基于自主设计的TTP/C(时间触发协议)总线控制器,提出了开放式DEEC(发动机数字式电子控制器)的冗余架构,将其划分为输入、核心计算及输出3种智能节点,并制定了各个智能节点的任务调度规划图.设计了基于DSP(digital signal processor)+FPG...基于自主设计的TTP/C(时间触发协议)总线控制器,提出了开放式DEEC(发动机数字式电子控制器)的冗余架构,将其划分为输入、核心计算及输出3种智能节点,并制定了各个智能节点的任务调度规划图.设计了基于DSP(digital signal processor)+FPGA(field-programmable gate array)的智能节点硬件平台,在此基础上完成各智能节点的软件设计.最后构建了开放式DEEC的PIL(process in the loop)仿真测试平台,以发动机模型为控制对象,展开了状态调节试验和总线故障注入试验.试验结果证明该开放式DEEC是可行的,并具有良好的重构特性.展开更多
[目的/意义]文章批判性研究了信息素养项目(Project Information Literacy,简称PIL)的主要研究成果与核心发现,旨在为中国的信息素养研究与实践提供参考。[方法/过程]作者通过历史分期、文献调查等方法,全面梳理了PIL主要研究成果和核...[目的/意义]文章批判性研究了信息素养项目(Project Information Literacy,简称PIL)的主要研究成果与核心发现,旨在为中国的信息素养研究与实践提供参考。[方法/过程]作者通过历史分期、文献调查等方法,全面梳理了PIL主要研究成果和核心发现,指出其系统梳理了不同情境下大学生的信息行为,全面总结了大学生身份转变中的信息挑战,并且针对不同群体提出了促进大学生学习研究的建议。[结果/结论]PIL项目为信息素养理论与实践工作提供一定的经验借鉴:(1)紧跟时代发展,重视大学生信息素养的持续变化;(2)整合多方力量,构建大型研究项目的长效机制;(3)理论联系实践,重视信息素养研究的实际作用。展开更多
Singapore leverages its strategic location as a logistics and financial hub serving Southeast Asia to help companies enhance regional operations and build resilient supply chains,according to Teo Siong Seng,Chairman o...Singapore leverages its strategic location as a logistics and financial hub serving Southeast Asia to help companies enhance regional operations and build resilient supply chains,according to Teo Siong Seng,Chairman of the Singapore Business Federation and Executive Chairman of Pacific International Lines(PIL),at the“Singapore Night”event held on the sidelines of the 21st China-ASEAN Expo.He also expressed hopes to work hand in hand with Chinese enterprises to explore emerging areas of cooperation and realize a vision of mutual benefits.展开更多
Objective:Plant hormones act as chemical messengers in the regulation of plant development and metabolism.The production of ginsenosides in Panax hybrid is promoted by auxins that are transported and accumulated by PI...Objective:Plant hormones act as chemical messengers in the regulation of plant development and metabolism.The production of ginsenosides in Panax hybrid is promoted by auxins that are transported and accumulated by PIN-FORMED(PIN)and PIN-LIKES(PILS)auxin transporters.However,genome-wide studies of PIN/PILS of ginseng are still scarce.In current study,identification and transcriptional profiling of PIN/PILS gene families,as well as their potential relationship with ginsenoside biosynthesis in Panax ginseng were investigated.Methods:PIN/PILS genes in P.ginseng was identified via in silico genome-wide analysis,followed by phylogenetic relationships,gene structure,and protein profiles investigation.Moreover,previously reported RNA-sequence data from various tissues and roots after infection were utilized for PIN/PILS genes expression pattern analysis.The Pearson’s correlation analysis of specific PIN/PILS genes expression level and main ginsenoside contents were taken to reveal the potential relationship between auxin transports and ginsenoside biosynthesis in P.ginseng.Results:A genome-wide search of P.ginseng genome for homologous auxin transporter genes identified a total of 17 PIN and 11 PILS genes.Sequence alignment,putative motif organization,and sub-cellular localization indicated redundant and complementary biological functions of these PIN/PILS genes.Most PIN/PILS genes were differentially expressed in a tissue-specific manner,and showed significant correlations with ginsenoside content correspondingly.Eight auxin transporter genes,including both PIN and PILS subfamily members,were positively correlated with ginsenoside content(cor>0.60;P-value<0.05).The expression levels of eleven auxin transporter genes were increased dramatically in the early stage(0–0.5 DPI)after Cylindrocarpon destructans infection,accompanied with various overall expression patterns,implying the dynamic auxin transport in response to biotic stress.Conclusion:Based on the results,we speculate that the accumulation or depletion in temporal or spatial manner of auxin by PIN/PILS transporters involved in the regulation of HMGR activity and subsequent ginsenoside biosynthesis.展开更多
目的观察早期个体化肠内营养支持联合安宫牛黄丸治疗对重型颅脑损伤(sTBI)患者免疫状态、炎症因子及神经功能的影响.方法选择保定市第一中心医院2020年7月至2023年6月收治80例sTBI患者作为研究对象.按不同治疗方法将患者分为对照组和观...目的观察早期个体化肠内营养支持联合安宫牛黄丸治疗对重型颅脑损伤(sTBI)患者免疫状态、炎症因子及神经功能的影响.方法选择保定市第一中心医院2020年7月至2023年6月收治80例sTBI患者作为研究对象.按不同治疗方法将患者分为对照组和观察组,每组40例.对照组进行了早期个体化营养支持治疗,观察组在对照组上述营养支持基础上加用安宫牛黄丸,每日1丸(每丸3g),两组疗程均为7d.收集治疗后1、3及7d两组患者血清免疫球蛋白(IgG、IgM、IgA)和淋巴细胞亚群,以及治疗前和治疗后7d两组血清白细胞介素-6(IL-6)、中性粒细胞计数(NEUT)、淋巴细胞计数(LYM),并计算中性粒细胞/淋巴细胞比值(NLR),同时观察两组神经功能的变化.结果①补体及免疫球蛋白:观察组治疗后3d补体C4水平较对照组明显下降(g/L:0.2±0.1比0.3±0.1,P<0.05),治疗后7d补体C3、IgA、IgG、IgM水平均较对照组明显升高[补体C3(g/L):1.2±0.2比0.9±0.2,IgA(g/L):2.7±0.8比2.0±0.6,IgG(g/L):9.3±1.2比8.0±1.0,IgM(g/L):1.2±0.4比0.7±0.3,均P<0.05].②淋巴细胞亚群水平:观察组治疗后3 d CD8+T及自然杀伤细胞(NK细胞)水平均较对照组明显下降(CD8+T:0.20±0.05比0.25±0.06,NK细胞:0.16±0.10比0.22±0.03,均P<0.05);观察组治疗后7 d CD3+T、CD4+T水平均较对照组明显升高(CD3+T:0.76±0.07比0.71±0.01,CD4+T:0.48±0.05比0.41±0.07,均P<0.05),NK细胞水平较对照组下降(0.12±0.05比0.17±0.02,P<0.05).③炎症指标和血常规指标:两组治疗7d后IL-6及NLR水平均较治疗前明显下降,且以观察组的下降更明显[IL-6(ng/L):26.4(15.3,38.4)比42.9(30.7,58.8),NLR:5.7±2.5比9.1±5.0,均P<0.01].两组治疗后LYM水平均较治疗前降低,但观察组治疗后明显高于对照组(×10^(9)/L:1.6±0.4比1.1±0.5,P<0.05).④GCS评分:两组治疗后7dGCS评分均较治疗前明显升高,但观察组治疗后GCS评分明显高于对照组(分:6.8±2.7比5.6±2.1,P<0.05).结论sTBI患者在早期个体化肠内营养支持基础上加用安宫牛黄丸治疗能有效减轻患者炎症反应,增强肌体体液及细胞免疫功能,并有助于改善神经功能.展开更多
文摘基于自主设计的TTP/C(时间触发协议)总线控制器,提出了开放式DEEC(发动机数字式电子控制器)的冗余架构,将其划分为输入、核心计算及输出3种智能节点,并制定了各个智能节点的任务调度规划图.设计了基于DSP(digital signal processor)+FPGA(field-programmable gate array)的智能节点硬件平台,在此基础上完成各智能节点的软件设计.最后构建了开放式DEEC的PIL(process in the loop)仿真测试平台,以发动机模型为控制对象,展开了状态调节试验和总线故障注入试验.试验结果证明该开放式DEEC是可行的,并具有良好的重构特性.
文摘[目的/意义]文章批判性研究了信息素养项目(Project Information Literacy,简称PIL)的主要研究成果与核心发现,旨在为中国的信息素养研究与实践提供参考。[方法/过程]作者通过历史分期、文献调查等方法,全面梳理了PIL主要研究成果和核心发现,指出其系统梳理了不同情境下大学生的信息行为,全面总结了大学生身份转变中的信息挑战,并且针对不同群体提出了促进大学生学习研究的建议。[结果/结论]PIL项目为信息素养理论与实践工作提供一定的经验借鉴:(1)紧跟时代发展,重视大学生信息素养的持续变化;(2)整合多方力量,构建大型研究项目的长效机制;(3)理论联系实践,重视信息素养研究的实际作用。
文摘Singapore leverages its strategic location as a logistics and financial hub serving Southeast Asia to help companies enhance regional operations and build resilient supply chains,according to Teo Siong Seng,Chairman of the Singapore Business Federation and Executive Chairman of Pacific International Lines(PIL),at the“Singapore Night”event held on the sidelines of the 21st China-ASEAN Expo.He also expressed hopes to work hand in hand with Chinese enterprises to explore emerging areas of cooperation and realize a vision of mutual benefits.
基金supported by grants from the National Science and Technology Major Project (No.2018ZX09201-011,2017ZX09301060-012)the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZXKT17027,ZXKT19027)+1 种基金the National Nature Science Foundation of China(81803672)the National Key Research and Development Program of China (2017YFC1702100)
文摘Objective:Plant hormones act as chemical messengers in the regulation of plant development and metabolism.The production of ginsenosides in Panax hybrid is promoted by auxins that are transported and accumulated by PIN-FORMED(PIN)and PIN-LIKES(PILS)auxin transporters.However,genome-wide studies of PIN/PILS of ginseng are still scarce.In current study,identification and transcriptional profiling of PIN/PILS gene families,as well as their potential relationship with ginsenoside biosynthesis in Panax ginseng were investigated.Methods:PIN/PILS genes in P.ginseng was identified via in silico genome-wide analysis,followed by phylogenetic relationships,gene structure,and protein profiles investigation.Moreover,previously reported RNA-sequence data from various tissues and roots after infection were utilized for PIN/PILS genes expression pattern analysis.The Pearson’s correlation analysis of specific PIN/PILS genes expression level and main ginsenoside contents were taken to reveal the potential relationship between auxin transports and ginsenoside biosynthesis in P.ginseng.Results:A genome-wide search of P.ginseng genome for homologous auxin transporter genes identified a total of 17 PIN and 11 PILS genes.Sequence alignment,putative motif organization,and sub-cellular localization indicated redundant and complementary biological functions of these PIN/PILS genes.Most PIN/PILS genes were differentially expressed in a tissue-specific manner,and showed significant correlations with ginsenoside content correspondingly.Eight auxin transporter genes,including both PIN and PILS subfamily members,were positively correlated with ginsenoside content(cor>0.60;P-value<0.05).The expression levels of eleven auxin transporter genes were increased dramatically in the early stage(0–0.5 DPI)after Cylindrocarpon destructans infection,accompanied with various overall expression patterns,implying the dynamic auxin transport in response to biotic stress.Conclusion:Based on the results,we speculate that the accumulation or depletion in temporal or spatial manner of auxin by PIN/PILS transporters involved in the regulation of HMGR activity and subsequent ginsenoside biosynthesis.
文摘目的观察早期个体化肠内营养支持联合安宫牛黄丸治疗对重型颅脑损伤(sTBI)患者免疫状态、炎症因子及神经功能的影响.方法选择保定市第一中心医院2020年7月至2023年6月收治80例sTBI患者作为研究对象.按不同治疗方法将患者分为对照组和观察组,每组40例.对照组进行了早期个体化营养支持治疗,观察组在对照组上述营养支持基础上加用安宫牛黄丸,每日1丸(每丸3g),两组疗程均为7d.收集治疗后1、3及7d两组患者血清免疫球蛋白(IgG、IgM、IgA)和淋巴细胞亚群,以及治疗前和治疗后7d两组血清白细胞介素-6(IL-6)、中性粒细胞计数(NEUT)、淋巴细胞计数(LYM),并计算中性粒细胞/淋巴细胞比值(NLR),同时观察两组神经功能的变化.结果①补体及免疫球蛋白:观察组治疗后3d补体C4水平较对照组明显下降(g/L:0.2±0.1比0.3±0.1,P<0.05),治疗后7d补体C3、IgA、IgG、IgM水平均较对照组明显升高[补体C3(g/L):1.2±0.2比0.9±0.2,IgA(g/L):2.7±0.8比2.0±0.6,IgG(g/L):9.3±1.2比8.0±1.0,IgM(g/L):1.2±0.4比0.7±0.3,均P<0.05].②淋巴细胞亚群水平:观察组治疗后3 d CD8+T及自然杀伤细胞(NK细胞)水平均较对照组明显下降(CD8+T:0.20±0.05比0.25±0.06,NK细胞:0.16±0.10比0.22±0.03,均P<0.05);观察组治疗后7 d CD3+T、CD4+T水平均较对照组明显升高(CD3+T:0.76±0.07比0.71±0.01,CD4+T:0.48±0.05比0.41±0.07,均P<0.05),NK细胞水平较对照组下降(0.12±0.05比0.17±0.02,P<0.05).③炎症指标和血常规指标:两组治疗7d后IL-6及NLR水平均较治疗前明显下降,且以观察组的下降更明显[IL-6(ng/L):26.4(15.3,38.4)比42.9(30.7,58.8),NLR:5.7±2.5比9.1±5.0,均P<0.01].两组治疗后LYM水平均较治疗前降低,但观察组治疗后明显高于对照组(×10^(9)/L:1.6±0.4比1.1±0.5,P<0.05).④GCS评分:两组治疗后7dGCS评分均较治疗前明显升高,但观察组治疗后GCS评分明显高于对照组(分:6.8±2.7比5.6±2.1,P<0.05).结论sTBI患者在早期个体化肠内营养支持基础上加用安宫牛黄丸治疗能有效减轻患者炎症反应,增强肌体体液及细胞免疫功能,并有助于改善神经功能.
