Plp1-lineage Schwann cells(SCs)of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing,and the abnormal plasticity of SCs would jeopardize ...Plp1-lineage Schwann cells(SCs)of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing,and the abnormal plasticity of SCs would jeopardize the bone regeneration.However,how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood.Here,by employing single-cell transcriptional profiling combined with lineage-specific tracing models,we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.Importantly,our data demonstrated that the Sonic hedgehog(Shh)signaling was responsible for the transition process initiation,which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers.Collectively,these findings depict an injuryspecific niche signal-mediated Plp1-lineage cells transition towards Gli1+MSCs and may be instructive for approaches to promote bone regeneration during aging or other bone diseases.展开更多
PLP City Range项目坐落在曼谷通罗地区一个宁静的高档社区内,是一座为尖端高尔夫模拟中心建造的创新性混合用途建筑。引人注目的建筑立面,采用曲面预制混凝土板正反向拼贴组合而成,兼具美学和功能性。这些造型独特的混凝土模块在自然...PLP City Range项目坐落在曼谷通罗地区一个宁静的高档社区内,是一座为尖端高尔夫模拟中心建造的创新性混合用途建筑。引人注目的建筑立面,采用曲面预制混凝土板正反向拼贴组合而成,兼具美学和功能性。这些造型独特的混凝土模块在自然光下形成光影交织的效果,巧妙地呼应了高尔夫运动挥杆时的优雅弧线,在视觉上呈现这项运动独特的魅力。展开更多
基金supported by the National Natural Science Foundation of China(grants 81970910 and 82370931)Jiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4)Jiangsu Provincial Medical Innovation Center(CXZX202227).
文摘Plp1-lineage Schwann cells(SCs)of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing,and the abnormal plasticity of SCs would jeopardize the bone regeneration.However,how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood.Here,by employing single-cell transcriptional profiling combined with lineage-specific tracing models,we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.Importantly,our data demonstrated that the Sonic hedgehog(Shh)signaling was responsible for the transition process initiation,which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers.Collectively,these findings depict an injuryspecific niche signal-mediated Plp1-lineage cells transition towards Gli1+MSCs and may be instructive for approaches to promote bone regeneration during aging or other bone diseases.
文摘PLP City Range项目坐落在曼谷通罗地区一个宁静的高档社区内,是一座为尖端高尔夫模拟中心建造的创新性混合用途建筑。引人注目的建筑立面,采用曲面预制混凝土板正反向拼贴组合而成,兼具美学和功能性。这些造型独特的混凝土模块在自然光下形成光影交织的效果,巧妙地呼应了高尔夫运动挥杆时的优雅弧线,在视觉上呈现这项运动独特的魅力。
