BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive ne...BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.展开更多
BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a prevalent neurodevelopmental disorder in adolescents characterized by inattention,hyperactivity,and impulsivity,which impact cognitive,behavioral,and emoti...BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a prevalent neurodevelopmental disorder in adolescents characterized by inattention,hyperactivity,and impulsivity,which impact cognitive,behavioral,and emotional functioning.Resting-state functional magnetic resonance imaging(rs-fMRI)provides critical insights into the functional architecture of the brain in ADHD.Despite extensive research,specific brain regions consistently affected in ADHD patients during these formative years have not been comprehensively delineated.AIM To identify consistent vulnerable brain regions in adolescent ADHD patients using rs-fMRI and activation likelihood estimation(ALE)meta-analysis.METHODS We conducted a comprehensive literature search up to August 31,2024,to identify studies investigating functional brain alterations in adolescents with ADHD.We utilized regional homogeneity(ReHo),amplitude of low-frequency fluctuations(ALFF),dynamic ALFF(dALFF)and fractional ALFF(fALFF)analyses.We compared the regions of aberrant spontaneous neural activity in adolescents with ADHD with those in healthy controls(HCs)using ALE.RESULTS Fifteen studies(468 adolescent ADHD patients and 466 HCs)were included.Combining the ReHo and ALFF/fALFF/dALFF data,the results revealed increased activity in the right lingual gyrus[LING,Brodmann Area(BA)18],left LING(BA 18),and right cuneus(CUN,BA 23)in adolescent ADHD patients compared with HCs(voxel size:592-32 mm³,P<0.05).Decreased activity was observed in the left medial frontal gyrus(MFG,BA 9)and left precuneus(PCUN,BA 31)in adolescent ADHD patients compared with HCs(voxel size:960-456 mm³,P<0.05).Jackknife sensitivity analyses demonstrated robust reproducibility in 11 of the 13 tests for the right LING,left LING,and right CUN and in 11 of the 14 tests for the left MFG and left PCUN.CONCLUSION We identified specific brain regions with both increased and decreased activity in adolescent ADHD patients,enhancing our understanding of the neural alterations that occur during this pivotal stage of development.展开更多
Background:Auditory verbal hallucinations(AVHs)of schizophrenia have been associated with structural and functional alterations of some brain regions.However,the brain regional homogeneity(ReHo)alterations specific to...Background:Auditory verbal hallucinations(AVHs)of schizophrenia have been associated with structural and functional alterations of some brain regions.However,the brain regional homogeneity(ReHo)alterations specific to AVHs of schizophrenia remain unclear.In the current study,we aimed to investigate ReHo alterations specific to schizophrenic AVHs.Methods:Thirty-five schizophrenic patients with AVH,41 schizophrenic patients without AVHs,and fifty healthy subjects underwent resting-state functional magnetic resonance imaging.ReHo differences across the three groups were tested using a voxel-wise analysis.Results:Compared with the healthy control group,the two schizophrenia groups showed significantly increased ReHo in the right caudate and inferior temporal gyrus and decreased ReHo in the bilateral postcentral gyrus and thalamus and the right inferior occipital gyrus(false discovery rate corrected,P〈0.05).More importantly,the AVH group exhibited significantly increased ReHo in the left precuneus compared with the non-AVH group.However,using correlation analysis,we did not find any correlation between the auditory hallucination rating scale score and the ReHo of brain regions.Conclusions:Our results suggest that increased ReHo in the left precuneus may be a pathological feature exclusive to schizophrenic AVHs.展开更多
Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined....Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging （R-fMRI） study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample （NKI-RS） to examine the relationship between the fractional amplitude of low-frequency fluctuation （fALFF） signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity （RSFC） between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.展开更多
Background:Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders,albeit its neurophysiological basis remains elusive.Existing neuroimaging studies have ...Background:Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders,albeit its neurophysiological basis remains elusive.Existing neuroimaging studies have highlighted the precuneus and hippocampus as two pivotal brain regions in rumination’s neural underpinnings.Methods:Here,we examined the intracranial electroencephalogram(iEEG)recordings from 21 patients with epilepsy during a naturalistic,continuous,active rumination state and measured the low frequency(1-8 Hz)and high gamma(70-150 Hz)band oscillation powers.Results:We observed enhanced low-frequency power in the precuneus and reduced high gamma power in the hippocampus during the rumination condition compared to the control condition.The hippocampal high gamma power reduction was associated with the self-reported reflection tendency.Conclusions:Our findings provided empirical evidence of the neurophysiological underpinnings of rumination and implicated a precuneus-hippocampus coupling across neural oscillation bands during an active rumination state.展开更多
Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to ex...Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest(ROIs)and the clinical symptoms of PD patients.Methods:Fifty-three drug-naïve,non-comorbid PD patients and 70 healthy controls(HCs)were recruited.Seed-based resting-state functional connectivity(rsFC)analyses were conducted using the bilateral amygdalae and its subregions as the ROI seed.Two samples t test was performed for the seed-based Fisher's z-transformed correlation maps.The relationship between the abnormal spontaneous functional connectivity patterns of the ROIs and the clinical symptoms of PD patients was investigated by Pearson correlation analysis.Results:PD patients showed increased rsFC of the bilateral amygdalae and almost all the amygdala subregions with the precuneus/posterior cingulate gyrus compared with the HC group(left amygdala[lAMY]:t=4.84,P<0.001;right amygdala[rAMY]:t=4.55,P<0.001;left centromedial amygdala[lCMA]:t=3.87,P<0.001;right centromedial amygdala[rCMA]:t=3.82,P=0.002;left laterobasal amygdala[lBLA]:t=4.33,P<0.001;right laterobasal amygdala[rBLA]:t=4.97,P<0.001;left superficial amygdala[lSFA]:t=3.26,P=0.006).The rsFC of the lBLA with the left angular gyrus/inferior parietal lobule remarkably increased in the PD group(t=3.70,P=0.003).And most of the altered rsFCs were located in the default mode network(DMN).A significant positive correlation was observed between the severity of anxiety and the rsFC between the lSFA and the left precuneus in PD patients(r=0.285,P=0.039).Conclusions:Our research suggested that the increased rsFC of amygdala subregions with DMN plays an important role in the pathogenesis of PD.Future studies may further explore whether the rsFC of amygdala subregions,especially with the regions in DMN,can be used as a biological marker of PD.展开更多
文摘BACKGROUND Over the past decade,resting-state functional magnetic resonance imaging(rsfMRI)has concentrated on brain networks such as the default mode network(DMN),the salience network(SN),and the central executive network(CEN),allowing for a better understanding of cognitive deficits observed in mental disorders,as well as other characteristic psychopathological phenomena such as thought and behavior disorganization.AIM To investigate differential patterns of effective connectivity across distributed brain networks involved in schizophrenia(SCH)and mood disorders.METHODS The sample comprised 58 patients with either paranoid syndrome in the context of SCH(n=26)or depressive syndrome(Ds)(n=32),in the context of major depressive disorder or bipolar disorder.The methods used include rs-fMRI and subsequent dynamic causal modeling to determine the direction and strength of connections to and from various nodes in the DMN,SN and CEN.RESULTS A significant excitatory connection from the dorsal anterior cingulate cortex to the anterior insula(aI)was observed in the SCH patient group,whereas inhibitory connections from the precuneus to the ventrolateral prefrontal cortex and from the aI to the precuneus were observed in the Ds group.CONCLUSION The results delineate specific patterns associated with SCH and Ds and offer a better explanation of the underlying mechanisms of these disorders,and inform differential diagnosis and precise treatment targeting.
基金Supported by National Natural Science Foundation of China,No.82460282Guizhou Province Science and Technology Plan Project,No.ZK-2023-195+1 种基金Guizhou High-Level Innovative Talent Project,No.gzwjrs2022-013Health Commission of Guizhou Province Project,No.gzwkj2024-475 and No.gzwkj2021-150.
文摘BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a prevalent neurodevelopmental disorder in adolescents characterized by inattention,hyperactivity,and impulsivity,which impact cognitive,behavioral,and emotional functioning.Resting-state functional magnetic resonance imaging(rs-fMRI)provides critical insights into the functional architecture of the brain in ADHD.Despite extensive research,specific brain regions consistently affected in ADHD patients during these formative years have not been comprehensively delineated.AIM To identify consistent vulnerable brain regions in adolescent ADHD patients using rs-fMRI and activation likelihood estimation(ALE)meta-analysis.METHODS We conducted a comprehensive literature search up to August 31,2024,to identify studies investigating functional brain alterations in adolescents with ADHD.We utilized regional homogeneity(ReHo),amplitude of low-frequency fluctuations(ALFF),dynamic ALFF(dALFF)and fractional ALFF(fALFF)analyses.We compared the regions of aberrant spontaneous neural activity in adolescents with ADHD with those in healthy controls(HCs)using ALE.RESULTS Fifteen studies(468 adolescent ADHD patients and 466 HCs)were included.Combining the ReHo and ALFF/fALFF/dALFF data,the results revealed increased activity in the right lingual gyrus[LING,Brodmann Area(BA)18],left LING(BA 18),and right cuneus(CUN,BA 23)in adolescent ADHD patients compared with HCs(voxel size:592-32 mm³,P<0.05).Decreased activity was observed in the left medial frontal gyrus(MFG,BA 9)and left precuneus(PCUN,BA 31)in adolescent ADHD patients compared with HCs(voxel size:960-456 mm³,P<0.05).Jackknife sensitivity analyses demonstrated robust reproducibility in 11 of the 13 tests for the right LING,left LING,and right CUN and in 11 of the 14 tests for the left MFG and left PCUN.CONCLUSION We identified specific brain regions with both increased and decreased activity in adolescent ADHD patients,enhancing our understanding of the neural alterations that occur during this pivotal stage of development.
基金This work was supported by grants from the Natural Science Foundation of China(No.81425013,No.91332113 and No.81271551)the Tianjin Key Technology R&D Program(No.14ZCZDSY00018)the National Key Clinical Specialty Project and the China Postdoctoral Science Foundation funded project(No.2012M520585).
文摘Background:Auditory verbal hallucinations(AVHs)of schizophrenia have been associated with structural and functional alterations of some brain regions.However,the brain regional homogeneity(ReHo)alterations specific to AVHs of schizophrenia remain unclear.In the current study,we aimed to investigate ReHo alterations specific to schizophrenic AVHs.Methods:Thirty-five schizophrenic patients with AVH,41 schizophrenic patients without AVHs,and fifty healthy subjects underwent resting-state functional magnetic resonance imaging.ReHo differences across the three groups were tested using a voxel-wise analysis.Results:Compared with the healthy control group,the two schizophrenia groups showed significantly increased ReHo in the right caudate and inferior temporal gyrus and decreased ReHo in the bilateral postcentral gyrus and thalamus and the right inferior occipital gyrus(false discovery rate corrected,P〈0.05).More importantly,the AVH group exhibited significantly increased ReHo in the left precuneus compared with the non-AVH group.However,using correlation analysis,we did not find any correlation between the auditory hallucination rating scale score and the ReHo of brain regions.Conclusions:Our results suggest that increased ReHo in the left precuneus may be a pathological feature exclusive to schizophrenic AVHs.
基金Project supported by the Natural Science Foundation of Zhejiang Province(No.LY17H180007)the Scientific Research Fund of Zhejiang Education Department(No.Y201431735)the Hangzhou Science and Technology Commission Foundation(No.20170533B06),China
文摘Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging （R-fMRI） study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample （NKI-RS） to examine the relationship between the fractional amplitude of low-frequency fluctuation （fALFF） signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity （RSFC） between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.
基金supported by the National Natural Science Foundation of China(32300933,82122035,81671774,and 81630031)the China Scholarship Council(202104910248)+6 种基金the Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology(2021ZD0200600)the National Key R&D Program of China(2017YFC1309902)the 13th Five-year Informatization Plan of Chinese Academy of Sciences(XXH13505)the Key Research Program of the Chinese Academy of Sciences(ZDBS-SSW-JSC006)the Beijing Nova Program of Science and Technology(Z191100001119104 and 20230484465)the Beijing Natural Science Foundation(J230040)the Scientific Foundation of Institute of Psychology,Chinese Academy of Sciences(E2CX4425YZ).
文摘Background:Rumination is a transdiagnostic psychological process that plays a prominent role in many common psychiatric disorders,albeit its neurophysiological basis remains elusive.Existing neuroimaging studies have highlighted the precuneus and hippocampus as two pivotal brain regions in rumination’s neural underpinnings.Methods:Here,we examined the intracranial electroencephalogram(iEEG)recordings from 21 patients with epilepsy during a naturalistic,continuous,active rumination state and measured the low frequency(1-8 Hz)and high gamma(70-150 Hz)band oscillation powers.Results:We observed enhanced low-frequency power in the precuneus and reduced high gamma power in the hippocampus during the rumination condition compared to the control condition.The hippocampal high gamma power reduction was associated with the self-reported reflection tendency.Conclusions:Our findings provided empirical evidence of the neurophysiological underpinnings of rumination and implicated a precuneus-hippocampus coupling across neural oscillation bands during an active rumination state.
基金Capital’s Funds for Health Improvement and Research(No.2020-1-2121)Beijing Municipal Science and Technology Commission(No.Z181100001718077)Special Funding of the Beijing Municipal Administration of Hospitals Clinical Medicine Development(No.ZYLX201815)
文摘Background:Amygdala plays an important role in the neurobiological basis of panic disorder(PD),and the amygdala contains different subregions,which may play different roles in PD.The aim of the present study was to examine whether there are common or distinct patterns of functional connectivity of the amygdala subregions in PD using resting-state functional magnetic resonance imaging and to explore the relationship between the abnormal spontaneous functional connectivity patterns of the regions of interest(ROIs)and the clinical symptoms of PD patients.Methods:Fifty-three drug-naïve,non-comorbid PD patients and 70 healthy controls(HCs)were recruited.Seed-based resting-state functional connectivity(rsFC)analyses were conducted using the bilateral amygdalae and its subregions as the ROI seed.Two samples t test was performed for the seed-based Fisher's z-transformed correlation maps.The relationship between the abnormal spontaneous functional connectivity patterns of the ROIs and the clinical symptoms of PD patients was investigated by Pearson correlation analysis.Results:PD patients showed increased rsFC of the bilateral amygdalae and almost all the amygdala subregions with the precuneus/posterior cingulate gyrus compared with the HC group(left amygdala[lAMY]:t=4.84,P<0.001;right amygdala[rAMY]:t=4.55,P<0.001;left centromedial amygdala[lCMA]:t=3.87,P<0.001;right centromedial amygdala[rCMA]:t=3.82,P=0.002;left laterobasal amygdala[lBLA]:t=4.33,P<0.001;right laterobasal amygdala[rBLA]:t=4.97,P<0.001;left superficial amygdala[lSFA]:t=3.26,P=0.006).The rsFC of the lBLA with the left angular gyrus/inferior parietal lobule remarkably increased in the PD group(t=3.70,P=0.003).And most of the altered rsFCs were located in the default mode network(DMN).A significant positive correlation was observed between the severity of anxiety and the rsFC between the lSFA and the left precuneus in PD patients(r=0.285,P=0.039).Conclusions:Our research suggested that the increased rsFC of amygdala subregions with DMN plays an important role in the pathogenesis of PD.Future studies may further explore whether the rsFC of amygdala subregions,especially with the regions in DMN,can be used as a biological marker of PD.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)the Fundamental Research Funds for the Central Universities(YD9100002033)+1 种基金the Hefei Comprehensive National Science Center Hefei Brain Projectthe Natural Science Foundation of Anhui Province(2308085QH265)。
