The associations of polymorphic Alu insertions(POALINs)with major histocompatibility complex(MHC)class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populatio...The associations of polymorphic Alu insertions(POALINs)with major histocompatibility complex(MHC)class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations.For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province,we investigated frequencies of five POALINs,their associations with HLA-A and-B,the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region.We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo,but not in Yunnan Han.These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations.展开更多
文摘The associations of polymorphic Alu insertions(POALINs)with major histocompatibility complex(MHC)class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations.For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province,we investigated frequencies of five POALINs,their associations with HLA-A and-B,the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region.We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo,but not in Yunnan Han.These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations.
