Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primaril...Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.展开更多
Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is...Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is an introduction to the 2024 global exploration trends and prospects for lithium,cobalt,and nickel battery metals.展开更多
The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helpi...The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.展开更多
Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compar...Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compared with conventional radiotherapy(CONV-RT)]in an extremely short time.This novel irradiation technique shows a protective effect on normal tissues,also known as the flash effect.At the same time,FLASH-RT is comparable to CONV-RT in terms of tumorkilling efficacy.As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage,clinical trials of FLASH-RT have been gradually conducted worldwide.This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.展开更多
This study focuses on the Gynostemma pentaphyllum industry in Pingli County, Shaanxi Province. Through literature analysis and data statistics, it systematically reviews the current status of cultivation, processing, ...This study focuses on the Gynostemma pentaphyllum industry in Pingli County, Shaanxi Province. Through literature analysis and data statistics, it systematically reviews the current status of cultivation, processing, sales, and research & development of G. pentaphyllum , identifies core industrial development issues, and proposes sustainable development strategies based on policy, market, and technological trends. The research reveals that Pingli County has established a large-scale cultivation and primary processing system for G. pentaphyllum , but faces challenges including insufficient development of high value-added products and weak brand influence. Future industrial upgrading should be achieved through technological innovation, brand building, and industrial chain extension.展开更多
Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affecte...Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.展开更多
Competition in science and technology is the core of the national game in the new era.The construction of science and technology education,as an important force to promote national strategic scientific and technologic...Competition in science and technology is the core of the national game in the new era.The construction of science and technology education,as an important force to promote national strategic scientific and technological power,is highly valued by all countries.Three developed countries in science and technology,the United States,Japan,and the United Kingdom,are the main research objects for analyzing their science and technology education.Domestic research on science and technology education mainly focuses on the theoretical and practical research of science and technology education activities.In the future,it is necessary to learn from the experience of foreign countries in the development of science and technology education,explore the localization of science and technology education activities,strengthen the top-level design of science and technology education,and highlight the strategic transformation of the trinity of“education,science and technology,and talents.”展开更多
All-perovskite tandem solar cells(TSCs)consist of a wide-bandgap(WBG,1.75-1.8 eV)top subcell and a low-bandgap(LBG,1.2-1.3 eV)bottom subcell,exhibit superior power conversion efficiencies(PCEs)compared to single-junct...All-perovskite tandem solar cells(TSCs)consist of a wide-bandgap(WBG,1.75-1.8 eV)top subcell and a low-bandgap(LBG,1.2-1.3 eV)bottom subcell,exhibit superior power conversion efficiencies(PCEs)compared to single-junction perovskite solar cells(PSCs).In addition,the advantages of lowtemperature solution preparation and low manufactu ring cost make the all-perovskite tandem solar cells widely concerned,and are considered to be one of the most potential next-generation high-performance thin film photovoltaic technologies.In this perspective,we briefly summarize the state-of-the-art advances in monolithic all-perovskite TSCs focusing on the following aspects:LBG perovskite bottom subcells,WBG perovskite top subcells,and interconnecting layers(ICLs).We then discuss the primary strategies to improve their performa nce and finally highlight the perspective regarding the achievement of efficient and stable all-perovskite tandems.展开更多
Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations ...Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic pathways.However,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable insights.EVs are membrane-bound particles secreted by all cells,mediating cell-to-cell communication.They contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other cells.Notably,EVs are increasingly recognized as regulators in the resistance to anti-cancer drugs.This review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even radiotherapy.Detecting Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug resistance.Additionally,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug resistance.We highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV subpopulations.These efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.展开更多
Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrati...Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrating deep learning techniques,such as Fully Connected Neural Networks(FCNNs)and Convolutional Neural Networks(CNNs),into geoengineering tasks,particularly in disaster prediction,resource exploration,and infrastructure health monitoring.The complexities of applying deep learning in geoengineering are multifaceted,involving mathematical,computational,and data processing challenges.However,the emergence of deep learning libraries,notably TensorFlow,has substantially lowered the technical barriers,enabling researchers and engineers to deploy these technologies more efficiently.Through case studies and practical examples,this paper demonstrates how TensorFlow can streamline the model development process,making deep learning more accessible to a broader audience in the field of geoengineering.The paper concludes with a discussion on the future prospects and potential advancements in the integration of deep learning within geoengineering,highlighting both the opportunities and the ongoing challenges.展开更多
Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery ...Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.展开更多
Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation ph...Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation phase.In order to explore people's cognitive process of building energy-saving information,this paper focuses on the representativeness of the research on building energy-saving reminder information.The results are summarized,sorted out and analyzed.Based on relevant research at home and abroad,this paper reviews the conceptual connotation of building energy-saving reminder information,research methods and influencing factors on the recognition of building energy-saving reminder information.Finally,it summarizes the research landscape of the cognitive process of building energy-saving reminder information and analyzes the existing research.In light of the shortcomings,three major research directions are proposed in the future:integrating research scenarios and focusing on the interaction of multiple scenarios in the Chinese cultural environment;broadening research methods to explore the diversity and feasibility of emerging research methods;increasing the time span and improving experimental design dynamic and continuous.展开更多
Deep natural gas is an important field and direction for oil and gas exploration and development in the Banqiao depression.The geochemical characteristics of the Paleogene Shahejie Formation source rocks in the Banqia...Deep natural gas is an important field and direction for oil and gas exploration and development in the Banqiao depression.The geochemical characteristics of the Paleogene Shahejie Formation source rocks in the Banqiao Sag were investigated based on pyrolysis,Total Organic Carbon(TOC),chloroform bitumen A,vitrinite reflectance,saturated hydrocarbon gas chromatographyemass spectrometry,and maceral determination.The results showed that the Es_(3) source rocks of the Paleogene Shahejie Formation were generally of better quality than the Es_(1) source rocks.Regarding the Es_(1) source rocks,the abundance of organic matter was variable,with mixed types and low maturity.The source rocks were formed in a saline-water reductive environment.Regarding the Es_(3) source rocks,the abundance of organic matter was relatively high,meaning that they were of mediumehigh quality,with mixed types of,yet highly mature,organic matter.The hydrocarbon generation environment was oxidative,and the source rocks were mainly deposited in fresh water with localized salinization.The main hydrocarbon-generating components of organic matter in the Shahejie Formation were amorphous humic components formed by intensive microbial modification of lower planktonic algae and terrestrial higher plants.Aquatic organisms were the main sources of organic matter,with localized mixing of higher-plant organic matter.The organic matter derived from these higher plant debris sources provided beneficial conditions for the generation of natural gas.At present,the Shasan source rock is at the peak of hydrocarbon generation.Under deep conditions,the maturity of organic matter increases,and organic matter rich in terrestrial higher plants can make a significant contribution to the generation of natural gas,especially shale gas.展开更多
The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countrie...The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countries since it was proposed by the Chinese President in 2013.This paper explores the economic cooperation modes among countries along the Silk Road Economic Belt,analyzing its cooperation mechanisms,current development status,and future prospects.By examining the diversity and complexity of economic cooperation in this region,the paper highlights both its potential and challenges,providing theoretical support for advancing regional collaboration and achieving shared prosperity.展开更多
In recent years,the nursing technology of traditional Chinese medicine(TCM)has developed rapidly in the country.TCM nursing technology mainly refers to the application of TCM therapy in clinical nursing practice,such ...In recent years,the nursing technology of traditional Chinese medicine(TCM)has developed rapidly in the country.TCM nursing technology mainly refers to the application of TCM therapy in clinical nursing practice,such as acupoint massage,cupping,ear point pressure beans,scraping,wet compress of traditional Chinese medicine,etc.Its application can not only effectively reduce the pain of patients,but also can promote the treatment effect,help patients recover early,but also help to further improve the quality of service of nursing staff.In clinical nursing practice,however,the application of TCM nursing technology still has some problems,such as the theory of traditional Chinese medicine nursing quality to promote,“Internet+TCM nursing”is still in the exploratory stage,etc.This article mainly discusses the application status and existing problems of Chinese medicine nursing technique,coping strategies and its future prospects for related analysis and research,hope to be able to improve the quality of TCM nursing technology application in China to provide some reference and reference.展开更多
China is tectonically composed of a series of plates and orogenic belts and has been influenced by the Pacific and Indian plates since the Late Paleozoic,forming a regular distribution of Mesozoic and Cenozoic granite...China is tectonically composed of a series of plates and orogenic belts and has been influenced by the Pacific and Indian plates since the Late Paleozoic,forming a regular distribution of Mesozoic and Cenozoic granites.As an important source of geothermal energy,granite is thefive elements of geothermal enrichment:geothermal sources;geothermal reservoirs;heat transmission;heat caprock;and heat preservation and it is possible to classify the types of geothermal resources in China according to their distribution in combination with neotectonic movements.China's geothermal energy can be divided into hydrothermal and hot dry rock types in basins and orogenic belts,respectively.Geothermal resources can be divided into hydrothermal,rock,magma,and hybrid geothermal types according to the heat carrier type.Basin geothermal resources are dominated by hydrothermal types,while geothermal energy in orogenic belts with granite includes both hydrothermal and hot dry rock types.Geothermal resources in China can be divided into 6 distinct geothermal regions and 13 subregions,of which the Southwest and Southeast China regions and the Qaidam-Qilian and Jiaoliao subregions in North China with Mesozoic and Cenozoic granites are the most favorable areas for high-temperature hydrothermal and hot dry rock sources.China has complex geological conditions,diverse types of geothermal resources,and broad prospects for development and utilization.Having performed extensive shallow hydrothermal geothermal development and utilization and completed various power generation tests,China's geothermal development and utilization is in a critical stage of transition from the direct utilization of shallow hydrothermal resources to high-temperature geothermal or hot dry rock power generation in middle and deep layers.Basic theoretical research,key technology breakthroughs,and policy incentives are the main issues that need to be addressed in the geothermal industry.展开更多
Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived ...Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.展开更多
Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives...Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives, migration of China＇s agricultural labor will slow and large-scale operation of farmland will accelerate. Although grain supply and demand have maintained a tight balance, new potentials still exist in improving grain production. Under the pressures of resource and environmental constraints, advancing the green and efficient transition of agriculture will become a new trend in China＇s agricultural development. In this context, the treatment of agricultural pollution, supply-side structural reform and innovation of agricultural subsidy policy are of strategic significance to the transition and upgrade of China＇s agriculture.展开更多
Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely appli...Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely applied in the field of geotechnical engineering.This paper systematically reviews the theoretical development of DDA,including the basic framework for solving two-dimensional and three-dimensional problems,improvements in contact detection algorithms,coupling with other numerical methods,and high-performance computing.In addition,the application of DDA in engineering problems such as wave propagation,rock blasting,slope instability,underground structures,and hydraulic structures is discussed in detail,demonstrating its wide applicability in solving complex geological and engineering problems.In the future,DDA deeply integrated with artificial intelligence(AI)may enhance its performance in simulation accuracy,computational efficiency,and engineering applications.Automated modelling,non-parametric simulation,and physical-numerical fusion in AI-based DDA may become new research directions.展开更多
The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoi...The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoirs trapped by favorable geological structures, identifiable through geophysical and seismic methods. The methodological approach is based on a combined analysis of studies and seismic data. Drilling data from well PA, including well logs and end-of-well reports, were used to characterize the lithological formations encountered, particularly those of the Albian. 3D seismic profiles were interpreted to identify structures conducive to hydrocarbon accumulation. Isochrone, isovelocity, and isobath maps were developed to refine the interpretation. Sedimentological analyses revealed five sandy/gritty levels between 2610 m and 3100 m, interspersed with clay, limestone, and siltstone beds. The seismic profiles highlighted two main prospects. These prospects exhibit favorable geological structures, including normal faults and structural traps that provide oil traps.展开更多
基金supported by the Higher Institution Centre of Excellence(HICoE)program(MO002-2019&TIDREC-2023)funded by the Bernhard Nocht Institute for Tropical Medicine,Hamburg,Germany[100-TNCPI/INT 16/6/2(005/2020)].
文摘Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.
文摘Exploration budgets for primary battery metals-nickel,lithium and cobalt-tempered in 2024 at$1.697 billion,reflecting a marginal 0.4%decline and a virtually flat annual total,compared to$1.704 billion in 2023.Below is an introduction to the 2024 global exploration trends and prospects for lithium,cobalt,and nickel battery metals.
文摘The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.
文摘Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compared with conventional radiotherapy(CONV-RT)]in an extremely short time.This novel irradiation technique shows a protective effect on normal tissues,also known as the flash effect.At the same time,FLASH-RT is comparable to CONV-RT in terms of tumorkilling efficacy.As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage,clinical trials of FLASH-RT have been gradually conducted worldwide.This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.
基金Supported by National College Students Innovation and Entrepreneurship Training Program(202314390006)National College Students Innovation and Entrepreneurship Training Program(202414390005)Teaching Reform Project of Shaanxi Xueqian Normal University(25JG018Y).
文摘This study focuses on the Gynostemma pentaphyllum industry in Pingli County, Shaanxi Province. Through literature analysis and data statistics, it systematically reviews the current status of cultivation, processing, sales, and research & development of G. pentaphyllum , identifies core industrial development issues, and proposes sustainable development strategies based on policy, market, and technological trends. The research reveals that Pingli County has established a large-scale cultivation and primary processing system for G. pentaphyllum , but faces challenges including insufficient development of high value-added products and weak brand influence. Future industrial upgrading should be achieved through technological innovation, brand building, and industrial chain extension.
文摘Periprosthetic fracture of femur is a common and complex complication after joint replacement. With the increase of operation volume, its incidence is increasing year by year. The treatment of this fracture is affected by many factors, including fracture type, prosthesis stability, patient age and comorbidities, and individualized treatment strategy is needed. In recent years, the internal fixation technology and prosthetic revision technology have made significant progress in surgical treatment, such as locking steel plate, titanium cable and bridge combined internal fixation system and other new technologies have effectively improved the treatment effect. In addition, the application of new materials and 3D printing technology, as well as the optimization of multidisciplinary cooperation mode, also provide new ideas for the treatment of complex fractures. However, there are still some problems such as inaccurate diagnosis, difficult choice of treatment options and high incidence of postoperative complications. In the future, technological innovation, the introduction of artificial intelligence and big data, and the further development of personalized treatment will bring more possibilities to improve the prognosis and quality of life of patients. This study summarizes the relevant research results and prospects the future development direction, providing references for clinical practice and subsequent research.
文摘Competition in science and technology is the core of the national game in the new era.The construction of science and technology education,as an important force to promote national strategic scientific and technological power,is highly valued by all countries.Three developed countries in science and technology,the United States,Japan,and the United Kingdom,are the main research objects for analyzing their science and technology education.Domestic research on science and technology education mainly focuses on the theoretical and practical research of science and technology education activities.In the future,it is necessary to learn from the experience of foreign countries in the development of science and technology education,explore the localization of science and technology education activities,strengthen the top-level design of science and technology education,and highlight the strategic transformation of the trinity of“education,science and technology,and talents.”
基金financially supported by the National Key R&D Program of China(no.2022YFB4200303)the National Natural Science Foundation of China(no.62174112)+2 种基金the Engineering Featured Team Fund of Sichuan University(no.2020SCUNG102)the Technical Application-Oriented Research Projects for Liaoning Provincial College of Communications(no.xyfzx202305)the Basic Research Projects for the Educational Department of Liaoning Province(LJ212411500014)。
文摘All-perovskite tandem solar cells(TSCs)consist of a wide-bandgap(WBG,1.75-1.8 eV)top subcell and a low-bandgap(LBG,1.2-1.3 eV)bottom subcell,exhibit superior power conversion efficiencies(PCEs)compared to single-junction perovskite solar cells(PSCs).In addition,the advantages of lowtemperature solution preparation and low manufactu ring cost make the all-perovskite tandem solar cells widely concerned,and are considered to be one of the most potential next-generation high-performance thin film photovoltaic technologies.In this perspective,we briefly summarize the state-of-the-art advances in monolithic all-perovskite TSCs focusing on the following aspects:LBG perovskite bottom subcells,WBG perovskite top subcells,and interconnecting layers(ICLs).We then discuss the primary strategies to improve their performa nce and finally highlight the perspective regarding the achievement of efficient and stable all-perovskite tandems.
基金supported by the National Natural Science Foundation of China(Grant No.:82341023)the Interdisciplinary Research Project of School of Stomatology,Wuhan University,China(Grant No.:XNJC202305)+1 种基金the Innovative Research Team of Highlevel Local Universities in Shanghai,China(Grant No.:SHSMUZLCX20212300)Planning Project of Innovation and Entrepreneurship Training of National Undergraduate of Wuhan University,China(Grant No.:202310486122).
文摘Drug resistance presents a significant challenge to achieving positive clinical outcomes in anti-tumor therapy.Prior research has illuminated reasons behind drug resistance,including increased drug efflux,alterations in drug targets,and abnormal activation of oncogenic pathways.However,there's a need for deeper investigation into the impact of drug-resistant cells on parental tumor cells and intricate crosstalk between tumor cells and the malignant tumor microenvironment(TME).Recent studies on extracellular vesicles(EVs)have provided valuable insights.EVs are membrane-bound particles secreted by all cells,mediating cell-to-cell communication.They contain functional cargoes like DNA,RNA,lipids,proteins,and metabolites from mother cells,delivered to other cells.Notably,EVs are increasingly recognized as regulators in the resistance to anti-cancer drugs.This review aims to summarize the mechanisms of EV-mediated anti-tumor drug resistance,covering therapeutic approaches like chemo-therapy,targeted therapy,immunotherapy and even radiotherapy.Detecting Ev-based biomarkers to predict drug resistance assists in bypassing anti-tumor drug resistance.Additionally,targeted inhibition of EV biogenesis and secretion emerges as a promising approach to counter drug resistance.We highlight the importance of conducting in-depth mechanistic research on EVs,their cargoes,and functional ap-proaches specifically focusing on EV subpopulations.These efforts will significantly advance the devel-opment of strategies to overcome drug resistance in anti-tumor therapy.
基金supported by National High-level Innovative Talents Scientific Research Project in Hebei Province,China(Grant No.405492).
文摘Deep learning,a pivotal technology within artificial intelligence,has made significant strides across various domains,including geoengineering.This paper explores the practical applications and challenges of integrating deep learning techniques,such as Fully Connected Neural Networks(FCNNs)and Convolutional Neural Networks(CNNs),into geoengineering tasks,particularly in disaster prediction,resource exploration,and infrastructure health monitoring.The complexities of applying deep learning in geoengineering are multifaceted,involving mathematical,computational,and data processing challenges.However,the emergence of deep learning libraries,notably TensorFlow,has substantially lowered the technical barriers,enabling researchers and engineers to deploy these technologies more efficiently.Through case studies and practical examples,this paper demonstrates how TensorFlow can streamline the model development process,making deep learning more accessible to a broader audience in the field of geoengineering.The paper concludes with a discussion on the future prospects and potential advancements in the integration of deep learning within geoengineering,highlighting both the opportunities and the ongoing challenges.
文摘Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.
基金supported by National Natural Science Foundation of China(Grant No.71872122).
文摘Traditional building energy-saving research focuses on technical energy-saving and energy system energy-saving,while neglecting the study of personnel's energy-consumption behavior during the building operation phase.In order to explore people's cognitive process of building energy-saving information,this paper focuses on the representativeness of the research on building energy-saving reminder information.The results are summarized,sorted out and analyzed.Based on relevant research at home and abroad,this paper reviews the conceptual connotation of building energy-saving reminder information,research methods and influencing factors on the recognition of building energy-saving reminder information.Finally,it summarizes the research landscape of the cognitive process of building energy-saving reminder information and analyzes the existing research.In light of the shortcomings,three major research directions are proposed in the future:integrating research scenarios and focusing on the interaction of multiple scenarios in the Chinese cultural environment;broadening research methods to explore the diversity and feasibility of emerging research methods;increasing the time span and improving experimental design dynamic and continuous.
基金supported by the National Natural Science Foundation of China(Grant Nos.U20A2093).
文摘Deep natural gas is an important field and direction for oil and gas exploration and development in the Banqiao depression.The geochemical characteristics of the Paleogene Shahejie Formation source rocks in the Banqiao Sag were investigated based on pyrolysis,Total Organic Carbon(TOC),chloroform bitumen A,vitrinite reflectance,saturated hydrocarbon gas chromatographyemass spectrometry,and maceral determination.The results showed that the Es_(3) source rocks of the Paleogene Shahejie Formation were generally of better quality than the Es_(1) source rocks.Regarding the Es_(1) source rocks,the abundance of organic matter was variable,with mixed types and low maturity.The source rocks were formed in a saline-water reductive environment.Regarding the Es_(3) source rocks,the abundance of organic matter was relatively high,meaning that they were of mediumehigh quality,with mixed types of,yet highly mature,organic matter.The hydrocarbon generation environment was oxidative,and the source rocks were mainly deposited in fresh water with localized salinization.The main hydrocarbon-generating components of organic matter in the Shahejie Formation were amorphous humic components formed by intensive microbial modification of lower planktonic algae and terrestrial higher plants.Aquatic organisms were the main sources of organic matter,with localized mixing of higher-plant organic matter.The organic matter derived from these higher plant debris sources provided beneficial conditions for the generation of natural gas.At present,the Shasan source rock is at the peak of hydrocarbon generation.Under deep conditions,the maturity of organic matter increases,and organic matter rich in terrestrial higher plants can make a significant contribution to the generation of natural gas,especially shale gas.
文摘The Silk Road Economic Belt,as a major initiative for global economic cooperation in the 21st century,has evolved into a critical economic cooperation region linking the Eurasian continent and its neighboring countries since it was proposed by the Chinese President in 2013.This paper explores the economic cooperation modes among countries along the Silk Road Economic Belt,analyzing its cooperation mechanisms,current development status,and future prospects.By examining the diversity and complexity of economic cooperation in this region,the paper highlights both its potential and challenges,providing theoretical support for advancing regional collaboration and achieving shared prosperity.
文摘In recent years,the nursing technology of traditional Chinese medicine(TCM)has developed rapidly in the country.TCM nursing technology mainly refers to the application of TCM therapy in clinical nursing practice,such as acupoint massage,cupping,ear point pressure beans,scraping,wet compress of traditional Chinese medicine,etc.Its application can not only effectively reduce the pain of patients,but also can promote the treatment effect,help patients recover early,but also help to further improve the quality of service of nursing staff.In clinical nursing practice,however,the application of TCM nursing technology still has some problems,such as the theory of traditional Chinese medicine nursing quality to promote,“Internet+TCM nursing”is still in the exploratory stage,etc.This article mainly discusses the application status and existing problems of Chinese medicine nursing technique,coping strategies and its future prospects for related analysis and research,hope to be able to improve the quality of TCM nursing technology application in China to provide some reference and reference.
基金supported by the National Natural Science Foundation of China(41927801)the Major Special Project of Yunnan Province(202302AF080001)the Key Research and Development Program of Yunnan Province(202303AA080006).
文摘China is tectonically composed of a series of plates and orogenic belts and has been influenced by the Pacific and Indian plates since the Late Paleozoic,forming a regular distribution of Mesozoic and Cenozoic granites.As an important source of geothermal energy,granite is thefive elements of geothermal enrichment:geothermal sources;geothermal reservoirs;heat transmission;heat caprock;and heat preservation and it is possible to classify the types of geothermal resources in China according to their distribution in combination with neotectonic movements.China's geothermal energy can be divided into hydrothermal and hot dry rock types in basins and orogenic belts,respectively.Geothermal resources can be divided into hydrothermal,rock,magma,and hybrid geothermal types according to the heat carrier type.Basin geothermal resources are dominated by hydrothermal types,while geothermal energy in orogenic belts with granite includes both hydrothermal and hot dry rock types.Geothermal resources in China can be divided into 6 distinct geothermal regions and 13 subregions,of which the Southwest and Southeast China regions and the Qaidam-Qilian and Jiaoliao subregions in North China with Mesozoic and Cenozoic granites are the most favorable areas for high-temperature hydrothermal and hot dry rock sources.China has complex geological conditions,diverse types of geothermal resources,and broad prospects for development and utilization.Having performed extensive shallow hydrothermal geothermal development and utilization and completed various power generation tests,China's geothermal development and utilization is in a critical stage of transition from the direct utilization of shallow hydrothermal resources to high-temperature geothermal or hot dry rock power generation in middle and deep layers.Basic theoretical research,key technology breakthroughs,and policy incentives are the main issues that need to be addressed in the geothermal industry.
基金Supported by the Key Research and Development Program of Sichuan Science and Technology Agency,No.2020YFS0043Natural Science Foundation of Sichuan Province of China,No.2023NSFSC1567+1 种基金Sichuan University Innovation Research Project,No.2023SCUH0033Innovation Team at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,No.2022-CXTD-05.
文摘Urine-derived stem cells(USCs)are derived from urine and harbor the potential of proliferation and multidirectional differentiation.Moreover,USCs could be reprogrammed into pluripotent stem cells[namely urine-derived induced pluripotent stem cells(UiPSCs)]through transcription factors,such as octamer binding transcription factor 4,sex determining region Y-box 2,kruppel-like factor 4,myelocytomatosis oncogene,and Nanog homeobox and protein lin-28,in which the first four are known as Yamanaka factors.Mounting evidence supports that USCs and UiPSCs possess high potential of neurogenic,myogenic,and osteogenic differentiation,indicating that they may play a crucial role in the treatment of neurological and musculoskeletal diseases.Therefore,we summarized the origin and physiological characteristics of USCs and UiPSCs and their therapeutic application in neurological and musculoskeletal disorders in this review,which not only contributes to deepen our understanding of hallmarks of USCs and UiPSCs but also provides the theoretical basis for the treatment of neurological and musculoskeletal disorders with USCs and UiPSCs.
文摘Remarkable achievements have been made in China＇s agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives, migration of China＇s agricultural labor will slow and large-scale operation of farmland will accelerate. Although grain supply and demand have maintained a tight balance, new potentials still exist in improving grain production. Under the pressures of resource and environmental constraints, advancing the green and efficient transition of agriculture will become a new trend in China＇s agricultural development. In this context, the treatment of agricultural pollution, supply-side structural reform and innovation of agricultural subsidy policy are of strategic significance to the transition and upgrade of China＇s agriculture.
文摘Since its proposal in 1985,the Discontinuous Deformation Analysis(DDA)has developed into a powerful tool for simulating the mechanical behaviour of rock masses and other discontinuous systems and has been widely applied in the field of geotechnical engineering.This paper systematically reviews the theoretical development of DDA,including the basic framework for solving two-dimensional and three-dimensional problems,improvements in contact detection algorithms,coupling with other numerical methods,and high-performance computing.In addition,the application of DDA in engineering problems such as wave propagation,rock blasting,slope instability,underground structures,and hydraulic structures is discussed in detail,demonstrating its wide applicability in solving complex geological and engineering problems.In the future,DDA deeply integrated with artificial intelligence(AI)may enhance its performance in simulation accuracy,computational efficiency,and engineering applications.Automated modelling,non-parametric simulation,and physical-numerical fusion in AI-based DDA may become new research directions.
文摘The study aims to identify Albian-age oil prospects in Block A of the San Pedro margin, Côte d’Ivoire, by conducting a detailed geological interpretation. The objective is to confirm the presence of oil reservoirs trapped by favorable geological structures, identifiable through geophysical and seismic methods. The methodological approach is based on a combined analysis of studies and seismic data. Drilling data from well PA, including well logs and end-of-well reports, were used to characterize the lithological formations encountered, particularly those of the Albian. 3D seismic profiles were interpreted to identify structures conducive to hydrocarbon accumulation. Isochrone, isovelocity, and isobath maps were developed to refine the interpretation. Sedimentological analyses revealed five sandy/gritty levels between 2610 m and 3100 m, interspersed with clay, limestone, and siltstone beds. The seismic profiles highlighted two main prospects. These prospects exhibit favorable geological structures, including normal faults and structural traps that provide oil traps.
