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Design and optimization of quadrupole and sextupole magnets for Shenzhen Innovation Light-source Facility storage ring
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作者 Zhu Jiawu Zhang Miao Wang Yong 《强激光与粒子束》 北大核心 2025年第7期83-90,共8页
As an advanced 4^(th) generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude redu... As an advanced 4^(th) generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude reduction in beam emittance compared to the 3^(rd) generation storage ring.This significantly enhance the radiation brightness and coherence.The multipole magnets of many types for SILF storage ring are under preliminary design,which require high integral field homogeneity.As a result,a dedicated pole tip optimization procedure with high efficiency is developed for quadrupole and sextupole magnets with Opera-2D^(■)python script.The procedure considers also the 3D field effect which makes the optimization more straightforward.In this paper,the design of the quadrupole and sextupole magnets for SILF storage ring is first presented,followed by a detailed description of the implemented pole shape optimization method. 展开更多
关键词 synchrotron radiation facility quadrupole magnet sextupole magnet pole shape optimization
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POLE突变多重分子特征的子宫内膜样腺癌临床病理特征及预后分析
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作者 吴珊 郭静伟 +2 位作者 张莹 田保玲 王哲 《中国医科大学学报》 北大核心 2025年第11期1023-1028,1035,共7页
目的探究DNA聚合酶ε催化亚基(POLE)基因突变多重分子特征的子宫内膜样腺癌临床病理特征及预后。方法选取中国医科大学附属盛京医院确诊子宫内膜样腺癌病例261例,应用基因测序技术检测POLE基因表达,应用免疫组织化学方法检测p53蛋白和... 目的探究DNA聚合酶ε催化亚基(POLE)基因突变多重分子特征的子宫内膜样腺癌临床病理特征及预后。方法选取中国医科大学附属盛京医院确诊子宫内膜样腺癌病例261例,应用基因测序技术检测POLE基因表达,应用免疫组织化学方法检测p53蛋白和错配修复(MMR)蛋白表达。用χ2检验或Fisher确切概率法分析不同分子分型与临床病理特征的相关性,用Kaplan-Meier生存曲线分析患者预后。结果261例中,具有POLE突变(POLE mut)的多重分子特征子宫内膜样腺癌9例,其中POLE mut+p53异常(POLE mut+p53abn)6例,POLE mut+MMR缺陷(POLE mut+dMMR)3例。POLE mut+p53abn患者与p53abn患者肿瘤浸润性淋巴细胞、是否存在肿瘤周围淋巴细胞浸润等特征比较差异有统计学意义(P<0.05),而与POLE mut患者特征比较差异无统计学意义(P>0.05)。Kaplan-Meier生存曲线分析显示,POLE mut+p53abn与POLE mut+dMMR患者无进展生存率(100.0%)明显高于p53abn(50.0%)与dMMR患者(8.8%),差异有统计学意义(P<0.05)。结论POLE mut+p53abn患者临床病理特征接近POLE mut患者。POLE mut+p53abn与POLE mut+dMMR患者预后良好。 展开更多
关键词 子宫内膜样腺癌 多重分子特征 pole突变 基因测序 p53 错配修复
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Fast and Accurate Prediction of Electromagnetic and Temperature Fields for SPMSM Equipped with Unequally Thick Magnetic Poles 被引量:2
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作者 Feng Liu Xiuhe Wang +1 位作者 Lingling Sun Hongye Wei 《CES Transactions on Electrical Machines and Systems》 2025年第2期199-211,共13页
With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher ... With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher and higher.The importance of fast and accurate electromagnetic thermal coupling analysis of such motors becomes more and more prominent.In view of this,the surfacemounted PMSM(SPMSM)equipped with unequally thick magnetic poles is taken as the main object and its electromagnetic thermal coupling analytical model(ETc AM)is investigated.First,the electromagnetic analytical model(EAM)is studied based on the modified subdomain method.It realizes the fast calculation of key electromagnetic characteristics.Subsequently,the 3D thermal analytical model(TAM)is developed by combining the EAM,the lumped parameter thermal network method(LPTNM),and the partial differential equation of heat flux.It realizes the fast calculation of key thermal characteristics in 3D space.Further,the information transfer channel between EAM and TAM is built with reference to the intrinsic connection between electromagnetic field and temperature field.Thereby,the novel ETcAM is proposed to realize the fast and accurate prediction of electromagnetic and temperature fields.Besides,ETcAM has a lot to commend it.One is that it well accounts for the complex structure,saturation,and heat exchange behavior.Second,it saves a lot of computer resources.It offers boundless possibilities for initial design,scheme evaluation,and optimization of motors.Finally,the validity,accuracy,and practicality of this study are verified by simulation and experiment. 展开更多
关键词 Electromagnetic field and temperature field Electromagnetic thermal coupling analytical model(ETcAM) Fast and accurate prediction SPMSM Unequally thick magnetic poles
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不同PD-1单抗治疗POLE基因突变型结直肠癌疗效的比较
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作者 陈盼盼 陈翠珊 +2 位作者 潘庆善 杨曦 周捷 《中国处方药》 2025年第18期6-10,共5页
目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替... 目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替雷利珠单抗组(Tis组)、信迪利单抗组(Sin组)四个组别。按Recist 1.1标准评价药物的疗效。以患者首次接受PD-1单抗治疗为生存时间起点计算无事件生存期(EFS),绘制Kaplan-Meier生存曲线,并用Log-Rank进行检验。对比分析用药前后癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和糖类抗原72-4(CA72-4)等肿瘤标志物的检测结果。统计分析用药过程中各组不良反应的发生率。结果客观缓解率(ORR)高低依次为Pem组(66.67%)、Tor组(53.33%)、Tis组(50.00%)、Sin组(43.75%),各组差异无统计学意义(P>0.05)。EFS依次为Pem组11.45个月、Tis组9.68个月、Tor组9.32个月、Sin组8.85个月。经Log-Rank检验,Pem组累计生存比例显著高于Sin组(P<0.05)。Pem组用药后CA19-9和CA72-4水平显著降低(P<0.05),而Tor组在用药后CA19-9和CA72-4水平显著降低(P<0.05)。各组患者均出现了皮疹、甲状腺功能异常、转氨酶升高、免疫性肺炎、结肠炎、外周神经炎、血细胞减少等免疫相关性不良反应,但发生率差异无统计学意义(P>0.05)。结论对于POLE基因突变型结直肠癌,可首选帕博利珠单抗进行治疗,特瑞普利单抗次选,最后考虑替雷利珠单抗或信迪利单抗。 展开更多
关键词 pole基因 结直肠癌 PD-1单抗
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POLE基因突变型子宫内膜癌的免疫特征分析
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作者 黄育刚 苏小敏 +1 位作者 王莉 汤显斌 《中国免疫学杂志》 北大核心 2025年第4期908-914,共7页
目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCG... 目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCGA数据库分析POLE基因突变型的免疫浸润情况,主要包括CD4、CD8、PD-L1 mRNA的表达及相关预后分析。结果:基于TCGA数据集,与POLE野生型EC相比,POLE突变型的趋化因子家族、免疫细胞表面标志物及溶菌酶等基因的表达差异显著(均P<0.05)。POLE突变型样本中,主要富集的信号途径包括免疫调控、间质上皮转化等(均P<0.01)。相较于POLE野生型,POLE突变型EC样本中CD4^(+)T细胞、CD8^(+)T细胞、M1型巨噬细胞及树突状细胞的丰度高(均P<0.05)。TISIDB平台分析表明,POLE突变状态下,显著驱动了免疫细胞的生物学行为,包括树突状细胞、NK细胞、T细胞等免疫细胞的募集和活化、淋巴细胞归巢等。另外,POLE突变型样本中,多种免疫检查点抑制基因(包括PD-L1、CTLA-4、TIM-3等)显著高表达。临床样本也证实POLE基因突变型与CD8、CD4、PD-L1的高表达显著相关(所有P<0.001)。基于TCGA数据库的预后分析显示,CD8或PD-L1高表达且POLE突变型亚组生存期显著延长,CD8或PD-L1低表达且POLE野生型亚组生存期最短(P<0.01);而CD4亚组差异无统计学意义(P>0.05)。结论:在EC患者中,CD8^(+)T细胞浸润丰度、PD-L1表达情况对POLE突变型的预后或治疗具有重要价值。 展开更多
关键词 子宫内膜癌 pole突变 免疫特征分析 生物信息学分析
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信迪利单抗联合贝伐珠单抗转化治疗POLE~(P286R)突变型结直肠癌1例
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作者 杨俊豪 姚光宇 +3 位作者 马晓婷 刘莲 王晰程 巴一 《中国肿瘤临床》 北大核心 2025年第18期971-972,共2页
患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节... 患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节样软组织密度影,边缘清晰光滑,与胰头分界欠清,增强呈不均匀强化,提示恶性可能。 展开更多
关键词 pole 结直肠癌 免疫治疗 抗血管生成治疗 转化治疗
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Bilateral sleeve fracture of the superior pole of the patella in a healthy adult:A case report
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作者 Wen-Ping He Ci-Meng Ren +5 位作者 Feng Luo Li Chen Wen-Tao Wang Bing-Tao Qiu Xiao-Cao Zhang Hai-Tao Chen 《World Journal of Orthopedics》 2025年第11期148-154,共7页
BACKGROUND Sleeve fracture of the patella is an unusual fracture,almost unique to children.The majority of sleeve fractures involve the inferior patellar pole.However,sleeve fractures of the superior pole of the patel... BACKGROUND Sleeve fracture of the patella is an unusual fracture,almost unique to children.The majority of sleeve fractures involve the inferior patellar pole.However,sleeve fractures of the superior pole of the patella are extremely rare in adults.CASE SUMMARY An 18-year-old male patient fell while running in the morning.The patient had tenderness to palpation at the superior pole of the patella,with a palpable gap over the upper part of the patella in both knees.We applied two 4.5-mm suture anchors with the Krackow stitch to repair the sleeve fracture,augmented by autogenous gracilis through performing the figure-of-eight technique.The patient regained approximately the full range of motion of the knee joint without any quadriceps weakness and a normal gait 6 weeks after surgery.CONCLUSION Sleeve fractures of the superior pole of the patella are extremely rare in adults,especially bilateral sleeve fractures.Suture anchors,augmented by autogenous gracilis,provided secure fixation and achieved excellent results in this rare injury. 展开更多
关键词 Sleeve fracture Patella Superior pole Adult Suture anchors Case report
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Simultaneous second and third harmonics generation in periodically poled lithium niobate:Coupling and competition
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作者 Junming Liu Liqiang Liu +1 位作者 Lihong Hong Zhiyuan Li 《Chinese Physics B》 2025年第8期591-599,共9页
Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bu... Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bulkiness of the device.In this work,we present a comprehensive theoretical and numerical investigation of the simultaneous generation and competition between the second harmonic waves(SHW)and the third harmonic waves(THW)in a single nonlinear crystal.Through analyzing both small-signal and large-signal regimes,we reveal the complex coupling mechanisms between SHW and THW generation processes.Using periodically poled lithium niobate as an example,we demonstrate that the relative conversion efficiencies between SHW and THW can be freely adjusted by controlling the input fundamental wave power.This work provides new insights for designing efficient frequency converters capable of generating both SHW and THW outputs with controllable intensity ratios. 展开更多
关键词 second harmonic generation third harmonic generation quasi-phase matching periodically poled lithium niobate
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Evaluating Euler pole parameters for the north American terrestrial reference frame of 2022
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作者 Mohammad Ali Goudarzi 《Geodesy and Geodynamics》 2025年第6期681-692,共12页
Euler Pole Parameters(EPPs)were estimated for the new plate-fixed North American Terrestrial Reference Frame of 2022(NATRF2022)based on the spherical model of Earth using different sets of continuously operating GPS(c... Euler Pole Parameters(EPPs)were estimated for the new plate-fixed North American Terrestrial Reference Frame of 2022(NATRF2022)based on the spherical model of Earth using different sets of continuously operating GPS(cGPS)station velocities.Two objectives were considered in this research:(1)the possibility of using the cGPS stations located in the areas affected by the Glacial Isostatic Adjustment(GIA),and(2)minimizing the reference frame velocities across the entire continent for conventional uses such as surveying and mapping.A key consideration in this analysis is accounting for the impact of the ongoing GIA on the horizontal velocities.The predicted horizontal velocities from the ICE-6G model were used to remove the GIA effect from the velocity field to mitigate such biases.As a proof of concept,different data sets from a large set of cGPS station velocities were selected,and EPPs were estimated for all these sets of stations with and without removing the GIA effect and estimating or not estimating the Plate Translation Rate(PTR).Considering the WRMS as the criterion for showing goodness of fit,the results show that accounting for the GIA effect reduces the NATRF2022 velocities.Using the same velocity dataset,the PTR was estimated along with the conventional Euler's rotation parameters,and it was shown that estimating the PTR term can further reduce the NATRF2022 velocities. 展开更多
关键词 Reference frame North America tectonic plate Euler pole parameters Plate translation rate NATRF2022
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Visualization of domain structure in periodically poled lithium niobate using radially polarized light
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作者 Yang Han Hongfei Zhang +3 位作者 Fei Chen Chen Yang Yue Wang Kebin Shi 《Advanced Photonics Nexus》 2025年第4期113-118,共6页
Due to its broken out-of-plane symmetry,z-cut periodically poled lithium niobate(PPLN)has exhibited ultrahigh second-order optical nonlinearity.Precise quantification of the domain structure of z-cut PPLN plays a crit... Due to its broken out-of-plane symmetry,z-cut periodically poled lithium niobate(PPLN)has exhibited ultrahigh second-order optical nonlinearity.Precise quantification of the domain structure of z-cut PPLN plays a critical role during poling fabrication.To enhance the imaging detection efficiency of the domain structure in z-cut PPLN,we have developed a second-harmonic generation microscope system specifically designed to produce a longitudinal electric field in foci for the imaging domain inversion.We demonstrated that imaging using a longitudinal electric field can achieve a contrast ratio enhancement by a factor of 1.77,showing high imaging efficiency and making the proposed method suitable for in situ monitoring of the z-cut PPLN poling process. 展开更多
关键词 domain structure periodically poled lithium niobate radially polarized light longitudinal electric field
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Advancing Railway Infrastructure Monitoring:A Case Study on Railway Pole Detection
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作者 Yuxin Yan Huirui Wang +2 位作者 Jingyi Wen Zerong Lan Liang Wang 《Computers, Materials & Continua》 2025年第5期3059-3073,共15页
The development of artificial intelligence(AI)technologies creates a great chance for the iteration of railway monitoring.This paper proposes a comprehensive method for railway utility pole detection.The framework of ... The development of artificial intelligence(AI)technologies creates a great chance for the iteration of railway monitoring.This paper proposes a comprehensive method for railway utility pole detection.The framework of this paper on railway systems consists of two parts:point cloud preprocessing and railway utility pole detection.Thismethod overcomes the challenges of dynamic environment adaptability,reliance on lighting conditions,sensitivity to weather and environmental conditions,and visual occlusion issues present in 2D images and videos,which utilize mobile LiDAR(Laser Radar)acquisition devices to obtain point cloud data.Due to factors such as acquisition equipment and environmental conditions,there is a significant amount of noise interference in the point cloud data,affecting subsequent detection tasks.We designed a Dual-Region Adaptive Point Cloud Preprocessing method,which divides the railway point cloud data into track and non-track regions.The track region undergoes projection dimensionality reduction,with the projected results being unique and subsequently subjected to 2D density clustering,greatly reducing data computation volume.The non-track region undergoes PCA-based dimensionality reduction and clustering operations to achieve preprocessing of large-scale point cloud scenes.Finally,the preprocessed results are used for training,achieving higher accuracy in utility pole detection and data communication.Experimental results show that our proposed preprocessing method not only improves efficiency but also enhances detection accuracy. 展开更多
关键词 Railway pole detection point cloud data mobile LiDAR dual-region adaptive method PCA-based dimensionality reduction
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Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis
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作者 Yan-Fei Feng Hui-Kun Zhou +8 位作者 Bo-Bin Hu Hang Wang Heng-Kai Liang Lu Wei Qing-Mei Li Tu-Mei Su Qian-Bing Yin Ming-Hua Su Jian-Ning Jiang 《World Journal of Hepatology》 2025年第7期221-232,共12页
BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging e... BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients. 展开更多
关键词 Extra spindle pole bodies-like 1 p53 antibody Hepatocellular carcinoma Hepatitis B virus Diagnostic biomarker Case-control study
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Reducing Greenhouse Gas Emissions through Improving the Life Span of Wooden Power Electric Poles of Eucalyptus saligna
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作者 Joseph Voufo Zakari Yaou +3 位作者 Florent Biyeme Rolland Djomi Richard Dadji Metangmo Théodore Tchotang 《Modern Mechanical Engineering》 2022年第1期1-26,共26页
The present work deals with reducing greenhouse gas emissions through improving the life span of wooden power electric poles of Eucalyptus saligna. Indeed, in Sub-Saharan African countries, Cameroon in particular, mos... The present work deals with reducing greenhouse gas emissions through improving the life span of wooden power electric poles of Eucalyptus saligna. Indeed, in Sub-Saharan African countries, Cameroon in particular, most of the power line networks are made of wooden supports and according to the Cameroon energy distribution company, wooden poles represent 32% of the causes of death linked to the state of the network. The company’s 2019 annual report indicates that 40,000 wooden poles were in critical condition and should be replaced. A significant number of mechanical failures affecting these supports have been observed. For example, on the HVA/LV power line “D17 Nko- abang” in Yaoundé in Cameroon, less than three years old, 10 (ten) cases of poles falling and/or breaking, due to their mechanical loading, were observed over a period of fewer than nine months, causing an average service stoppage for more than 11 hours and affecting an average of 3280 customers. These incidents lead to questions about how the supports are dimensioned and what load capacities they are designed to support. The aim of this work is, therefore, to suggest a method of dimensioning wooden poles hence reducing green- house gas emissions due to the deforestation by reducing the number of woo- den poles at risk to be replaced on Cameroon’s electricity distribution network. And more specifically, to reduce the number of mechanical failures affecting the wooden supports observed by analyzing the current wooden supports with their loads and to make proposals for improving the actual dimensioning me- thods. From the study carried out, it appears that 449 out of 845 supports, i.e., 53% needed to be replaced or monitored because they support the nominal forces ranging from 85% to 150% of their admissible limit and proposals have been made to improve their dimensioning. 展开更多
关键词 Electrical Power Line Dimensioning Wooden pole Efforts on pole pole’s Height Method of Loading Overload Coefficients
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POLE突变在肿瘤发生发展中的作用 被引量:6
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作者 黄茜 张声 《临床与病理杂志》 2015年第12期2173-2179,共7页
POLE为DNA聚合酶的催化亚基,具有5'3'DNA聚合酶活性和3'→5'核酸外切酶活性,对DNA复制和校正具有重要作用。POLE突变将引起校正功能缺失,可能导致肿瘤发生。近年来,TCGA在多种肿瘤中检出POLE突变,POLE突变的肿瘤以其独... POLE为DNA聚合酶的催化亚基,具有5'3'DNA聚合酶活性和3'→5'核酸外切酶活性,对DNA复制和校正具有重要作用。POLE突变将引起校正功能缺失,可能导致肿瘤发生。近年来,TCGA在多种肿瘤中检出POLE突变,POLE突变的肿瘤以其独特超强突变分子表型及良好的预后成为近期研究热点。本文综述POLE的结构、功能及其突变在肿瘤发生发展中的作用的研究进展。 展开更多
关键词 pole 肿瘤 预后
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South Pole温度风速廓线的统计分析 被引量:1
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作者 汪平 吴晓庆 《大气与环境光学学报》 CAS 2013年第5期334-343,共10页
利用2008年South Pole的探空资料,通过大气温度和风速廓线,确定了South Pole地区冬季(6,7,8月)和夏季(12,1,2月)的大气边界层结构、边界层和对流层顶的高度。对近地面的温度、水汽压、风速和风向进行了统计分析。结果表明,South Pole大... 利用2008年South Pole的探空资料,通过大气温度和风速廓线,确定了South Pole地区冬季(6,7,8月)和夏季(12,1,2月)的大气边界层结构、边界层和对流层顶的高度。对近地面的温度、水汽压、风速和风向进行了统计分析。结果表明,South Pole大气边界层大多时候为稳定型,但在夏季也存在不稳定的情况,尤其在1月份较多;夏季夜晚的边界层平均高度为389 m,比白天的304 m大,冬季夜晚的边界层平均高度为591 m,大于夏季夜晚;夏季白天对流层顶平均高度比夜晚略大,分别为6172 m和5770m。South Pole高层大气理查森数的倒数基本都小于4,发生湍流的可能性很小。 展开更多
关键词 SOUTH pole 温度风速廓线 边界层顶 对流层顶
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Design and field measurement of a dipole magnet for a newly developed superconducting proton cyclotron beamline 被引量:1
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作者 Jun-Sheng Zhang Jin-Xing Zheng +3 位作者 Yun-Tao Song Wu-Quan Zhang Ming Li Xian-Hu Zeng 《Nuclear Science and Techniques》 SCIE CAS CSCD 2018年第9期214-221,共8页
The design, field quality optimization, multipole field analysis, and field measurement of a dipole for a newly developed superconducting proton cyclotron(SC200) beamline are presented in this paper. The maximum magne... The design, field quality optimization, multipole field analysis, and field measurement of a dipole for a newly developed superconducting proton cyclotron(SC200) beamline are presented in this paper. The maximum magnetic field of the dipole is 1.35 T; the bending radius is 1.6 m with a proton beam energy in the range of70–200 Me V. The magnetic field was calculated with 2 D and 3 D simulations, and measured with a Hall mapping system. The pole shim and end chamfer were optimized to improve the field quality. Based on the simulated results,the multipole field components in the good-field region were studied to evaluate the field quality. The results showed that the field quality is better than ± 5 × 10^(-4) at1.35 T with shimming and chamfering. For the transverse field homogeneity, the third-order(B3) and fifth-order(B5)components should be controlled with symmetrical shims.The second-order(B2) component was the main disturbance for the integral field homogeneity; it could be improved with an end chamfer. The magnet manufacturing and field measurement were performed in this project. The measurement results demonstrated that the magnetic design and field quality optimization of the 45° dipole magnet can achieve the desired high field quality and satisfy the physical requirements. 展开更多
关键词 Magnet FIELD quality pole shim End CHAMFER MULTIpole FIELD component
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POLE/POLD1突变对结直肠癌预后及免疫治疗影响的生物信息学分析
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作者 赵龙 杨长江 +1 位作者 叶颖江 申占龙 《肿瘤学杂志》 CAS 2024年第6期439-448,共10页
[目的]利用生物信息学方法对结直肠癌(colorectal cancer,CRC)中的DNA聚合酶ε(POLE)和DNA聚合酶δ1(POLD1)的突变情况进行分析,并探索两者对CRC预后及免疫治疗的影响。[方法]基于TCGA数据库的数据集,利用c BioPortal工具对所有癌症中的... [目的]利用生物信息学方法对结直肠癌(colorectal cancer,CRC)中的DNA聚合酶ε(POLE)和DNA聚合酶δ1(POLD1)的突变情况进行分析,并探索两者对CRC预后及免疫治疗的影响。[方法]基于TCGA数据库的数据集,利用c BioPortal工具对所有癌症中的POLE/POLD1的改变及其预后进行分析,利用MSIsensor、MANTIS两种评分系统对POLE/POLD1野生型和突变型的CRC患者微卫星不稳定性进行评价,并利用TIMER数据库分析CRC的免疫细胞浸润以及免疫检查点表达与POLE/POLD1突变之间相关性。[结果]在CRC中POLE/POLD1基因的改变频率为6%,且均以错义突变为主。在泛癌中POLE的突变后患者无进展生存期(P<0.001)、无病生存期(P<0.001)及疾病特异性生存期(P=0.017 8)均显著延长。POLE/POLD1突变型CRC患者的微卫星不稳定性占比相比较于野生型患者显著提高(P<0.001),且免疫检查点相关基因CD274、HAVCR2、PDCD1、CTLA4、LAG3、TIGIT和PDCD1LG2的表达均显著上升。CRC中POLE和POLD1基因表达均与肿瘤突变负荷显著相关。此外,CRC中POLE/POLD1突变还与CD8^(+)T细胞、中性粒细胞、树突状细胞等免疫细胞的浸润相关。[结论]POLE/POLD1基因的改变在CRC中较为常见,在泛癌中POLD1突变与患者预后相关。POLE/POLD1基因突变后可能造成微卫星不稳定性增高、免疫检查点的表达上调和免疫细胞浸润程度增加,其可能成为免疫治疗的新靶点。 展开更多
关键词 pole突变 POLD1突变 结直肠肿瘤 生物信息学 免疫治疗
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Rugged Resonant Pole and Its Applications in Soft-Switching Converter
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作者 肖岚 严仰光 《Journal of Southeast University(English Edition)》 EI CAS 2002年第3期225-232,共8页
The soft switching operation principle and operation performance of rugged resonant pole (RRP) is given. The applications of RRP in soft switching DC DC converter and soft switching inverter are discussed in detail. R... The soft switching operation principle and operation performance of rugged resonant pole (RRP) is given. The applications of RRP in soft switching DC DC converter and soft switching inverter are discussed in detail. RRP can constitute buck boost soft switching DC DC converter and isolated soft switching DC DC converter with the automatic limitation performance of output power. Partial series resonant DC DC converter with RRP can realize the zero voltage/zero current switching of power devices. RR... 展开更多
关键词 rugged resonant pole soft switching DC DC converter INVERTER
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POLE/POLD1突变在肿瘤免疫治疗预后中的价值 被引量:4
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作者 周越 苑珩珩 +1 位作者 韩宇 白玉贤 《中国肿瘤》 CAS CSCD 北大核心 2022年第3期215-220,共6页
免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已在多种肿瘤中显示出持续的临床疗效。错配修复蛋白缺陷(mismatch repair deficient,dMMR)或微卫星高度不稳定性(microsatellite instability-high,MSI-H)的转移性结直肠癌患者已... 免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已在多种肿瘤中显示出持续的临床疗效。错配修复蛋白缺陷(mismatch repair deficient,dMMR)或微卫星高度不稳定性(microsatellite instability-high,MSI-H)的转移性结直肠癌患者已从免疫治疗中获益。然而,部分PD-L1阴性和微卫星稳定(microsatellite stability,MSS)型结直肠癌患者对免疫治疗也有持续的反应。因此,为了给患者制定最佳治疗方案,选择能够识别免疫检查点阻断疗效的可靠生物标志物,实现精准治疗是至关重要的。DNA聚合酶亚基的关键编码基因POLE/POLD1是除MSI-H和肿瘤突变负荷(tumor mutation burden,TMB)外,最具潜力的免疫治疗预测指标。全文就POLE/POLD1的分子机制及其突变在免疫治疗中的研究进展进行综述。 展开更多
关键词 pole/POLD1 免疫治疗 生物标志物 肿瘤
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基于South Pole站和McMurdo站的极区电离层闪烁统计特性 被引量:2
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作者 李鹏辉 胡红桥 +2 位作者 方涵先 刘瑞源 杨升高 《极地研究》 CAS CSCD 2016年第1期19-24,共6页
利用South Pole和Mc Murdo两站2013年12月至2014年11月期间的电离层相位闪烁数据,统计分析了两站电离层相位闪烁发生率的周日分布和季节分布。统计结果表明,两站的相位闪烁发生率在季节分布上,春秋季明显大于夏冬季;在周日分布上呈双峰... 利用South Pole和Mc Murdo两站2013年12月至2014年11月期间的电离层相位闪烁数据,统计分析了两站电离层相位闪烁发生率的周日分布和季节分布。统计结果表明,两站的相位闪烁发生率在季节分布上,春秋季明显大于夏冬季;在周日分布上呈双峰结构。在磁中午附近和磁子夜后有较大的闪烁发生率。磁中午附近是因为极隙区的软电子沉降和电离层对流导致的电离层不均匀性,造成较强的无线电波闪烁;磁子夜附近闪烁增强可能是穿越极盖区的等离子体云破碎造成较大密度梯度导致。总体上说,Mc Murdo站的闪烁发生率高于South Pole站,这可能是因为它们所处的磁纬不同所致。 展开更多
关键词 SOUTH pole McMurdo站 极区电离层 相位 闪烁发生率
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