目的探讨Phoenix评分在儿童脓毒症的应用价值及预后影响因素。方法回顾性收集2018年1月—2021年12月首都医科大学附属北京儿童医院保定医院儿童重症监护病房确诊为严重脓毒症及脓毒性休克的患儿96例。收集患儿临床资料,包括性别、年龄...目的探讨Phoenix评分在儿童脓毒症的应用价值及预后影响因素。方法回顾性收集2018年1月—2021年12月首都医科大学附属北京儿童医院保定医院儿童重症监护病房确诊为严重脓毒症及脓毒性休克的患儿96例。收集患儿临床资料,包括性别、年龄、基础病、病原资料、器官功能障碍、血清胆红素值、格拉斯哥昏迷评分(Glasgow coma scale,GCS)、血清肌酐等数值计算儿童序贯器官衰竭评估(pediatric sequential organ failure assessment,pSOFA)评分、第三代小儿死亡危险(pediatric risk of mortalityIII,PRISMIII)评分,并统计血清乳酸、C反应蛋白、降钙素原、纤维蛋白原(fibrinogen,FIB)、国际标准化比值(international normalized ratio,INR)、D-二聚体、血小板等数值。根据预后不同将入选患儿分为了存活组和预后不良组,采用Logistic回归分析确定脓毒症患儿预后的影响因素。结果以2005年国际专家共识标准诊断为严重脓毒症的患儿共96例,其中脓毒性休克患儿46例。以Phoenix评分标准可诊断为脓毒症的患儿共91例,阳性率为94.8%,排除者5例,阴性率5.2%。Phoenix评分标准可诊断为脓毒症休克的患儿70例,与原有脓毒症休克患儿存在一定交叉。脓毒症患儿91例,根据临床转归情况分为存活组51例和预后不良组40例。预后不良组FIB低于存活组,D-二聚体、GCS评分、乳酸、血管活性药数量、确诊时Phoenix评分、确诊时pSOFA评分以及确诊时PRISMIII评分高于存活组(P<0.05)。Logistic回归分析结果表明,GCS和FIB水平为严重脓毒症患儿预后转归的影响因素(OR=3.736、2.897,P=0.010、0.039),FIB数值越低,昏迷程度越深,预后越差。脓毒性休克患儿70例,根据临床转归情况分为存活组38例和预后不良组32例。预后不良组FIB低于存活组,INR、D-二聚体、GCS评分、乳酸、血管活性药数量、确诊时Phoenix评分、确诊时pSOFA评分以及确诊时PRISMIII评分高于存活组(P<0.05);Logistic回归分析结果显示,GCS评分是脓毒性休克患儿预后转归的影响因素(OR=3.841,P=0.021),GCS评分越低,昏迷程度越深,预后越差。结论Phoenix评分标准在儿童脓毒症的识别方面具有较高的临床应用价值,有助于更早启动干预。FIB和GCS评分是脓毒症患儿不良预后的影响因素。FIB水平降低可作为脓毒症诱发弥散性血管内凝血的早期预警指标,为临床早期干预提供了参考依据。GCS评分作为评估神经系统功能的重要指标,其下降提示脑功能障碍,这在脓毒症患儿中常预示着更高的死亡风险。展开更多
随着集群技术的普及,集群系统如何对外提供服务成为十分重要的课题。Phoenix是一体化、高可靠、高可扩展的集群操作系统。PWP(Phoenix Web Portal)位于Phoenix系统的最上层,旨在为各类用户访问Phoenix系统提供一站式的服务。该文介绍了...随着集群技术的普及,集群系统如何对外提供服务成为十分重要的课题。Phoenix是一体化、高可靠、高可扩展的集群操作系统。PWP(Phoenix Web Portal)位于Phoenix系统的最上层,旨在为各类用户访问Phoenix系统提供一站式的服务。该文介绍了PWP的设计与实现。展开更多
Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment us...Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment using plant extracts may be even broader than is already known when one considers plants that have not been extensively studied in this context, such as the regional species Phoenix dactylifera and Ziziphus spina-christi. This study compared the antimicrobial activity of Phoenix dactylifera and Ziziphus spina-christi extracts in terms of their biochemical and molecular effects on Candida albicans (ATCC CA 10231). These effects included altered levels of intracellular sterols, changes in the permeability of the cell membrane, and changes in the TEF1: QRTTEF1, CaERG1: ERG1, CdERG12: CdERG1, and ERG25: ERG25 genes. Scanning electron microscopy (SEM) was used to identify morphological characteristics, and energy-dispersive X-ray spectroscopy (EDAX) analyses were conducted. In treated samples, the SEM and EDAX analyses showed cell cavities and shrinkage of the cell wall, and the number of cells was reduced to only a few abnormal cells as compared with that in the untreated samples. Yttrium was detected in the cells treated with Z. spina-christi, and high levels of osmium were detected in the cells treated with P. dactylifera. Compared with control cells, cells exposed to the concentration 150 μl/ml of Z. spina-christi extract had an average sterol concentration that was nearly 3 times higher, while the concentration was 5.5 times higher for cells treated with the 150 μl/ml of P. dactylifera extract. The ethanol extracts affected the permeability of C. albicans cell membrane. Gene sequencing showed gaps and mismatches in the ERG1, ERG12, and ERG25 genes after treatment with P. dactylifera and Z. spina-christi extracts compared with that in the controls. The results were highly significant (p ≤ 0.01). We conclude that the ethanol extracts of P. dactylifera and Z. spina-christi have antimicrobial activity through several mechanisms in the yeast cell.展开更多
Based on the measured data, suspended sediment concentration, surface sediment grain size, current and waves, the sediment transport mechanisms and pathways in the Phoenix Island area were analyzed using methods of fl...Based on the measured data, suspended sediment concentration, surface sediment grain size, current and waves, the sediment transport mechanisms and pathways in the Phoenix Island area were analyzed using methods of flux decomposition and Grain Size Trend Analysis(GSTA). The results show that net suspended sediment is mainly transported by average current, Stokes drift, and gravitational circulation. The transport direction of suspended sediment is varying and basically following the direction of residual tidal currents. Surface sediment transport pathways are primarily parallel to the coastline along with two convergent centers. Waves and longshore currents have a significant influence on sediment transport, but the influence is limited due to a steep and deep underwater bank. Tidal current is the main controlling factor for sediment transport, especially in the deep water area. Neither suspended nor surface sediment is transported towards the southwest. The South Shandong Coastal Current(SSCC) has little effect on sediment transport processes in the nearshore area of Phoenix Island.展开更多
Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were e...Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time(PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time(BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut(5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT(P<0.05), significantly in a time-dependent manner followed by Khalas date(P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group(P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process.展开更多
Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmi...Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.展开更多
Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphro...Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphrodisiac. However, the validity has not been scientifically tested. Dopamine is known to facilitate male sexual function. Therefore, the present study was undertaken to evaluate the effect of aqueous extract of Phoenix dactylifera pollen on the sexual behavior of male rats and to measure of serum Estradiol and Testostrone. Also, dopamine transmission in the nucleus accumbence (NAc) was studied in male rats using in vivo microdialysis. Methods and Materials: sixty male rats were randomized into 6 groups (A-F). Group A received 0.2 ml of Normal Saline mixed with Dimethyl Sulphate (DMSO), while groups B-F were injected same volume containing 35 mg/kg, 70 mg/kg, 105 mg/kg, 140 mg/kg and 350 mg/kg of DPP extract, respectively. Sexual behavioral parameters including mounting, intromission and ejaculation frequencies and latencies were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). The male serum testosterone and estradiol concentrations were also determined. Results: All doses stimulated male sexual behavior. Extract significantly increased mount, ejaculation, intromission frequencies and ejaculation latency in comparison to controlled ones (p 0.001). Mount and intromission latencies significantly reduced (p 0.001). Maximum effect was observed in dose 140 mg/kg. This extract was found to enhance Testestrone, Estradiol and the orientation of males toward female ones by increasing mounting and ano-genital investigatory behavior. Conclusions: Data from this study identified that the aqueous extract of Phoenix dactylifera pollen grain enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats may be attributed, to the alkaloids, saponins, and or flavonoids since these phytochemicals has engorgement, androgen enhancing. Also, our findings support the traditional use of this plant as acclaimed aphrodisiac and for the treatment of pre-ejaculation and impotency.展开更多
Phoenix, a very beautiful and popular image in China,like dragon, is an imagined and legendary animal existing only in people's mind. It is such an important component of Chinese culture that we can see a sort of ...Phoenix, a very beautiful and popular image in China,like dragon, is an imagined and legendary animal existing only in people's mind. It is such an important component of Chinese culture that we can see a sort of phenomenon called phoenix phenomenon comes into being in Chinese culture, which deserves efforts to elaborate and whose origin is worth probing. As the totem worshipped by the ancient Chu people, phoenix also displays the basic features of Chinese culture: integratedness and inclusiveness.展开更多
文摘目的探讨Phoenix评分在儿童脓毒症的应用价值及预后影响因素。方法回顾性收集2018年1月—2021年12月首都医科大学附属北京儿童医院保定医院儿童重症监护病房确诊为严重脓毒症及脓毒性休克的患儿96例。收集患儿临床资料,包括性别、年龄、基础病、病原资料、器官功能障碍、血清胆红素值、格拉斯哥昏迷评分(Glasgow coma scale,GCS)、血清肌酐等数值计算儿童序贯器官衰竭评估(pediatric sequential organ failure assessment,pSOFA)评分、第三代小儿死亡危险(pediatric risk of mortalityIII,PRISMIII)评分,并统计血清乳酸、C反应蛋白、降钙素原、纤维蛋白原(fibrinogen,FIB)、国际标准化比值(international normalized ratio,INR)、D-二聚体、血小板等数值。根据预后不同将入选患儿分为了存活组和预后不良组,采用Logistic回归分析确定脓毒症患儿预后的影响因素。结果以2005年国际专家共识标准诊断为严重脓毒症的患儿共96例,其中脓毒性休克患儿46例。以Phoenix评分标准可诊断为脓毒症的患儿共91例,阳性率为94.8%,排除者5例,阴性率5.2%。Phoenix评分标准可诊断为脓毒症休克的患儿70例,与原有脓毒症休克患儿存在一定交叉。脓毒症患儿91例,根据临床转归情况分为存活组51例和预后不良组40例。预后不良组FIB低于存活组,D-二聚体、GCS评分、乳酸、血管活性药数量、确诊时Phoenix评分、确诊时pSOFA评分以及确诊时PRISMIII评分高于存活组(P<0.05)。Logistic回归分析结果表明,GCS和FIB水平为严重脓毒症患儿预后转归的影响因素(OR=3.736、2.897,P=0.010、0.039),FIB数值越低,昏迷程度越深,预后越差。脓毒性休克患儿70例,根据临床转归情况分为存活组38例和预后不良组32例。预后不良组FIB低于存活组,INR、D-二聚体、GCS评分、乳酸、血管活性药数量、确诊时Phoenix评分、确诊时pSOFA评分以及确诊时PRISMIII评分高于存活组(P<0.05);Logistic回归分析结果显示,GCS评分是脓毒性休克患儿预后转归的影响因素(OR=3.841,P=0.021),GCS评分越低,昏迷程度越深,预后越差。结论Phoenix评分标准在儿童脓毒症的识别方面具有较高的临床应用价值,有助于更早启动干预。FIB和GCS评分是脓毒症患儿不良预后的影响因素。FIB水平降低可作为脓毒症诱发弥散性血管内凝血的早期预警指标,为临床早期干预提供了参考依据。GCS评分作为评估神经系统功能的重要指标,其下降提示脑功能障碍,这在脓毒症患儿中常预示着更高的死亡风险。
文摘Our overall knowledge of the medicinal uses of plants suggests that natural compounds could be useful in the treatment of cutaneous fungal infections in tropical regions. Furthermore, the possibilities of treatment using plant extracts may be even broader than is already known when one considers plants that have not been extensively studied in this context, such as the regional species Phoenix dactylifera and Ziziphus spina-christi. This study compared the antimicrobial activity of Phoenix dactylifera and Ziziphus spina-christi extracts in terms of their biochemical and molecular effects on Candida albicans (ATCC CA 10231). These effects included altered levels of intracellular sterols, changes in the permeability of the cell membrane, and changes in the TEF1: QRTTEF1, CaERG1: ERG1, CdERG12: CdERG1, and ERG25: ERG25 genes. Scanning electron microscopy (SEM) was used to identify morphological characteristics, and energy-dispersive X-ray spectroscopy (EDAX) analyses were conducted. In treated samples, the SEM and EDAX analyses showed cell cavities and shrinkage of the cell wall, and the number of cells was reduced to only a few abnormal cells as compared with that in the untreated samples. Yttrium was detected in the cells treated with Z. spina-christi, and high levels of osmium were detected in the cells treated with P. dactylifera. Compared with control cells, cells exposed to the concentration 150 μl/ml of Z. spina-christi extract had an average sterol concentration that was nearly 3 times higher, while the concentration was 5.5 times higher for cells treated with the 150 μl/ml of P. dactylifera extract. The ethanol extracts affected the permeability of C. albicans cell membrane. Gene sequencing showed gaps and mismatches in the ERG1, ERG12, and ERG25 genes after treatment with P. dactylifera and Z. spina-christi extracts compared with that in the controls. The results were highly significant (p ≤ 0.01). We conclude that the ethanol extracts of P. dactylifera and Z. spina-christi have antimicrobial activity through several mechanisms in the yeast cell.
文摘Based on the measured data, suspended sediment concentration, surface sediment grain size, current and waves, the sediment transport mechanisms and pathways in the Phoenix Island area were analyzed using methods of flux decomposition and Grain Size Trend Analysis(GSTA). The results show that net suspended sediment is mainly transported by average current, Stokes drift, and gravitational circulation. The transport direction of suspended sediment is varying and basically following the direction of residual tidal currents. Surface sediment transport pathways are primarily parallel to the coastline along with two convergent centers. Waves and longshore currents have a significant influence on sediment transport, but the influence is limited due to a steep and deep underwater bank. Tidal current is the main controlling factor for sediment transport, especially in the deep water area. Neither suspended nor surface sediment is transported towards the southwest. The South Shandong Coastal Current(SSCC) has little effect on sediment transport processes in the nearshore area of Phoenix Island.
基金supported by Grant from College of Medicine and Health Sciences,Sultan Qaboos University,Sultanate of Oman
文摘Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates(Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time(PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time(BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut(5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT(P<0.05), significantly in a time-dependent manner followed by Khalas date(P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group(P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process.
文摘Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.
文摘Aim of study: Ancient literature alluded to the use of a number of plants/preparations as sex enhancer. One of such botanicals is Phoenix dactylifera in which the pollen grain has been acclaimed to be used as an aphrodisiac. However, the validity has not been scientifically tested. Dopamine is known to facilitate male sexual function. Therefore, the present study was undertaken to evaluate the effect of aqueous extract of Phoenix dactylifera pollen on the sexual behavior of male rats and to measure of serum Estradiol and Testostrone. Also, dopamine transmission in the nucleus accumbence (NAc) was studied in male rats using in vivo microdialysis. Methods and Materials: sixty male rats were randomized into 6 groups (A-F). Group A received 0.2 ml of Normal Saline mixed with Dimethyl Sulphate (DMSO), while groups B-F were injected same volume containing 35 mg/kg, 70 mg/kg, 105 mg/kg, 140 mg/kg and 350 mg/kg of DPP extract, respectively. Sexual behavioral parameters including mounting, intromission and ejaculation frequencies and latencies were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). The male serum testosterone and estradiol concentrations were also determined. Results: All doses stimulated male sexual behavior. Extract significantly increased mount, ejaculation, intromission frequencies and ejaculation latency in comparison to controlled ones (p 0.001). Mount and intromission latencies significantly reduced (p 0.001). Maximum effect was observed in dose 140 mg/kg. This extract was found to enhance Testestrone, Estradiol and the orientation of males toward female ones by increasing mounting and ano-genital investigatory behavior. Conclusions: Data from this study identified that the aqueous extract of Phoenix dactylifera pollen grain enhanced sexual behaviour in male rats. The improved sexual appetitive behaviour in male rats may be attributed, to the alkaloids, saponins, and or flavonoids since these phytochemicals has engorgement, androgen enhancing. Also, our findings support the traditional use of this plant as acclaimed aphrodisiac and for the treatment of pre-ejaculation and impotency.
文摘Phoenix, a very beautiful and popular image in China,like dragon, is an imagined and legendary animal existing only in people's mind. It is such an important component of Chinese culture that we can see a sort of phenomenon called phoenix phenomenon comes into being in Chinese culture, which deserves efforts to elaborate and whose origin is worth probing. As the totem worshipped by the ancient Chu people, phoenix also displays the basic features of Chinese culture: integratedness and inclusiveness.
