Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) ...Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) and Thelp typeII(Th2) m ay play an importantrolein theprocess. Study of thedistribution and functionalstatusof Th1/Th2 m ay behelpfulforevaluating thepathogenesisof POF.13 patientsw ith id- iopathic POFand 7 w om en of reproductiveagew ith norm alcyclew ereenrolled in this study.The percentage of Th1 and Th2 cellsfrom peripheralblood of thepatientsand the controls w as studied using FITC labelled CD4 m Ab to separate CD4+ cells by FACS, in com bination w ith in situ hybridization using Dig-labelled IL2, IL6 cDNA probes.Results:The patients w ith POF had significantly higher percentage of Th1 cellsascompared w ith the controls(49.76±9.22,20.06±7.10respectively, P< 0.001).The ratio of Th1/Th2 in thepatientsw ith POFw assignificantly higherthan thatof thecontrols(1.15±0.17, 0.63±0.09, P< 0.001). Conclusions: Thefindings of thisstudy suggestthatpatientsw ith POFhaveincreased Th1 cellactivation, w hich m ay be related to the pathogenesisof POF. Corresponding author: WANG Yi-li E-m ail: w yl@ irix. xam u. edu. cn展开更多
Surface deformation calculations due to environmental loading typically rely on the Preliminary Reference Earth Model(PREM),which assumes a homogeneous and isotropic Earth structure,leading to noticeable errors.To enh...Surface deformation calculations due to environmental loading typically rely on the Preliminary Reference Earth Model(PREM),which assumes a homogeneous and isotropic Earth structure,leading to noticeable errors.To enhance accuracy,the high-precision crustal model CRUST 1.0 is used to refine calculations of regional surface deformation caused by hydrological and non-tidal atmospheric loading.The improved model is applied to 27 Global Navigation Satellite System(GNSS)reference stations in the first phase of the Crustal Movement Observation Network of China(CMONOC),considering their geographical locations.Green's functions are employed to compute surface deformation at each site.Results indicate relative discrepancies of 11.78%and 14.14%for non-tidal atmospheric and hydrological loading compared to PREM,with vertical deformation differences reaching an average of 18.95%.Additionally,the distinct spatial distribution characteristics of the relative differences in each direction indicate that the improved RPREM model is more responsive to the mass variations derived from Gravity Recovery and Climate Experiment(GRACE).The results suggest that the improved PRREM model demonstrates higher sensitivity to loading variations than the PREM model.Utilizing the enhanced method of calculating surface deformation through the utilization of Green's function at the site could effectively reduce the calculation error caused by regional structure,leading to enhanced uniformity and isotropy of PREM.展开更多
文摘Thepathogenesisof prem ature ovarian failure (POF) rem ains unknow n. Accu- m ulated evidences indicate that abnorm ality in the im m une system m ay be one of the m ajor reasonsand theim balanceof Thelp typeI(Th1) and Thelp typeII(Th2) m ay play an importantrolein theprocess. Study of thedistribution and functionalstatusof Th1/Th2 m ay behelpfulforevaluating thepathogenesisof POF.13 patientsw ith id- iopathic POFand 7 w om en of reproductiveagew ith norm alcyclew ereenrolled in this study.The percentage of Th1 and Th2 cellsfrom peripheralblood of thepatientsand the controls w as studied using FITC labelled CD4 m Ab to separate CD4+ cells by FACS, in com bination w ith in situ hybridization using Dig-labelled IL2, IL6 cDNA probes.Results:The patients w ith POF had significantly higher percentage of Th1 cellsascompared w ith the controls(49.76±9.22,20.06±7.10respectively, P< 0.001).The ratio of Th1/Th2 in thepatientsw ith POFw assignificantly higherthan thatof thecontrols(1.15±0.17, 0.63±0.09, P< 0.001). Conclusions: Thefindings of thisstudy suggestthatpatientsw ith POFhaveincreased Th1 cellactivation, w hich m ay be related to the pathogenesisof POF. Corresponding author: WANG Yi-li E-m ail: w yl@ irix. xam u. edu. cn
基金supported by the National Natural Science Foundation of China(Grant 42204006)the Education Commission of Hubei Province of China(Grant D20232802)+1 种基金the Open Fund of Wuhan,Gravitationand Solid EarthTides,National Observationand Research Station(Grant WHYWZ202407)the Open Fund of Hubei Luojia Laboratory(Grant 230100020,230100019).
文摘Surface deformation calculations due to environmental loading typically rely on the Preliminary Reference Earth Model(PREM),which assumes a homogeneous and isotropic Earth structure,leading to noticeable errors.To enhance accuracy,the high-precision crustal model CRUST 1.0 is used to refine calculations of regional surface deformation caused by hydrological and non-tidal atmospheric loading.The improved model is applied to 27 Global Navigation Satellite System(GNSS)reference stations in the first phase of the Crustal Movement Observation Network of China(CMONOC),considering their geographical locations.Green's functions are employed to compute surface deformation at each site.Results indicate relative discrepancies of 11.78%and 14.14%for non-tidal atmospheric and hydrological loading compared to PREM,with vertical deformation differences reaching an average of 18.95%.Additionally,the distinct spatial distribution characteristics of the relative differences in each direction indicate that the improved RPREM model is more responsive to the mass variations derived from Gravity Recovery and Climate Experiment(GRACE).The results suggest that the improved PRREM model demonstrates higher sensitivity to loading variations than the PREM model.Utilizing the enhanced method of calculating surface deformation through the utilization of Green's function at the site could effectively reduce the calculation error caused by regional structure,leading to enhanced uniformity and isotropy of PREM.
