In this study, the allotropic phase transition and its effect on the magnetic behavior of Fe Co–7 wt%V alloy were investigated. It was found that c phase is observed in the microstructure in the as-cast condition, an...In this study, the allotropic phase transition and its effect on the magnetic behavior of Fe Co–7 wt%V alloy were investigated. It was found that c phase is observed in the microstructure in the as-cast condition, and it diminishes after severe cold rolling（90% reduction）. After annealing at temperatures higher than 500 up to 750 ℃, the c phase is observed in the structure, again. But, this phase is disappeared by annealing at temperatures above 750 ℃ due to the formation of vanadium-rich precipitates. Thermocalc software was used in order to elucidate the influence of vanadium percent on the stability of c phase in Fe–Co alloys. Also, magnetic studies showed that the saturation induction is reduced by annealing at temperatures from 500 up to 750 ℃, which is related to the formation of residual non-magnetic γ phase.展开更多
A novel class of molecules with structure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides （20- 29） were designed by generating a pharmacophore for potent MDR reversal activity using phase drug design so...A novel class of molecules with structure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides （20- 29） were designed by generating a pharmacophore for potent MDR reversal activity using phase drug design software. The designed molecules were synthesized by a novel synthesis route and evaluated for their inhibitory effects on the transport activity of P-glycoprotein （P-gp） by standard Hoechst 33342 assay method. Based on the pIC50 values of ten title compounds screened, three compounds exhibited better activity as compared to Verapamil used as standard.展开更多
文摘In this study, the allotropic phase transition and its effect on the magnetic behavior of Fe Co–7 wt%V alloy were investigated. It was found that c phase is observed in the microstructure in the as-cast condition, and it diminishes after severe cold rolling（90% reduction）. After annealing at temperatures higher than 500 up to 750 ℃, the c phase is observed in the structure, again. But, this phase is disappeared by annealing at temperatures above 750 ℃ due to the formation of vanadium-rich precipitates. Thermocalc software was used in order to elucidate the influence of vanadium percent on the stability of c phase in Fe–Co alloys. Also, magnetic studies showed that the saturation induction is reduced by annealing at temperatures from 500 up to 750 ℃, which is related to the formation of residual non-magnetic γ phase.
文摘A novel class of molecules with structure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides （20- 29） were designed by generating a pharmacophore for potent MDR reversal activity using phase drug design software. The designed molecules were synthesized by a novel synthesis route and evaluated for their inhibitory effects on the transport activity of P-glycoprotein （P-gp） by standard Hoechst 33342 assay method. Based on the pIC50 values of ten title compounds screened, three compounds exhibited better activity as compared to Verapamil used as standard.
