POEMS综合征是一种罕见的单克隆浆细胞疾病,其临床特征为多发性神经病、脏器肿大、内分泌病变、单克隆免疫球蛋白血症以及皮肤改变。腹泻症状在POEMS综合征中并不常见。我们报告了一例以腹泻为主要表现的复发性POEMS综合征患者的病例。...POEMS综合征是一种罕见的单克隆浆细胞疾病,其临床特征为多发性神经病、脏器肿大、内分泌病变、单克隆免疫球蛋白血症以及皮肤改变。腹泻症状在POEMS综合征中并不常见。我们报告了一例以腹泻为主要表现的复发性POEMS综合征患者的病例。该患者接受了多次胃镜检查和息肉切除术,但症状并未改善。随后的免疫固定电泳显示存在IgA-λ型M蛋白条带,且血管内皮生长因子升高,提示可能存在POEMS综合征复发。腹泻作为POEMS综合征罕见且不典型的症状,给POEMS综合征复发的诊断带来了重大挑战。全面评估和管理对于POEMS综合征及早诊断及改善预后具有重要作用。POEMS syndrome is a rare monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Diarrhea is an uncommon manifestation in POEMS syndrome. We report a case of recurrent POEMS syndrome presenting predominantly with diarrhea. The patient underwent multiple gastroscopies and polypectomies without symptomatic improvement. Subsequent immunofixation electrophoresis revealed an IgA-λ monoclonal protein band, and elevated vascular endothelial growth factor (VEGF) levels suggested potential disease recurrence. Diarrhea, as a rare and atypical symptom of POEMS syndrome, posed significant diagnostic challenges in identifying disease relapse. Comprehensive evaluation and management are critical for early diagnosis and improving prognosis in POEMS syndrome.展开更多
E.E. Cummings＇ poems are popular for the whimsical form. This paper, taking his dual identity-both a poet and a painter-as a starting point, is making an analysis of his poem-picture and the relationship between his ...E.E. Cummings＇ poems are popular for the whimsical form. This paper, taking his dual identity-both a poet and a painter-as a starting point, is making an analysis of his poem-picture and the relationship between his poems and the concrete poem, and illustrating the main features of the whimsical form. It is the vivid images and the mood of picture that contribute to his poems the whimsical form.展开更多
文摘POEMS综合征是一种罕见的单克隆浆细胞疾病,其临床特征为多发性神经病、脏器肿大、内分泌病变、单克隆免疫球蛋白血症以及皮肤改变。腹泻症状在POEMS综合征中并不常见。我们报告了一例以腹泻为主要表现的复发性POEMS综合征患者的病例。该患者接受了多次胃镜检查和息肉切除术,但症状并未改善。随后的免疫固定电泳显示存在IgA-λ型M蛋白条带,且血管内皮生长因子升高,提示可能存在POEMS综合征复发。腹泻作为POEMS综合征罕见且不典型的症状,给POEMS综合征复发的诊断带来了重大挑战。全面评估和管理对于POEMS综合征及早诊断及改善预后具有重要作用。POEMS syndrome is a rare monoclonal plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Diarrhea is an uncommon manifestation in POEMS syndrome. We report a case of recurrent POEMS syndrome presenting predominantly with diarrhea. The patient underwent multiple gastroscopies and polypectomies without symptomatic improvement. Subsequent immunofixation electrophoresis revealed an IgA-λ monoclonal protein band, and elevated vascular endothelial growth factor (VEGF) levels suggested potential disease recurrence. Diarrhea, as a rare and atypical symptom of POEMS syndrome, posed significant diagnostic challenges in identifying disease relapse. Comprehensive evaluation and management are critical for early diagnosis and improving prognosis in POEMS syndrome.
文摘E.E. Cummings＇ poems are popular for the whimsical form. This paper, taking his dual identity-both a poet and a painter-as a starting point, is making an analysis of his poem-picture and the relationship between his poems and the concrete poem, and illustrating the main features of the whimsical form. It is the vivid images and the mood of picture that contribute to his poems the whimsical form.
