Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,...Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,can be an adjuvant therapy to benefit patients with ICH by improving clinical efficacy.However,in theory,using PBCRBS to treat ICH carries the risk of hematoma enlargement and rebleeding,which has led to controversy over its application in ICH treatment.To demonstrate the effectiveness and safety of PBCRBS in treating ICH,this review first analyzes the pathological and physiological basis of ICH and secondly,the cascade of response after ICH and the involvement of cytokines and signaling pathways in this process.Finally,experimental and clinical studies on the treatment of ICH with PBCRBS over the past decade were retrieved from the Pub Med and China National Knowledge Infrastructure databases,and the content of these studies was used to summarize commonly used herbs with PBCRBS effects and their mechanisms of action.Through analysis,hypertension has been identified as the most common cause of ICH.Heme,interleukin,reactive oxygen species,coagulation promoting particles and other induced mass effects,inflammation,oxidative stress,and coagulation cascade reactions lead to brain damage following ICH.This review includes 56 experimental studies and 83 clinical studies summarizing 28 commonly used herbs,demonstrating the positive impact of PBCRBS as an adjuvant therapy for ICH.In summary,PBCRBS appears effective and safe for treating ICH.展开更多
[Objectives]This study was conducted to explore the culture conditions for siderophore production and preliminarily investigate the growth-promoting effects of strains.[Methods]Endophytic bacteria secreting siderophor...[Objectives]This study was conducted to explore the culture conditions for siderophore production and preliminarily investigate the growth-promoting effects of strains.[Methods]Endophytic bacteria secreting siderophores were isolated and screened from the roots of the plant Saposhnikovia divaricata(Trucz.)Schischk.The siderophore-producing capability was confirmed through qualitative detection and gene cluster analysis.[Results]The screened endophytic bacterium PB-2 belonged to the genus Paenibacillus sp.and could produce catechol-type or carboxylate-type siderophores.When cultured in MKB medium with 15 g/L glycerol as the carbon source and 6 g/L glycine as the nitrogen source for 3 d,the strain exhibited efficient siderophore secretion.Appropriate concentrations of Fe^(3+),Co^(2+),Cu^(2+)and Al^(3+)promoted siderophore production,with 15μmol/L Fe^(3+)being the most effective.Under the combined influences of siderophores,volatile compounds and other factors,strain PB-2 altered the root morphology of mulberry seedlings and increased their biomass.The primary root length decreased by 9.15%,while the number and length of root hairs increased by 37.93%and 16.37%,respectively,and the total biomass increased by 10.26%,all showing significant differences(P<0.05).Additionally,strain PB-2 enhanced the activities of defense-related enzymes in mulberry seedling leaves.The activities of superoxide dismutase(SOD)and peroxidase(POD)increased significantly(P<0.05)by 247.27%and 189.47%,respectively,compared with the control group.The activities of phenylalanine ammonialyase(PAL)and polyphenol oxidase(PPO)also showed varying degrees of increase.[Conclusions]This study provided a theoretical basis for rational utilization of endophytic growth-promoting strains secreting siderophores in the sustainable development of agriculture.展开更多
With a global vision and a strong sense of responsibility,the CPC has been committed to promoting exchanges and mutual learning among civilizations and advancing the progress of human civilization.In March 2023,Genera...With a global vision and a strong sense of responsibility,the CPC has been committed to promoting exchanges and mutual learning among civilizations and advancing the progress of human civilization.In March 2023,General Secretary Xi Jinping put forth the Global Civilization Initiative(GCI)at the CPC in Dialogue with World Political Parties High-level Meeting,emphasizing the need to advocate the respect for the diversity of civilizations,the common values of humanity,the importance of inheritance and innovation of civilizations,and robust international people-to-people exchanges and cooperation.展开更多
Currently,talent cultivation faces numerous challenges,such as a shortage of school-enterprise tutors and a disconnection between curriculum construction and industry demands.The“promoting research through courses”m...Currently,talent cultivation faces numerous challenges,such as a shortage of school-enterprise tutors and a disconnection between curriculum construction and industry demands.The“promoting research through courses”model has emerged in response to these challenges.Its goals include training students’research capabilities,cultivating their interdisciplinary learning and application abilities,and establishing an ecological closed loop between education and research.The reform measures involve innovating curriculum design to create new,advanced,and practical courses,adopting a hierarchical and progressive classroom teaching method combined with post-class diversion guidance,and conducting online-offline integrated case-based and scenario-based teaching.The reform has achieved remarkable results.Students have enhanced their research abilities,knowledge application,and professional qualities.Schools have strengthened their discipline construction,teaching staff,and social influence.Enterprises have realized their talent reserves and technological innovations.The teaching model has integrated theory and practice,promoting the high-quality development of education and teaching,and providing a new path to solve the problems in education and industry development.展开更多
Background Health promotion(HP)interventions delivered through sports clubs have demonstrated promising outcomes among men,but less is known about which aspects of the interventions work,for whom,and under what circum...Background Health promotion(HP)interventions delivered through sports clubs have demonstrated promising outcomes among men,but less is known about which aspects of the interventions work,for whom,and under what circumstances.This rapid realist review aimed to understand the contexts,mechanisms,and outcomes of HP interventions for men delivered through sports clubs.Methods A systematic literature search was conducted in February 2023 for studies published after 2013 in MEDLINE,Embase,and SPORTDiscus databases.Included studies:(a)were delivered by or in collaboration with sports clubs,(b)targeted men aged 18+years,and(c)reported 1 or more HP outcomes.A grey literature search was also performed.Studies were included in a realist synthesis based on richness and rigor.Hereafter,context-mechanism-outcome(CMO)configurations were developed.Results We identified and screened 3358 studies,finally including 59 studies describing 22 interventions.Most HP interventions were delivered in high income countries,included Caucasian men aged 35-65 years with overweight/obesity,and used professional sports clubs(mostly football)for recruitment and facilities.Quantitative HP outcomes were reported across 19 interventions.Of these 19 interventions,the majority reported on weight(n=18),physical activity(n=12),mental health(n=10),and diet(n=9).We identified 13 CMOs related to how HP interventions affected men's recruitment,engagement,and health behavior maintenance.Conclusion Our findings show that using sports clubs for HP interventions is effective for engaging men.Recruitment was facilitated by leveraging sports clubs’identity,addressing masculinity-related barriers,improving accessibility,and building trust.Engagement was enhanced through shared identity experiences,safe spaces,inclusive competition,and self-efficacy.However,there's limited evidence on behavior maintenance post-intervention,though involving community stakeholders seemed vital.In general,considerations should be made to avoid perpetuating traditional masculine norms,which may exclude some men and reinforce unhealthy behaviors.These findings can guide intervention development,emphasizing the need to harness men's perspectives in the process.展开更多
A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency,abioticstress tolerance,and/or crop quality traits,regardless of its nutrient content.The application of Plant b...A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency,abioticstress tolerance,and/or crop quality traits,regardless of its nutrient content.The application of Plant biostimulants(PBs)in production can reduce the application of traditional pesticides and chemical fertilizers and improvethe quality and yield of crops,which is conducive to the sustainable development of agriculture.An in-depthunderstanding of the mechanism and effect of various PBs is very important for how to apply PBs reasonablyand effectively in the practice of crop production.This paper summarizes the main classification of PBs;Thegrowth promotion mechanism of PBs was analyzed from four aspects:improving soil physical and chemical properties,enhancing crop nutrient absorption capacity,photosynthesis capacity,and abiotic stress tolerance;At thesame time,the effects of PBs application on seed germination,seedling vigor,crop yield,and quality were summarized;Finally,how to continue to explore and study the use and mechanism of PBs in the future is analyzedand prospected,to better guide the application of PBs in crop production in the future.展开更多
In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus...In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.展开更多
Cu-based catalysts have been extensively used in methanol steam reforming(MSR)reactions because of their low cost and high effi ciency.ZnO is often used in commercial Cu-based catalysts as both a structural and an ele...Cu-based catalysts have been extensively used in methanol steam reforming(MSR)reactions because of their low cost and high effi ciency.ZnO is often used in commercial Cu-based catalysts as both a structural and an electronic promoter to stabilize metal Cu nanoparticles and modify metal–support interfaces.Still,the further addition of chemical promoters is essential to further enhance the MSR reaction performance of the Cu/ZnO catalyst.In this work,CeO_(2)-doped Cu/ZnO catalysts were prepared using the coprecipitation method,and the eff ects of CeO_(2)on Cu-based catalysts were systematically investigated.Doping with appropriate CeO_(2)amounts could stabilize small Cu nanoparticles through a strong interaction between CeO_(2)and Cu,leading to the formation of more Cu+–ZnO x interfacial sites.However,higher CeO_(2)contents resulted in the formation of larger Cu nanoparticles and an excess of Cu+–CeO x interfacial sites.Consequently,the Cu/5CeO_(2)/ZnO catalyst with maximal Cu–ZnO interfaces exhibited the highest H 2 production rate of 94.6 mmolH2/(gcat·h),which was 1.5 and 10.2 times higher than those of Cu/ZnO and Cu/CeO_(2),respectively.展开更多
Objective To observe the effects on the range of motion （ROM） of ankle joint and muscular spasm of the lower limbs treated with Chinese massage for promoting the Governor Vessel, benefiting the kidney and strengthen...Objective To observe the effects on the range of motion （ROM） of ankle joint and muscular spasm of the lower limbs treated with Chinese massage for promoting the Governor Vessel, benefiting the kidney and strengthening the spleen combined with music therapy in infantile cerebral palsy （CP）. Methods In 286 cases of spasmodic CP, 7 kinds of Chinese massage were adopted, named massage on acupoints to promote circulation of the Governor Vessel, massage for strengthening the spleen and benefiting qi, spine-pinching therapy, segmental massage, foot massage, massage for promoting the recovery of muscle strength and massage for promoting ROM of joints. Chinese massage was applied in musical background. Buddha music and five-element music of Chinese medicine （music of the Heart, Liver and Kidney Meridians） were optioned. The treatment was given once or twice a day and 30 days made one course. The angles of femoral adductor and dorsal flexion of foot as well as the score of composite spasticity scale （CSS） were observed before and after treatment so that the therapeutic effect was assessed. Results In 30 days of treatment, 106 cases （37. 1%） were effective markedly, 172 cases （60. 1%） effective and 8 cases （2.8%） failed. The angle of dorsal flexion of foot was （105.64± 12.66）° and （76.58± 9.89）° before and after treatment respectively; the angle of femoral adductor was （119.89±25.47）° and （158.99± 18.66）° before and after treatment respectively; the score of CSS was （12.39±2.56） and （7. 069 ± 2.97） before and after treatment respectivel, there was significant difference before and after treatment （all P〈0.01）. Conclusion Chinese massage for promoting the Governor Vessel, benefiting the kidney and strengthening the spleen combined with music therapy brings the extremely active effect into play on the recovery of sitting, kneeling, standing and walking for children with CP.展开更多
The paper first introduces the definition and classification of plant growth promoting rhizobacteria （PGPR）, then reviews the research achievements on the mechanism of action of plant growth promoting rhizobacteria,...The paper first introduces the definition and classification of plant growth promoting rhizobacteria （PGPR）, then reviews the research achievements on the mechanism of action of plant growth promoting rhizobacteria, including growth pro-moting mechanism and bio-control mechanism, subsequently lists the use of excel-lent plant growth promoting rhizobacteria strains in recent years, especial y Pseu-domonas and Bacil us strains, and final y discusses problems existing in this area and points out issues requiring further exploration, including PGPR screening meth-ods, preservation methods, mechanism of action, in order to commercialize PGPR as soon as possible and practical y realize its application to production.展开更多
This study aims to explore the role of animating Zhuang non-heritage folktales in promoting the national culture industry.Using literature research,case studies,and comparative research methods,the positive impacts ar...This study aims to explore the role of animating Zhuang non-heritage folktales in promoting the national culture industry.Using literature research,case studies,and comparative research methods,the positive impacts are analyzed in depth across four dimensions:cultural value inheritance,market demand,dissemination channels,and industrial innovation.The results show that animating Zhuang non-heritage folktales can help inherit national culture,meet market demand,broaden communication channels,and promote industrial innovation.Finally,this paper proposes corresponding policy suggestions and implementation paths to provide references for the sustainable development of the ethnic culture industry.展开更多
Graduate enrollment is crucial for improving the quality of graduate education and building a high-quality education system.The current enrollment situation in some universities is severe,with problems such as insuffi...Graduate enrollment is crucial for improving the quality of graduate education and building a high-quality education system.The current enrollment situation in some universities is severe,with problems such as insufficient attention to enrollment promotion and a single mode.To solve these problems,this article proposes measures such as leveraging the joint efforts of schools,formulating enrollment promotion plans at different levels,strengthening the construction of enrollment teams at both the school and college levels,enriching enrollment promotion forms,strengthening the construction of high-quality student sources,and building a quality evaluation system for student sources to attract more students to apply and continuously improve the quality of student sources.展开更多
Fe_2O_3 nanorods and hexagonal nanoplates were synthesized and used as the promoters for Pt electrocatalysts toward the methanol oxidation reaction（MOR） in an alkaline electrolyte.The catalysts were characterized by...Fe_2O_3 nanorods and hexagonal nanoplates were synthesized and used as the promoters for Pt electrocatalysts toward the methanol oxidation reaction（MOR） in an alkaline electrolyte.The catalysts were characterized by scanning electron microscopy,transmission electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,cyclic voltammetry and chronoamperometry.The results show that the presence of Fe_2O_3 in the electrocatalysts can promote the kinetic processes of MOR on Pt,and this promoting effect is related to the morphology of the Fe_2O_3 promoter.The catalyst with Fe_2O_3 nanorods as the promoter（Pt-Fe_2O_3/C-R） exhibits much higher catalytic activity and stability than that with Fe_2O_3 nanoplates as the promoter（Pt-Fe_2O_3/C-P）.The mass activity and specific activity of Pt in a Pt-Fe_2O_3/C-R catalyst are 5.32 A/mgpt and 162.7 A/m^2_（Pt）,respectively,which are approximately 1.67 and 2.04 times those of the Pt-Fe_2O_3/C-P catalyst,and 4.19 and 6.16 times those of a commercial PtRu/C catalyst,respectively.Synergistic effects between Fe_2O_3 and Pt and the high content of Pt oxides in the catalysts are responsible for the improvement.These findings contribute not only to our understanding of the MOR mechanism but also to the development of advanced electrocatalysts with high catalytic properties for direct methanol fuel cells.展开更多
The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the ...The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.展开更多
Aiming at searching for plant growth promoting rhizobacteria (PGPR), a bacterium strain coded as 7016 was isolated from soybean rhizosphere and was characterized in the present study. It was identiifed as Burkholderia...Aiming at searching for plant growth promoting rhizobacteria (PGPR), a bacterium strain coded as 7016 was isolated from soybean rhizosphere and was characterized in the present study. It was identiifed as Burkholderia sp. based on 16S rDNA sequence analysis, as wel as phenotypic and biochemical characterizations. This bacterium presented nitrogenase activity, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity and phosphate solubilizing ability;inhibited the growth of Sclerotinia sclerotiorum, Gibberel a zeae and Verticil ium dahliae;and produced smal quantities of indole acetic acid (IAA). In green house experiments, signiifcant increases in shoot height and weight, root length and weight, and stem diameter were observed on tomato plants in 30 d after inoculation with strain 7016. Result of 16S rDNA PCR-DGGE showed that 7016 survived in the rhizosphere of tomato seedlings. In the ifeld experiments, Burkholderia sp. 7016 enhanced the tomato yield and signiifcantly promoted activities of soil urease, phosphatase, sucrase, and catalase. Al these results demonstrated Burkholderia sp. 7016 as a valuable PGPR and a candidate of biofertilizer.展开更多
The effect of super absorbent polymer（SAP） on the formation of tetrahydrofuran（THF） hydrate was studied by the successional cooling method.It was found that THF solution samples with 0.004 wt% and 0.03 wt% of SAP ...The effect of super absorbent polymer（SAP） on the formation of tetrahydrofuran（THF） hydrate was studied by the successional cooling method.It was found that THF solution samples with 0.004 wt% and 0.03 wt% of SAP formed THF hydrate completely during the same cooling process.The corresponding induction time was 16-29 min,14-31 min,respectively,which was obviously shorter than that of THF solution samples without SAP（25-62 min）.It indicated that SAP accelerated the formation of THF hydrate.At the same time,the pictures of hydrate formation with and without SAP had been compared.It was found that SAP did not change the morphology of the hydrate.Finally,the mechanism of SAP promoting effect on the formation of THF hydrate was suggested.展开更多
Ferula spp. are traditional medicinal plants found in arid land. Large-scale excavation for extracting bioactive compounds from the plants in arid regions of Xinjiang over the last few years has, however, significandy...Ferula spp. are traditional medicinal plants found in arid land. Large-scale excavation for extracting bioactive compounds from the plants in arid regions of Xinjiang over the last few years has, however, significandy decreased their distributions. Due to the urgent need for preservation of these plant resources, along with the need of searching for alternative source of the useful metabolites, it is important to screen the endophytic microbial resources associated with the plant Ferula sinkiangensis K. M. Shen. In the study, a total of 125 endophytic bacteria belonging to 3 phyla, 13 orders, 23 families, and 29 genera were isolated based on 16S rRNA gene sequencing data. Among the different isolates, three strains isolated from roots were potential novel species of the genera Porphyrobacter, Paracoccus and draycofatopsis. In this study, 79.4% and 57.1% of the total isolates were capable of producing indole-3-acetic acid （IAA） and siderophore, respectively. And, 40.6% of the strains inhibit the growth of fungal pathogen Afternaria alternata, 17.2% and 20.2% strains were positive for antagonism against Vertidllium dahlia 991 and V. dahlia 7, respectively. These results demonstrated that E sinkiangensis is a rich reservoir of endophytic bacterial resources with potential for production of biologically important functions such as plant growth-promoting factors.展开更多
Neuregulin-1 (NRG1) is a well known growth factor playing contradictory roles in myelination depending on the existing isoform. Transmembrane NRG1 acts as a promyelinating factor, while the soluble isoform inhibits my...Neuregulin-1 (NRG1) is a well known growth factor playing contradictory roles in myelination depending on the existing isoform. Transmembrane NRG1 acts as a promyelinating factor, while the soluble isoform inhibits myelination. In this perspective, we would like to emphasize this conflicting role played by NRG1 isofbrms regarding their roles in myelination, remyelination and the entire process of peripheral nerve regeneration.展开更多
OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sh...OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sham operation(Sham),(b)myocardial ischemia(Model),(c)treatment that regulates Qi(Qi),(d)treatment that promotes blood circulation(Blood),(e)treatment that both regulates Qi and promotes blood circulation(QB).The rat model was established via activities restriction for 6 h followed by tail clamp stimulation for 5 mins every day for 7 d and occlusion left coronary anterior descending artery.Afterwards rats were treated with medicines that regulate Qi and/or promote blood circulation via gavage for 14 d.Behavioral parameters were evaluated using open field and elevated plus-maze tests.The tongue color and sublingual vein were visually examined.Blood flow perfusion of tongue and auricle were detected using PIMⅡ.The mesenteric microcirculation was examined via capillaroscopy,and hemodynamics was assessed using a polygraph system.Serum homocysteine(Hcy),creatine kinase isoenzyme(CKMB)levels and endothelin-1(ET-1)were measured.Hematoxylin and eosin staining and transmission electron microscopy were employed to detect the myocardial morphology and ultrastructure,respectively.RESULTS:Compared with findings in Sham group,rats in model group had coarse hair,dark mucosa of the lips and claw,low activity,and increased anxiety.Compared with findings in Model group,rats in the three treatment groups exhibited a lighter tongue color without an extended and varicose sublingual vein.There were significant increases of auricle blood flow perfusion in the Qi group and tongue bottom blood flow perfusion in the QB group.Compared with findings in Model rats,rats in Blood group exhibited improved mesenteric microcirculation associated with increased mesenteric blood flow and a larger arteriole diameter.Moreover,compared with findings in Model rats,Qi and QB rats exhibited increased left ventricular±dp/dtmax,decreased serum CKMB,Hcy,ET-1 levels,and reduced myocardial ultrastructural damage.CONCLUSION:Myocardial ischemia damage was suppressed by Traditional Chinese Medicines that regulate Qi and promote blood circulation.展开更多
BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hep...BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hepatic growthfactor (PHGF) in the treatment of heavy type hepatitis andsevere chronic hepatitis.METHODS: 347 patients with heavy type hepatitis and 324with severe chronic hepatitis were subjected to administra-tion of 120 μg of PHGF per day for 4 weeks on the basis ofgeneral treatment. Those who were being effectively treat-ed would last additional 2 to 4 weeks. Blood routine, urineroutine, blood urea nitrogen (BUN), blood creatinine(Cr), blood ammonia, alpha fetoprotein (AFP), electro-lyte, alanine transaminase (ALT), aspartate transaminase(AST), serum total bilirubin (TBIL), serum direct biliru-bin (DBIL), prothrombin time activity (PTA), total pro-tein (TP) and albumin (ALB) were detected in the pa-tients before treatment, 2 weeks after treatment, and at theend of the treatment. Any side-effect would be recorded.RESULTS: In the patients with severe chronic hepatitis, thetotal effective rate of the treatment was 88. 9% The levelsof ALT, AST and TBIL decreased significantly (P<0.001),whereas those of PTA and ALB increased significantly (P <0.001), and the level of AFP increased slightly. In patientswith heavy type hepatitis, the total effective rate of thistreatment was 78.4%, and patients at different stage showeddifferent results. The total effective rates of patients withearly, medium and terminal stage heavy type hepatitis were89.9%, 84.8% and 27.5%, respectively. No severe side-effect was shown.CONCLUSION: PHGF is effective and safe in the treat-ment of patients with heavy type hepatitis and severe chro-nic hepatitis. But it should be administered early in patientswith heavy type hepatitis so as to get better curative effects.展开更多
基金National Natural Science Foundation of China:Study on the Intervention Mechanism of Zhilong Huoxue Tongyu Capsule in Hypertensive Myocardial Fibrosis by Regulating Transforming Growth Factor-β/Smad3/Erbb4-IR/miR29b Loop (No.82074378)Project of Science & Technology Department of Sichuan Province:Research on the Optimization of Basic and Clinical Plans for Treating Coronary Heart Disease and Heart Failure based on Xuanfu Theory (No.2022YFS0618)+1 种基金Luzhou Science and Technology Bureau Project:the Mechanism of Hirudin Inhibiting AngⅡInduced Myocardial Hypertrophy by Regulating Autophagy and NOD-like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome (No.2023JYJ029)Southwest Medical University Project:Study on the Mechanism of Zhilong Huoxue Tongyu Capsules in Improving NOD-like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome Mediated Cardiomyocyte Pyroptosis in Heart Failure by Regulating the HippoYes-Associated Protein Pathway (No.2023ZYYQ04)。
文摘Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,can be an adjuvant therapy to benefit patients with ICH by improving clinical efficacy.However,in theory,using PBCRBS to treat ICH carries the risk of hematoma enlargement and rebleeding,which has led to controversy over its application in ICH treatment.To demonstrate the effectiveness and safety of PBCRBS in treating ICH,this review first analyzes the pathological and physiological basis of ICH and secondly,the cascade of response after ICH and the involvement of cytokines and signaling pathways in this process.Finally,experimental and clinical studies on the treatment of ICH with PBCRBS over the past decade were retrieved from the Pub Med and China National Knowledge Infrastructure databases,and the content of these studies was used to summarize commonly used herbs with PBCRBS effects and their mechanisms of action.Through analysis,hypertension has been identified as the most common cause of ICH.Heme,interleukin,reactive oxygen species,coagulation promoting particles and other induced mass effects,inflammation,oxidative stress,and coagulation cascade reactions lead to brain damage following ICH.This review includes 56 experimental studies and 83 clinical studies summarizing 28 commonly used herbs,demonstrating the positive impact of PBCRBS as an adjuvant therapy for ICH.In summary,PBCRBS appears effective and safe for treating ICH.
基金Supported by Doctoral Start-up Fund of Jiangsu University of Science and Technology(1102931901).
文摘[Objectives]This study was conducted to explore the culture conditions for siderophore production and preliminarily investigate the growth-promoting effects of strains.[Methods]Endophytic bacteria secreting siderophores were isolated and screened from the roots of the plant Saposhnikovia divaricata(Trucz.)Schischk.The siderophore-producing capability was confirmed through qualitative detection and gene cluster analysis.[Results]The screened endophytic bacterium PB-2 belonged to the genus Paenibacillus sp.and could produce catechol-type or carboxylate-type siderophores.When cultured in MKB medium with 15 g/L glycerol as the carbon source and 6 g/L glycine as the nitrogen source for 3 d,the strain exhibited efficient siderophore secretion.Appropriate concentrations of Fe^(3+),Co^(2+),Cu^(2+)and Al^(3+)promoted siderophore production,with 15μmol/L Fe^(3+)being the most effective.Under the combined influences of siderophores,volatile compounds and other factors,strain PB-2 altered the root morphology of mulberry seedlings and increased their biomass.The primary root length decreased by 9.15%,while the number and length of root hairs increased by 37.93%and 16.37%,respectively,and the total biomass increased by 10.26%,all showing significant differences(P<0.05).Additionally,strain PB-2 enhanced the activities of defense-related enzymes in mulberry seedling leaves.The activities of superoxide dismutase(SOD)and peroxidase(POD)increased significantly(P<0.05)by 247.27%and 189.47%,respectively,compared with the control group.The activities of phenylalanine ammonialyase(PAL)and polyphenol oxidase(PPO)also showed varying degrees of increase.[Conclusions]This study provided a theoretical basis for rational utilization of endophytic growth-promoting strains secreting siderophores in the sustainable development of agriculture.
文摘With a global vision and a strong sense of responsibility,the CPC has been committed to promoting exchanges and mutual learning among civilizations and advancing the progress of human civilization.In March 2023,General Secretary Xi Jinping put forth the Global Civilization Initiative(GCI)at the CPC in Dialogue with World Political Parties High-level Meeting,emphasizing the need to advocate the respect for the diversity of civilizations,the common values of humanity,the importance of inheritance and innovation of civilizations,and robust international people-to-people exchanges and cooperation.
基金funded by the Teaching Reform Project of Heilongjiang Province,China,titled“Research and Quantitative Analysis of the‘Three Integrations+Double Traction’Cultivation Model for Professional Degree Master Students”(SJGY20210190)the Key Teaching Reform Project of Shandong Province,China,titled“Research on the Cultivation Model of the Integration of Industry and Education for Engineering Professional Degree Postgraduates under the Background of‘Marine Engineering Complex’”(SDYJG21053)and the Postgraduate Teaching Reform Project of Harbin Engineering University,titled“Research on Key Core Issues of Scientific Research Practice for Professional Master Students——Taking the Electronic Information Major of Yantai Institute as an Example”(JG2021Y074).
文摘Currently,talent cultivation faces numerous challenges,such as a shortage of school-enterprise tutors and a disconnection between curriculum construction and industry demands.The“promoting research through courses”model has emerged in response to these challenges.Its goals include training students’research capabilities,cultivating their interdisciplinary learning and application abilities,and establishing an ecological closed loop between education and research.The reform measures involve innovating curriculum design to create new,advanced,and practical courses,adopting a hierarchical and progressive classroom teaching method combined with post-class diversion guidance,and conducting online-offline integrated case-based and scenario-based teaching.The reform has achieved remarkable results.Students have enhanced their research abilities,knowledge application,and professional qualities.Schools have strengthened their discipline construction,teaching staff,and social influence.Enterprises have realized their talent reserves and technological innovations.The teaching model has integrated theory and practice,promoting the high-quality development of education and teaching,and providing a new path to solve the problems in education and industry development.
基金supported by the 5 Steno Diabetes Centers in Denmark,which are partly funded by the Novo Nordisk Foundation.
文摘Background Health promotion(HP)interventions delivered through sports clubs have demonstrated promising outcomes among men,but less is known about which aspects of the interventions work,for whom,and under what circumstances.This rapid realist review aimed to understand the contexts,mechanisms,and outcomes of HP interventions for men delivered through sports clubs.Methods A systematic literature search was conducted in February 2023 for studies published after 2013 in MEDLINE,Embase,and SPORTDiscus databases.Included studies:(a)were delivered by or in collaboration with sports clubs,(b)targeted men aged 18+years,and(c)reported 1 or more HP outcomes.A grey literature search was also performed.Studies were included in a realist synthesis based on richness and rigor.Hereafter,context-mechanism-outcome(CMO)configurations were developed.Results We identified and screened 3358 studies,finally including 59 studies describing 22 interventions.Most HP interventions were delivered in high income countries,included Caucasian men aged 35-65 years with overweight/obesity,and used professional sports clubs(mostly football)for recruitment and facilities.Quantitative HP outcomes were reported across 19 interventions.Of these 19 interventions,the majority reported on weight(n=18),physical activity(n=12),mental health(n=10),and diet(n=9).We identified 13 CMOs related to how HP interventions affected men's recruitment,engagement,and health behavior maintenance.Conclusion Our findings show that using sports clubs for HP interventions is effective for engaging men.Recruitment was facilitated by leveraging sports clubs’identity,addressing masculinity-related barriers,improving accessibility,and building trust.Engagement was enhanced through shared identity experiences,safe spaces,inclusive competition,and self-efficacy.However,there's limited evidence on behavior maintenance post-intervention,though involving community stakeholders seemed vital.In general,considerations should be made to avoid perpetuating traditional masculine norms,which may exclude some men and reinforce unhealthy behaviors.These findings can guide intervention development,emphasizing the need to harness men's perspectives in the process.
基金the National Natural Science Foundation of China(No.32001984).
文摘A Plant Biostimulant is any substance or microorganism applied to plants to enhance nutrition efficiency,abioticstress tolerance,and/or crop quality traits,regardless of its nutrient content.The application of Plant biostimulants(PBs)in production can reduce the application of traditional pesticides and chemical fertilizers and improvethe quality and yield of crops,which is conducive to the sustainable development of agriculture.An in-depthunderstanding of the mechanism and effect of various PBs is very important for how to apply PBs reasonablyand effectively in the practice of crop production.This paper summarizes the main classification of PBs;Thegrowth promotion mechanism of PBs was analyzed from four aspects:improving soil physical and chemical properties,enhancing crop nutrient absorption capacity,photosynthesis capacity,and abiotic stress tolerance;At thesame time,the effects of PBs application on seed germination,seedling vigor,crop yield,and quality were summarized;Finally,how to continue to explore and study the use and mechanism of PBs in the future is analyzedand prospected,to better guide the application of PBs in crop production in the future.
基金Under the auspices of National Key Research and Development Program of China(No.2023YFB4302200)National Natural Science Foundation of China(No.71831002,72174053)+1 种基金Liaoning Province Xingliao Talent Plan(No.XLYC2008030)Talent Planning in Dalian(No.2022RG05)。
文摘In the context of building a country with a strong transportation network,railway container transportation(RCT)is an important means of reducing costs,increasing efficiency,and adjusting transportation structures.Thus,its impact on regional economic development is important.Based on data from railway container-handling stations and spatial econometric models,this study discusses the differences in the development of RCT and their impact on regional economic development at different leves.This study has three main findings:first,there are significant regional differences in the development of the RCT.The intra-regional differences between the eastern and central regions of China(which do not include Hong Kong,Macao and Taiwan)are gradually narrowing,while the regional differences in the western region are widening.Meanwhile,the intra-regional differences in important economic zones such as Pearl River Delta Economic Zone(PRDEZ),Chengdu-Chongqing Economic Zone(CYEZ),Bohai Rim Economic Zone(BHEZ),and Yangtze River Delta Economic Zone(YRDEZ)are narrowing daily.Second,the development differences of RCT in regional level and important economic regions level show different trends.The unbalanced features of large regions are increasingly evident,whereas the differences in economic regions are decreasing.However,the problem of overlapping RCT remains prominent.Third,the transformation of RCT development mode and fierce competition among transportation modes cause RCT to have a restraining effect on the regional economy at three levels.Rational allocation of resources and other means must be used to guide the transformation from inhibition to promotion,and by formulating targeted policies that will promote the development of RCT,which will improve the transportation structure and help construct a country with a strong transportation system.
基金This work was supported by the National Key R&D Program of China(2022YFB3805504),National Natural Science Foundation of China(22078089)China Postdoctoral Science Foundation(2023M731081)+3 种基金Shanghai Pilot Program for Basic Research(22TQ1400100-7)the Basic Research Program of Science and Technology Commission of Shanghai Municipality(22JC1400600)Open Foundation of Shanghai Jiao Tong University Shaoxing Research Institute of Renewable Energy and Molecular Engineering(Grant No.JDSX2022046)Shanghai Super Postdoctoral Fellow.
文摘Cu-based catalysts have been extensively used in methanol steam reforming(MSR)reactions because of their low cost and high effi ciency.ZnO is often used in commercial Cu-based catalysts as both a structural and an electronic promoter to stabilize metal Cu nanoparticles and modify metal–support interfaces.Still,the further addition of chemical promoters is essential to further enhance the MSR reaction performance of the Cu/ZnO catalyst.In this work,CeO_(2)-doped Cu/ZnO catalysts were prepared using the coprecipitation method,and the eff ects of CeO_(2)on Cu-based catalysts were systematically investigated.Doping with appropriate CeO_(2)amounts could stabilize small Cu nanoparticles through a strong interaction between CeO_(2)and Cu,leading to the formation of more Cu+–ZnO x interfacial sites.However,higher CeO_(2)contents resulted in the formation of larger Cu nanoparticles and an excess of Cu+–CeO x interfacial sites.Consequently,the Cu/5CeO_(2)/ZnO catalyst with maximal Cu–ZnO interfaces exhibited the highest H 2 production rate of 94.6 mmolH2/(gcat·h),which was 1.5 and 10.2 times higher than those of Cu/ZnO and Cu/CeO_(2),respectively.
文摘Objective To observe the effects on the range of motion （ROM） of ankle joint and muscular spasm of the lower limbs treated with Chinese massage for promoting the Governor Vessel, benefiting the kidney and strengthening the spleen combined with music therapy in infantile cerebral palsy （CP）. Methods In 286 cases of spasmodic CP, 7 kinds of Chinese massage were adopted, named massage on acupoints to promote circulation of the Governor Vessel, massage for strengthening the spleen and benefiting qi, spine-pinching therapy, segmental massage, foot massage, massage for promoting the recovery of muscle strength and massage for promoting ROM of joints. Chinese massage was applied in musical background. Buddha music and five-element music of Chinese medicine （music of the Heart, Liver and Kidney Meridians） were optioned. The treatment was given once or twice a day and 30 days made one course. The angles of femoral adductor and dorsal flexion of foot as well as the score of composite spasticity scale （CSS） were observed before and after treatment so that the therapeutic effect was assessed. Results In 30 days of treatment, 106 cases （37. 1%） were effective markedly, 172 cases （60. 1%） effective and 8 cases （2.8%） failed. The angle of dorsal flexion of foot was （105.64± 12.66）° and （76.58± 9.89）° before and after treatment respectively; the angle of femoral adductor was （119.89±25.47）° and （158.99± 18.66）° before and after treatment respectively; the score of CSS was （12.39±2.56） and （7. 069 ± 2.97） before and after treatment respectivel, there was significant difference before and after treatment （all P〈0.01）. Conclusion Chinese massage for promoting the Governor Vessel, benefiting the kidney and strengthening the spleen combined with music therapy brings the extremely active effect into play on the recovery of sitting, kneeling, standing and walking for children with CP.
基金Supported by the Science and Technology Project of Nanping Tobacco Company(201203)~~
文摘The paper first introduces the definition and classification of plant growth promoting rhizobacteria （PGPR）, then reviews the research achievements on the mechanism of action of plant growth promoting rhizobacteria, including growth pro-moting mechanism and bio-control mechanism, subsequently lists the use of excel-lent plant growth promoting rhizobacteria strains in recent years, especial y Pseu-domonas and Bacil us strains, and final y discusses problems existing in this area and points out issues requiring further exploration, including PGPR screening meth-ods, preservation methods, mechanism of action, in order to commercialize PGPR as soon as possible and practical y realize its application to production.
基金2023 Innovation Project of Guangxi Graduate Education“Innovation Transformation-Integration of Industry and Education-Research on the Integration Path of Zhuang Intangible Cultural Heritage and Master of Arts Course Teaching”(Project number:JGY2023052)2023 Special Project of Guangxi 14th Five-Year Plan for Educational Science“Revitalization of Non-Heritage-Integration of Industry and Education-Research on the Service of Regional Economic Development of Design Professional Innovation and Entrepreneurship Education in Guangxi Colleges and Universities”(Project number:2023ZJY1836)。
文摘This study aims to explore the role of animating Zhuang non-heritage folktales in promoting the national culture industry.Using literature research,case studies,and comparative research methods,the positive impacts are analyzed in depth across four dimensions:cultural value inheritance,market demand,dissemination channels,and industrial innovation.The results show that animating Zhuang non-heritage folktales can help inherit national culture,meet market demand,broaden communication channels,and promote industrial innovation.Finally,this paper proposes corresponding policy suggestions and implementation paths to provide references for the sustainable development of the ethnic culture industry.
文摘Graduate enrollment is crucial for improving the quality of graduate education and building a high-quality education system.The current enrollment situation in some universities is severe,with problems such as insufficient attention to enrollment promotion and a single mode.To solve these problems,this article proposes measures such as leveraging the joint efforts of schools,formulating enrollment promotion plans at different levels,strengthening the construction of enrollment teams at both the school and college levels,enriching enrollment promotion forms,strengthening the construction of high-quality student sources,and building a quality evaluation system for student sources to attract more students to apply and continuously improve the quality of student sources.
基金supported by the National Natural Science Foundation of China(21403125,21403124)the Scientific Research Foundation for the Outstanding Young Scientist of Shandong Province(BS2011NJ009)~~
文摘Fe_2O_3 nanorods and hexagonal nanoplates were synthesized and used as the promoters for Pt electrocatalysts toward the methanol oxidation reaction（MOR） in an alkaline electrolyte.The catalysts were characterized by scanning electron microscopy,transmission electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,cyclic voltammetry and chronoamperometry.The results show that the presence of Fe_2O_3 in the electrocatalysts can promote the kinetic processes of MOR on Pt,and this promoting effect is related to the morphology of the Fe_2O_3 promoter.The catalyst with Fe_2O_3 nanorods as the promoter（Pt-Fe_2O_3/C-R） exhibits much higher catalytic activity and stability than that with Fe_2O_3 nanoplates as the promoter（Pt-Fe_2O_3/C-P）.The mass activity and specific activity of Pt in a Pt-Fe_2O_3/C-R catalyst are 5.32 A/mgpt and 162.7 A/m^2_（Pt）,respectively,which are approximately 1.67 and 2.04 times those of the Pt-Fe_2O_3/C-P catalyst,and 4.19 and 6.16 times those of a commercial PtRu/C catalyst,respectively.Synergistic effects between Fe_2O_3 and Pt and the high content of Pt oxides in the catalysts are responsible for the improvement.These findings contribute not only to our understanding of the MOR mechanism but also to the development of advanced electrocatalysts with high catalytic properties for direct methanol fuel cells.
文摘The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.
基金supported by the National Natural Science Foundation of China (31100364)the National Nonprofit Institute Research Grant of Chinese Academy of Agricultural Sciences (CAAS, IARRP-2014-20)
文摘Aiming at searching for plant growth promoting rhizobacteria (PGPR), a bacterium strain coded as 7016 was isolated from soybean rhizosphere and was characterized in the present study. It was identiifed as Burkholderia sp. based on 16S rDNA sequence analysis, as wel as phenotypic and biochemical characterizations. This bacterium presented nitrogenase activity, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity and phosphate solubilizing ability;inhibited the growth of Sclerotinia sclerotiorum, Gibberel a zeae and Verticil ium dahliae;and produced smal quantities of indole acetic acid (IAA). In green house experiments, signiifcant increases in shoot height and weight, root length and weight, and stem diameter were observed on tomato plants in 30 d after inoculation with strain 7016. Result of 16S rDNA PCR-DGGE showed that 7016 survived in the rhizosphere of tomato seedlings. In the ifeld experiments, Burkholderia sp. 7016 enhanced the tomato yield and signiifcantly promoted activities of soil urease, phosphatase, sucrase, and catalase. Al these results demonstrated Burkholderia sp. 7016 as a valuable PGPR and a candidate of biofertilizer.
文摘The effect of super absorbent polymer（SAP） on the formation of tetrahydrofuran（THF） hydrate was studied by the successional cooling method.It was found that THF solution samples with 0.004 wt% and 0.03 wt% of SAP formed THF hydrate completely during the same cooling process.The corresponding induction time was 16-29 min,14-31 min,respectively,which was obviously shorter than that of THF solution samples without SAP（25-62 min）.It indicated that SAP accelerated the formation of THF hydrate.At the same time,the pictures of hydrate formation with and without SAP had been compared.It was found that SAP did not change the morphology of the hydrate.Finally,the mechanism of SAP promoting effect on the formation of THF hydrate was suggested.
基金supported by the National Natural Science Foundation of China(U1403101,31200008)the China Postdoctoral Science Foundation(2016M602566)+3 种基金the Visiting Scholar Grant of State Key Laboratory of Biocontrol,Sun Yat-Sen University(SKLBC14F02)the West Light Foundation of the Chinese Academy of Sciencessupported by Hundred Talents Program of the Chinese Academy of SciencesGuangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme(2014)
文摘Ferula spp. are traditional medicinal plants found in arid land. Large-scale excavation for extracting bioactive compounds from the plants in arid regions of Xinjiang over the last few years has, however, significandy decreased their distributions. Due to the urgent need for preservation of these plant resources, along with the need of searching for alternative source of the useful metabolites, it is important to screen the endophytic microbial resources associated with the plant Ferula sinkiangensis K. M. Shen. In the study, a total of 125 endophytic bacteria belonging to 3 phyla, 13 orders, 23 families, and 29 genera were isolated based on 16S rRNA gene sequencing data. Among the different isolates, three strains isolated from roots were potential novel species of the genera Porphyrobacter, Paracoccus and draycofatopsis. In this study, 79.4% and 57.1% of the total isolates were capable of producing indole-3-acetic acid （IAA） and siderophore, respectively. And, 40.6% of the strains inhibit the growth of fungal pathogen Afternaria alternata, 17.2% and 20.2% strains were positive for antagonism against Vertidllium dahlia 991 and V. dahlia 7, respectively. These results demonstrated that E sinkiangensis is a rich reservoir of endophytic bacterial resources with potential for production of biologically important functions such as plant growth-promoting factors.
文摘Neuregulin-1 (NRG1) is a well known growth factor playing contradictory roles in myelination depending on the existing isoform. Transmembrane NRG1 acts as a promyelinating factor, while the soluble isoform inhibits myelination. In this perspective, we would like to emphasize this conflicting role played by NRG1 isofbrms regarding their roles in myelination, remyelination and the entire process of peripheral nerve regeneration.
基金Supported by National key basic research and development plan(973 Program)(No.2015CB554405,2015CB554402)。
文摘OBJECTIVE:To investigate the efficacy of Chinese medicines on Qi stagnation and blood stasis in rats with myocardial ischemia.METHODS:Fifty male Wistar rats were randomly divided into five groups(n=10)as follows:(a)sham operation(Sham),(b)myocardial ischemia(Model),(c)treatment that regulates Qi(Qi),(d)treatment that promotes blood circulation(Blood),(e)treatment that both regulates Qi and promotes blood circulation(QB).The rat model was established via activities restriction for 6 h followed by tail clamp stimulation for 5 mins every day for 7 d and occlusion left coronary anterior descending artery.Afterwards rats were treated with medicines that regulate Qi and/or promote blood circulation via gavage for 14 d.Behavioral parameters were evaluated using open field and elevated plus-maze tests.The tongue color and sublingual vein were visually examined.Blood flow perfusion of tongue and auricle were detected using PIMⅡ.The mesenteric microcirculation was examined via capillaroscopy,and hemodynamics was assessed using a polygraph system.Serum homocysteine(Hcy),creatine kinase isoenzyme(CKMB)levels and endothelin-1(ET-1)were measured.Hematoxylin and eosin staining and transmission electron microscopy were employed to detect the myocardial morphology and ultrastructure,respectively.RESULTS:Compared with findings in Sham group,rats in model group had coarse hair,dark mucosa of the lips and claw,low activity,and increased anxiety.Compared with findings in Model group,rats in the three treatment groups exhibited a lighter tongue color without an extended and varicose sublingual vein.There were significant increases of auricle blood flow perfusion in the Qi group and tongue bottom blood flow perfusion in the QB group.Compared with findings in Model rats,rats in Blood group exhibited improved mesenteric microcirculation associated with increased mesenteric blood flow and a larger arteriole diameter.Moreover,compared with findings in Model rats,Qi and QB rats exhibited increased left ventricular±dp/dtmax,decreased serum CKMB,Hcy,ET-1 levels,and reduced myocardial ultrastructural damage.CONCLUSION:Myocardial ischemia damage was suppressed by Traditional Chinese Medicines that regulate Qi and promote blood circulation.
文摘BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hepatic growthfactor (PHGF) in the treatment of heavy type hepatitis andsevere chronic hepatitis.METHODS: 347 patients with heavy type hepatitis and 324with severe chronic hepatitis were subjected to administra-tion of 120 μg of PHGF per day for 4 weeks on the basis ofgeneral treatment. Those who were being effectively treat-ed would last additional 2 to 4 weeks. Blood routine, urineroutine, blood urea nitrogen (BUN), blood creatinine(Cr), blood ammonia, alpha fetoprotein (AFP), electro-lyte, alanine transaminase (ALT), aspartate transaminase(AST), serum total bilirubin (TBIL), serum direct biliru-bin (DBIL), prothrombin time activity (PTA), total pro-tein (TP) and albumin (ALB) were detected in the pa-tients before treatment, 2 weeks after treatment, and at theend of the treatment. Any side-effect would be recorded.RESULTS: In the patients with severe chronic hepatitis, thetotal effective rate of the treatment was 88. 9% The levelsof ALT, AST and TBIL decreased significantly (P<0.001),whereas those of PTA and ALB increased significantly (P <0.001), and the level of AFP increased slightly. In patientswith heavy type hepatitis, the total effective rate of thistreatment was 78.4%, and patients at different stage showeddifferent results. The total effective rates of patients withearly, medium and terminal stage heavy type hepatitis were89.9%, 84.8% and 27.5%, respectively. No severe side-effect was shown.CONCLUSION: PHGF is effective and safe in the treat-ment of patients with heavy type hepatitis and severe chro-nic hepatitis. But it should be administered early in patientswith heavy type hepatitis so as to get better curative effects.
