A short synthesis starting from 4-imidazolylmethanol(2)was developed for the phosphonoisostere of histidine,-amino-β-(4-imidazolyl)- ethylphosphosphonic acid,His(P)(1).The synthesis features Wittig-Horner reaction of...A short synthesis starting from 4-imidazolylmethanol(2)was developed for the phosphonoisostere of histidine,-amino-β-(4-imidazolyl)- ethylphosphosphonic acid,His(P)(1).The synthesis features Wittig-Horner reaction of aldehyde(4)with diphosphonate(5)followed by selective detritylation with 50% formic acid.展开更多
文摘A short synthesis starting from 4-imidazolylmethanol(2)was developed for the phosphonoisostere of histidine,-amino-β-(4-imidazolyl)- ethylphosphosphonic acid,His(P)(1).The synthesis features Wittig-Horner reaction of aldehyde(4)with diphosphonate(5)followed by selective detritylation with 50% formic acid.
