Irregularities in the DNA repair pathways are frequently observed in cancer.Dysregulated DNA repair pathways support growth advantages to tumor cells.DNA polymerase-theta(POLQ)is an error-prone DNA polymerase involved...Irregularities in the DNA repair pathways are frequently observed in cancer.Dysregulated DNA repair pathways support growth advantages to tumor cells.DNA polymerase-theta(POLQ)is an error-prone DNA polymerase involved in double-strand break repair through microhomology-mediated end joining(MMEJ).POLQ also mediates translesion DNA synthesis and it is largely not expressed in normal cells.POLQ is overexpressed in a range of cancer cells,including homologous recombination(HR)deficient cancer cells.In HR deficient cells,MMEJ is crucial as a backup DNA repair pathway,indicating the indispensable role of POLQ-mediated MMEJ in HR deficient cancer cells.In addition,POLQ is synthetic lethal with a number of oncogenes.This viewpoint highlights the potential role of POLQ as a new target in the treatment of HR-deficient tumors and aims to develop enthusiasm to introduce fundamental aspects of Molecular Biology and Biochemistry to basic research related to Molecular Life Sciences,Cell Biology and Genetics in Sri Lanka as Molecular Biology and Biochemistry fundamentals can still do wonders in modern research.展开更多
Chromosomal instability(CIN)drives cancer development by causing the accumulation of significant gains,losses,and rearrangements of DNA,although the degree to which this impact relies on DNA damage is uncertain in ter...Chromosomal instability(CIN)drives cancer development by causing the accumulation of significant gains,losses,and rearrangements of DNA,although the degree to which this impact relies on DNA damage is uncertain in terms of mechanisms and key molecules.Nevertheless,a structured system for evaluating various forms of CIN and their impact on hepatocellular carcinoma(HCC)is lacking.展开更多
文摘Irregularities in the DNA repair pathways are frequently observed in cancer.Dysregulated DNA repair pathways support growth advantages to tumor cells.DNA polymerase-theta(POLQ)is an error-prone DNA polymerase involved in double-strand break repair through microhomology-mediated end joining(MMEJ).POLQ also mediates translesion DNA synthesis and it is largely not expressed in normal cells.POLQ is overexpressed in a range of cancer cells,including homologous recombination(HR)deficient cancer cells.In HR deficient cells,MMEJ is crucial as a backup DNA repair pathway,indicating the indispensable role of POLQ-mediated MMEJ in HR deficient cancer cells.In addition,POLQ is synthetic lethal with a number of oncogenes.This viewpoint highlights the potential role of POLQ as a new target in the treatment of HR-deficient tumors and aims to develop enthusiasm to introduce fundamental aspects of Molecular Biology and Biochemistry to basic research related to Molecular Life Sciences,Cell Biology and Genetics in Sri Lanka as Molecular Biology and Biochemistry fundamentals can still do wonders in modern research.
基金supported by grants from the National Natural Science Foundation of China(No.82403106,82100217)Chongqing Postdoctoral Science Foundation of China(No.cstc2021jcyj-bshX0118)+3 种基金Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-msxmX0292,CSTB2024NSCQ-MSX0179)Scientific and Technological Research Program of Chongqing Municipal Education Commission(China)(No.KJQN202300451)Chongqing Medical University Future Medical Youth Innovation Team Support Program(China)(No.W0008)Program for Nursing Collaborative Innovation,Chongqing Medical University,Chongqing,China(No.20240203,20240211).
文摘Chromosomal instability(CIN)drives cancer development by causing the accumulation of significant gains,losses,and rearrangements of DNA,although the degree to which this impact relies on DNA damage is uncertain in terms of mechanisms and key molecules.Nevertheless,a structured system for evaluating various forms of CIN and their impact on hepatocellular carcinoma(HCC)is lacking.
