Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
A new extended distribution called the Odd Exponential Generalized Exponential-Exponential distribution(EOEGE-E)is proposed based on generalization of the odd generalized exponential family(OEGE-E).The statistical pro...A new extended distribution called the Odd Exponential Generalized Exponential-Exponential distribution(EOEGE-E)is proposed based on generalization of the odd generalized exponential family(OEGE-E).The statistical properties of the proposed distribution are derived.The study evaluates the accuracy of six estimation methods under complete samples.Estimation techniques include maximumlikelihood,ordinary least squares,weighted least squares,maximumproduct of spacing,Cramer vonMises,and Anderson-Darling methods.Twomethods of estimation for the involved parameters are considered based on progressively type Ⅱ censored data(PTⅡC).These methods are maximum likelihood and maximum product of spacing.The proposed distribution’s effectiveness was evaluated using different data sets from various fields.The proposed distribution provides a better fit for these datasets than existing probability distributions.展开更多
Accelerated life tests play a vital role in reliability analysis,especially as advanced technologies lead to the production of highly reliable products to meet market demands and competition.Among these tests,progress...Accelerated life tests play a vital role in reliability analysis,especially as advanced technologies lead to the production of highly reliable products to meet market demands and competition.Among these tests,progressive-stress accelerated life tests(PSALT)allow for continuous changes in applied stress.Additionally,the generalized progressive hybrid censoring(GPHC)scheme has attracted significant attention in reliability and survival analysis,particularly for handling censored data in accelerated testing.It has been applied to various failure models,including competing risks and step-stress models.However,despite its growing relevance,a notable gap remains in the literature regarding the application of GPHC in PSALT models.This paper addresses that gap by studying PSALT under a GPHC scheme with binomial removal.Specifically,it considers lifetimes following the quasi-Xgamma distribution.Model parameters are estimated using both maximum likelihood and Bayesian methods under gamma priors.Interval estimation is provided through approximate confidence intervals,bootstrap methods,and Bayesian credible intervals.Bayesian estimators are derived under squared error and entropy loss functions,using informative priors in simulation and non-informative priors in real data applications.A simulation study is conducted to evaluate various censoring schemes,with coverage probabilities and interval widths assessed via Monte Carlo simulations.Additionally,Bayesian predictive estimates and intervals are presented.The proposed methodology is illustrated through the analysis of two real-world accelerated life test datasets.展开更多
The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics ...The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics of frozen sodium sulfate saline sandy soil,a series of uniaxial compression tests were performed by integrating digital image correlation(DIC)technology into the testing apparatus.The evolution law of the uniaxial compression strength(UCS),the failure strain,and the formation of the shear band of the frozen sodium sulfate saline sandy soil were analyzed.The test results show that within the scope of this study,with the increase of salt content,both the UCS and the shear band angle initially decrease with increasing salt content before showing an increase.In contrast,the failure strain and the width of the shear band exhibit an initial increase followed by a decrease in the samples.In addition,to investigate the brittle failure characteristics of frozen sodium sulfate saline sandy soil,two classic brittleness evaluation methods were employed to quantitatively assess the brittleness level for the soil samples.The findings suggest that the failure characteristics under all test conditions in this study belong to the transition stage between brittle and ductile,indicating that frozen sodium sulfate saline sandy soil exhibits certain brittle behavior under uniaxial compression conditions,and the brittleness index basically decreases and then increases with the rise in salt content.展开更多
The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmiss...The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.展开更多
Background Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation.However,studies on t...Background Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation.However,studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little attention.The present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene(PTE)on maternal oxidative stress status and placental nutrient transport.Results PTE increased the antioxidant capacity and immunoglobulin content in mothers’blood and milk,reduced the level of inflammatory factors,and improved the nutrient content of milk.PTE also reduced sow backfat loss and the number of weak sons,and increased piglet weaning weight and total weaning litter weight.We subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL,PYGM,and Gbe-1,which activated the PI3K phosphorylation pathway.Moreover,PTE addition altered the relative abundance of the Firmicutes,Proteobacteria,Parabacillus,and Bacteroidetes-like RF16 groups in sow faeces.PTE increased the levels of acetate,propionate,butyrate and isovalerate in the faeces.Conclusions These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient trans-port capacity.展开更多
This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of 3D4D(three-dimensional four-directional)braided composite I-beam under four-point flexure spectrum loading.New fatigue damage...This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of 3D4D(three-dimensional four-directional)braided composite I-beam under four-point flexure spectrum loading.New fatigue damage models of fibre yarn,matrix and fibre–matrix interface are proposed,and fatigue failure criteria and PFDA(Progressive Fatigue Damage Algorithm)are thus presented for meso-scale fatigue damage modelling of 3D4D braided composite I-beam.To validate the aforementioned model and algorithm,fatigue tests are conducted on the 3D4D braided composite I-beam under four-point flexure spectrum loading,and fatigue failure mechanisms are analyzed and discussed.Novel global–local FE(Finite Element)model based on the PFDA is generated for modelling progressive fatigue failure process and predicting fatigue life of 3D4D braided composite I-beam under four-point flexure spectrum loading.Good agreement has been achieved between experimental results and predictions,demonstrating the effective usage of new model.It is shown that matrix cracking and interfacial debonding initially initiates on top surface of top flange of I-beam,and then gradually propagates from the side surface of top flange to the intermediate web along the braiding angle,and considerable fiber breakage finally causes final fatigue failure of I-beam.展开更多
In this present work,we propose the expected Bayesian and hierarchical Bayesian approaches to estimate the shape parameter and hazard rate under a generalized progressive hybrid censoring scheme for the Kumaraswamy di...In this present work,we propose the expected Bayesian and hierarchical Bayesian approaches to estimate the shape parameter and hazard rate under a generalized progressive hybrid censoring scheme for the Kumaraswamy distribution.These estimates have been obtained using gamma priors based on various loss functions such as squared error,entropy,weighted balance,and minimum expected loss functions.An investigation is carried out using Monte Carlo simulation to evaluate the effectiveness of the suggested estimators.The simulation provides a quantitative assessment of the estimates accuracy and efficiency under various conditions by comparing them in terms of mean squared error.Additionally,the monthly water capacity of the Shasta reservoir is examined to offer real-world examples of how the suggested estimations may be used and performed.展开更多
Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 wer...Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.展开更多
Frost heave and thaw settlement in cold regions pose a significant threat to engineering construction.Optical frequency domain reflectometry(OFDR)based on Rayleigh scattering can be applied to monitor ground deformati...Frost heave and thaw settlement in cold regions pose a significant threat to engineering construction.Optical frequency domain reflectometry(OFDR)based on Rayleigh scattering can be applied to monitor ground deformation in frozen soil areas,where the interface behavior of soil-embedded fiber optic sensors governs the monitoring accuracy.In this paper,a series of pullout tests were conducted on fiber optic(FO)cables embedded in the frozen soil to investigate the cable‒soil interface behavior.An experimental study was performed on interaction effects,particularly focused on the water content of unfrozen soil,freezing duration,and differential distribution of water content in frozen soil.The highresolution axial strains of FO cables were obtained using a sensing interrogator,and were used to calculate the interface shear stress.The interfacial mechanical response was analytically modeled using the ideal elasto‒plastic and softening constitutive models.Three freezing periods,correlating with the phase change process between ice and water,were analyzed.The results shows that the freezing effect can amplify the peak shear stress at the cable-soil interface by eight times.A criterion for the interface coupling states was proposed by normalizing the pullout force‒displacement information.Additionally,the applicability of existing theoretical models was discussed by comparing the results of theoretical back‒calculations with experimental measurements.This study provides new insights into the progressive interfacial failure behavior between strain sensing cable and frozen soil,which can be used to assist the interpretation of FO monitoring results of frozen soil deformation.展开更多
With breakthroughs in data processing and pattern recognition through deep learning technologies,the use of advanced algorithmic models for analyzing and interpreting soil spectral information has provided an efficien...With breakthroughs in data processing and pattern recognition through deep learning technologies,the use of advanced algorithmic models for analyzing and interpreting soil spectral information has provided an efficient and economical method for soil quality assessment.However,traditional single-output networks exhibit limitations in the prediction process,particularly in their inability to fully utilize the correlations among various elements.As a result,single-output networks tend to be optimized for a single task,neglecting the interrelationships among different soil elements,which limits prediction accuracy and model generalizability.To overcome this limitation,in this study,a multi-task learning architecture with a progressive extraction network was implemented for the simultaneous prediction of multiple indicators in soil,including nitrogen(N),organic carbon(OC),calcium carbonate(CaCO 3),cation exchange capacity(CEC),and pH.Furthermore,while incorporating the Pearson correlation coefficient,convolutional neural networks,long short-term memory networks and attention mechanisms were combined to extract local abstract features from the original spectra,thereby further improving the model.This architecture is referred to as the Relevance-sharing Progressive Layered Extraction Network.The model employs an adaptive joint loss optimization method to update the weights of individual task losses in the multi-task learning training process.展开更多
Microcrack growth during progressive compressive failure in brittle rocks strongly influences the safety of deep underground engineering.The external shear stressτxy on brittle rocks greatly affects microcrack growth...Microcrack growth during progressive compressive failure in brittle rocks strongly influences the safety of deep underground engineering.The external shear stressτxy on brittle rocks greatly affects microcrack growth and progressive failure.However,the theoretical mechanism of the growth direction evolution of the newly generated wing crack during progressive failure has rarely been studied.A novel analytical method is proposed to evaluate the shear stress effect on the progressive compressive failure and microcrack growth direction in brittle rocks.This model consists of the wing crack growth model under the principal compressive stresses,the direction correlation of the general stress,the principal stress and the initial microcrack inclination,and the relationship between the wing crack length and strain.The shear stress effect on the relationship between y-direction stress and wing crack growth and the relationship between y-direction stress and y-direction strain are analyzed.The shear stress effect on the wing crack growth direction during the progressive compressive failure is determined.The initial crack angle effect on the y-direction peak stress and the wing crack growth direction during the progressive compressive failure considering shear stress is also discussed.A crucial conclusion is that the direction of wing crack growth has a U-shaped variation with the growth of the wing crack.The rationality of the analytical results is verified by an experiment and from numerical results.The study results provide theoretical support for the evaluation of the safety and stability of surrounding rocks in deep underground engineering.展开更多
BACKGROUND Progressive familial intrahepatic cholestasis type 1(PFIC-1)is a genetic cholestatic disease causing end-stage liver disease,which needs liver transplantation(LT).Simultaneous biliary diversion(BD)was recom...BACKGROUND Progressive familial intrahepatic cholestasis type 1(PFIC-1)is a genetic cholestatic disease causing end-stage liver disease,which needs liver transplantation(LT).Simultaneous biliary diversion(BD)was recommended to prevent allograft steatosis after transplantation,while increasing the risk of infection.Here,an attempt was made to perform BD using appendix to prevent bacterial translocation after LT.CASE SUMMARY An 11-month-old boy diagnosed with PFIC-1 received ABO compatible living donor LT due to refractory jaundice and pruritus.His mother donated her left lateral segment with a graft-to-recipient weight ratio of 2.9%.Internal BD was constructed during LT using the appendix by connecting its proximal end with the intrahepatic biliary duct and the distal end with colon.Biliary leakage was suspected on the 5th day after transplantation and exploratory laparotomy indicated biliary leakage at the cutting surface of liver.The liver function returned to normal on the 9th day post-operation and maintained normal during the 15-month follow-up.Cholangiography at 10 months after transplantation confirmed the direct secretion of bile into colon.Computerized tomography scan(4 months and 10 months)and liver biopsy(10 months)indicated no steatosis in the allograft.No complaint of recurrent diarrhea,infection or growth retardation was reported during follow-up.CONCLUSION Internal BD using appendix during LT is effective in preventing allograft steatosis and post-transplant infection in PFIC-1 recipients.展开更多
Deep learning-based Joint Source-Channel Coding(JSCC)is a crucial component in semantic communication,and recent research has made significant progress in adapting to different channels.In this paper,we propose a mult...Deep learning-based Joint Source-Channel Coding(JSCC)is a crucial component in semantic communication,and recent research has made significant progress in adapting to different channels.In this paper,we propose a multi-stage progressive technique called Deep learning based Progressive Joint Source-Channel Coding(DP-JSCC).This approach partitions the source into multiple stages and transmits the signals continuously.The receiver gradually enhances the quality of image reconstruction by progressively receiving the signals,offering greater flexibility compared to existing dynamic rate transmission methods.The model adopts a lightweight architectural design,where we introduce an efficient module called the Inverted Shuffle Attention Bottleneck(ISAB)and incorporate self-attention mechanisms in the encoding and decoding process to capture signal correlations and establish long-range dependencies.Additionally,we introduce the Progressive Focus Weight Allocation(PFWA)method to improve the image reconstruction capability in progressive transmission tasks.These design enhance the expressive capacity of the model.Simulation results demonstrate that DP-JSCC can flexibly adjust the transmission rate according to requirements without the need for retraining or deployment,enabling continuous optimization of signals at different rates.Furthermore,compared to stateof-the-art JSCC methods,DP-JSCC exhibits advantages in terms of computational complexity,parameter count,and reconstruction performance.展开更多
Progressive familial intrahepatic cholestasis(PFIC)is a group of rare,inherited cholestatic liver disorders presenting in infants and children and are associated with impaired bile flow(i.e.,cholestasis),pruritus and ...Progressive familial intrahepatic cholestasis(PFIC)is a group of rare,inherited cholestatic liver disorders presenting in infants and children and are associated with impaired bile flow(i.e.,cholestasis),pruritus and progressive liver disease.Historically there has been no effective or approved pharmacologic treatments for these disorders and standard medical treatment has only been supportive.The impaired bile flow within the liver,leads to accumulation in the liver and inflammation.Historically there has been no effective or approved pharmacologic treatments for these disorders and standard medical treatment has only been supportive.A potential for reducing pathologic bile accumulation in the liver is surgical biliary diversion,with an aim to interrupt the enterohepatic circulation.These procedures have demonstrated a positive effect in PFIC by normalizing serum bile acids,reducing pruritus and liver injury and improving the patient quality of life.Nonsurgical approach to interrupting the enterohepatic circulation is inhibition of the ileal bile acid transporter(IBAT).IBAT inhibition has demonstrated efficacy in reducing serum bile acids and pruritus.We aim to present the 13 types of PFIC and the current evidence on the use of IBAT inhibitors in treating children with PFIC.展开更多
patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayes...patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayesian adaptive two-stage trial,hoping to provide new ideas for the rapid evaluation of the effectiveness of TCM in PPF.An open-label,two-stage,adaptive Bayesian randomized controlled trial will be conducted in China.Based on Bayesian methods,the trial will employ response-adaptive randomization to allocate patients to study groups based on data collected over the course of the trial.The adaptive Bayesian trial design will employ a Bayesian hierarchical model with“stopping”and“continuation”criteria once a predetermined posterior probability of superiority or futility and a decision threshold are reached.The trial can be implemented more efficiently by sharing the master protocol and organizational management mechanisms of the sub-trial we have implemented.The primary patient-reported outcome is a change in the Leicester Cough Questionnaire score,reflecting an improvement in cough-specific quality of life.The adaptive Bayesian trial design may be a promising method to facilitate the rapid clinical evaluation of TCM effectiveness for PPF,and will provide an example for how to evaluate TCM effectiveness in rare and refractory diseases.However,due to the complexity of the trial implementation,sufficient simulation analysis by professional statistical analysts is required to construct a Bayesian response-adaptive randomization procedure for timely response.Moreover,detailed standard operating procedures need to be developed to ensure the feasibility of the trial implementation.展开更多
Landslides triggered by high gas pressure represent a distinct geotechnical hazard,especially in scenarios without significant rainfall.Recent studies have revealed that high-pressure gas accumulation within slopes ca...Landslides triggered by high gas pressure represent a distinct geotechnical hazard,especially in scenarios without significant rainfall.Recent studies have revealed that high-pressure gas accumulation within slopes can be a dominant trigger for large-scale failures although the processes behind this remain not well understood.This study examines how unsaturated soil slopes fail under high gas pressure using a combination of laboratory experiments and numerical simulations.A key discovery is that gas pressure changes slope stability by redistributing pore fluids and altering effective stress,with distinct depthdependent effects.Moreover,a novel concept of critical stable gas pressure(P_(ac))is proposed as a practical threshold for stability assessment,which is depthdependent,with extreme values at shallow and intermediate depths,reflecting the interplay between gas diffusion and overburden resistance.This study advances the mechanistic understanding of gasinduced slope instability and offers actionable benchmarks for managing related risks in engineering projects including waste landfill management and shale gas operations.展开更多
Underwater target detection in forward-looking sonar(FLS)images is a challenging but promising endeavor.The existing neural-based methods yield notable progress but there remains room for improvement due to overlookin...Underwater target detection in forward-looking sonar(FLS)images is a challenging but promising endeavor.The existing neural-based methods yield notable progress but there remains room for improvement due to overlooking the unique characteristics of underwater environments.Considering the problems of low imaging resolution,complex background environment,and large changes in target imaging of underwater sonar images,this paper specifically designs a sonar images target detection Network based on Progressive sensitivity capture,named ProNet.It progressively captures the sensitive regions in the current image where potential effective targets may exist.Guided by this basic idea,the primary technical innovation of this paper is the introduction of a foundational module structure for constructing a sonar target detection backbone network.This structure employs a multi-subspace mixed convolution module that initially maps sonar images into different subspaces and extracts local contextual features using varying convolutional receptive fields within these heterogeneous subspaces.Subsequently,a Scale-aware aggregation module effectively aggregates the heterogeneous features extracted from different subspaces.Finally,the multi-scale attention structure further enhances the relational perception of the aggregated features.We evaluated ProNet on three FLS datasets of varying scenes,and experimental results indicate that ProNet outperforms the current state-of-the-art sonar image and general target detectors.展开更多
Rationale:IgA vasculitis or Henoch-Schonlein purpura is an immune complex mediated small vessel vasculitis characterized by clinical triad of arthritis,palpable purpura and gastrointestinal symptoms.It is commonly see...Rationale:IgA vasculitis or Henoch-Schonlein purpura is an immune complex mediated small vessel vasculitis characterized by clinical triad of arthritis,palpable purpura and gastrointestinal symptoms.It is commonly seen in children below 10-year-old,though adults may be affected.Patient’s Concern:A 40-year-old man with type-2 diabetes mellitus presented with fever,melena,palpable purpuric rash and hematuria with acute kidney injury,associated with nephrotic range proteinuria.Skin biopsy revealed leukocytoclastic vasculitis and renal biopsy showed IgA deposits in the mesangium and capillary loops with fibro cellular crescents confirming the diagnosis of IgA vasculitis with crescentic rapidly progressive glomerulonephritis.Diagnosis:IgA vasculitis with rapidly progressive glomerulonephritis.Interventions:The patient was treated with pulse intravenous methylprednisolone 500 mg/day for 3 days with tapering doses of oral prednisolone and intravenous cyclophosphamide(0.5 gm/m^(2) body surface area)under the cover of intravenous antibiotics for diabetic foot ulcer.Outcomes:Patient improved gradually with return to baseline creatinine after 3 months of follow up.Lessons:Rapidly progressive glomerulonephritis is a rare manifestation of IgA vasculitis and warrants special care and early treatment.The incidence of rapidly progressive glomerulonephritis in IgA vasculitis is unknown.It carries a high risk of progression to chronic kidney disease and thus should be treated as soon as feasible after diagnosis.展开更多
The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementa...The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementation of the progressive talent training model featuring the integration of industry and education and work-study alternation is conducive to carrying out talent cultivation activities,improving the effectiveness of professional talent development,and effectively meeting the needs of market development.From the perspective of Meizhou Hakka cuisine cooking talents,this paper analyzes the problems existing in the implementation of the industry-education integration and work-study alternation model,and puts forward specific practical strategies for talent cultivation.The purpose is to enhance the training effect of Hakka cuisine cooking talents and provide reference for the subsequent optimization of professional teaching.展开更多
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘A new extended distribution called the Odd Exponential Generalized Exponential-Exponential distribution(EOEGE-E)is proposed based on generalization of the odd generalized exponential family(OEGE-E).The statistical properties of the proposed distribution are derived.The study evaluates the accuracy of six estimation methods under complete samples.Estimation techniques include maximumlikelihood,ordinary least squares,weighted least squares,maximumproduct of spacing,Cramer vonMises,and Anderson-Darling methods.Twomethods of estimation for the involved parameters are considered based on progressively type Ⅱ censored data(PTⅡC).These methods are maximum likelihood and maximum product of spacing.The proposed distribution’s effectiveness was evaluated using different data sets from various fields.The proposed distribution provides a better fit for these datasets than existing probability distributions.
基金supported and funded by the Deanship of Scientifc Research at ImamMohammad Ibn Saud Islamic University(IMSIU)(grant number IMSIU-DDRSP2503).
文摘Accelerated life tests play a vital role in reliability analysis,especially as advanced technologies lead to the production of highly reliable products to meet market demands and competition.Among these tests,progressive-stress accelerated life tests(PSALT)allow for continuous changes in applied stress.Additionally,the generalized progressive hybrid censoring(GPHC)scheme has attracted significant attention in reliability and survival analysis,particularly for handling censored data in accelerated testing.It has been applied to various failure models,including competing risks and step-stress models.However,despite its growing relevance,a notable gap remains in the literature regarding the application of GPHC in PSALT models.This paper addresses that gap by studying PSALT under a GPHC scheme with binomial removal.Specifically,it considers lifetimes following the quasi-Xgamma distribution.Model parameters are estimated using both maximum likelihood and Bayesian methods under gamma priors.Interval estimation is provided through approximate confidence intervals,bootstrap methods,and Bayesian credible intervals.Bayesian estimators are derived under squared error and entropy loss functions,using informative priors in simulation and non-informative priors in real data applications.A simulation study is conducted to evaluate various censoring schemes,with coverage probabilities and interval widths assessed via Monte Carlo simulations.Additionally,Bayesian predictive estimates and intervals are presented.The proposed methodology is illustrated through the analysis of two real-world accelerated life test datasets.
基金supported by the National Natural Science Foundation of China(Grant Nos.42372312,and 42172299)the Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture(Grant No.JDYC20220807).
文摘The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics of frozen sodium sulfate saline sandy soil,a series of uniaxial compression tests were performed by integrating digital image correlation(DIC)technology into the testing apparatus.The evolution law of the uniaxial compression strength(UCS),the failure strain,and the formation of the shear band of the frozen sodium sulfate saline sandy soil were analyzed.The test results show that within the scope of this study,with the increase of salt content,both the UCS and the shear band angle initially decrease with increasing salt content before showing an increase.In contrast,the failure strain and the width of the shear band exhibit an initial increase followed by a decrease in the samples.In addition,to investigate the brittle failure characteristics of frozen sodium sulfate saline sandy soil,two classic brittleness evaluation methods were employed to quantitatively assess the brittleness level for the soil samples.The findings suggest that the failure characteristics under all test conditions in this study belong to the transition stage between brittle and ductile,indicating that frozen sodium sulfate saline sandy soil exhibits certain brittle behavior under uniaxial compression conditions,and the brittleness index basically decreases and then increases with the rise in salt content.
基金supported by the National Key R&D Program of China(No.2017YFB0304402)。
文摘The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.
基金Natural Science Foundation of Heilongjiang Province(YQ2022C014)National Natural Science Foundation of China(32302768).
文摘Background Progressive oxidative stress easily occurs as a result of a gradual increase in the intensity of maternal metabolism due to rapid foetal development and increased intensity of lactation.However,studies on the effects of processive oxidative stress on nutrient transport in the placenta have received little attention.The present study was conducted on sows at 85 days of gestation to study the effects of pterostilbene(PTE)on maternal oxidative stress status and placental nutrient transport.Results PTE increased the antioxidant capacity and immunoglobulin content in mothers’blood and milk,reduced the level of inflammatory factors,and improved the nutrient content of milk.PTE also reduced sow backfat loss and the number of weak sons,and increased piglet weaning weight and total weaning litter weight.We subsequently found that PTE enhanced placental glucose and fatty acid transport and further affected glycolipid metabolism by increasing the expression of LAL,PYGM,and Gbe-1,which activated the PI3K phosphorylation pathway.Moreover,PTE addition altered the relative abundance of the Firmicutes,Proteobacteria,Parabacillus,and Bacteroidetes-like RF16 groups in sow faeces.PTE increased the levels of acetate,propionate,butyrate and isovalerate in the faeces.Conclusions These findings reveal that the addition of PTE during pregnancy and lactation mitigates the effects of processive oxidative stress on offspring development by altering maternal microbial and placental nutrient trans-port capacity.
基金supported by the National Natural Science Foundation of China(No.12472340).
文摘This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of 3D4D(three-dimensional four-directional)braided composite I-beam under four-point flexure spectrum loading.New fatigue damage models of fibre yarn,matrix and fibre–matrix interface are proposed,and fatigue failure criteria and PFDA(Progressive Fatigue Damage Algorithm)are thus presented for meso-scale fatigue damage modelling of 3D4D braided composite I-beam.To validate the aforementioned model and algorithm,fatigue tests are conducted on the 3D4D braided composite I-beam under four-point flexure spectrum loading,and fatigue failure mechanisms are analyzed and discussed.Novel global–local FE(Finite Element)model based on the PFDA is generated for modelling progressive fatigue failure process and predicting fatigue life of 3D4D braided composite I-beam under four-point flexure spectrum loading.Good agreement has been achieved between experimental results and predictions,demonstrating the effective usage of new model.It is shown that matrix cracking and interfacial debonding initially initiates on top surface of top flange of I-beam,and then gradually propagates from the side surface of top flange to the intermediate web along the braiding angle,and considerable fiber breakage finally causes final fatigue failure of I-beam.
基金funded by Researchers Supporting Project number(RSPD2025R969),King Saud University,Riyadh,Saudi Arabia.
文摘In this present work,we propose the expected Bayesian and hierarchical Bayesian approaches to estimate the shape parameter and hazard rate under a generalized progressive hybrid censoring scheme for the Kumaraswamy distribution.These estimates have been obtained using gamma priors based on various loss functions such as squared error,entropy,weighted balance,and minimum expected loss functions.An investigation is carried out using Monte Carlo simulation to evaluate the effectiveness of the suggested estimators.The simulation provides a quantitative assessment of the estimates accuracy and efficiency under various conditions by comparing them in terms of mean squared error.Additionally,the monthly water capacity of the Shasta reservoir is examined to offer real-world examples of how the suggested estimations may be used and performed.
文摘Objective:To investigate the impact of progressive effect nutritional care on uremia patients undergoing dialysis.Methods:A total of 101 uremia patients undergoing dialysis admitted from January 2024 to March 2025 were selected as the study subjects and divided into two groups by lottery method.The control group(55 cases)received routine care,while the observation group(56 cases)received a combination of routine care and progressive effect nutritional care.Results:After 4 weeks of care,the observation group demonstrated higher treatment adherence(P<0.05),better quality of life(P<0.05),and improved nutritional status(P<0.05)compared to the control group.Conclusion:Progressive effect nutritional care can significantly enhance treatment adherence,quality of life,and nutritional status in uremia patients undergoing dialysis.
基金the National Key Research and Development Program of China(Grant No.2023YFF1303501)the National Science Fund for Distinguished Young Scholars of China(Grant No.42225702)the Open Fund of State Key Laboratory of Frozen Soil Engineering(Grant No.SKLFSE201814).
文摘Frost heave and thaw settlement in cold regions pose a significant threat to engineering construction.Optical frequency domain reflectometry(OFDR)based on Rayleigh scattering can be applied to monitor ground deformation in frozen soil areas,where the interface behavior of soil-embedded fiber optic sensors governs the monitoring accuracy.In this paper,a series of pullout tests were conducted on fiber optic(FO)cables embedded in the frozen soil to investigate the cable‒soil interface behavior.An experimental study was performed on interaction effects,particularly focused on the water content of unfrozen soil,freezing duration,and differential distribution of water content in frozen soil.The highresolution axial strains of FO cables were obtained using a sensing interrogator,and were used to calculate the interface shear stress.The interfacial mechanical response was analytically modeled using the ideal elasto‒plastic and softening constitutive models.Three freezing periods,correlating with the phase change process between ice and water,were analyzed.The results shows that the freezing effect can amplify the peak shear stress at the cable-soil interface by eight times.A criterion for the interface coupling states was proposed by normalizing the pullout force‒displacement information.Additionally,the applicability of existing theoretical models was discussed by comparing the results of theoretical back‒calculations with experimental measurements.This study provides new insights into the progressive interfacial failure behavior between strain sensing cable and frozen soil,which can be used to assist the interpretation of FO monitoring results of frozen soil deformation.
文摘With breakthroughs in data processing and pattern recognition through deep learning technologies,the use of advanced algorithmic models for analyzing and interpreting soil spectral information has provided an efficient and economical method for soil quality assessment.However,traditional single-output networks exhibit limitations in the prediction process,particularly in their inability to fully utilize the correlations among various elements.As a result,single-output networks tend to be optimized for a single task,neglecting the interrelationships among different soil elements,which limits prediction accuracy and model generalizability.To overcome this limitation,in this study,a multi-task learning architecture with a progressive extraction network was implemented for the simultaneous prediction of multiple indicators in soil,including nitrogen(N),organic carbon(OC),calcium carbonate(CaCO 3),cation exchange capacity(CEC),and pH.Furthermore,while incorporating the Pearson correlation coefficient,convolutional neural networks,long short-term memory networks and attention mechanisms were combined to extract local abstract features from the original spectra,thereby further improving the model.This architecture is referred to as the Relevance-sharing Progressive Layered Extraction Network.The model employs an adaptive joint loss optimization method to update the weights of individual task losses in the multi-task learning training process.
基金National Natural Science Foundation of China,Grant/Award Numbers:51708016,12172036R&D Program of Beijing Municipal Education Commission,Grant/Award Number:KM202110016014+1 种基金Government of Perm Krai,Research Project,Grant/Award Numbers:СED-26-08-08-28,С-26/628Graduate Innovation Program of Beijing University of Civil Engineering and Architecture,Grant/Award Number:PG2024035。
文摘Microcrack growth during progressive compressive failure in brittle rocks strongly influences the safety of deep underground engineering.The external shear stressτxy on brittle rocks greatly affects microcrack growth and progressive failure.However,the theoretical mechanism of the growth direction evolution of the newly generated wing crack during progressive failure has rarely been studied.A novel analytical method is proposed to evaluate the shear stress effect on the progressive compressive failure and microcrack growth direction in brittle rocks.This model consists of the wing crack growth model under the principal compressive stresses,the direction correlation of the general stress,the principal stress and the initial microcrack inclination,and the relationship between the wing crack length and strain.The shear stress effect on the relationship between y-direction stress and wing crack growth and the relationship between y-direction stress and y-direction strain are analyzed.The shear stress effect on the wing crack growth direction during the progressive compressive failure is determined.The initial crack angle effect on the y-direction peak stress and the wing crack growth direction during the progressive compressive failure considering shear stress is also discussed.A crucial conclusion is that the direction of wing crack growth has a U-shaped variation with the growth of the wing crack.The rationality of the analytical results is verified by an experiment and from numerical results.The study results provide theoretical support for the evaluation of the safety and stability of surrounding rocks in deep underground engineering.
基金Supported by the National Natural Science Foundation of China,No.82471804.
文摘BACKGROUND Progressive familial intrahepatic cholestasis type 1(PFIC-1)is a genetic cholestatic disease causing end-stage liver disease,which needs liver transplantation(LT).Simultaneous biliary diversion(BD)was recommended to prevent allograft steatosis after transplantation,while increasing the risk of infection.Here,an attempt was made to perform BD using appendix to prevent bacterial translocation after LT.CASE SUMMARY An 11-month-old boy diagnosed with PFIC-1 received ABO compatible living donor LT due to refractory jaundice and pruritus.His mother donated her left lateral segment with a graft-to-recipient weight ratio of 2.9%.Internal BD was constructed during LT using the appendix by connecting its proximal end with the intrahepatic biliary duct and the distal end with colon.Biliary leakage was suspected on the 5th day after transplantation and exploratory laparotomy indicated biliary leakage at the cutting surface of liver.The liver function returned to normal on the 9th day post-operation and maintained normal during the 15-month follow-up.Cholangiography at 10 months after transplantation confirmed the direct secretion of bile into colon.Computerized tomography scan(4 months and 10 months)and liver biopsy(10 months)indicated no steatosis in the allograft.No complaint of recurrent diarrhea,infection or growth retardation was reported during follow-up.CONCLUSION Internal BD using appendix during LT is effective in preventing allograft steatosis and post-transplant infection in PFIC-1 recipients.
文摘Deep learning-based Joint Source-Channel Coding(JSCC)is a crucial component in semantic communication,and recent research has made significant progress in adapting to different channels.In this paper,we propose a multi-stage progressive technique called Deep learning based Progressive Joint Source-Channel Coding(DP-JSCC).This approach partitions the source into multiple stages and transmits the signals continuously.The receiver gradually enhances the quality of image reconstruction by progressively receiving the signals,offering greater flexibility compared to existing dynamic rate transmission methods.The model adopts a lightweight architectural design,where we introduce an efficient module called the Inverted Shuffle Attention Bottleneck(ISAB)and incorporate self-attention mechanisms in the encoding and decoding process to capture signal correlations and establish long-range dependencies.Additionally,we introduce the Progressive Focus Weight Allocation(PFWA)method to improve the image reconstruction capability in progressive transmission tasks.These design enhance the expressive capacity of the model.Simulation results demonstrate that DP-JSCC can flexibly adjust the transmission rate according to requirements without the need for retraining or deployment,enabling continuous optimization of signals at different rates.Furthermore,compared to stateof-the-art JSCC methods,DP-JSCC exhibits advantages in terms of computational complexity,parameter count,and reconstruction performance.
文摘Progressive familial intrahepatic cholestasis(PFIC)is a group of rare,inherited cholestatic liver disorders presenting in infants and children and are associated with impaired bile flow(i.e.,cholestasis),pruritus and progressive liver disease.Historically there has been no effective or approved pharmacologic treatments for these disorders and standard medical treatment has only been supportive.The impaired bile flow within the liver,leads to accumulation in the liver and inflammation.Historically there has been no effective or approved pharmacologic treatments for these disorders and standard medical treatment has only been supportive.A potential for reducing pathologic bile accumulation in the liver is surgical biliary diversion,with an aim to interrupt the enterohepatic circulation.These procedures have demonstrated a positive effect in PFIC by normalizing serum bile acids,reducing pruritus and liver injury and improving the patient quality of life.Nonsurgical approach to interrupting the enterohepatic circulation is inhibition of the ileal bile acid transporter(IBAT).IBAT inhibition has demonstrated efficacy in reducing serum bile acids and pruritus.We aim to present the 13 types of PFIC and the current evidence on the use of IBAT inhibitors in treating children with PFIC.
基金supported by National Natural Science Foundation of China(No.81973713)。
文摘patients with PPF.TCM treatments are typically diverse and individualized,requiring urgent development of efficient and precise design strategies to identify effective treatment options.We designed an innovative Bayesian adaptive two-stage trial,hoping to provide new ideas for the rapid evaluation of the effectiveness of TCM in PPF.An open-label,two-stage,adaptive Bayesian randomized controlled trial will be conducted in China.Based on Bayesian methods,the trial will employ response-adaptive randomization to allocate patients to study groups based on data collected over the course of the trial.The adaptive Bayesian trial design will employ a Bayesian hierarchical model with“stopping”and“continuation”criteria once a predetermined posterior probability of superiority or futility and a decision threshold are reached.The trial can be implemented more efficiently by sharing the master protocol and organizational management mechanisms of the sub-trial we have implemented.The primary patient-reported outcome is a change in the Leicester Cough Questionnaire score,reflecting an improvement in cough-specific quality of life.The adaptive Bayesian trial design may be a promising method to facilitate the rapid clinical evaluation of TCM effectiveness for PPF,and will provide an example for how to evaluate TCM effectiveness in rare and refractory diseases.However,due to the complexity of the trial implementation,sufficient simulation analysis by professional statistical analysts is required to construct a Bayesian response-adaptive randomization procedure for timely response.Moreover,detailed standard operating procedures need to be developed to ensure the feasibility of the trial implementation.
基金supported by the Postdoctoral Science Foundation of the Power China Chengdu Engineering Corporation Limited(No.P66725)Science and Technology Fund Support Project of Power China Chengdu Engineering Corporation.(No.PA1717)。
文摘Landslides triggered by high gas pressure represent a distinct geotechnical hazard,especially in scenarios without significant rainfall.Recent studies have revealed that high-pressure gas accumulation within slopes can be a dominant trigger for large-scale failures although the processes behind this remain not well understood.This study examines how unsaturated soil slopes fail under high gas pressure using a combination of laboratory experiments and numerical simulations.A key discovery is that gas pressure changes slope stability by redistributing pore fluids and altering effective stress,with distinct depthdependent effects.Moreover,a novel concept of critical stable gas pressure(P_(ac))is proposed as a practical threshold for stability assessment,which is depthdependent,with extreme values at shallow and intermediate depths,reflecting the interplay between gas diffusion and overburden resistance.This study advances the mechanistic understanding of gasinduced slope instability and offers actionable benchmarks for managing related risks in engineering projects including waste landfill management and shale gas operations.
基金supported in part by Youth Innovation Promotion Association,Chinese Academy of Sciences under Grant 2022022in part by South China Sea Nova project of Hainan Province under Grant NHXXRCXM202340in part by the Scientific Research Foundation Project of Hainan Acoustics Laboratory under grant ZKNZ2024001.
文摘Underwater target detection in forward-looking sonar(FLS)images is a challenging but promising endeavor.The existing neural-based methods yield notable progress but there remains room for improvement due to overlooking the unique characteristics of underwater environments.Considering the problems of low imaging resolution,complex background environment,and large changes in target imaging of underwater sonar images,this paper specifically designs a sonar images target detection Network based on Progressive sensitivity capture,named ProNet.It progressively captures the sensitive regions in the current image where potential effective targets may exist.Guided by this basic idea,the primary technical innovation of this paper is the introduction of a foundational module structure for constructing a sonar target detection backbone network.This structure employs a multi-subspace mixed convolution module that initially maps sonar images into different subspaces and extracts local contextual features using varying convolutional receptive fields within these heterogeneous subspaces.Subsequently,a Scale-aware aggregation module effectively aggregates the heterogeneous features extracted from different subspaces.Finally,the multi-scale attention structure further enhances the relational perception of the aggregated features.We evaluated ProNet on three FLS datasets of varying scenes,and experimental results indicate that ProNet outperforms the current state-of-the-art sonar image and general target detectors.
文摘Rationale:IgA vasculitis or Henoch-Schonlein purpura is an immune complex mediated small vessel vasculitis characterized by clinical triad of arthritis,palpable purpura and gastrointestinal symptoms.It is commonly seen in children below 10-year-old,though adults may be affected.Patient’s Concern:A 40-year-old man with type-2 diabetes mellitus presented with fever,melena,palpable purpuric rash and hematuria with acute kidney injury,associated with nephrotic range proteinuria.Skin biopsy revealed leukocytoclastic vasculitis and renal biopsy showed IgA deposits in the mesangium and capillary loops with fibro cellular crescents confirming the diagnosis of IgA vasculitis with crescentic rapidly progressive glomerulonephritis.Diagnosis:IgA vasculitis with rapidly progressive glomerulonephritis.Interventions:The patient was treated with pulse intravenous methylprednisolone 500 mg/day for 3 days with tapering doses of oral prednisolone and intravenous cyclophosphamide(0.5 gm/m^(2) body surface area)under the cover of intravenous antibiotics for diabetic foot ulcer.Outcomes:Patient improved gradually with return to baseline creatinine after 3 months of follow up.Lessons:Rapidly progressive glomerulonephritis is a rare manifestation of IgA vasculitis and warrants special care and early treatment.The incidence of rapidly progressive glomerulonephritis in IgA vasculitis is unknown.It carries a high risk of progression to chronic kidney disease and thus should be treated as soon as feasible after diagnosis.
基金2025 Meizhou Municipal Planning Project of Philosophy and Social Sciences(Project No.:mzsklx2025101)。
文摘The development of Meizhou Hakka cuisine relies on the role of professional cooking talents.Higher vocational colleges serve as the platform for cultivating cooking talents.Among various training models,the implementation of the progressive talent training model featuring the integration of industry and education and work-study alternation is conducive to carrying out talent cultivation activities,improving the effectiveness of professional talent development,and effectively meeting the needs of market development.From the perspective of Meizhou Hakka cuisine cooking talents,this paper analyzes the problems existing in the implementation of the industry-education integration and work-study alternation model,and puts forward specific practical strategies for talent cultivation.The purpose is to enhance the training effect of Hakka cuisine cooking talents and provide reference for the subsequent optimization of professional teaching.
