BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity...BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.展开更多
目的探讨抑郁症大鼠脑组织及血清中蛋白激酶Cα相互作用蛋白(protein interacting with Cαkinase 1,PICK1)的表达水平及意义。方法将30只Wistar大鼠随机分为抑郁症模型组和正常对照组,抑郁症模型组应用慢性温和不可预见性刺激构建模型...目的探讨抑郁症大鼠脑组织及血清中蛋白激酶Cα相互作用蛋白(protein interacting with Cαkinase 1,PICK1)的表达水平及意义。方法将30只Wistar大鼠随机分为抑郁症模型组和正常对照组,抑郁症模型组应用慢性温和不可预见性刺激构建模型,采用体重测量、畅箱实验、糖水消耗实验及Morris水迷宫实验进行行为学检测。蛋白印迹法及酶联免疫吸附试验检测两组脑组织、外周血中PICK1表达的变化。结果与正常对照组相比,抑郁模型组大鼠体重、糖水偏好、水平运动、垂直运动明显降低(P<0.05),逃避潜伏期明显延长(P<0.05)。抑郁症大鼠脑组织中PICK1表达水平较正常大鼠显著增高(P<0.05),血清中PICK1的表达与正常大鼠无显著差异(P>0.05)。结论抑郁模型大鼠脑组织中PICK1表达水平上调,可能参与了抑郁症发生发展的病理过程。展开更多
文摘BACKGROUND Picky eating is a commonly observed behavior among children globally,negatively impacting their physical and mental growth.Although common characteristics distinguish peaky eaters,including food selectivity,food neophobia,and food avoidance,there is no clear definition to assess this behavior.Due to the unavailability of data regarding picky eating,it wasn’t easy to estimate its prevalence.AIM To develop a regional protocol to help healthcare professionals identify and manage mild and moderate picky eating cases.METHODS A virtual roundtable discussion was held in April 2021 to gather the opinions of seven pediatricians and two pediatric dietitians from eight Middle Eastern countries who had great experience in the management of picky eating.The discussion covered different topics,including clearly defining mild and moderate picky eating,identifying the role of diet fortification in these cases,and the possibility of developing a systematic approach to diet fortification.RESULTS The panel identified picky eating as consuming an inadequate amount and variety of foods by rejecting familiar and unfamiliar food.Most of the time,moderate picky eating cases had micronutrient deficiencies with over-or undernutrition;the mild cases only showed inadequate food consumption and/or poor diet quality.Paying attention to the organic red flags like growth faltering and development delay and behavioral red flags,including food fixation and anticipatory gagging,will help healthcare professionals evaluate the picky eaters and the caregivers to care for their children.Although dietary supplementation and commercial food fortification play an important role in picky eating,they were no benefit in the Middle East.CONCLUSION The panel agreed that food fortification through a food-first approach and oral nutritional supplements would be the best for Middle Eastern children.These recommendations would facilitate identifying and managing picky-eating children in the Middle East.
文摘目的探讨抑郁症大鼠脑组织及血清中蛋白激酶Cα相互作用蛋白(protein interacting with Cαkinase 1,PICK1)的表达水平及意义。方法将30只Wistar大鼠随机分为抑郁症模型组和正常对照组,抑郁症模型组应用慢性温和不可预见性刺激构建模型,采用体重测量、畅箱实验、糖水消耗实验及Morris水迷宫实验进行行为学检测。蛋白印迹法及酶联免疫吸附试验检测两组脑组织、外周血中PICK1表达的变化。结果与正常对照组相比,抑郁模型组大鼠体重、糖水偏好、水平运动、垂直运动明显降低(P<0.05),逃避潜伏期明显延长(P<0.05)。抑郁症大鼠脑组织中PICK1表达水平较正常大鼠显著增高(P<0.05),血清中PICK1的表达与正常大鼠无显著差异(P>0.05)。结论抑郁模型大鼠脑组织中PICK1表达水平上调,可能参与了抑郁症发生发展的病理过程。
