Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury.Notably,the gene regulatory network of regenerated myelin differs from that ...Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury.Notably,the gene regulatory network of regenerated myelin differs from that of native myelin.Silencing of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in vitro.To further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were generated.Our results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain unmyelinated.This highlights the crucial role of Ezh2 in initiating Schwann cell myelination.Furthermore,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type littermates.This suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and remyelination.In conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve injury.Modulating EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.展开更多
Investing in disaster risk reduction is crucial for minimizing the impacts of disasters.However,little is known about the factors that influence changes in investment levels over time.This study aims to identify the k...Investing in disaster risk reduction is crucial for minimizing the impacts of disasters.However,little is known about the factors that influence changes in investment levels over time.This study aims to identify the key socio-economic drivers behind increases and decreases in flood protection investment in People’s Republic of China(PRC).Such information is crucial for policy makers to justify flood investments.By analyzing data on flood protection expenditures,economic losses from floods,and other relevant indicators from 1980 to 2020,the study evaluates the relationship between investment and disaster impacts through the lens of the flood investment cycle model.It was found that the country succeeded in reducing flood damage because of increasing investment in flood protection.The results indicate that changes in PRC’s flood protection investment have been driven by three major factors:the occurrence of major disasters,the fiscal situation,and shifts in government policies.Investment tended to increase following large-scale events,such as the 1998 Yangtze River Basin flood and the 2008 Wenchuan earthquake,which prompted policy changes and renewed focus on DRR measures.Fiscal constraints limited investment in the 1990s,but reforms and stimulus measures improved the financial situation,enabling increased spending on flood protection.PRC’s experience in steadily reducing flood damage through sustained investment and policy commitment offers valuable lessons for other developing countries facing similar challenges.展开更多
基金financially supported by the National Natural Science Foundation of China,Nos.82172104(to CX),81873767(to HZ)a grant from Jiangsu Provincial Research Hospital,Nos.YJXYY202204(to HZ),YJXYY202204-ZD04(to HZ)+5 种基金a grant from Jiangsu Provincial Key Medical CenterJiangsu Provincial Medical Innovation Center,No.CXZX202212Jiangsu Provincial Medical Key Discipline,No.ZDXK202240the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)Technology Project of Nantong,No.MS22022008(to HZ)Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.SJCX21_1457(to WW)。
文摘Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve injury.Notably,the gene regulatory network of regenerated myelin differs from that of native myelin.Silencing of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in vitro.To further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were generated.Our results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain unmyelinated.This highlights the crucial role of Ezh2 in initiating Schwann cell myelination.Furthermore,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type littermates.This suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and remyelination.In conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve injury.Modulating EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.
文摘Investing in disaster risk reduction is crucial for minimizing the impacts of disasters.However,little is known about the factors that influence changes in investment levels over time.This study aims to identify the key socio-economic drivers behind increases and decreases in flood protection investment in People’s Republic of China(PRC).Such information is crucial for policy makers to justify flood investments.By analyzing data on flood protection expenditures,economic losses from floods,and other relevant indicators from 1980 to 2020,the study evaluates the relationship between investment and disaster impacts through the lens of the flood investment cycle model.It was found that the country succeeded in reducing flood damage because of increasing investment in flood protection.The results indicate that changes in PRC’s flood protection investment have been driven by three major factors:the occurrence of major disasters,the fiscal situation,and shifts in government policies.Investment tended to increase following large-scale events,such as the 1998 Yangtze River Basin flood and the 2008 Wenchuan earthquake,which prompted policy changes and renewed focus on DRR measures.Fiscal constraints limited investment in the 1990s,but reforms and stimulus measures improved the financial situation,enabling increased spending on flood protection.PRC’s experience in steadily reducing flood damage through sustained investment and policy commitment offers valuable lessons for other developing countries facing similar challenges.
