Oral ulcers are a common ulcerative injury that occurs in the oral mucosa.When occurring,they can cause mucosal pain and affect eating and communication.The oral cavity,characterized by its moist environment and const...Oral ulcers are a common ulcerative injury that occurs in the oral mucosa.When occurring,they can cause mucosal pain and affect eating and communication.The oral cavity,characterized by its moist environment and constant movement of the lips and tongue,presents challenges for conventional drug delivery systems due to its suboptimal adhesion.Therefore,there is a need for the development of adhesive materials specifically designed for use within the oral cavity.In this research,a sticky coacervate incorporating tea polyphenols(TP)was formulated based on the adhesive properties observed in sandcastle worms.The coacervate is composed of Pluronic F68(F68)and TP,synthesized through the coacervation reaction.The F68-TP coacervates are attached to porcine skin easily.It also reduces bacterial viability and has the ability to clear reactive oxygen species.In animal ulcer models,these coacervates demonstrate anti-inflammatory effects and enhance collagen and muscle fiber synthesis.Overall,these adhesive coacervates with antioxidative and antibacterial properties hold potential as a therapeutic option for oral ulcers in the oral cavity.展开更多
基金supported by the National Natural Science Foundation(No.32271468)Sichuan Science and Technology Program(No.2021JDTD0001)+2 种基金1·3·5 Project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYYC23005)the Fundamental Research Funds for the Central Universities(No.2022SCU12046)Innovation Research Project of Sichuan University(No.2022SCUH0046).
文摘Oral ulcers are a common ulcerative injury that occurs in the oral mucosa.When occurring,they can cause mucosal pain and affect eating and communication.The oral cavity,characterized by its moist environment and constant movement of the lips and tongue,presents challenges for conventional drug delivery systems due to its suboptimal adhesion.Therefore,there is a need for the development of adhesive materials specifically designed for use within the oral cavity.In this research,a sticky coacervate incorporating tea polyphenols(TP)was formulated based on the adhesive properties observed in sandcastle worms.The coacervate is composed of Pluronic F68(F68)and TP,synthesized through the coacervation reaction.The F68-TP coacervates are attached to porcine skin easily.It also reduces bacterial viability and has the ability to clear reactive oxygen species.In animal ulcer models,these coacervates demonstrate anti-inflammatory effects and enhance collagen and muscle fiber synthesis.Overall,these adhesive coacervates with antioxidative and antibacterial properties hold potential as a therapeutic option for oral ulcers in the oral cavity.
