In an era marked by rising protectionism and geopolitical tensions,the world faces a stark choice:embrace multilateral cooperation or succumb to unilateral hegemony.The United States’punitive tariff policies have exp...In an era marked by rising protectionism and geopolitical tensions,the world faces a stark choice:embrace multilateral cooperation or succumb to unilateral hegemony.The United States’punitive tariff policies have exposed the negative effect of economic coercion and isolation.Meanwhile,China’s commitment to openness,innovation,and shared prosperity offers a contrast,a testament to the enduring vitality of multilateralism and global integration.展开更多
Europe’s shift toward selective protectionism,particularly targeting China,undermines its commitment to free trade,threatens its industrial competitiveness,and ultimately jeopardizes European prosperity.
There is a deep historical foundation of economic protectionism in Europe, which runs through its capitalist development and regional integration process. Over the past two years, the EU's economic protectionism h...There is a deep historical foundation of economic protectionism in Europe, which runs through its capitalist development and regional integration process. Over the past two years, the EU's economic protectionism has risen again. Both its official statements and policies show some new trends and characteristics. The basic cause of these latest trends is the relative decline in the overall strength of the EU, especially in regard to the ongoing impact of the financial and debt crisis on its economic, political and social fields. In general, the EU is likely to become more radical in its foreign economic relations, but its protectionism will not solve the fundamental problems it faces. China and Europe still need to further strengthen risk control and management in their economic and trade relations.展开更多
During its rise as a world power, the United States(U.S.) adopted a traditional form of mercantilism, and most US politicians followed a protectionist approach. From the end of the Civil War to the eve of World War I,...During its rise as a world power, the United States(U.S.) adopted a traditional form of mercantilism, and most US politicians followed a protectionist approach. From the end of the Civil War to the eve of World War I, the United States blazed a new trail of industrial development and implemented protective policies such as high tariffs. This historical tradition has had a profound influence on some current US politicians. After the collapse of the Bretton Woods system, the United States developed a new form of mercantilism, as manifested in the emergence of nontariff barriers instead of tariff barriers to restrict imports and protect domestic industries and employment. Although export regulations have avoided affecting the technology industry, they have led to hefty trade deficits for the United States. National interests have prevailed in U.S. decision-making and have influenced its choices to accede to or walk away from international organizations or treaties. The dollar's hegemony has played a pivotal role in U.S. economic policymaking. These factors have led to the twin deficits in the U.S. economy, i.e. a trade deficit and a fiscal deficit. The real intention of the United States in waging a trade war against China is to maintain and even strengthen the dollar's hegemony and the U.S.' international predominance.展开更多
"Samuelson's Concern" and "Kindleberger Trap" are cited as justifications for trade protectionism under the Trump administration. After reviewing Samuelson's and Kindleberger's trade th..."Samuelson's Concern" and "Kindleberger Trap" are cited as justifications for trade protectionism under the Trump administration. After reviewing Samuelson's and Kindleberger's trade theories, this paper finds that both Samuelson and Kindleberger are actually proponents of free trade, and that their common concern is falling US competitiveness due to its economic model, domestic institutional rules, and unilateralism. Both the "Samuelson's Concern" and "Kindleberger Trap" are distortions of Samuelson's and Kindleberger's original theories and the arguments' defense of protectionism cannot overcome the challenges confronting the U.S. and will destabilize international economic order.展开更多
Both COFCO and SINOCHEM participate in trading business with Australian enterprises,such as the import of barley,wheat,diary and meat products,or chemical products and coal.Free trade has always been the foundation of...Both COFCO and SINOCHEM participate in trading business with Australian enterprises,such as the import of barley,wheat,diary and meat products,or chemical products and coal.Free trade has always been the foundation of Sino-Australia relations.In the B20 trade and investment working group discussion,I want to emphasize the展开更多
With the textile export to EU growing at a pace faster than anticipated, the joint efforts to slow down Chinese shipment to this market in a predetermined arrangement known as "bilateral check" seem to be ab...With the textile export to EU growing at a pace faster than anticipated, the joint efforts to slow down Chinese shipment to this market in a predetermined arrangement known as "bilateral check" seem to be abortive, more and more producers there seem to grow out of their patience with EU’s past deal with China. A new wave of trade protectionism is coming on the surge…展开更多
Shipbuilding is among the latest industries scheduled for protectionist measures in the U.S.,with the Office of the U.S.Trade Representative(USTR)holding hearings from March 24 to 26 to discuss newly proposed actions ...Shipbuilding is among the latest industries scheduled for protectionist measures in the U.S.,with the Office of the U.S.Trade Representative(USTR)holding hearings from March 24 to 26 to discuss newly proposed actions targeting China.The proposed actions include the imposition of substantial port fees on Chinese vessel operators,non-Chinese operators of China-built vessels,and operators who have placed orders for China-built vessels.展开更多
The world economy is now in a period of indepth adjustment.The intensification of geopolitical conflicts,a rise of trade protectionism,and reconfiguration of global supply chains have prompted all countries to re-exam...The world economy is now in a period of indepth adjustment.The intensification of geopolitical conflicts,a rise of trade protectionism,and reconfiguration of global supply chains have prompted all countries to re-examine their openness to trade amid rising uncertainties.Against this backdrop,China’s continuing commitment to promoting higherlevel opening up and building the Hainan Free Trade Port(Hainan FTP)has distinct contemporary significance and strategic value.展开更多
Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-borde...Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-border trade and investment.The ASEAN region enjoys strong economic growth momentum with a distinct demographic advantage while China boasts a complete industrial system and manufacturing capacity.展开更多
Topical Issues for the Future of Radiation Protection Kevin Nelson1, Renate Czarwinski2, Charles Wilson3, Bernard LeGuen4, Jing Chen5, Hildegarde Annie Vandenhove6, Shengli Niu7, Thierry Schneider8, John Damilakis9,10...Topical Issues for the Future of Radiation Protection Kevin Nelson1, Renate Czarwinski2, Charles Wilson3, Bernard LeGuen4, Jing Chen5, Hildegarde Annie Vandenhove6, Shengli Niu7, Thierry Schneider8, John Damilakis9,10 and Peter Alfred Bryant11,12(1.Mayo Clinic, Scottsdale, AZ 85259.展开更多
Evaluating Adherence to Safety Standards for Physical Space Design, Equipment, and Patient and Staff Protection in Magnetic Resonance Imaging Centers:A Descriptive Cross-sectional Study Amirreza Sadeghinasab1, Jafar F...Evaluating Adherence to Safety Standards for Physical Space Design, Equipment, and Patient and Staff Protection in Magnetic Resonance Imaging Centers:A Descriptive Cross-sectional Study Amirreza Sadeghinasab1, Jafar Fatahiasl2, Mahmoud Mohammadi-Sadr1, Masoud Heydari Kahkesh3, and Marziyeh Tahmasbi2(1.Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;2.Department of Radiologic Technology, School of Allied Medical Sciences, Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, Iran;3.Department of Radiology and Radiotherapy, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran)Abstract:Magnetic resonance imaging(MRI) has revolutionized disease diagnosis and treatment.However, the technology poses safety risks, such as exposure to magnetic fields, RF pulses, and cryogens, necessitating strict adherence to safety protocols to protect patients and healthcare workers.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Int...The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Intermittent theta-burst stimulation is a repetitive transcranial magnetic stimulation that operates within the theta wave range and can either promote or inhibit cortical excitability.Previous studies have shown that intermittent theta wave stimulation has neuroprotective effects,but the underlying mechanisms remain unclear.In this study,mice subjected to middle cerebral artery occlusion/reperfusion were treated with intermittent theta-burst stimulation.The results showed that intermittent theta-burst stimulation significantly improved neurological function and motor recovery,reduced apoptosis in the peri-infarct region,and activated the PI3K/AKT/GSK3β/β-catenin signaling pathway.Additionally,intermittent theta-burst stimulation suppressed inflammation through the PI3K/AKT/GSK3βand NF-κB pathways.Notably,intermittent theta-burst stimulation strengthened A2 astrocyte-blood vessel coupling,and the effects of intermittent theta-burst stimulation were reversed by the PI3K inhibitor LY294002.These findings demonstrate that intermittent theta-burst stimulation promotes neurovascular unit remodeling and improves neurological outcomes by modulating microglia and astrocytes via the PI3K/AKT/GSK3βand NF-κB signaling pathways.展开更多
BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chin...BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.展开更多
Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord inj...Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord injury mainly relies on pharmacological and surgical interventions;however,significant challenges remain in the protection and repair of neural tissues.Autophagy,an intracellular process responsible for the degradation and recycling of macromolecular components,plays a vital role in spinal cord injury,alleviating the severity of injury by inhibiting cell apoptosis and inflammatory responses.In this review,we provide an overview of the physiological mechanisms underlying autophagy and spinal cord injury and detail the crosstalk between autophagy and other modes of cell death in spinal cord injury.In addition,we discuss the potential of targeting autophagy as a therapeutic strategy for spinal cord injury through approaches that focus on promoting or inhibiting this process,targeting specific autophagic substrates or pathways,and combining autophagy modulation with other neuroprotective or restorative interventions.In summary,this review proposes that strict regulation of autophagy may represent a viable strategy for the treatment of spinal cord injury.展开更多
Objective: To investigate the efficacy of multidimensional protective nursing interventions in reducing occupational exposure risks to hydrofluoric acid in dental departments. Methods: The study was conducted between ...Objective: To investigate the efficacy of multidimensional protective nursing interventions in reducing occupational exposure risks to hydrofluoric acid in dental departments. Methods: The study was conducted between January 2024 and January 2025, involving 60 healthcare workers who were randomly assigned to groups. The control group (n = 30) received conventional occupational protective nursing care, while the observation group underwent multidimensional protective nursing interventions. Results: Following intervention, the observation group demonstrated significantly higher scores than the control group in knowledge of hydrofluoric acid occupational exposure, occupational exposure risk perception, and protective skill operation (p < 0.05). Emergency response capability scores and protective behavior implementation scores were also higher in the observation group (p < 0.05). Compared to the control group, the observation group exhibited higher occupational health satisfaction rates and lower occupational exposure incidence rates (p < 0.05). Conclusion: Multidimensional protective nursing interventions effectively enhance dental healthcare personnel’s awareness and protective capabilities regarding hydrofluoric acid occupational exposure, improve compliance with protective measures, and significantly reduce occupational exposure risks. This approach warrants promotion and application in occupational protective nursing interventions within dental departments.展开更多
Tourism’s link to the Sustainable Development Goals has been a continuing emphasis,adding momentum to longstandingefforts to ensure tourism’s sustainability.Tourism transport is one of the largest sources of anthrop...Tourism’s link to the Sustainable Development Goals has been a continuing emphasis,adding momentum to longstandingefforts to ensure tourism’s sustainability.Tourism transport is one of the largest sources of anthropogenic carbonemissions,driving global ecological change with profound consequences for ecosystem functioning and biodiversity.Large-scale infrastructure projects such as railway expansion are increasingly promoted for their potential to reducetourism-related carbon dioxide emissions,yet their spatial ecological impacts on regional carbon cycles and ecosystemservices remain poorly understood.This study introduces the concept of Tourism Transport Ecological Efficiency(TTEE)to assess the relationship between human infrastructure,carbon emissions,and ecological sustainability.Using panel datafrom China’s railway expansion between 2011 and 2018,the study provides spatially explicit evidence of how transportinfrastructure shapes tourism’s ecological footprint.Results show that non-Eastern regions experienced a greater increasein TTEE(8.7%)compared to Eastern regions(5.5%),highlighting regional disparities in tourism transport ecologicalsustainability.Railway density had a significant positive direct effect on TTEE,particularly pronounced in non-Easternregions.Additionally,a significant indirect effect of railway density in nearby regions was identified.These findings revealthe interconnected ecological impacts of transport systems and underscore the importance of regionally targeted railwayinvestment strategies.By bridging infrastructure development with ecological processes,this study advances understandingof how tourism transport can be aligned with global carbon reduction goals and ecosystem protection.展开更多
The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axona...The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.展开更多
文摘In an era marked by rising protectionism and geopolitical tensions,the world faces a stark choice:embrace multilateral cooperation or succumb to unilateral hegemony.The United States’punitive tariff policies have exposed the negative effect of economic coercion and isolation.Meanwhile,China’s commitment to openness,innovation,and shared prosperity offers a contrast,a testament to the enduring vitality of multilateralism and global integration.
文摘Europe’s shift toward selective protectionism,particularly targeting China,undermines its commitment to free trade,threatens its industrial competitiveness,and ultimately jeopardizes European prosperity.
文摘There is a deep historical foundation of economic protectionism in Europe, which runs through its capitalist development and regional integration process. Over the past two years, the EU's economic protectionism has risen again. Both its official statements and policies show some new trends and characteristics. The basic cause of these latest trends is the relative decline in the overall strength of the EU, especially in regard to the ongoing impact of the financial and debt crisis on its economic, political and social fields. In general, the EU is likely to become more radical in its foreign economic relations, but its protectionism will not solve the fundamental problems it faces. China and Europe still need to further strengthen risk control and management in their economic and trade relations.
基金funded by the National Social Sciences Fund (NSSF) project “Study on U.S. Mercantilist Tradition and New Forms of Mercantilism (Approval No. 17BJL021)”
文摘During its rise as a world power, the United States(U.S.) adopted a traditional form of mercantilism, and most US politicians followed a protectionist approach. From the end of the Civil War to the eve of World War I, the United States blazed a new trail of industrial development and implemented protective policies such as high tariffs. This historical tradition has had a profound influence on some current US politicians. After the collapse of the Bretton Woods system, the United States developed a new form of mercantilism, as manifested in the emergence of nontariff barriers instead of tariff barriers to restrict imports and protect domestic industries and employment. Although export regulations have avoided affecting the technology industry, they have led to hefty trade deficits for the United States. National interests have prevailed in U.S. decision-making and have influenced its choices to accede to or walk away from international organizations or treaties. The dollar's hegemony has played a pivotal role in U.S. economic policymaking. These factors have led to the twin deficits in the U.S. economy, i.e. a trade deficit and a fiscal deficit. The real intention of the United States in waging a trade war against China is to maintain and even strengthen the dollar's hegemony and the U.S.' international predominance.
文摘"Samuelson's Concern" and "Kindleberger Trap" are cited as justifications for trade protectionism under the Trump administration. After reviewing Samuelson's and Kindleberger's trade theories, this paper finds that both Samuelson and Kindleberger are actually proponents of free trade, and that their common concern is falling US competitiveness due to its economic model, domestic institutional rules, and unilateralism. Both the "Samuelson's Concern" and "Kindleberger Trap" are distortions of Samuelson's and Kindleberger's original theories and the arguments' defense of protectionism cannot overcome the challenges confronting the U.S. and will destabilize international economic order.
文摘Both COFCO and SINOCHEM participate in trading business with Australian enterprises,such as the import of barley,wheat,diary and meat products,or chemical products and coal.Free trade has always been the foundation of Sino-Australia relations.In the B20 trade and investment working group discussion,I want to emphasize the
文摘With the textile export to EU growing at a pace faster than anticipated, the joint efforts to slow down Chinese shipment to this market in a predetermined arrangement known as "bilateral check" seem to be abortive, more and more producers there seem to grow out of their patience with EU’s past deal with China. A new wave of trade protectionism is coming on the surge…
文摘Shipbuilding is among the latest industries scheduled for protectionist measures in the U.S.,with the Office of the U.S.Trade Representative(USTR)holding hearings from March 24 to 26 to discuss newly proposed actions targeting China.The proposed actions include the imposition of substantial port fees on Chinese vessel operators,non-Chinese operators of China-built vessels,and operators who have placed orders for China-built vessels.
文摘The world economy is now in a period of indepth adjustment.The intensification of geopolitical conflicts,a rise of trade protectionism,and reconfiguration of global supply chains have prompted all countries to re-examine their openness to trade amid rising uncertainties.Against this backdrop,China’s continuing commitment to promoting higherlevel opening up and building the Hainan Free Trade Port(Hainan FTP)has distinct contemporary significance and strategic value.
文摘Against a backdrop of rising global trade protectionism and accelerated restructuring of international industrial and supply chains,regional institutional cooperation is becoming a key force in stabilizing cross-border trade and investment.The ASEAN region enjoys strong economic growth momentum with a distinct demographic advantage while China boasts a complete industrial system and manufacturing capacity.
文摘Topical Issues for the Future of Radiation Protection Kevin Nelson1, Renate Czarwinski2, Charles Wilson3, Bernard LeGuen4, Jing Chen5, Hildegarde Annie Vandenhove6, Shengli Niu7, Thierry Schneider8, John Damilakis9,10 and Peter Alfred Bryant11,12(1.Mayo Clinic, Scottsdale, AZ 85259.
文摘Evaluating Adherence to Safety Standards for Physical Space Design, Equipment, and Patient and Staff Protection in Magnetic Resonance Imaging Centers:A Descriptive Cross-sectional Study Amirreza Sadeghinasab1, Jafar Fatahiasl2, Mahmoud Mohammadi-Sadr1, Masoud Heydari Kahkesh3, and Marziyeh Tahmasbi2(1.Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran;2.Department of Radiologic Technology, School of Allied Medical Sciences, Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, Iran;3.Department of Radiology and Radiotherapy, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran)Abstract:Magnetic resonance imaging(MRI) has revolutionized disease diagnosis and treatment.However, the technology poses safety risks, such as exposure to magnetic fields, RF pulses, and cryogens, necessitating strict adherence to safety protocols to protect patients and healthcare workers.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
基金supported by the National Key R&D Program of China,Nos.2021ZD0202805(to XX),2019YFA0709504(to XX)the National Natural Science Foundation of China,Nos.82172544(to YW),32471083(to XX),81972140(to JW),82272604(to HX),82102491(to SC)+1 种基金the Brain Science and Brain-Like Research Project of Shanghai Sixth People’s Hospital,No.ynnkxyb202410(to JZ)Shanghai Science and Technology Committee Sailing Program,No.23YF1403800(to LL).
文摘The neurovascular unit plays a critical role in maintaining brain structure,function,and homeostasis.Following ischemic stroke,dysfunction and dysregulation of this unit contribute to nerve-blood vessel uncoupling.Intermittent theta-burst stimulation is a repetitive transcranial magnetic stimulation that operates within the theta wave range and can either promote or inhibit cortical excitability.Previous studies have shown that intermittent theta wave stimulation has neuroprotective effects,but the underlying mechanisms remain unclear.In this study,mice subjected to middle cerebral artery occlusion/reperfusion were treated with intermittent theta-burst stimulation.The results showed that intermittent theta-burst stimulation significantly improved neurological function and motor recovery,reduced apoptosis in the peri-infarct region,and activated the PI3K/AKT/GSK3β/β-catenin signaling pathway.Additionally,intermittent theta-burst stimulation suppressed inflammation through the PI3K/AKT/GSK3βand NF-κB pathways.Notably,intermittent theta-burst stimulation strengthened A2 astrocyte-blood vessel coupling,and the effects of intermittent theta-burst stimulation were reversed by the PI3K inhibitor LY294002.These findings demonstrate that intermittent theta-burst stimulation promotes neurovascular unit remodeling and improves neurological outcomes by modulating microglia and astrocytes via the PI3K/AKT/GSK3βand NF-κB signaling pathways.
基金Supported by the Special Project for Supporting the Development of Biomedicine and Health Industry in Hangzhou City,No.2022WJC123Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project,No.2022ZA143.
文摘BACKGROUND Long-term antipsychotic therapy in psychiatric patients carries significant cardiovascular risks,including QT interval prolongation,myocardial injury,and functional impairment.Guanxinning,a traditional Chinese medicine formulation,has demonstrated cardioprotective potential in preclinical studies,but clinical evidence in this population remains limited.AIM To evaluate the cardioprotective effects of Guanxinning against antipsychotic-induced cardiac injury in long-term hospitalized psychiatric patients.METHODS A randomized,double-blind,placebo-controlled trial was conducted with 120 psychiatric inpatients receiving chronic antipsychotic therapy.Participants were allocated to:Intervention group:Conventional antipsychotics+Guanxinning tablets(0.38 g×4 tablets,ter in die);Control group:Conventional antipsychotics+identical placebo;Cardiac assessments at baseline and 12 months included:Electrocardiography(corrected QT interval),echocardiography(left ventricular ejection fraction,left ventricular end-diastolic diameter),serum biomarkers(cardiac troponin I,B-type natriuretic peptide,superoxide dismutase,malondialdehyde,high-sensitivity C-reactive protein).RESULTS Compared to controls,the Guanxinning group showed:Electrophysiological improvement:Corrected QT shortening(438±25 milliseconds vs 465±30 milliseconds,P<0.01).Functional enhancement:Left ventricular ejection fraction increase(58.5%±5.2%vs 53.8%±4.8%,P<0.05),left ventricular end-diastolic diameter reduction(49.8±3.5 mm vs 52.6±3.8 mm,P<0.05),Biochemical modulation:Reduced myocardial injury markers(cardiac troponin I:0.009 ng/mL vs 0.014 ng/mL;B-type natriuretic peptide:52 pg/mL vs 78 pg/mL,P<0.001),improved oxidative stress(superoxide dismutase:↑13.3 U/mL;malondialdehyde:↓0.9 nmol/mL,P<0.001),attenuated inflammation(high-sensitivity C-reactive protein:2.0 mg/L vs 3.2 mg/L,P<0.001).CONCLUSION Guanxinning significantly mitigates antipsychotic-induced cardiac injury in psychiatric patients,demonstrating:Normalization of electrophysiological parameters,Preservation of systolic/diastolic function,suppression of oxidative stress and inflammation.These findings support its clinical application as an adjunctive cardioprotective therapy,potentially through inhibition of myocardial apoptosis and antioxidant upregulation.
基金funded by the National Natural Science Foundation of China,No.82271395(to GL),the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030073(to GL)the grants from University of Macao Research Committee,China,No.MYRG2022-00074-ICMS(to CTV)Guangzhou Science and Technology Program Project,No.2025A04J4740(to GL).
文摘Spinal cord injury is a neurological disorder resulting from trauma,typically affecting sensory and motor function at the injury site,even leading to paralysis and internal dysfunction.The treatment of spinal cord injury mainly relies on pharmacological and surgical interventions;however,significant challenges remain in the protection and repair of neural tissues.Autophagy,an intracellular process responsible for the degradation and recycling of macromolecular components,plays a vital role in spinal cord injury,alleviating the severity of injury by inhibiting cell apoptosis and inflammatory responses.In this review,we provide an overview of the physiological mechanisms underlying autophagy and spinal cord injury and detail the crosstalk between autophagy and other modes of cell death in spinal cord injury.In addition,we discuss the potential of targeting autophagy as a therapeutic strategy for spinal cord injury through approaches that focus on promoting or inhibiting this process,targeting specific autophagic substrates or pathways,and combining autophagy modulation with other neuroprotective or restorative interventions.In summary,this review proposes that strict regulation of autophagy may represent a viable strategy for the treatment of spinal cord injury.
基金Construction of Standardized Protective Nursing Plan for Hydrofluoric Acid Operations in Dentistry and Research on Injury Prevention Effects(Project No.:FZ2025101)。
文摘Objective: To investigate the efficacy of multidimensional protective nursing interventions in reducing occupational exposure risks to hydrofluoric acid in dental departments. Methods: The study was conducted between January 2024 and January 2025, involving 60 healthcare workers who were randomly assigned to groups. The control group (n = 30) received conventional occupational protective nursing care, while the observation group underwent multidimensional protective nursing interventions. Results: Following intervention, the observation group demonstrated significantly higher scores than the control group in knowledge of hydrofluoric acid occupational exposure, occupational exposure risk perception, and protective skill operation (p < 0.05). Emergency response capability scores and protective behavior implementation scores were also higher in the observation group (p < 0.05). Compared to the control group, the observation group exhibited higher occupational health satisfaction rates and lower occupational exposure incidence rates (p < 0.05). Conclusion: Multidimensional protective nursing interventions effectively enhance dental healthcare personnel’s awareness and protective capabilities regarding hydrofluoric acid occupational exposure, improve compliance with protective measures, and significantly reduce occupational exposure risks. This approach warrants promotion and application in occupational protective nursing interventions within dental departments.
文摘Tourism’s link to the Sustainable Development Goals has been a continuing emphasis,adding momentum to longstandingefforts to ensure tourism’s sustainability.Tourism transport is one of the largest sources of anthropogenic carbonemissions,driving global ecological change with profound consequences for ecosystem functioning and biodiversity.Large-scale infrastructure projects such as railway expansion are increasingly promoted for their potential to reducetourism-related carbon dioxide emissions,yet their spatial ecological impacts on regional carbon cycles and ecosystemservices remain poorly understood.This study introduces the concept of Tourism Transport Ecological Efficiency(TTEE)to assess the relationship between human infrastructure,carbon emissions,and ecological sustainability.Using panel datafrom China’s railway expansion between 2011 and 2018,the study provides spatially explicit evidence of how transportinfrastructure shapes tourism’s ecological footprint.Results show that non-Eastern regions experienced a greater increasein TTEE(8.7%)compared to Eastern regions(5.5%),highlighting regional disparities in tourism transport ecologicalsustainability.Railway density had a significant positive direct effect on TTEE,particularly pronounced in non-Easternregions.Additionally,a significant indirect effect of railway density in nearby regions was identified.These findings revealthe interconnected ecological impacts of transport systems and underscore the importance of regionally targeted railwayinvestment strategies.By bridging infrastructure development with ecological processes,this study advances understandingof how tourism transport can be aligned with global carbon reduction goals and ecosystem protection.
基金supported by NIH(R01 NS094402 and R21 EY029386)Shriners Children’s(#85190 PHI and#87400 PHI)by BrightFocus Foundation(G2019267)(to GMT).
文摘The field of neurodegeneration research has long been focused on finding therapeutic strategies to effectively decrease or halt neuronal loss while minimizing side effects.A recent study titled“Inhibiting acute,axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition”(Zhang et al.,2025),describes an innovative approach to achieve this goal.The authors target a specific post-translational modification of dual leucine-zipper kinase(DLK),palmitoylation,to selectively inhibit DLK-dependent pro-degenerative signaling and protect neurons,thereby revealing a new way to intervene and block neurodegeneration.This Perspective aims to explore the significance of these findings and propose directions for future research.
