Plant growth depends on tightly coordinated auxin signaling and directional auxin transport,yet the molecular feedback mechanism that directly links these processes during root gravitropism has remained mechanisticall...Plant growth depends on tightly coordinated auxin signaling and directional auxin transport,yet the molecular feedback mechanism that directly links these processes during root gravitropism has remained mechanistically unresolved.The recent study by Rodriguez et al.(Cell,2025)reveals a novel cell-surface auxin signaling pathway.It is shown that gravity perception-induced initial auxin asymmetry activates transmembrane kinase 1(TMK1)in the lower side cells of the root.The activated TMK1 then interacts with pin-formed 2(PIN2)and phosphorylates its hydrophilic loop,thereby stabilizing the PIN2 protein.This asymmetric distribution of PIN2 further enhances the auxin flow on the lower side,thus forming a self-reinforcing positive feedback loop that drives force for root tip gravitropic bending.This study provides an updated perspective on the auxin signal and transport feedback,signifying a new advancement in our comprehension of the mechanisms underlying plant adaptive growth.展开更多
BACKGROUND Infection at the pin tract is a frequent and feared complication of external fixators(EF).The type of pin material and coatings have been regarded as possibly influencing infection rates.Over the last 20 ye...BACKGROUND Infection at the pin tract is a frequent and feared complication of external fixators(EF).The type of pin material and coatings have been regarded as possibly influencing infection rates.Over the last 20 years,few prospective clinical studies and systematic reviews addressed the role of coated pins on the rate of pin site infection in human clinical studies.AIM To assess the EF literature over the past 20 years on the clinical benefits of pins manufactured from varied materials and coating systems and their possible role in pin tract infection rates.METHODS We performed a systematic review according to the PRISMA and PICOS guidelines using four scientific platforms:PubMed,LiLacs,SciELO,and Cochrane.We searched the literature for related publications over the past 20 years.RESULTS A literature search yielded 29 articles,among which seven met the inclusion criteria.These studies compared stainless-steel pins and pins coated with hydroxyapatite(HA),titanium and silver.The pin tract infection definitions were arbitrary and not standardized among studies.Most studies included a low number of patients in the analysis and used a short follow-up time.Three metaanalyses were carried out,comparing stainless steel vs silver pins,stainless steel vs HA-coated pins,and titanium vs HA-coated pins.None of this analysis resulted in statistically significant differences in pin tract infection rates.CONCLUSION Currently,no clinical evidence supports the advantage of EF pins manufactured with materials other than stainless steel or coated over uncoated pins in reducing the rates of pin tract infections.A standardized definition of pin tract infection in external fixation is still lacking.展开更多
Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configura...Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configuration transformation is prominent feature of the metamorphic mechanism. The number of constraints or properties of the kinematic pairs provided by the metamorphic kinematic pairs will change under certain conditions, its dynamic performance is much more complex than that of traditional kinematic pairs with immutable constraints. However, the clearance model about traditional kinematic pairs with immutable constraints established by long-term research is difficult to be directly applied to the metachromatic kinematic pairs. Referring to the experience of the traditional kinematic pairs with immutable constraints, the continuous contact model of Metamorphic Groove pin pair with clearance is established. According to the traditional continuous contact model of the kinematic pairs with immutable constraints, the forces between the elements of kinematic pair of the mechanism with clearance and the ideal mechanism without clearance are regarded as the same, and the inertia force and inertia moment of the components are also calculated according to the acceleration of the ideal mechanism. The clearance is regarded as a massless virtual bar with length r. For the rotating pair part, the massless virtual bar length r is the difference between the radius of the shaft and the hole, and for the sliding pair part, the massless virtual bar length r is half of the difference between the height of the slider and the guide groove. According to the new mechanism without gap after adding the imaginary bar, kinetic energy and potential energy of the system are calculated for the two configurations of mechanism with metamorphic Groove pin pair with clearance. The kinetic energy and potential energy of the system are calculated according to the new mechanism without clearance after adding the massless virtual bar. The kinetic energy, potential energy and generalized force are substituted into the Lagrangian equation to obtain the motion equation of the metamorphic mechanism, which lays the foundation for the dynamic performance study of the mechanism with metamorphic groove pin pair with clearance.展开更多
In modern industrial applications,ensuring the reliability of mechanical fittings is critical for maintaining operational safety and efficiency,particularly in power grid systems where split pins serve a pivotal role ...In modern industrial applications,ensuring the reliability of mechanical fittings is critical for maintaining operational safety and efficiency,particularly in power grid systems where split pins serve a pivotal role despite being susceptible to environmental degradation and failure.Existing UAV-based inspection systems are hampered by a low representation of split pin elements and complex backgrounds,leading to challenges in accurate fault detection and timely maintenance.To address this pressing issue,our study proposes an innovative fault detection method for split pins.The approach employs a three-step process:first,cropping operations are used to accurately isolate the fittings containing split pins;second,super-resolution reconstruction is applied to enhance image clarity and detail;and finally,an improved YOLOv8 network,augmented with inner-shape IoU and local window attention mechanisms,is utilized to refine local feature extraction and annotation accuracy.Experimental evaluations on a split pin defect dataset demonstrate robust performance,achieving an accuracy rate of 72.1%and a mean average precision(mAP)of 67.7%,thereby validating the method’s effectiveness under challenging conditions.The proposed approach contributes to the field by specifically targeting the challenges associated with split pin detection in UAV-based inspections,offering a practically applicable and reliably precise method.展开更多
基金supported by the National Natural Science Foundation of China(32372599)the Agricultural Science and Technology Innovation Program(No.CAAS-BRC-GLCA-2025-01).
文摘Plant growth depends on tightly coordinated auxin signaling and directional auxin transport,yet the molecular feedback mechanism that directly links these processes during root gravitropism has remained mechanistically unresolved.The recent study by Rodriguez et al.(Cell,2025)reveals a novel cell-surface auxin signaling pathway.It is shown that gravity perception-induced initial auxin asymmetry activates transmembrane kinase 1(TMK1)in the lower side cells of the root.The activated TMK1 then interacts with pin-formed 2(PIN2)and phosphorylates its hydrophilic loop,thereby stabilizing the PIN2 protein.This asymmetric distribution of PIN2 further enhances the auxin flow on the lower side,thus forming a self-reinforcing positive feedback loop that drives force for root tip gravitropic bending.This study provides an updated perspective on the auxin signal and transport feedback,signifying a new advancement in our comprehension of the mechanisms underlying plant adaptive growth.
文摘BACKGROUND Infection at the pin tract is a frequent and feared complication of external fixators(EF).The type of pin material and coatings have been regarded as possibly influencing infection rates.Over the last 20 years,few prospective clinical studies and systematic reviews addressed the role of coated pins on the rate of pin site infection in human clinical studies.AIM To assess the EF literature over the past 20 years on the clinical benefits of pins manufactured from varied materials and coating systems and their possible role in pin tract infection rates.METHODS We performed a systematic review according to the PRISMA and PICOS guidelines using four scientific platforms:PubMed,LiLacs,SciELO,and Cochrane.We searched the literature for related publications over the past 20 years.RESULTS A literature search yielded 29 articles,among which seven met the inclusion criteria.These studies compared stainless-steel pins and pins coated with hydroxyapatite(HA),titanium and silver.The pin tract infection definitions were arbitrary and not standardized among studies.Most studies included a low number of patients in the analysis and used a short follow-up time.Three metaanalyses were carried out,comparing stainless steel vs silver pins,stainless steel vs HA-coated pins,and titanium vs HA-coated pins.None of this analysis resulted in statistically significant differences in pin tract infection rates.CONCLUSION Currently,no clinical evidence supports the advantage of EF pins manufactured with materials other than stainless steel or coated over uncoated pins in reducing the rates of pin tract infections.A standardized definition of pin tract infection in external fixation is still lacking.
文摘Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configuration transformation is prominent feature of the metamorphic mechanism. The number of constraints or properties of the kinematic pairs provided by the metamorphic kinematic pairs will change under certain conditions, its dynamic performance is much more complex than that of traditional kinematic pairs with immutable constraints. However, the clearance model about traditional kinematic pairs with immutable constraints established by long-term research is difficult to be directly applied to the metachromatic kinematic pairs. Referring to the experience of the traditional kinematic pairs with immutable constraints, the continuous contact model of Metamorphic Groove pin pair with clearance is established. According to the traditional continuous contact model of the kinematic pairs with immutable constraints, the forces between the elements of kinematic pair of the mechanism with clearance and the ideal mechanism without clearance are regarded as the same, and the inertia force and inertia moment of the components are also calculated according to the acceleration of the ideal mechanism. The clearance is regarded as a massless virtual bar with length r. For the rotating pair part, the massless virtual bar length r is the difference between the radius of the shaft and the hole, and for the sliding pair part, the massless virtual bar length r is half of the difference between the height of the slider and the guide groove. According to the new mechanism without gap after adding the imaginary bar, kinetic energy and potential energy of the system are calculated for the two configurations of mechanism with metamorphic Groove pin pair with clearance. The kinetic energy and potential energy of the system are calculated according to the new mechanism without clearance after adding the massless virtual bar. The kinetic energy, potential energy and generalized force are substituted into the Lagrangian equation to obtain the motion equation of the metamorphic mechanism, which lays the foundation for the dynamic performance study of the mechanism with metamorphic groove pin pair with clearance.
基金Fundamental Research Funds for the Central Universities(2023MS134)。
文摘In modern industrial applications,ensuring the reliability of mechanical fittings is critical for maintaining operational safety and efficiency,particularly in power grid systems where split pins serve a pivotal role despite being susceptible to environmental degradation and failure.Existing UAV-based inspection systems are hampered by a low representation of split pin elements and complex backgrounds,leading to challenges in accurate fault detection and timely maintenance.To address this pressing issue,our study proposes an innovative fault detection method for split pins.The approach employs a three-step process:first,cropping operations are used to accurately isolate the fittings containing split pins;second,super-resolution reconstruction is applied to enhance image clarity and detail;and finally,an improved YOLOv8 network,augmented with inner-shape IoU and local window attention mechanisms,is utilized to refine local feature extraction and annotation accuracy.Experimental evaluations on a split pin defect dataset demonstrate robust performance,achieving an accuracy rate of 72.1%and a mean average precision(mAP)of 67.7%,thereby validating the method’s effectiveness under challenging conditions.The proposed approach contributes to the field by specifically targeting the challenges associated with split pin detection in UAV-based inspections,offering a practically applicable and reliably precise method.
