A new isopimarane-type diterpene(liwariverol,1)and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus.The structure of 1 was elucidated to be 17-hydr...A new isopimarane-type diterpene(liwariverol,1)and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus.The structure of 1 was elucidated to be 17-hydroxy-8c^H-isopimara-9(11),15-diene by means of spectroscopic methods.Among the isolates,crenulatoside A(2),an acyclic sesquiterpene glycoside,was found to have anti-oxidative activity with enhancement of the expression of the NAD(P)H:quinone oxidoreductase 1(NQO1)in human neuroblastoma SH-SY5Y cells at 100μmol/L after a 24-h incubation.展开更多
基金supported by an NSFC grant(No90713040)STCSM grants(Nos06DZ19002,07DZ22006,and 11DZ1921203)
文摘A new isopimarane-type diterpene(liwariverol,1)and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant of Potamogeton crispus.The structure of 1 was elucidated to be 17-hydroxy-8c^H-isopimara-9(11),15-diene by means of spectroscopic methods.Among the isolates,crenulatoside A(2),an acyclic sesquiterpene glycoside,was found to have anti-oxidative activity with enhancement of the expression of the NAD(P)H:quinone oxidoreductase 1(NQO1)in human neuroblastoma SH-SY5Y cells at 100μmol/L after a 24-h incubation.
