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A High Precision Forecasting Model and Its Constructing Method for Vein Type Gold Deposits
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作者 Zhang Jun Faculty of Earth Resources, China University of Geosciences, Wuhan 430074 《Journal of China University of Geosciences》 SCIE CSCD 2001年第2期100-107,共8页
A high precision forecasting and prospecting model incorporating the “field theory field structure analysis field simulation”, a temporal and spatial structural framework reflecting local extremely fine structure... A high precision forecasting and prospecting model incorporating the “field theory field structure analysis field simulation”, a temporal and spatial structural framework reflecting local extremely fine structures, is established to make an effective extraction and an integrated analysis of multivariate forecasting information. This model can best show not only the coupling between metallogenic anomalous structure, mineralized structure and information structure, but also the extraction, optimization, matching and summarization of key forecasting information. The technological keys to this model are the fine structural analysis of geological and geophysical and geochemical anomalous fields and metallogenic fields, and the establishment of occurrence patterns for the spatial location of orebodies. 展开更多
关键词 high precision forecasting model anomalous structure mineralized structure orebody location.
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Optimization of a precise integration method for seismic modeling based on graphic processing unit 被引量:2
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作者 Jingyu Li Genyang Tang Tianyue Hu 《Earthquake Science》 CSCD 2010年第4期387-393,共7页
General purpose graphic processing unit (GPU) calculation technology is gradually widely used in various fields. Its mode of single instruction, multiple threads is capable of seismic numerical simulation which has ... General purpose graphic processing unit (GPU) calculation technology is gradually widely used in various fields. Its mode of single instruction, multiple threads is capable of seismic numerical simulation which has a huge quantity of data and calculation steps. In this study, we introduce a GPU-based parallel calculation method of a precise integration method (PIM) for seismic forward modeling. Compared with CPU single-core calculation, GPU parallel calculating perfectly keeps the features of PIM, which has small bandwidth, high accuracy and capability of modeling complex substructures, and GPU calculation brings high computational efficiency, which means that high-performing GPU parallel calculation can make seismic forward modeling closer to real seismic records. 展开更多
关键词 precise integration method seismic modeling general purpose GPU graphic processing unit
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Effects of Continuous Precision Nursing Model on Knowledge, Attitudes, and Practices (KAP) Behavior and Cardiac Function in Patients after Percutaneous Coronary Angiography and Stent Implantation
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作者 Cuiying Han 《Journal of Clinical and Nursing Research》 2024年第3期1-6,共6页
Objective:To explore the impact of a continuous precision nursing model on patients’Knowledge,Attitudes,and Practices(KAP)and cardiac function during the nursing process of patients undergoing percutaneous coronary a... Objective:To explore the impact of a continuous precision nursing model on patients’Knowledge,Attitudes,and Practices(KAP)and cardiac function during the nursing process of patients undergoing percutaneous coronary angiography and stent implantation.Methods:Ninety patients who underwent percutaneous coronary angiography and stent implantation in our hospital from April 2022 to April 2023 were selected and randomly divided into the control group(45 cases),in which routine nursing support was carried out during the treatment process,and the observation group(45 cases),in which continuous precision nursing model was carried out during the treatment process.Comparisons were made between the two groups of patients on their KAP,cardiac function,and quality of life during recovery.Results:There was no difference in the left ventricular ejection fraction(LVEF),cardiac output(CO),and cardiac index(CI)levels before intervention.After the intervention,the levels of cardiac function in the observation group were higher than those of the control group(P<0.05).There was no difference in the Exercise of Self-Care Agency(ESCA)self-care ability scale scores before the intervention.After the intervention,the observation group had higher ESCA scores than the control group(P<0.05).Conclusion:Implementation of a continuous precision nursing model in the care of patients undergoing percutaneous coronary angiography and stent implantation improved the patient’s cardiac function,and KAP,and promoted recovery. 展开更多
关键词 Continuous precision nursing model Percutaneous coronary angiography Stent implantation Knowledge attitudes and practices(KAP) Cardiac function
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Approaches for Detailed Modelling of Ultra-Precision Positioning Systems
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作者 Dominik Dahlmann Nesrine Sassi Berend Denkena 《Modern Mechanical Engineering》 2016年第1期44-50,共7页
Nowadays, the productivity of ultra-precision machining is fundamentally limited by low feed rates because of the required accuracies in the nanometre range. An increase in motion dynamics leads to disturbances that a... Nowadays, the productivity of ultra-precision machining is fundamentally limited by low feed rates because of the required accuracies in the nanometre range. An increase in motion dynamics leads to disturbances that affect the toolpath’s accuracy. Existing control concepts are not able to reliably detect and compensate the deviations caused by increased dynamics. This paper compares modelling approaches for ultra-precision positioning systems aiming to predict and compensate occurring deviations. 展开更多
关键词 ULTRA-precisION modelLING COMPENSATION
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Data-driven Nonparametric Model Adaptive Precision Control for Linear Servo Systems 被引量:2
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作者 Rong-Min Cao Zhong-Sheng Hou Hui-Xing Zhou 《International Journal of Automation and computing》 EI CSCD 2014年第5期517-526,共10页
Nowadays, high-precision motion controls are needed in modern manufacturing industry. A data-driven nonparametric model adaptive control(NMAC) method is proposed in this paper to control the position of a linear servo... Nowadays, high-precision motion controls are needed in modern manufacturing industry. A data-driven nonparametric model adaptive control(NMAC) method is proposed in this paper to control the position of a linear servo system. The controller design requires no information about the structure of linear servo system, and it is based on the estimation and forecasting of the pseudo-partial derivatives(PPD) which are estimated according to the voltage input and position output of the linear motor. The characteristics and operational mechanism of the permanent magnet synchronous linear motor(PMSLM) are introduced, and the proposed nonparametric model control strategy has been compared with the classic proportional-integral-derivative(PID) control algorithm. Several real-time experiments on the motion control system incorporating a permanent magnet synchronous linear motor showed that the nonparametric model adaptive control method improved the system s response to disturbances and its position-tracking precision, even for a nonlinear system with incompletely known dynamic characteristics. 展开更多
关键词 Data-driven control nonparametric model adaptive control precision motion control permanent magnet synchronous linear motor ROBUSTNESS
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Local Precise Large Deviations for Independent Sums in Multi-Risk Model 被引量:2
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作者 Jinghai FENG Panpan ZHAO Libin JIAO 《Journal of Mathematical Research with Applications》 CSCD 2014年第2期240-248,共9页
In this paper, we study the case of independent sums in multi-risk model. Assume that there exist k types of variables. The ith are denoted by (Xij,j ≥ 1), which are i.i.d. with common density function fi(x) ∈ O... In this paper, we study the case of independent sums in multi-risk model. Assume that there exist k types of variables. The ith are denoted by (Xij,j ≥ 1), which are i.i.d. with common density function fi(x) ∈ OR and finite mean, i =- 1,., k. We investigate local large deviations for partial sums ∑i=1^k Sni=∑i=1^k ∑j=1^ni Xij. 展开更多
关键词 multi-risk model O-regularly varying function local precise large deviations regular density.
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High-Precision Sub-Seafloor Velocity Building Based on Joint Tomography and Deep Learning on OBS Data in the South China Sea
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作者 Guoxin Chen Jun Li +5 位作者 Jinxin Chen Rongsen Du Yutao Liu Yuli Qi Chun-Feng Li Xingguo Huang 《Journal of Earth Science》 2025年第2期830-834,共5页
INTRODUCTION.Crustal velocity model is crucial for describing the subsurface composition and structure,and has significant implications in offshore oil and gas exploration and marine geophysical engineering(Xie et al.... INTRODUCTION.Crustal velocity model is crucial for describing the subsurface composition and structure,and has significant implications in offshore oil and gas exploration and marine geophysical engineering(Xie et al.,2024).Currently,travel time tomography is the most commonly used method for velocity modeling based on ocean bottom seismometer(OBS)data(Zhang et al.,2023;Sambolian et al.,2021).This method usually assumes that the sub-seafloor structure is layered,and therefore faces challenges in high-precision modeling with strong lateral discontinuities. 展开更多
关键词 velocity modeling time tomography marine geophysical engineering xie joint tomography describing subsurface composition structureand high precision velocity modeling offshore oil gas exploration ocean bottom seismometer obs data zhang
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Application Research of Multi-Dimensional Customer Behavior Analysis Model in Precision Marketing
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作者 Shuotong Dong 《Open Journal of Applied Sciences》 2024年第12期3589-3600,共12页
The advent of the digital era has provided unprecedented opportunities for businesses to collect and analyze customer behavior data. Precision marketing, as a key means to improve marketing efficiency, highly depends ... The advent of the digital era has provided unprecedented opportunities for businesses to collect and analyze customer behavior data. Precision marketing, as a key means to improve marketing efficiency, highly depends on a deep understanding of customer behavior. This study proposes a theoretical framework for multi-dimensional customer behavior analysis, aiming to comprehensively capture customer behavioral characteristics in the digital environment. This framework integrates concepts of multi-source data including transaction history, browsing trajectories, social media interactions, and location information, constructing a theoretically more comprehensive customer profile. The research discusses the potential applications of this theoretical framework in precision marketing scenarios such as personalized recommendations, cross-selling, and customer churn prevention. Through analysis, the study points out that multi-dimensional analysis may significantly improve the targeting and theoretical conversion rates of marketing activities. However, the research also explores theoretical challenges that may be faced in the application process, such as data privacy and information overload, and proposes corresponding conceptual coping strategies. This study provides a new theoretical perspective on how businesses can optimize marketing decisions using big data thinking while respecting customer privacy, laying a foundation for future empirical research. 展开更多
关键词 Customer Behavior Analysis precision Marketing Multi-Dimensional model Data Theory Personalized Recommendation
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Precise large deviations for sums of random vectors in a multidimensional size-dependent renewal risk model 被引量:1
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作者 SHEN Xin-mei FU Ke-ang ZHONG Xue-ting 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2018年第4期491-502,共12页
Consider a multidimensional renewal risk model, in which the claim sizes {Xk, k ≥1} form a sequence of independent and identically distributed random vectors with nonnegative components that are allowed to be depende... Consider a multidimensional renewal risk model, in which the claim sizes {Xk, k ≥1} form a sequence of independent and identically distributed random vectors with nonnegative components that are allowed to be dependent on each other. The univariate marginal distributions of these vectors have consistently varying tails and finite means. Suppose that the claim sizes and inter-arrival times correspondingly form a sequence of independent and identically distributed random pairs, with each pair obeying a dependence structure. A precise large deviation for the multidimensional renewal risk model is obtained. 展开更多
关键词 precise large deviation SIZE-DEPENDENT Consistent variation Multidimensional risk model Renewal counting process
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深部特殊空间探测-评价-利用技术研究进展
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作者 杨科 袁亮 +8 位作者 王同 易晓峰 张乐乐 刘凯 黄艳利 熊清蓉 贾云中 王同涛 韩家章 《煤炭学报》 北大核心 2026年第1期689-720,共32页
以关闭矿井地下空间、盐穴、孔隙性含水层、深部不可采煤层为代表的深部特殊空间安全高效开发是保障国家深部资源能源安全的重要途径和重大战略需求。聚焦深部特殊空间探测-评价-利用中瓶颈背后的科技难题,系统梳理深部特殊空间探测、... 以关闭矿井地下空间、盐穴、孔隙性含水层、深部不可采煤层为代表的深部特殊空间安全高效开发是保障国家深部资源能源安全的重要途径和重大战略需求。聚焦深部特殊空间探测-评价-利用中瓶颈背后的科技难题,系统梳理深部特殊空间探测、评价、利用研究现状,凝练构建深部特殊空间探测-评价-利用亟待突破的关键技术体系。研究结果表明:高精度探测与反演建模是实现深部特殊空间利用的前提;深部空间结构形态与灾害的精准探测与智能判识技术处于从单项突破向系统集成转变的阶段,但复杂环境适应性仍是主要挑战。多场多资源动态识别并科学评价开发潜力,是深地空间开发利用的核心挑战;机器学习与智能算法在深部地下空间评价与利用中正引发技术范式变革。矿山地下空间资源化、能源化、功能化再利用已成为推动资源型城市转型、实现“双碳”目标的关键路径;评价模型、适配体系、技术体系缺失,再利用案例较少是标准制定的最大障碍。深部煤层CO_(2)地质封存、盐穴储氢、沉渣扩容与压缩空气储能、含水层储气、废弃巷硐物理储能是现阶段深部特殊空间的主要利用方式,但缺乏系统性、权威性的国家标准/行业标准,示范工程建设处于起步阶段。突破“精准探测与封存空间精细表征”“多资源多物理场动态智能识别评估”“矿山地下空间再利用全场景智能监测与安全保障”“深部煤层CO_(2)存储全生命周期安全监测与检测”“多场扰动下深部地下空间物理储能动态密封性评价”五大技术体系,可为国家深地战略实施提供科技支撑。 展开更多
关键词 深部特殊空间 高精度探测与建模 动态精准耦合评价 矿山地下空间再利用 大规模储能
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基于Transformer模型堤坝渗漏入口精准识别方法研究
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作者 梁越 赵硕 +4 位作者 喻金桃 许彬 张斌 龚胜勇 舒云林 《岩土工程学报》 北大核心 2026年第1期187-195,共9页
渗漏是堤坝工程面临的主要安全隐患,渗漏入口精确识别与定位对降低堤坝风险至关重要。通过堤坝渗漏入口示踪剂分布及其运移特征模拟数据,训练学习Transformer模型以确定最优参数条件并分析该条件下该模型的预测效果,进一步通过室内模型... 渗漏是堤坝工程面临的主要安全隐患,渗漏入口精确识别与定位对降低堤坝风险至关重要。通过堤坝渗漏入口示踪剂分布及其运移特征模拟数据,训练学习Transformer模型以确定最优参数条件并分析该条件下该模型的预测效果,进一步通过室内模型试验验证该模型的可靠性。研究表明:①当迭代次数达600次时,模型预测的流速最大值相对误差最小,且最大流速值坐标与真实渗漏入口坐标最为接近,预测效果最佳;在此条件下,当数据采集时长为50 s时,模型预测的流速最大值相对偏差最小,预测效果最优。②在最佳迭代次数和数据采集时长条件下,模型预测精度超过95%,渗漏入口大小和渗漏流量的预测值与真实值差异极小,且流速和位置预测相对误差均较低,其中位置预测相对误差低于5%。③将电导率试验采集数据转换为示踪剂浓度并输入至该模型进行流速分布预测,可知该模型能准确定位渗漏入口位置,且流速和渗漏入口坐标的预测平均相对误差均低于10%,进而验证了该模型在渗漏入口定位中的有效性与准确性。相关研究成果可为堤坝渗漏入口精确识别奠定理论基础和提供技术支撑。 展开更多
关键词 堤坝 渗漏入口 Transformer模型 精准识别 室内模型试验
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One-to-Any Command and Control Model:Precisely Coordinated Operation on Uncooperative Controlled Nodes 被引量:1
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作者 QIU Han LI Yufeng +1 位作者 LI Heshuai ZHU Junhu 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2015年第6期490-498,共9页
New precisely cooperative attacks, such as the coordi- nated cross plane session termination (CXPST) attack, need thou- sands upon thousands machines to attack diverse selected links simultaneously with the given ra... New precisely cooperative attacks, such as the coordi- nated cross plane session termination (CXPST) attack, need thou- sands upon thousands machines to attack diverse selected links simultaneously with the given rate. However, almost all command and control(C&C) mechanisms only provide publishing one com- mand to the whole once, so-called one-to-all C&C model, and are not productive to support CXPST-alike attacks. In this paper, we present one-to-any C&C model on coordination among the unco- operative controlled nodes. As an instance of one-to-any C&C model, directional command publishing (DCP) mechanism lever- aging on Kademlia is provided with a range-mapping key creating algorithm for commands to compute the publishing range and a statistically stochastic node querying scheme to obtain the com- mands immediately. With theoretical analysis and simulation, it is indicated that one-to-any C&C model fits for precisely coordi- nated operation on uncooperative controlled nodes with least complexity, better accuracy and efficiency. Furthermore, DCP mechanism can support one-to-all command publishing at the same time. As an example of future C&C model, studying on one-to-any C&C model may help to promote the development of more efficient countermeasures. 展开更多
关键词 one-to-any command and control(C&C) model directional command publishing(DCP) mechanism precisely cooperative attack uncooperative controlled node
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变量灌溉技术研究新进展与展望
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作者 严海军 李久生 +2 位作者 徐云成 王文涛 王晶晶 《水利学报》 北大核心 2026年第1期141-152,共12页
农业水资源高效利用对保障全球粮食安全至关重要。变量灌溉作为精准农业的一项核心技术,是应对水资源挑战、实现作物精准灌溉的关键途径。本文在阐明变量灌溉内涵与系统架构的基础上,系统梳理了灌溉决策模型、管理区划分、动态处方图生... 农业水资源高效利用对保障全球粮食安全至关重要。变量灌溉作为精准农业的一项核心技术,是应对水资源挑战、实现作物精准灌溉的关键途径。本文在阐明变量灌溉内涵与系统架构的基础上,系统梳理了灌溉决策模型、管理区划分、动态处方图生成和时空精度等关键技术的研究进展,阐述了变量灌溉系统的感知、决策、执行、反馈等核心模块与关键部件,讨论了变量灌溉技术在大田作物的应用中面临的多源数据融合难度大、决策模型适应性不足、技术推广成本高等挑战,展望了未来变量灌溉技术的重点发展方向:与物联网、人工智能、大数据平台等深度融合,着重在提升应用适应性、降低产品成本、优化决策模型等方面开展研究。本文旨在为变量灌溉技术的研发与应用提供理论参考,为高水效农业与绿色农业高质量发展提供技术支撑。 展开更多
关键词 变量灌溉 精准农业 灌溉决策模型 管理区划分 灌溉处方图
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直齿插齿刀展成磨削误差建模及误差敏感性分析
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作者 丁国龙 李盛豪 吴斌 《组合机床与自动化加工技术》 北大核心 2026年第2期110-116,共7页
直齿插齿刀结构复杂,从大端到小端,本质上是连续变位的变位齿轮,且侧后刀面是特殊的渐开螺旋面,磨削加工会出现齿面误差。为提高直齿插齿刀展成磨削精度,建立一种基于检测方法的误差分析模型,分析展成磨削参数对齿面误差的敏感性大小。... 直齿插齿刀结构复杂,从大端到小端,本质上是连续变位的变位齿轮,且侧后刀面是特殊的渐开螺旋面,磨削加工会出现齿面误差。为提高直齿插齿刀展成磨削精度,建立一种基于检测方法的误差分析模型,分析展成磨削参数对齿面误差的敏感性大小。分析直齿插齿刀结构和展成磨削运动,计算展成运动数学关系,规划砂轮运动轨迹,准确描述出插齿刀和砂轮的位置关系,分析插齿刀检测方法原理,基于检测原理建立误差分析模型。计算砂轮截形参数误差、砂轮运动参数误差造成的齿面误差,并分析对齿面误差的影响特点,得出各参数误差敏感性大小,其中砂轮齿形角误差对齿面误差的影响最大,为提高直齿插齿刀磨削精度提供了重要理论参考。 展开更多
关键词 直齿插齿刀 精度检测原理 误差建模 误差敏感性
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汽车动力电池模组机器人装配线精度与可靠性设计研究
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作者 肖潇 《汽车电器》 2026年第1期157-159,共3页
动力电池模组装配品质直接关乎整车性能与安全,本研究旨在系统性提升电池模组机器人装配线精度与可靠性,解决误差累积及部件故障导致的品质不一致问题,满足产品对高性能与高安全性的要求。通过分析装配精度要求,建立基于多体系统理论的... 动力电池模组装配品质直接关乎整车性能与安全,本研究旨在系统性提升电池模组机器人装配线精度与可靠性,解决误差累积及部件故障导致的品质不一致问题,满足产品对高性能与高安全性的要求。通过分析装配精度要求,建立基于多体系统理论的误差传递模型,量化关键部件误差影响;定义可靠性指标,采用故障模式与影响分析及威布尔分布模型建模,提出精度控制与可靠性提升协同设计方法,并结合某型号装配线案例进行验证。应用结果表明,该协同设计方法可有效提升装配线综合性能,为电池模组高精度、高可靠性自动化生产提供技术方案,对新能源汽车制造业升级具有实用价值。 展开更多
关键词 动力电池模组 机器人装配线 精度设计 可靠性建模 协同优化
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融合KANO模型与知识管理理论的乡村图书馆服务效能提升路径
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作者 王键 《乡村科技》 2026年第3期41-46,共6页
乡村振兴战略背景下,乡村图书馆亟须从“知识供给”向“知识治理”转型。针对其服务效能提升面临的资源供需错配困境,该研究将质量管理中的KANO模型与知识管理理论融合起来,构建了“需求识别—精准供给”的分析框架,通过对江苏省6县18... 乡村振兴战略背景下,乡村图书馆亟须从“知识供给”向“知识治理”转型。针对其服务效能提升面临的资源供需错配困境,该研究将质量管理中的KANO模型与知识管理理论融合起来,构建了“需求识别—精准供给”的分析框架,通过对江苏省6县18个乡镇623名读者的分层抽样调查,系统识别了28项服务要素的需求属性(基本型、期望型、魅力型、反向型)。研究发现:基础借阅服务构成高敏感度的期望型需求(Worse系数-0.85),是效能的保障底线;农业科技资源与培训对务农群体呈现显著的刚需属性(Worse系数-0.84),凸显其生产支持功能;数字资源对中青年读者群体为魅力型需求(Better系数0.66),但强制数字化易引发老年群体反向需求(Worse系数0.35),揭示了“数字鸿沟”的挑战。基于此,该研究从知识管理的分众化识别、动态化响应、协同化评估等3个维度,系统建构了乡村图书馆服务效能提升的整合性路径,为优化乡村知识服务体系、驱动乡村振兴提供了理论依据与实践范式。 展开更多
关键词 乡村图书馆 服务效能 KANO模型 知识管理 精准服务 乡村振兴
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凹型弹性梁结构的电容式六维力传感器
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作者 林虎 冯浩彬 蒲明辉 《仪表技术与传感器》 北大核心 2026年第1期21-27,共7页
以十字单直梁为基础,结合柔性机构的特点,构建了一种凹型弹性梁结构的电容式六维力传感器,与其他类型弹性梁相比,凹型弹性梁具有更多的结构参数,更易于实现灵敏度各向同性。传感器的弹性梁各支链、差动电容器相对中心加载台呈旋转对称分... 以十字单直梁为基础,结合柔性机构的特点,构建了一种凹型弹性梁结构的电容式六维力传感器,与其他类型弹性梁相比,凹型弹性梁具有更多的结构参数,更易于实现灵敏度各向同性。传感器的弹性梁各支链、差动电容器相对中心加载台呈旋转对称分布,分别间隔120°。使用SolidWorks与COMSOL Multiphysics进行协同仿真,并对COMSOL Multiphysics进行二次开发,以传感器精度为目标函数,结合粒子群算法实现对结构的优化。有限元分析结果表明满量程下传感器理论精度为0.393%。进行了传感器样机的实物实验,满量程下实验精度为0.643%。 展开更多
关键词 电容式六维力传感器 弹性梁结构 优化方法 精度模型
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基于ModelCenter的精密气浮工件台系统建模与参数优化 被引量:3
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作者 陈鹏飞 王彦伟 《组合机床与自动化加工技术》 北大核心 2014年第4期26-29,34,共5页
针对精密气浮工件台运动时部件会不可避免地产生偏转和振动,建立了精密气浮工件台的系统模型,包括工件台几何模型,直线电机模型,气体轴承模型。在设定工况下对工件台系统的动态特性进行了数值仿真分析,得到了工件台系统的运动偏转误差... 针对精密气浮工件台运动时部件会不可避免地产生偏转和振动,建立了精密气浮工件台的系统模型,包括工件台几何模型,直线电机模型,气体轴承模型。在设定工况下对工件台系统的动态特性进行了数值仿真分析,得到了工件台系统的运动偏转误差曲线和气膜的垂向振动曲线,为工件台系统的设计提供了重要的理论参考价值。基于多学科协同设计集成优化平台ModelCenter进行系统集成,并建立了精密气浮工件台的多学科设计优化模型。利用遗传算法实现了精密气浮工件台的总体参数优化设计,优化结果满足设计要求。 展开更多
关键词 modelCenter 精密气浮工件台 系统模型 参数优化 偏转振动
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儿科万古霉素模型引导精准用药的临床应用与挑战
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作者 姚昀璐 许海鑫 +2 位作者 刘昕竹 陈霁晖 卜书红 《临床儿科杂志》 北大核心 2026年第1期84-90,共7页
万古霉素是治疗革兰阳性菌感染,尤其是耐甲氧西林金黄色葡萄球菌感染的关键糖肽类抗生素。然而,儿科患者显著的药代动力学异质性导致传统给药方案较难平衡儿童患者的疗效与肾毒性风险。模型引导的精准用药(MIPD)策略通过整合定量药理学... 万古霉素是治疗革兰阳性菌感染,尤其是耐甲氧西林金黄色葡萄球菌感染的关键糖肽类抗生素。然而,儿科患者显著的药代动力学异质性导致传统给药方案较难平衡儿童患者的疗效与肾毒性风险。模型引导的精准用药(MIPD)策略通过整合定量药理学模型(如PPK、PBPK及机器学习模型)与患者个体数据,为实现基于24小时药时曲线下面积与最低抑菌浓度比值(AUC0-24h/MIC)的个体化治疗提供了新途径。MIPD策略相较于传统治疗药物监测(TDM),能显著提升药代动力学/药效学靶标的达标率,尤其在新生儿和重症患者中可缩短达标时间,同时有效降低肾毒性风险。本文综述了MIPD策略在新生儿、重症患儿及特殊疾病儿童中指导万古霉素应用的临床价值,以期为临床精准用药提供参考。 展开更多
关键词 模型引导精准用药 万古霉素 群体药代动力学 有效性 安全性 儿科
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面向多机动目标的资源分配与精细化跟踪算法
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作者 焦浩 严俊坤 +4 位作者 郝佳 高畅 党旭东 刘宏伟 齐崇英 《雷达学报(中英文)》 北大核心 2026年第1期292-306,共15页
雷达系统在对多机动目标进行跟踪时,跟踪性能会因为多雷达发射资源的非匹配预设和先验信息的不充分利用而下降。针对该问题,提出了一种面向多机动目标的资源分配与精细化跟踪算法,以期在同等资源消耗条件下获取更高的目标跟踪性能。首先... 雷达系统在对多机动目标进行跟踪时,跟踪性能会因为多雷达发射资源的非匹配预设和先验信息的不充分利用而下降。针对该问题,提出了一种面向多机动目标的资源分配与精细化跟踪算法,以期在同等资源消耗条件下获取更高的目标跟踪性能。首先,该文结合跟踪器反馈的目标预测信息,利用多模型交互的思想对目标预测位置分布函数进行拟合,建立了基于多模型交互的检测跟踪一体化方法,实现了系统对机动目标的精细化跟踪。而后,分析了多雷达发射资源和机动目标跟踪性能的耦合机理,结合机动目标贝叶斯克拉美罗下界的推导,建立了跟踪性能驱动的多模型加权资源分配框架。最后通过仿真验证了所提方法在相同资源消耗条件下,能够显著提升多机动目标的综合跟踪精度。 展开更多
关键词 机动目标 资源分配 精细化跟踪 先验信息 多模型
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