A were both lower than group B and group C on 2 weeks and 90 days after treatment,and both of them showed statistically significant(p<0.05);Barthel Index of group A was higher than group B and group C on 90 days after treatment,it showed statistically significant(p<0.05);The total effective rate of group A(96.7%)>group B(88.9%)>group C(77.8%),showed statistically significant(p<0.05).Conclusions:Butylphthalide joint human albumin treatment of PTCI has good therapeutic effect and safety,it is useful to clinical promotion and further research.
文摘目的研究创伤性颅脑损伤术后脑梗死(posttraumatic cerebral infarction, PTCI)患者血浆中D-二聚体和血清超敏 C 反应蛋白(high-sensitivity C reaction protein, hs-CRP)表达水平及临床意义。方法以2011年至2017年在我院接受治疗的53例PTCI患者为研究对象,格拉斯哥昏迷评分(Glasgow coma scale,GCS)评估病情,检测患者血浆D-二聚体浓度及血清hs-CRP表达情况,分析其与病情进展的相关性,以同期77例无PTCI患者作为对照。结果 PTCI患者血浆D-二聚体和血清hs-CRP水平随着缺血病变的严重程度增加明显升高,术后第7天分别达到(7015.3±402.6)μg/L和(505.3±10.7)μg/L,而非梗死组的测量值为(3866.7±201.2)μg/L和(278.7±17.4)μg/L,差异均具有统计学意义(P<0.05)。Logistic回归分析显示,术后D-二聚体及hs-CRP与继发性脑梗死之间具有相关性(OR=1.061和1.019)。结论 D-二聚体和hs-CRP水平是评价PTCI的重要指标,检测患者D-二聚体和hs-CRP的表达有助于预测和诊断PTCI。
