Panax notoginseng saponins(PNS)is the primary active component of the traditional Chinese medicine P.notoginseng.This compound exhibits a range of pharmacological effects,including anti-inflammatory,antioxidant,and an...Panax notoginseng saponins(PNS)is the primary active component of the traditional Chinese medicine P.notoginseng.This compound exhibits a range of pharmacological effects,including anti-inflammatory,antioxidant,and antiplatelet aggregation properties,as well as the enhancement of microcirculation.The extensive research on the modernization of traditional Chinese medicine has garnered significant attention regarding the application of PNS in the treatment of cardiovascular diseases.Research has demonstrated that PNS interventions significantly improve the pathological progression of cardiovascular disease through synergistic effects involving multiple targets and pathways.This paper summarizes the pharmacological mechanisms,clinical research advancements,safety,and potential adverse reactions associated with PNS in the treatment of cardiovascular diseases,in order to provide theoretical references for future research and practical applications in this field.展开更多
The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine(Dex),propofol,ketamine,etomidate,midazolam,and remimazolam.Apart from their established sedative,analgesic,and anxiolytic pro...The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine(Dex),propofol,ketamine,etomidate,midazolam,and remimazolam.Apart from their established sedative,analgesic,and anxiolytic properties,an increasing body of research has uncovered neuroprotective efects of intravenous anesthetics in various animal and cellular models,as well as in clinical studies.However,there also exists conficting evidence pointing to the potential neurotoxic efects of these intravenous anesthetics.The role of intravenous anesthetics for neuro on both sides of protection or toxicity has been rarely summarized.Considering the mentioned above,this work aims to ofer a comprehensive understanding of the underlying mechanisms involved both in the central nerve system(CNS)and the peripheral nerve system(PNS)and provide valuable insights into the potential safety and risk associated with the clinical use of intravenous anesthetics.展开更多
文摘Panax notoginseng saponins(PNS)is the primary active component of the traditional Chinese medicine P.notoginseng.This compound exhibits a range of pharmacological effects,including anti-inflammatory,antioxidant,and antiplatelet aggregation properties,as well as the enhancement of microcirculation.The extensive research on the modernization of traditional Chinese medicine has garnered significant attention regarding the application of PNS in the treatment of cardiovascular diseases.Research has demonstrated that PNS interventions significantly improve the pathological progression of cardiovascular disease through synergistic effects involving multiple targets and pathways.This paper summarizes the pharmacological mechanisms,clinical research advancements,safety,and potential adverse reactions associated with PNS in the treatment of cardiovascular diseases,in order to provide theoretical references for future research and practical applications in this field.
基金supported by the National Key Research and Development Program of China(2018YFC2001802)the National Natural Science Foundation of China(82303765 and 82071251)+4 种基金Hubei Province Key Research and Development Program(2021BCA145)Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research(2022zsyx008)Program of Scientifc and Technological Project in Guizhou Province(Qian Ke He Ji Chu ZK[2022]Yi Ban 516 and Qian Ke He Ji Chu ZK[2021]Yi Ban 559)the Science and Technology Talents Growth Project in Education Department of Guizhou Province(Qian Jiao He KY Zi[2021]4Y211)Research project of Guizhou Administration of Traditional Chinese Medicine(QZYY-2021-082).
文摘The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine(Dex),propofol,ketamine,etomidate,midazolam,and remimazolam.Apart from their established sedative,analgesic,and anxiolytic properties,an increasing body of research has uncovered neuroprotective efects of intravenous anesthetics in various animal and cellular models,as well as in clinical studies.However,there also exists conficting evidence pointing to the potential neurotoxic efects of these intravenous anesthetics.The role of intravenous anesthetics for neuro on both sides of protection or toxicity has been rarely summarized.Considering the mentioned above,this work aims to ofer a comprehensive understanding of the underlying mechanisms involved both in the central nerve system(CNS)and the peripheral nerve system(PNS)and provide valuable insights into the potential safety and risk associated with the clinical use of intravenous anesthetics.
