Prdm1(PR domain zinc fi nger protein 1),又称为Blimp1(B-lymphocyte-induced maturation protein-1),是一个具有锌指结构的转录因子,通过调控多个基因的表达影响哺乳动物多种类型细胞的发育分化。从1991年发现至今,有关Prdm1的研究...Prdm1(PR domain zinc fi nger protein 1),又称为Blimp1(B-lymphocyte-induced maturation protein-1),是一个具有锌指结构的转录因子,通过调控多个基因的表达影响哺乳动物多种类型细胞的发育分化。从1991年发现至今,有关Prdm1的研究进展迅速,Prdm1在促进B细胞向浆细胞终末分化过程中的作用已经得到共识。但是,在小鼠及其他哺乳动物的胚胎发育过程中,尤其是关于Prdm1在生殖细胞发育分化中的作用机理研究则起步相对较晚。近期发现,在哺乳动物胚胎发育过程中,Prdm1在原始生殖细胞的形成、干细胞全能性的维持以及其他组织器官的形成中都发挥了重要的作用。展开更多
We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An imag...We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An image layout error occurred while processing Figure 3e,and some of the images in Figure 3f,4d,and 4e have errors due to incorrect image grouping.We carried out a detailed investigation and rechecked the original data of these figures.Unfortunately,the original pathological data have not been properly archived;thus,we are unable to investigate this issue.展开更多
文摘Prdm1(PR domain zinc fi nger protein 1),又称为Blimp1(B-lymphocyte-induced maturation protein-1),是一个具有锌指结构的转录因子,通过调控多个基因的表达影响哺乳动物多种类型细胞的发育分化。从1991年发现至今,有关Prdm1的研究进展迅速,Prdm1在促进B细胞向浆细胞终末分化过程中的作用已经得到共识。但是,在小鼠及其他哺乳动物的胚胎发育过程中,尤其是关于Prdm1在生殖细胞发育分化中的作用机理研究则起步相对较晚。近期发现,在哺乳动物胚胎发育过程中,Prdm1在原始生殖细胞的形成、干细胞全能性的维持以及其他组织器官的形成中都发挥了重要的作用。
文摘We are retracting this article due to certain errors in two figures in the article"TGF-β1-regulated miR-3691-3p targets E2F3 and PRDM1 to inhibit prostate cancer progression"which has been published.An image layout error occurred while processing Figure 3e,and some of the images in Figure 3f,4d,and 4e have errors due to incorrect image grouping.We carried out a detailed investigation and rechecked the original data of these figures.Unfortunately,the original pathological data have not been properly archived;thus,we are unable to investigate this issue.
