Traumatic spinal cord injury(SCI)is a devastating central nervous system(CNS)disorder characterized by significant neurological dysfunction and sensory loss,and effective therapies that prevent neuronal loss and funct...Traumatic spinal cord injury(SCI)is a devastating central nervous system(CNS)disorder characterized by significant neurological dysfunction and sensory loss,and effective therapies that prevent neuronal loss and functional recovery remain elusive.After SCI,lesions are surrounded by neuroprotective borders formed by newly proliferated reactive astrocytes.Astrocyte proliferation and activation mediate the formation and function of the glial scar and influence the balance between protection and inflammation.展开更多
基金supported by a Grant-in-Aid of AMED under Grant Numbers(JP22gm1510009)to RM.
文摘Traumatic spinal cord injury(SCI)is a devastating central nervous system(CNS)disorder characterized by significant neurological dysfunction and sensory loss,and effective therapies that prevent neuronal loss and functional recovery remain elusive.After SCI,lesions are surrounded by neuroprotective borders formed by newly proliferated reactive astrocytes.Astrocyte proliferation and activation mediate the formation and function of the glial scar and influence the balance between protection and inflammation.
