Inorganic phosphate(Pi)homeostasis in plants is regulated by inositol pyrophosphates(PP-InsPs),which mediate phosphate starvation responses.While beneficial microorganisms,such as arbuscular mycorrhizal fungi,contribu...Inorganic phosphate(Pi)homeostasis in plants is regulated by inositol pyrophosphates(PP-InsPs),which mediate phosphate starvation responses.While beneficial microorganisms,such as arbuscular mycorrhizal fungi,contribute to phosphate uptake,pathogenic fungi often exploit phosphate metabolism to enhance virulence.However,the exact mechanisms by which pathogens manipulate plant phosphate signaling remain largely unknown.Here,we highlight a recent study by Ulrich Schaffrath and colleagues(Science,2025)revealing that plant pathogenic fungi deploy conserved Nudix hydrolase effectors to hydrolyze PP-InsPs,thereby mimicking phosphate starvation and suppressing host immunity.These findings not only expand our understanding of plantpathogen interactions,but also open new avenues for crop protection and resistance breeding.展开更多
基金the financial support from China Youth Science Foundation(22207037).
文摘Inorganic phosphate(Pi)homeostasis in plants is regulated by inositol pyrophosphates(PP-InsPs),which mediate phosphate starvation responses.While beneficial microorganisms,such as arbuscular mycorrhizal fungi,contribute to phosphate uptake,pathogenic fungi often exploit phosphate metabolism to enhance virulence.However,the exact mechanisms by which pathogens manipulate plant phosphate signaling remain largely unknown.Here,we highlight a recent study by Ulrich Schaffrath and colleagues(Science,2025)revealing that plant pathogenic fungi deploy conserved Nudix hydrolase effectors to hydrolyze PP-InsPs,thereby mimicking phosphate starvation and suppressing host immunity.These findings not only expand our understanding of plantpathogen interactions,but also open new avenues for crop protection and resistance breeding.
