The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(ε- caprolactone)(PLGA/PCL)blending on the morphology,shrinkage and degradation behaviors of the electrospun fi...The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(ε- caprolactone)(PLGA/PCL)blending on the morphology,shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers,the average diameter of the electrospun fibers increased from 1.35μm to 1.95μm.The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers,resulting from the semi-crystalline nature of ...展开更多
Nano-hydroxyapatite/poly（e-caprolactone） （nHA/PCL） composite materials are among the best candidates for application in bone tissue engineering. As the main technique to fabricate porous scaffolds, electrospilming...Nano-hydroxyapatite/poly（e-caprolactone） （nHA/PCL） composite materials are among the best candidates for application in bone tissue engineering. As the main technique to fabricate porous scaffolds, electrospilming produce scaffolds with unsatisfactory mechanical strength and limited pore size for cdi infiltration. Micron-sized fiber assembly with higher mechanical strength is qualified to structure hybrid scaffolds. In this study, nHA/PCL monofilament fibers with different mass ratios were fabricated through melt-spinning. Transmission electron microscope （TEM） was used to observe the aggregation between nHA parfides. Other characterizations including scanning electron microscopy （SEM）, attenuated total reflection Fourier transform infrared spectroscopy （ATR.FTIR） and X-ray diffraction （XRD） were done to discuss the morphology, components and crystallization of the nHA/PCL composite fibers, respectively. The influence of nHA/PCL mass ratio on the tensile properties and water contact angle of composite fibers was also studied. The SEM images show the homogeneous dispersion of nano partides in the polymer matrix. Besides, nHA content increases the tensile strength, initial modulus and hydrophillcity of the composite fibers under the premise of spinnability. This kind of fibers is strong enough to fabricate fiber assembly which may have potential application in bone tissue engineering.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(No. 20304013)partially by Natural Science Foundation of Zhejiang Province(No.Y405029).
文摘The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(ε- caprolactone)(PLGA/PCL)blending on the morphology,shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers,the average diameter of the electrospun fibers increased from 1.35μm to 1.95μm.The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers,resulting from the semi-crystalline nature of ...
基金Science and Technology Support Program of Shanghai,China(No.16441903803)National Postdoctoral Foundation,China(No.2016M590299)
文摘Nano-hydroxyapatite/poly（e-caprolactone） （nHA/PCL） composite materials are among the best candidates for application in bone tissue engineering. As the main technique to fabricate porous scaffolds, electrospilming produce scaffolds with unsatisfactory mechanical strength and limited pore size for cdi infiltration. Micron-sized fiber assembly with higher mechanical strength is qualified to structure hybrid scaffolds. In this study, nHA/PCL monofilament fibers with different mass ratios were fabricated through melt-spinning. Transmission electron microscope （TEM） was used to observe the aggregation between nHA parfides. Other characterizations including scanning electron microscopy （SEM）, attenuated total reflection Fourier transform infrared spectroscopy （ATR.FTIR） and X-ray diffraction （XRD） were done to discuss the morphology, components and crystallization of the nHA/PCL composite fibers, respectively. The influence of nHA/PCL mass ratio on the tensile properties and water contact angle of composite fibers was also studied. The SEM images show the homogeneous dispersion of nano partides in the polymer matrix. Besides, nHA content increases the tensile strength, initial modulus and hydrophillcity of the composite fibers under the premise of spinnability. This kind of fibers is strong enough to fabricate fiber assembly which may have potential application in bone tissue engineering.
