Addressing the persistent challenge of shale hydration and swelling in water-based drilling fluids(WBDFs),this study developed a smart thermo-responsive shale inhibitor,Hyperbranched PolyethyleneiminePropylene Oxide-N...Addressing the persistent challenge of shale hydration and swelling in water-based drilling fluids(WBDFs),this study developed a smart thermo-responsive shale inhibitor,Hyperbranched PolyethyleneiminePropylene Oxide-N-isopropylacrylamide(HPN).It was synthesized by grafting hyperbranched polyethyleneimine(HPEI)with propylene oxide(PO)and N-isopropylacrylamide(NIPAM),creating a synergistic hydration barrier through hydrophobic association and temperature-triggered pore plugging.Structural characterization by Fourier-Transform Infrared(FTIR)spectroscopy and gel permeation chromatography(GPC)confirmed the successful formation of the HPN terpolymer,revealing a unique“cationic–nonionic”amphiphilic architecture with temperature-responsive properties.Performance evaluation demonstrated that HPN significantly outperforms conventional inhibitors,including potassium chloride(KCl),cationic polyacrylamide(C-PAM),polyethylene glycol(PEG),polyetheramine(PEA),and HPEI.It achieved a superior performance profile:a low yield point of 14.6 Pa,a maximum linear expansion of only 3.1 mm,and a high shale recovery rate of 62.8%at 20%bentonite content.The inhibition mechanism is attributed to a powerful synergy of electrostatic adsorption,hydrophobic association,and thermally induced aggregation,which provides robust performance under demanding conditions such as high salinity(200,000 mg/L NaCl)and high temperature(120℃ ).Thermogravimetric analysis confirmed excellent thermal stability,and the inhibitor exhibited low biological toxicity,complying with stringent environmental standards.These results establish HPN as an efficient,eco-friendly,and field-ready shale inhibitor well-suited for challenging drilling operations.展开更多
Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid （FA） modified electrospun poly（vinyl alcohol） （PVA）/polyethyl...Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid （FA） modified electrospun poly（vinyl alcohol） （PVA）/polyethyleneimine （PEI） nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA via a poly（ethylene glycol） （PEG） spacer, followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition, the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly, the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors, which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications.展开更多
Polyethyleneimine(PEI)modified palygorskite(Pal)was used for the adsorption of Cr(VI)in aqueous solution.The absorbent was characterized by Fourier transform infrared spectroscopy(FT-IR)and thermogravimetric analysis(...Polyethyleneimine(PEI)modified palygorskite(Pal)was used for the adsorption of Cr(VI)in aqueous solution.The absorbent was characterized by Fourier transform infrared spectroscopy(FT-IR)and thermogravimetric analysis(TGA).Characterized results confirmed that the Pal has been successfully modified by PEI.The modification of PEI increased the Cr(VI)adsorption performance of the Pal by the adsorption combined reduction mechanism,and amino groups of the adsorbent play the main role in the enhanced Cr(VI)adsorption.The maximum adsorption capacity was 51.10 mg·g^-1 at pH4.0 and 25°C.The adsorption kinetics of Cr(VI)on the adsorbent conforms to the Langmuir isotherm model.The maximum adsorption occurs at pH3,and then the adsorption capacity of PEI-Pal was decreased with the increase of p H values.The adsorption kinetics of Cr(VI)on PEI-Pal was modeled with pseudo-second-order model.The addition of Cl^-,SO4^2-and PO4^3-reduced the Cr(VI)adsorption by competition with Cr(VI)for the active sites of PEI-Pal.The Cr(VI)saturated PEI-Pal can be regenerated in alkaline solution,and the adsorption capacity can still be maintained at 30.44 mg·g^-1 after 4 cycles.The results demonstrate that PEI-Pal can be used as a potential adsorbent of Cr(VI)in aqueous solutions.展开更多
As humidity is one of the most widely demanded environmental parameters,the precision of its detection is significant.An advanced humidity sensor will improve the validity of the humidity monitoring system.In this stu...As humidity is one of the most widely demanded environmental parameters,the precision of its detection is significant.An advanced humidity sensor will improve the validity of the humidity monitoring system.In this study,a facile chemical layer-by-layer self-assembly(CLS)method was developed for fabricating graphene oxide(GO)/polyethyleneimine(PEI)multilayer films.Owing to the chemical bonding between the PEI and GO,and the intrinsic stickiness of the PEI,layered films with different numbers of layers were successfully prepared using the CLS method and confirmed through ultraviolet-visible(UV-Vis)spectroscopy and the mass loading of quartz crystal microbalance(QCM).Morphological measurements revealed that the roughness and thickness of the films increased exponentially with the number of bilayers.The GO/PEI films were deposited on QCM electrodes using the CLS method to produce the humidity sensors.The humidity measurement results showed a high sensitivity(37.84 Hz/%RH)and rapid response/recovery(<5 s/8 s)of the optimal sensor,which was superior to that of recently developed QCM sensors.展开更多
Guanidine was introduced to low molecular weight linear polyethyleneimine （LPEI） via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting ...Guanidine was introduced to low molecular weight linear polyethyleneimine （LPEI） via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting guanidinoamidized LPEIs （GLPEIs） could dramatically reduce LPEI＇s toxicity, enhance its DNA-packaging capability, cellular uptake and therefore transfection efficiency. These polyplexes were taken up very efficiently via caveolae-mediated endocytosis and their transfection efficiencies in ovarian cancer cells were significantly improved compared to native LPEIlok polyplexes. Among these GLPEIs, LPEI-C3-G100 showed higher DNA affinity even than LPEI25k and the highest transfection efficiency, probably due to the optimization of polymer chain flexibility. Of notice, LPEI-C3-G100 polyplexes could more effectively accumulate into cytoplasm than LPEI25k, although the transfection efficiency of LPEI-C3-G100 polyplexes was not superior to that of LPEI25k polyplexes, which would be probably attributed to the more efficient release of LPEI25k polyplexes than LPEI-C3-G100 polyplexes in the cytoplasm.展开更多
In this work, a series of polyethyleneimine （PEI） functionalized commercial silica gel were prepared by wet impregnation method and used as CO2 sorbent. The as-prepared sorbents were characterized by N2 adsorption, ...In this work, a series of polyethyleneimine （PEI） functionalized commercial silica gel were prepared by wet impregnation method and used as CO2 sorbent. The as-prepared sorbents were characterized by N2 adsorption, FT-1R and SEM techniques. CO2 capture was tested in a fixed bed reactor using a simulated flue gas containing 15.1% CO2 in a temperature range of 25-100 ~C. The effects of sorption temperature and amine content on CO2 uptake of the adsorbents were investigated. The silica gel with a 30 wt% PEI loading manifested the largest CO2 uptake of 93.4 mgcoz/gadsorbent （equal to 311.3 mg^oz/gPEI） among the tested sorbents under the conditions of 15.1% （v/v） CO2 in N2 at 75 ~C and atmospheric pressure. Moreover, it was rather low-cost. In addition, the PEI-impregnated silica gel exhibited stable adsorption-desorption behavior during 5 consecutive test cycles. These results suggest that the PEI-impregnated silica gel is a promising and cost-effective sorbent for CO2 capture from flue gas and other stationary sources with low CO2 concentration.展开更多
Polyethyleneimine(PEI),as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its cytotoxicity.However,research aimed at preparing degrada...Polyethyleneimine(PEI),as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its cytotoxicity.However,research aimed at preparing degradable PEI is scarce.In this work,the hydrogen peroxide(H_(2)O_(2))oxidation method was used to introduce degradable amide groups in the PEI and a series of oxidized PEI22k(oxPEI22k)with different degrees of oxidation were synthesized by regulating the dosage of H_(2)O_(2).The relationship between the oxidation degree of oxPEI22k and the gene transfection efficiency of oxPEI22k was studied in detail,confirming that the oxPEI22k with oxidation degrees of 16.7%and 28.6%achieved improved transfection efficiency compared to unmodified PEI.These oxPEI22k also proved reduced cytotoxicity and improved degradability.Further,this strategy was extended to the synthesis of low-molecular-weight oxPEI1.8k.The oxPEI1.8k with suitable oxidation degree also achieved improved transfection efficiency and reduced cytotoxicity.In brief,this work provided high-efficiency and low-cytotoxicity degradable gene delivery carriers by regulating the oxidation degree of PEI,which was of great significance for promoting clinical applications of PEI.展开更多
Co-delivery of chemical drugs and therapeutic genes for synergistic therapy provides a promising strategy to treat devastating diseases. However, the real-time coordination patterns between chemical drugs and therapeu...Co-delivery of chemical drugs and therapeutic genes for synergistic therapy provides a promising strategy to treat devastating diseases. However, the real-time coordination patterns between chemical drugs and therapeutic genes remain poorly understood. Herein, the complexes of doxorubicin/graphene oxidepolyethyleneimine/p53 plasmid（Dox/GO-PEI/p53） were fabricated and employed to investigate the synergistic manner between Dox and p53 in the inhibition of He La cell growth. GO was conjugated with PEI to form the GO-PEI backbone as the delivery vector. The GO backbone provided surfaces with a high specific area to load Dox via the π-π stacking interaction, and was able to release Dox significantly faster at pH 5.0 than at pH 7.0, while the positively charged PEI section of GO-PEI could condense plasmids into GO-PEI/DNA nanoparticles via the electrostatic interaction. The nanoparticles efficiently mediated the transfection of DNA in He La cells, with lower cytotoxicity compared to PEI/DNA nanoparticles. Furthermore, the complexes of Dox/GO-PEI/p53 released Dox and expressed p53 gene in a sequential manner,and showed successive inhibition of the in vitro growth of He La cells. This type of drug/GO-PEI/DNA complex can be employed as a platform to investigate the coordination pattern between chemical drugs and therapeutic genes for tumor therapy.展开更多
At present,in-situ leaching of weathered crust elution-deposited rare earth ores(WCE-DREOs) encounter with problems such as long leaching cycles,slow infiltration rate and low product purity.In order to solve the abov...At present,in-situ leaching of weathered crust elution-deposited rare earth ores(WCE-DREOs) encounter with problems such as long leaching cycles,slow infiltration rate and low product purity.In order to solve the above problems,the conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4)) was compounded with polymeric surfactant polyethyleneimine(PEI) to form a composite leaching agent.The effects of leaching temperature,PEI concentration.flow rate and pH on leaching kinetics and permeability of rare earths(RE) and aluminum(AI) in orebody were studied.It is found that with temperature increasing,the time required to reach leaching equilibrium for both RE and Al is shortened,the apparent activation energies of RE and AI are 14.79 and 13.45 kJ/mol,respectively,and the leaching processes are in accordance with the outer diffusion control,When the concentrations of(NH_(4))_(2)SO_(4) and PEI in the composite leaching agent are 2.0 wt% and 0.4 wt%;the time required to reach leaching equilibrium for RE and AI is about 50% shorter than that using(NH_(4))_(2)SO_(4) alone,and the leaching efficiencies of RE are slightly higher than that of Al.Properly increasing the temperature and flow rate of the composite leaching agent can improve the leaching efficiencies of RE and Al,but pH has neglected effects on the leaching efficiencies of RE.At PEI concentrations below 0,4 wt%, the addition of PEI promotes the leaching of RE and AI.In column leaching studies of the WCE-DREO,the addition of 0.4 wt% PEI to the traditional leaching agent(NH_(4))_(2)SO_(4) has no impact on the leaching efficiencies of RE.However,it can significantly increase the infiltration rate of WCE-DREO,shortening the leaching time per 10 mL effluent from about 30 min for(NH_(4))_(2)SO_(4) leaching system to 20 min for the composite leaching system.The leaching time is shortened by one-third,and the leaching cost is reduced,which can provide theoretical guidance for the development and commercial implementation of novel composite leaching agent for WCE-DREO.展开更多
A novel method to prepare crosslinked polyethyleneimine （CPEI） hollow nanospheres was reported. Uniform silica nanospheres were used as templates, 3-aminopropyl trimethoxysilane （APS） was immobilized on the surfac...A novel method to prepare crosslinked polyethyleneimine （CPEI） hollow nanospheres was reported. Uniform silica nanospheres were used as templates, 3-aminopropyl trimethoxysilane （APS） was immobilized on the surface of silica nanospheres as couple agent. Aziridine was initiated ring-opening polymerization with the amino groups in APS to form polyethyleneimine （PEI） shell layer. 1,4-Butanediol diacrylate was utilized to crosslink PEI polymeric shell. The silica nanospheres in core were etched by hydrofluoric acid to obtain hollow CPEI nanospheres. The hollow nanospheres were characterized by X-ray photoelectron spectroscopy （XPS）, transmission electron microscopy （TEM）, and thermogravimetric analysis （TGA）.展开更多
Biomedical molecule has received extensive application in surface modification coating.In this paper,polyethyleneimine （PEI）/heparin coating and chitosan/heparin coating on NiTi alloy substrates were prepared by lay...Biomedical molecule has received extensive application in surface modification coating.In this paper,polyethyleneimine （PEI）/heparin coating and chitosan/heparin coating on NiTi alloy substrates were prepared by layer-by-layer method,and differences of corrosion behavior and biocompatibility of the coatings were studied.Static contact angles and Fourier transform infrared （FT-IR） test were used to analysis the surface morphology and structure character of the materials,and atomic absorption spectrum was used to verify the corrosion behavior of the materials.Furthermore,hemolysis,dynamic clotting time and platelet binding test were utilized to investigate the biocompatibility of the materials.The results revealed that the blood compatibility of PEI/heparin coating is better than that of the chitosan/heparin coating as well as the substrate.展开更多
The removal and enrichment of pollutants in industrial wastewater using efficient adsorption processes have been a hot scientific topic in the field of environmental chemistry and green chemistry.Compared with the pro...The removal and enrichment of pollutants in industrial wastewater using efficient adsorption processes have been a hot scientific topic in the field of environmental chemistry and green chemistry.Compared with the progress in the design,synthesis,and performance of polyethyleneimine-modified adsorbent materials at home and abroad,there are few reviews on how to modify polyethyleneimine(PEI)in adsorbent materials through functional group reactions.Therefore,this review attempts to provide a systematic review of how PEI can prepare adsorbent materials by functional group reaction and the adsorption mechanism of inorganic metal ions,phosphates,and dyes in wastewater by PEI.On this basis,future research directions of adsorbent materials are prepared by PEI prospects.展开更多
Mechanism of citrate alkaline copper electrodeposition in presence of polyethyleneimine was researched.Tested by SEM,It's propitious to obtain fine and symmetrical copper film at wider current densities with polye...Mechanism of citrate alkaline copper electrodeposition in presence of polyethyleneimine was researched.Tested by SEM,It's propitious to obtain fine and symmetrical copper film at wider current densities with polyethyleneimine.XRD analysis indicated copper deposits exhibited growth orientation of crystal face(111),which remained with parallel growth.Cyclic voltammograms results indicated that polyethyleneimine adsorbing preferentially at cathode high current density area could make a stronger inhibition on copper electrodeposit.Studied by chronoamperometry,it's showed that initial stage behavior of copper electrodeposition belonged to diffusion controlled and three-dimensional progressive nucleation.展开更多
Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent years.However,the underlying interaction betw...Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent years.However,the underlying interaction between their fluorescent properties and phase transition remains unclear.In this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as pH.Notably,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence emission.We further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous solutions.Moreover,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of doxorubicin.Our study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.展开更多
A branched polyethyleneimine (BPEI) was applied to poly(ethylene terephthalate)(PET) fabric to improve its surface moisture absorption so that the fabric becomes lessliable to retention of electrostatic charg. The dur...A branched polyethyleneimine (BPEI) was applied to poly(ethylene terephthalate)(PET) fabric to improve its surface moisture absorption so that the fabric becomes lessliable to retention of electrostatic charg. The durability of this treatment was assessed bywashing and followed by measurement of charge development on the fabric. The treatedsamples showed improved surface wetting compared to the untreated. The results areconsistent with attachment of the BPEI to the PET surface by a cross-linking mechanism.展开更多
A facile preparation strategy was proposed for preparation of compact zeolite LTA membranes on polyethyleneimine(PEI)modified substrates without seeding.Through the functionalization of substrates by using PEI,compact...A facile preparation strategy was proposed for preparation of compact zeolite LTA membranes on polyethyleneimine(PEI)modified substrates without seeding.Through the functionalization of substrates by using PEI,compact LTA membranes can be formed on various kinds of substrates.A well-intergrown and phase-pure LTA membrane with a thickness of about 3.0μm is successfully prepared on the a-Al_(2)O_(3)disk after crystallization for 24 h at 60℃.Besides LTA membrane,wellintergrown zeolite FAU membranes can also be formed on PEI-modified a-Al_(2)O_(3)substrates,suggesting the universality of this strategy.The zeolite LTA membranes synthesized on PEI-modified a-Al_(2)O_(3)tubes were evaluated for the separation of alcohols/water mixture through pervaporation.The as-synthesized zeolite LTA membranes display high pervaporation performances.For the separation of 10 wt%isopropanol/water solution at 90℃,a high separation factor of44991 and a water flux of 1.73 kg m^(-2)h^(-1)are achieved.展开更多
We report on the ability to create complex 3D flower-like SiO2 in vitro via CaCO3 micropar- icles supported by polyethyleneimine mediated biosilicification under experimentally altered chemical influences. The morphol...We report on the ability to create complex 3D flower-like SiO2 in vitro via CaCO3 micropar- icles supported by polyethyleneimine mediated biosilicification under experimentally altered chemical influences. The morphology, structure, composition of the product have been inves- tigated with the X-ray photoelectron spectrum, scanning electron microscope, transmission electron microscope, and energy-dispersive spectroscopy. Tile overall morphologies could be controlled to shift from a characteristic network of flower-like silica sphere to a sheet-like structure by adjusting physical adsorption of different amount of polyethyleneimine onto the surface of the CaCO3 microparticles.展开更多
Abstracts . In this paper, a silicas-supportedpolyethyleneimine resin is synthesized and its adsorption proper-ties are studied. Its selectivity of sorbing heavy metal ion will vary considerably as the pH v...Abstracts . In this paper, a silicas-supportedpolyethyleneimine resin is synthesized and its adsorption proper-ties are studied. Its selectivity of sorbing heavy metal ion will vary considerably as the pH value of solution varies. In hy-drochloric acid,the resin only sorbs Au(Ⅱ). This suggests that the resin is applicable to the separation of copper (Ⅱ) or gold (Ⅲ).展开更多
In order to improve the selectivity of anion exchange resin, the surface of gel type anion exchange resin was modified with polyethyleneimine (PEI). In the proposed work an attempt to the utilization of commercial ani...In order to improve the selectivity of anion exchange resin, the surface of gel type anion exchange resin was modified with polyethyleneimine (PEI). In the proposed work an attempt to the utilization of commercial anion exchange resin modified by adsorption of polyethyleneimine was investigated. Many conditions of modification of anion exchange resin surface were studied. The influent parameters on the DOWEX 1X8 resin modification were determined using a factorial experimental design. The ion exchange reactions were studied for modified and unmodified resin and electrolyte solutions containing Cl-,NO3-,SO42-. All experiments were performed at constant ionic strength I = 0.3 mol·L-1 and constant temperature T = 298 K. Ionic exchange isotherms were established for the binary systems:Cl-/NO3-,Cl-/SO42- and NO3-/SO42-. The obtained results show that nitrate ion was more sorbed than chloride and sulfate. The order of preference for the anions studied in this investigation is:NO3->Cl->SO42-. All the results given by this resin were compared with those obtained with the AMX anion exchange membrane. Selectivity coefficients and thermodynamic constants for the three binary systems and for the two resins were determined. The modified resin became more selective towards monovalent anions.展开更多
A novel biodegradable and biocompatible multilayer hollow microcapsules, modified by folate-conjugated polyethyleneimine （PEI）, as targeted and sustained release carriers of doxorubicin （DOX）, were successfully sy...A novel biodegradable and biocompatible multilayer hollow microcapsules, modified by folate-conjugated polyethyleneimine （PEI）, as targeted and sustained release carriers of doxorubicin （DOX）, were successfully synthesized using the sequential layer-by-layer electrostatic assembly technique from the sacrificial microtemplates （CaCOs/CMC, spherical, 1.7 pro） with chitosan （CS） and sodium earboxymethyl cellulose （ CMC ） as the polycation and polyanion polyelectrolyte. Scanning electron microscope （SEM） observation showed that the diameter of the seven assembly multilayer microparticles was about 2.0 pm with relatively regular sphere. After the microparticle cores was removed by complexation with ethylene diamine tctraacetic acid （EDTA） for calcium ions, the range of 200- 300 nm wall thickness of microcapsules was built, and it made the forming microeapsules to be stable. Thermogravimctric analysis confirms the deposition and modification total amount of polymer on the microtemplates is about 33.5 %. The assembly microparticles were modified by introducing PEI, and the grafting rate of folate could reach 20. 0 %. It was 4 times that of traditional method. The high grafting rate helped to improve targeting action of microcapsules. The deposition of DOX was prominent and the encapsulation efficiency was 96.9 %, and the plateaued release of loaded drug reached 78 % in pH 7.4 buffer solution, and then in pH 5.7 showed significantly a slow release.展开更多
基金supported by the Major Scientific and Technological Project of China National Offshore Oil Corporation(CNOOC-KJ135ZDXM38ZJ05ZJ).
文摘Addressing the persistent challenge of shale hydration and swelling in water-based drilling fluids(WBDFs),this study developed a smart thermo-responsive shale inhibitor,Hyperbranched PolyethyleneiminePropylene Oxide-N-isopropylacrylamide(HPN).It was synthesized by grafting hyperbranched polyethyleneimine(HPEI)with propylene oxide(PO)and N-isopropylacrylamide(NIPAM),creating a synergistic hydration barrier through hydrophobic association and temperature-triggered pore plugging.Structural characterization by Fourier-Transform Infrared(FTIR)spectroscopy and gel permeation chromatography(GPC)confirmed the successful formation of the HPN terpolymer,revealing a unique“cationic–nonionic”amphiphilic architecture with temperature-responsive properties.Performance evaluation demonstrated that HPN significantly outperforms conventional inhibitors,including potassium chloride(KCl),cationic polyacrylamide(C-PAM),polyethylene glycol(PEG),polyetheramine(PEA),and HPEI.It achieved a superior performance profile:a low yield point of 14.6 Pa,a maximum linear expansion of only 3.1 mm,and a high shale recovery rate of 62.8%at 20%bentonite content.The inhibition mechanism is attributed to a powerful synergy of electrostatic adsorption,hydrophobic association,and thermally induced aggregation,which provides robust performance under demanding conditions such as high salinity(200,000 mg/L NaCl)and high temperature(120℃ ).Thermogravimetric analysis confirmed excellent thermal stability,and the inhibitor exhibited low biological toxicity,complying with stringent environmental standards.These results establish HPN as an efficient,eco-friendly,and field-ready shale inhibitor well-suited for challenging drilling operations.
基金financially supported by the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learningthe Key Laboratory of Textile Science&Technology,Ministry of Education,“111 Project”(B07024)+4 种基金the Fundamental Research Funds for the Central Universitiesthe Chinese Universities Scientific Fund(No.101-06-0019014)the support from Shanghai Pujiang Program(No.14PJ1400400)the National Natural Science Foundation of China(No.21405012)the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University(No.LK1429)
文摘Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid （FA） modified electrospun poly（vinyl alcohol） （PVA）/polyethyleneimine （PEI） nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA via a poly（ethylene glycol） （PEG） spacer, followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition, the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly, the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors, which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications.
基金funded by the National Natural Science Foundation of China(21677092)the Scientific Research Program funded by Shaanxi Provincial Education Department(15JK1095)。
文摘Polyethyleneimine(PEI)modified palygorskite(Pal)was used for the adsorption of Cr(VI)in aqueous solution.The absorbent was characterized by Fourier transform infrared spectroscopy(FT-IR)and thermogravimetric analysis(TGA).Characterized results confirmed that the Pal has been successfully modified by PEI.The modification of PEI increased the Cr(VI)adsorption performance of the Pal by the adsorption combined reduction mechanism,and amino groups of the adsorbent play the main role in the enhanced Cr(VI)adsorption.The maximum adsorption capacity was 51.10 mg·g^-1 at pH4.0 and 25°C.The adsorption kinetics of Cr(VI)on the adsorbent conforms to the Langmuir isotherm model.The maximum adsorption occurs at pH3,and then the adsorption capacity of PEI-Pal was decreased with the increase of p H values.The adsorption kinetics of Cr(VI)on PEI-Pal was modeled with pseudo-second-order model.The addition of Cl^-,SO4^2-and PO4^3-reduced the Cr(VI)adsorption by competition with Cr(VI)for the active sites of PEI-Pal.The Cr(VI)saturated PEI-Pal can be regenerated in alkaline solution,and the adsorption capacity can still be maintained at 30.44 mg·g^-1 after 4 cycles.The results demonstrate that PEI-Pal can be used as a potential adsorbent of Cr(VI)in aqueous solutions.
基金financially supported by the National Natural Science Foundation of China(No.U19A2070)the National Science Funds for Excellent Young Scholars of China(No.61822106)the National Science Funds for Creative Research Groups of China(No.61421002)。
文摘As humidity is one of the most widely demanded environmental parameters,the precision of its detection is significant.An advanced humidity sensor will improve the validity of the humidity monitoring system.In this study,a facile chemical layer-by-layer self-assembly(CLS)method was developed for fabricating graphene oxide(GO)/polyethyleneimine(PEI)multilayer films.Owing to the chemical bonding between the PEI and GO,and the intrinsic stickiness of the PEI,layered films with different numbers of layers were successfully prepared using the CLS method and confirmed through ultraviolet-visible(UV-Vis)spectroscopy and the mass loading of quartz crystal microbalance(QCM).Morphological measurements revealed that the roughness and thickness of the films increased exponentially with the number of bilayers.The GO/PEI films were deposited on QCM electrodes using the CLS method to produce the humidity sensors.The humidity measurement results showed a high sensitivity(37.84 Hz/%RH)and rapid response/recovery(<5 s/8 s)of the optimal sensor,which was superior to that of recently developed QCM sensors.
基金financially supported by the Qianjiang Talent Program of Zhejiang Province(2014.1-2015.12,Zhang Bo)the National Natural Science Fund for Distinguished Young Scholars(No.50888001)+3 种基金the National Natural Science Foundation of China(No.20974096)Zhejiang Provicial Program for the Cultivation of High-level Innovative Health Talents(2010-190-4)the U.S.National Science Foundation(No.CBET 0753109,DMR-0705298)Department of Defense(No.BC083821)
文摘Guanidine was introduced to low molecular weight linear polyethyleneimine （LPEI） via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting guanidinoamidized LPEIs （GLPEIs） could dramatically reduce LPEI＇s toxicity, enhance its DNA-packaging capability, cellular uptake and therefore transfection efficiency. These polyplexes were taken up very efficiently via caveolae-mediated endocytosis and their transfection efficiencies in ovarian cancer cells were significantly improved compared to native LPEIlok polyplexes. Among these GLPEIs, LPEI-C3-G100 showed higher DNA affinity even than LPEI25k and the highest transfection efficiency, probably due to the optimization of polymer chain flexibility. Of notice, LPEI-C3-G100 polyplexes could more effectively accumulate into cytoplasm than LPEI25k, although the transfection efficiency of LPEI-C3-G100 polyplexes was not superior to that of LPEI25k polyplexes, which would be probably attributed to the more efficient release of LPEI25k polyplexes than LPEI-C3-G100 polyplexes in the cytoplasm.
文摘In this work, a series of polyethyleneimine （PEI） functionalized commercial silica gel were prepared by wet impregnation method and used as CO2 sorbent. The as-prepared sorbents were characterized by N2 adsorption, FT-1R and SEM techniques. CO2 capture was tested in a fixed bed reactor using a simulated flue gas containing 15.1% CO2 in a temperature range of 25-100 ~C. The effects of sorption temperature and amine content on CO2 uptake of the adsorbents were investigated. The silica gel with a 30 wt% PEI loading manifested the largest CO2 uptake of 93.4 mgcoz/gadsorbent （equal to 311.3 mg^oz/gPEI） among the tested sorbents under the conditions of 15.1% （v/v） CO2 in N2 at 75 ~C and atmospheric pressure. Moreover, it was rather low-cost. In addition, the PEI-impregnated silica gel exhibited stable adsorption-desorption behavior during 5 consecutive test cycles. These results suggest that the PEI-impregnated silica gel is a promising and cost-effective sorbent for CO2 capture from flue gas and other stationary sources with low CO2 concentration.
基金financially supported by National Key Research and Development Program of China(No.2021YFB3800900)the National Natural Science Foundation of China(Nos.51925305,51833010 and 52203183)+2 种基金Natural Science Foundation of Xiamen,China(No.3502Z202371004)Fundamental Research Funds for the Central Universities(No.20720230004)the talent cultivation project Funds for the Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(No.HRTP-[2022]52)。
文摘Polyethyleneimine(PEI),as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its cytotoxicity.However,research aimed at preparing degradable PEI is scarce.In this work,the hydrogen peroxide(H_(2)O_(2))oxidation method was used to introduce degradable amide groups in the PEI and a series of oxidized PEI22k(oxPEI22k)with different degrees of oxidation were synthesized by regulating the dosage of H_(2)O_(2).The relationship between the oxidation degree of oxPEI22k and the gene transfection efficiency of oxPEI22k was studied in detail,confirming that the oxPEI22k with oxidation degrees of 16.7%and 28.6%achieved improved transfection efficiency compared to unmodified PEI.These oxPEI22k also proved reduced cytotoxicity and improved degradability.Further,this strategy was extended to the synthesis of low-molecular-weight oxPEI1.8k.The oxPEI1.8k with suitable oxidation degree also achieved improved transfection efficiency and reduced cytotoxicity.In brief,this work provided high-efficiency and low-cytotoxicity degradable gene delivery carriers by regulating the oxidation degree of PEI,which was of great significance for promoting clinical applications of PEI.
基金supported by the National Natural Science Foundation of China(No.31670997)the Natural Science Foundation of Hunan Province(No.2015JJ1007)the Basic Research Program of Shenzhen City(No.JCYJ20160530193417959)
文摘Co-delivery of chemical drugs and therapeutic genes for synergistic therapy provides a promising strategy to treat devastating diseases. However, the real-time coordination patterns between chemical drugs and therapeutic genes remain poorly understood. Herein, the complexes of doxorubicin/graphene oxidepolyethyleneimine/p53 plasmid（Dox/GO-PEI/p53） were fabricated and employed to investigate the synergistic manner between Dox and p53 in the inhibition of He La cell growth. GO was conjugated with PEI to form the GO-PEI backbone as the delivery vector. The GO backbone provided surfaces with a high specific area to load Dox via the π-π stacking interaction, and was able to release Dox significantly faster at pH 5.0 than at pH 7.0, while the positively charged PEI section of GO-PEI could condense plasmids into GO-PEI/DNA nanoparticles via the electrostatic interaction. The nanoparticles efficiently mediated the transfection of DNA in He La cells, with lower cytotoxicity compared to PEI/DNA nanoparticles. Furthermore, the complexes of Dox/GO-PEI/p53 released Dox and expressed p53 gene in a sequential manner,and showed successive inhibition of the in vitro growth of He La cells. This type of drug/GO-PEI/DNA complex can be employed as a platform to investigate the coordination pattern between chemical drugs and therapeutic genes for tumor therapy.
基金supported by the National Natural Science Foundation of China (U2002215)the National Key Research and Development Program of China (2021YFC2902202)。
文摘At present,in-situ leaching of weathered crust elution-deposited rare earth ores(WCE-DREOs) encounter with problems such as long leaching cycles,slow infiltration rate and low product purity.In order to solve the above problems,the conventional leaching agent ammonium sulfate((NH_(4))_(2)SO_(4)) was compounded with polymeric surfactant polyethyleneimine(PEI) to form a composite leaching agent.The effects of leaching temperature,PEI concentration.flow rate and pH on leaching kinetics and permeability of rare earths(RE) and aluminum(AI) in orebody were studied.It is found that with temperature increasing,the time required to reach leaching equilibrium for both RE and Al is shortened,the apparent activation energies of RE and AI are 14.79 and 13.45 kJ/mol,respectively,and the leaching processes are in accordance with the outer diffusion control,When the concentrations of(NH_(4))_(2)SO_(4) and PEI in the composite leaching agent are 2.0 wt% and 0.4 wt%;the time required to reach leaching equilibrium for RE and AI is about 50% shorter than that using(NH_(4))_(2)SO_(4) alone,and the leaching efficiencies of RE are slightly higher than that of Al.Properly increasing the temperature and flow rate of the composite leaching agent can improve the leaching efficiencies of RE and Al,but pH has neglected effects on the leaching efficiencies of RE.At PEI concentrations below 0,4 wt%, the addition of PEI promotes the leaching of RE and AI.In column leaching studies of the WCE-DREO,the addition of 0.4 wt% PEI to the traditional leaching agent(NH_(4))_(2)SO_(4) has no impact on the leaching efficiencies of RE.However,it can significantly increase the infiltration rate of WCE-DREO,shortening the leaching time per 10 mL effluent from about 30 min for(NH_(4))_(2)SO_(4) leaching system to 20 min for the composite leaching system.The leaching time is shortened by one-third,and the leaching cost is reduced,which can provide theoretical guidance for the development and commercial implementation of novel composite leaching agent for WCE-DREO.
基金This work was financially supported by the National Basic Research Program of China(National 973 program,No.2005 CB623903).
文摘A novel method to prepare crosslinked polyethyleneimine （CPEI） hollow nanospheres was reported. Uniform silica nanospheres were used as templates, 3-aminopropyl trimethoxysilane （APS） was immobilized on the surface of silica nanospheres as couple agent. Aziridine was initiated ring-opening polymerization with the amino groups in APS to form polyethyleneimine （PEI） shell layer. 1,4-Butanediol diacrylate was utilized to crosslink PEI polymeric shell. The silica nanospheres in core were etched by hydrofluoric acid to obtain hollow CPEI nanospheres. The hollow nanospheres were characterized by X-ray photoelectron spectroscopy （XPS）, transmission electron microscopy （TEM）, and thermogravimetric analysis （TGA）.
基金supported by the National Natural Science Foundation of China (Grant No.50732004)
文摘Biomedical molecule has received extensive application in surface modification coating.In this paper,polyethyleneimine （PEI）/heparin coating and chitosan/heparin coating on NiTi alloy substrates were prepared by layer-by-layer method,and differences of corrosion behavior and biocompatibility of the coatings were studied.Static contact angles and Fourier transform infrared （FT-IR） test were used to analysis the surface morphology and structure character of the materials,and atomic absorption spectrum was used to verify the corrosion behavior of the materials.Furthermore,hemolysis,dynamic clotting time and platelet binding test were utilized to investigate the biocompatibility of the materials.The results revealed that the blood compatibility of PEI/heparin coating is better than that of the chitosan/heparin coating as well as the substrate.
基金Financial support from the National Natural Science Foundation of China(21776026,22075034,and 22178037)Liaoning Revitalization Talents Program(XLYC1902037,XLYC2002114,and XLYC2007104)+1 种基金Dalian Leading Talents Project(No.2018-192 and 2019RQ034)are highly appreciatedsupported by the National Re-search Foundation of Korea(NRF)grant funded by the Ministry of Sci-ence and ICT,Korea(2021R1I1A3060098 and Brain Korea 21 Plus Pro-gram(4199990414196)).
文摘The removal and enrichment of pollutants in industrial wastewater using efficient adsorption processes have been a hot scientific topic in the field of environmental chemistry and green chemistry.Compared with the progress in the design,synthesis,and performance of polyethyleneimine-modified adsorbent materials at home and abroad,there are few reviews on how to modify polyethyleneimine(PEI)in adsorbent materials through functional group reactions.Therefore,this review attempts to provide a systematic review of how PEI can prepare adsorbent materials by functional group reaction and the adsorption mechanism of inorganic metal ions,phosphates,and dyes in wastewater by PEI.On this basis,future research directions of adsorbent materials are prepared by PEI prospects.
文摘Mechanism of citrate alkaline copper electrodeposition in presence of polyethyleneimine was researched.Tested by SEM,It's propitious to obtain fine and symmetrical copper film at wider current densities with polyethyleneimine.XRD analysis indicated copper deposits exhibited growth orientation of crystal face(111),which remained with parallel growth.Cyclic voltammograms results indicated that polyethyleneimine adsorbing preferentially at cathode high current density area could make a stronger inhibition on copper electrodeposit.Studied by chronoamperometry,it's showed that initial stage behavior of copper electrodeposition belonged to diffusion controlled and three-dimensional progressive nucleation.
基金supported by Nature Science Foundation of Shandong Province,China(Nos.ZR2021MB112 and ZR2022MB051)Science and Technology Bureau of Jinan City(2021GXRC105)+1 种基金Postdoctoral Science Foundation of China(2022M712343)as well as by Basic and Applied Basic Research Foundation(2020A1515110374)of Guangdong Province,China.
文摘Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent years.However,the underlying interaction between their fluorescent properties and phase transition remains unclear.In this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as pH.Notably,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence emission.We further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous solutions.Moreover,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of doxorubicin.Our study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.
文摘A branched polyethyleneimine (BPEI) was applied to poly(ethylene terephthalate)(PET) fabric to improve its surface moisture absorption so that the fabric becomes lessliable to retention of electrostatic charg. The durability of this treatment was assessed bywashing and followed by measurement of charge development on the fabric. The treatedsamples showed improved surface wetting compared to the untreated. The results areconsistent with attachment of the BPEI to the PET surface by a cross-linking mechanism.
基金Financial supports by the National Natural Science Foundation of China(Nos.21761132003,21878100)the Fundamental Research Funds for the Central Universities(No.40500-20101222093)are acknowledged。
文摘A facile preparation strategy was proposed for preparation of compact zeolite LTA membranes on polyethyleneimine(PEI)modified substrates without seeding.Through the functionalization of substrates by using PEI,compact LTA membranes can be formed on various kinds of substrates.A well-intergrown and phase-pure LTA membrane with a thickness of about 3.0μm is successfully prepared on the a-Al_(2)O_(3)disk after crystallization for 24 h at 60℃.Besides LTA membrane,wellintergrown zeolite FAU membranes can also be formed on PEI-modified a-Al_(2)O_(3)substrates,suggesting the universality of this strategy.The zeolite LTA membranes synthesized on PEI-modified a-Al_(2)O_(3)tubes were evaluated for the separation of alcohols/water mixture through pervaporation.The as-synthesized zeolite LTA membranes display high pervaporation performances.For the separation of 10 wt%isopropanol/water solution at 90℃,a high separation factor of44991 and a water flux of 1.73 kg m^(-2)h^(-1)are achieved.
文摘We report on the ability to create complex 3D flower-like SiO2 in vitro via CaCO3 micropar- icles supported by polyethyleneimine mediated biosilicification under experimentally altered chemical influences. The morphology, structure, composition of the product have been inves- tigated with the X-ray photoelectron spectrum, scanning electron microscope, transmission electron microscope, and energy-dispersive spectroscopy. Tile overall morphologies could be controlled to shift from a characteristic network of flower-like silica sphere to a sheet-like structure by adjusting physical adsorption of different amount of polyethyleneimine onto the surface of the CaCO3 microparticles.
文摘Abstracts . In this paper, a silicas-supportedpolyethyleneimine resin is synthesized and its adsorption proper-ties are studied. Its selectivity of sorbing heavy metal ion will vary considerably as the pH value of solution varies. In hy-drochloric acid,the resin only sorbs Au(Ⅱ). This suggests that the resin is applicable to the separation of copper (Ⅱ) or gold (Ⅲ).
文摘In order to improve the selectivity of anion exchange resin, the surface of gel type anion exchange resin was modified with polyethyleneimine (PEI). In the proposed work an attempt to the utilization of commercial anion exchange resin modified by adsorption of polyethyleneimine was investigated. Many conditions of modification of anion exchange resin surface were studied. The influent parameters on the DOWEX 1X8 resin modification were determined using a factorial experimental design. The ion exchange reactions were studied for modified and unmodified resin and electrolyte solutions containing Cl-,NO3-,SO42-. All experiments were performed at constant ionic strength I = 0.3 mol·L-1 and constant temperature T = 298 K. Ionic exchange isotherms were established for the binary systems:Cl-/NO3-,Cl-/SO42- and NO3-/SO42-. The obtained results show that nitrate ion was more sorbed than chloride and sulfate. The order of preference for the anions studied in this investigation is:NO3->Cl->SO42-. All the results given by this resin were compared with those obtained with the AMX anion exchange membrane. Selectivity coefficients and thermodynamic constants for the three binary systems and for the two resins were determined. The modified resin became more selective towards monovalent anions.
基金National Natural Science Foundation of China(No.21472126)
文摘A novel biodegradable and biocompatible multilayer hollow microcapsules, modified by folate-conjugated polyethyleneimine （PEI）, as targeted and sustained release carriers of doxorubicin （DOX）, were successfully synthesized using the sequential layer-by-layer electrostatic assembly technique from the sacrificial microtemplates （CaCOs/CMC, spherical, 1.7 pro） with chitosan （CS） and sodium earboxymethyl cellulose （ CMC ） as the polycation and polyanion polyelectrolyte. Scanning electron microscope （SEM） observation showed that the diameter of the seven assembly multilayer microparticles was about 2.0 pm with relatively regular sphere. After the microparticle cores was removed by complexation with ethylene diamine tctraacetic acid （EDTA） for calcium ions, the range of 200- 300 nm wall thickness of microcapsules was built, and it made the forming microeapsules to be stable. Thermogravimctric analysis confirms the deposition and modification total amount of polymer on the microtemplates is about 33.5 %. The assembly microparticles were modified by introducing PEI, and the grafting rate of folate could reach 20. 0 %. It was 4 times that of traditional method. The high grafting rate helped to improve targeting action of microcapsules. The deposition of DOX was prominent and the encapsulation efficiency was 96.9 %, and the plateaued release of loaded drug reached 78 % in pH 7.4 buffer solution, and then in pH 5.7 showed significantly a slow release.
