China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co....China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.展开更多
Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field face...Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.展开更多
Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before ...Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before fully understanding their molecular mechanisms,yeast systems now provide valuable insights for drug discovery and personalized medicine.Recent advancements in genetic engineering,metabolic engineering,and synthetic biology have improved the efficiency and scalability of yeast-based production systems,enabling more sustainable and cost-effective manufacturing processes.This paper reviews the latest developments in yeast-based technologies,focusing on their use as model organisms to study disease mechanisms,identify drug targets,and develop novel therapies.We highlight key platforms such as the yeast two-hybrid system,surface display technologies,and optimized expression systems.Additionally,we explore the future integration of yeast engineering with artificial intelligence(AI),machine learning(ML),and advanced genome editing technologies like CRISPR/Cas9,which are expected to accelerate drug discovery and enable personalized therapies.Furthermore,yeast-based systems are increasingly employed in largescale drug production,vaccine development,and therapeutic protein expression,offering promising applications in clinical and industrial settings.This paper discusses the practical implications of these systems and their potential to revolutionize drug development,paving the way for safer,more effective therapies.展开更多
A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection...A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
Innately designed to induce physiological changes,pharmaceuticals are foreknowingly hazardous to the ecosystem.Advanced oxidation processes(AOPs)are recognized as a set of contemporary and highly efficient methods bei...Innately designed to induce physiological changes,pharmaceuticals are foreknowingly hazardous to the ecosystem.Advanced oxidation processes(AOPs)are recognized as a set of contemporary and highly efficient methods being used as a contrivance for the removal of pharmaceutical residues.Since reactive oxygen species(ROS)are formed in these processes to interact and contribute directly toward the oxidation of target contaminant(s),a profound insight regarding the mechanisms of ROS leading to the degradation of pharmaceuticals is fundamentally significant.The conceptualization of some specific reaction mechanisms allows the design of an effective and safe degradation process that can empirically reduce the environmental impact of themicropollutants.This review mainly deliberates themechanistic reaction pathways for ROS-mediated degradation of pharmaceuticals often leading to complete mineralization,with a focus on acetaminophen as a drug waste model.展开更多
With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient pur...With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.展开更多
The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and e...The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and efficacy of drugs.Unlike the inherent molecular structures of active pharmaceutical ingredients(APIs)and excipients,the microstructures of pharmaceutical preparations are developed during the formulation process,presenting unique analytical challenges.In this review,we primarily focus on presenting the research methods used to elucidate the microstructures of pharmaceutical preparations,including X-ray imaging(XRI),scanning electron microscopy(SEM),atomic force microscopy(AFM),Raman spectroscopy,infrared(IR)spectroscopy,and rheometer technology.Subsequently,we highlight the applications,advantages,and limitations of these methods.Finally,we discuss the current challenges and future perspectives in this field.This review aims to provide a comprehensive reference for understanding the microstructures of pharmaceutical preparations,offering new insights and potential advancements in their development.展开更多
Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challeng...Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challenge emerges from the misalignment between the mid-IR light wavelength range and molecular dimensions,culminating in a constrained absorption cross-section and diminished vibrational absorption coefficients(Supplementary data).展开更多
Pharmaceuticals and personal care products(PPCPs)have been considered as potential contributors to thyroid nodule(TN)and abnormal thyroid homeostasis,but epidemiological evidence is scarce.A total of 1261 individuals ...Pharmaceuticals and personal care products(PPCPs)have been considered as potential contributors to thyroid nodule(TN)and abnormal thyroid homeostasis,but epidemiological evidence is scarce.A total of 1261 individuals comprised of 367 TN patients and 895 controls were recruited from Sichuan,China.The urinary concentrations of fourteen PPCPs were measured.Five thyroid hormones(THs)in serum were determined as indicators of thyroid homeostasis,including thyroid-stimulating hormone,triiodothyronine(T3),thyroxine(T4),free-T3 and free-T4.Serum levels of thyroglobulin antibody(TGAb)and thyroperoxidase antibody(TPOAb)were quantified to identify individual thyroid antibody(TA)statuses.TN patients exhibited higher propyl-paraben(PrP)(median:1.30μg/g Cr)level than controls(0.64μg/g Cr).PrP were significantly associated with TN risk with ORs of 1.060(95%CI:1.002,1.122).The relationship of methyl-paraben with TN risk was nonlinear(p=0.049).PPCP exposurewas significantwith TN risk only in females and TA positive(TPOAb or TGAb)groups,indicating that PPCP susceptibility to TN differs by sex and TA status.Linear regression models showed ethyl-paraben was significantly negatively associated with T4(β:-0.005,95%CI:-0.011,-0.002)and T3(β:-0.007,95%CI:-0.015,-0.002),and positively associated with TPOAb(β:0.059,95%CI:0.000,0.119),suggesting that certain PPCP exposure could affect thyroid homeostasis and autoimmunity.The effects of PPCP exposure on TH and TA levels presented sex-specific.Our findings suggest that PPCP exposure increases TN risk and affects thyroid homeostasis,exhibiting sex and antibody status dependence.展开更多
With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,pa...With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,particularly in aligning with the holistic education model,which emphasizes moral,intellectual,physical,aesthetic,and labor development.To bridge this gap,Guangdong Pharmaceutical University has implemented a comprehensive reform of its holistic education system,aiming to cultivate well-rounded cosmetics professionals.Key initiatives include integrating professional ethics into moral education,strengthening the integration of theory and practice in intellectual training,emphasizing skin health management in physical education,enhancing aesthetic appreciation and creative thinking,and promoting labor spirit and practical skills through hands-on experiences.These reform efforts have yielded significant results,contributing high-quality talent to the cosmetics industry and offering a valuable model for other institutions seeking to align education with industry demands.展开更多
Objective To empirically analyze the relationship between Government R&D funding and R&D investment of the enterprises in different sub industries of pharmaceutical industry,and to provide reference for the de...Objective To empirically analyze the relationship between Government R&D funding and R&D investment of the enterprises in different sub industries of pharmaceutical industry,and to provide reference for the development of policies related to R&D funding input.Methods Granger causality test was performed using the data of relevant indicators in different sub industries of China’s pharmaceutical industry from 1995 to 2019 based on the theory of covariance.Results and Conclusion The funding of R&D from the government had a significant positive effect on their R&D funding inputs to enterprises with chemo products,Chinese patent products,and biological products.It means the improvement of government funding was beneficial in promoting the R&D investment from various sub industries of pharmaceutical industry.The order of this influence was biological products,chemo products,and Chinese patent drugs.As to chemical drugs and biological products,the government’s R&D funding and enterprises R&D funding input showed a good trend of mutual promotion in a certain lag period.The government can fully leverage its funding to promote the investment of all sub industries of pharmaceutical industry.Meanwhile,regulatory mechanisms should be refined for government funding.For the inheritance,innovation,and development of traditional Chinese medicine,the government should give more policy support than financial support.展开更多
AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to i...AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.展开更多
Introduction: In recent times, satisfaction studies have gained importance in the health sector as a way to monitor services and products. The main aim of this study was to explore patient satisfaction with pharmaceut...Introduction: In recent times, satisfaction studies have gained importance in the health sector as a way to monitor services and products. The main aim of this study was to explore patient satisfaction with pharmaceutical care provided in Nampula healthcare centers. Material and Methods: The study was conducted at the 25 de Setembro, 1˚ de Maio, and Muhala-Expansão healthcare centers in Nampula. The sample consisted of 381 patients, with 127 from each center, selected for accessibility. Data were collected through a questionnaire with an internal consistency of 0.816, calculated using McDonald’s total Omega (ωt). The analysis included frequencies, descriptive statistics (mean and standard deviation), and inferential statistics like Binary Logistic Regression. Results: Overall satisfaction was 3.62 ± 0.627 on a scale of 1 to 5, or 69.8%. The binary regression associated a higher education level with dissatisfaction (COR 0.204, 95% CI: −2.752 to −0.427) and living in Marrere (COR 0.083, 95% CI: -5.098 to 0.120) and Muahivir-Expansão (COR 0.589, 95% CI: −1.824 to 0.767) with dissatisfaction as well. Conclusion: Satisfaction was generally high, mainly influenced by the availability of medicines and medical supplies, and less by other factors such as healthcare center accessibility, facility quality, and relationships with pharmacy professionals. Although variables like sex, religion, age, marital status, profession, occupation, and the number of pharmacy visits in the last five years were not statistically significant for general satisfaction in this study, they should be considered in future studies as they are often linked to pharmaceutical satisfaction.展开更多
Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micr...Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.展开更多
Objective To provide effective decision making for the subsidy policies given by the government to pharmaceutical enterprises and the coordination model adopted by pharmaceutical stakeholders under the carbon emission...Objective To provide effective decision making for the subsidy policies given by the government to pharmaceutical enterprises and the coordination model adopted by pharmaceutical stakeholders under the carbon emission trading policy.Methods The Stackelberg model was used to discuss the optimal profits of each member and the whole supply chain under different decision-making models while considering the technical capacity of emission reduction and cost sharing contract.Based on this,the impact of the combined contract decisionmaking model on the technical efforts of drug manufacturers to reduce carbon emission,the profits of supply chain members and the overall profits of supply chain was investigated.Results and Conclusion Research has found that improving the research and development efforts of emission reduction technologies by pharmaceutical enterprises can increase drug sales and enhance the expected profits of pharmaceutical supply chain members.The members of the secondary pharmaceutical supply chain can achieve the optimal expected profit when reaching cooperation.Besides,when the cost sharing contract and quantity discount contract meet the constraint conditions,the combined contract decision model can perfectly coordinate the pharmaceutical supply chain,enabling supply chain members to achieve Pareto improvement and gradually reach Pareto optimum.展开更多
Universities serve as pivotal platforms for cultivating postdoctoral talent,particularly in pharmaceutical sciences.This study provided an empirical assessment of the key determinants influencing research productivity...Universities serve as pivotal platforms for cultivating postdoctoral talent,particularly in pharmaceutical sciences.This study provided an empirical assessment of the key determinants influencing research productivity among postdoctoral fellows in this field.We analyzed a cohort of postdoctoral researchers who entered the School of Pharmaceutical Sciences at Peking University between October 2016 and December 2024,gathering comprehensive data on their demographic characteristics and scholarly accomplishments throughout their fellowship.Indicators of postdoctoral success encompassed securing research funding,publishing scholarly articles,and filing patent applications.To identify the principal factors shaping these outcomes,we employed logistic regression analysis.The findings demonstrated that postdoctoral fellows enrolled in incentive programs exhibited markedly higher success rates in acquiring research grants,especially high-tier funding,as well as in publishing both general and high-impact research articles.Conversely,fellows engaged in interdisciplinary research showed significantly reduced success rates in obtaining both general and high-level grants.Additionally,extended fellowship durations were positively correlated with greater likelihoods of publishing high-impact papers and achieving patents.Notably,postdoctoral fellows specializing in Pharmaceutical Analysis had a significantly higher probability of securing prestigious research grants,while those focusing on Pharmaceutics demonstrated a superior capacity for research publication.Regarding intellectual property,fellows mentored by supervisors with overseas experience were substantially more likely to obtain patents,whereas those guided by tenure-track supervisors exhibited lower patent acquisition rates.In light of these insights,we proposed several recommendations for postdoctoral management bodies within pharmaceutical academic institutions.These included refining selection criteria for postdoctoral candidates,amplifying support through incentive mechanisms,enhancing interdisciplinary fellows’integration into pharmaceutical research paradigms,and optimizing postdoctoral training frameworks to nurture academic excellence and research innovation.展开更多
文摘China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.
基金supported by Nanjing Science and Technology Bureau International,Hong Kong,Macao,and Taiwan Science and Technology Cooperation Program(No.202401042)。
文摘Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.
基金funded by 2024 Scientific Research Project of Chongqing Medical and Pharmaceutical College(No.ygzrc2024101)Chongqing Education Commission Natural Science Foundation(No.KJQN202402821)+2 种基金Chongqing Shapingba District Science and Technology Bureau Project(No.2024071)2024 Chongqing Medical and Pharmaceutical College Innovation Research Group Project(No.ygz2024401)Chongqing Science and Health Joint Medical Research Project(No.2024SQKWLHMS051),respectively.
文摘Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before fully understanding their molecular mechanisms,yeast systems now provide valuable insights for drug discovery and personalized medicine.Recent advancements in genetic engineering,metabolic engineering,and synthetic biology have improved the efficiency and scalability of yeast-based production systems,enabling more sustainable and cost-effective manufacturing processes.This paper reviews the latest developments in yeast-based technologies,focusing on their use as model organisms to study disease mechanisms,identify drug targets,and develop novel therapies.We highlight key platforms such as the yeast two-hybrid system,surface display technologies,and optimized expression systems.Additionally,we explore the future integration of yeast engineering with artificial intelligence(AI),machine learning(ML),and advanced genome editing technologies like CRISPR/Cas9,which are expected to accelerate drug discovery and enable personalized therapies.Furthermore,yeast-based systems are increasingly employed in largescale drug production,vaccine development,and therapeutic protein expression,offering promising applications in clinical and industrial settings.This paper discusses the practical implications of these systems and their potential to revolutionize drug development,paving the way for safer,more effective therapies.
基金Undergraduate Teaching Quality and Teaching Reform Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2024]No.9)Graduate Education Innovation Plan Project,Guangdong Province(Project No.:Yue Jiao Tong Han[2024]No.1)+2 种基金First-Class Undergraduate Course Construction Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2022]No.10)Undergraduate Curriculum Ideological and Political Reform Demonstration Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2021]No.22)Higher Education Research Project,Guangdong Pharmaceutical University(Project No.:GGP202402).
文摘A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
基金the Ministry of Higher Education,Research and Innovation-Oman for their support of this research through TRC block funding grant No.BFP/RGP/EBR/22/378.
文摘Innately designed to induce physiological changes,pharmaceuticals are foreknowingly hazardous to the ecosystem.Advanced oxidation processes(AOPs)are recognized as a set of contemporary and highly efficient methods being used as a contrivance for the removal of pharmaceutical residues.Since reactive oxygen species(ROS)are formed in these processes to interact and contribute directly toward the oxidation of target contaminant(s),a profound insight regarding the mechanisms of ROS leading to the degradation of pharmaceuticals is fundamentally significant.The conceptualization of some specific reaction mechanisms allows the design of an effective and safe degradation process that can empirically reduce the environmental impact of themicropollutants.This review mainly deliberates themechanistic reaction pathways for ROS-mediated degradation of pharmaceuticals often leading to complete mineralization,with a focus on acetaminophen as a drug waste model.
文摘With the rapid growth of the“Internet+Healthcare”model,pharmaceutical e-commerce has swiftly gained a substantial market share in China’s pharmaceutical retail sector,thanks to its competitive prices,convenient purchasing channels,and online consultation services.This has put considerable pressure on traditional retail chain pharmacies.This paper provides an overview of the current state of pharmaceutical e-commerce,and analyzes the main challenges faced by retail chain pharmacies,including intense price competition,changes in consumer habits,insufficient digitalization and severe homogenized competition.Drawing on industry practices and case studies,the paper proposes strategies to enhance competitiveness,such as promoting digital transformation and online-offline(O2O)integration,strengthening pharmacist services and health management capabilities,optimizing supply chain management,building differentiated brand advantages,and proactively responding to policy and regulatory requirements.The study argues that,while leveraging their advantages in specialization,community-based operations,service orientation and retail chain pharmacies,should actively embrace digitalization and industrial collaboration in order to achieve sustainable development in the context of e-commerce.This research provides theoretical references for the strategic transformation of retail chain pharmacies and offers practical significance for the high-quality development of the pharmaceutical retail industry.
文摘The microstructures of pharmaceutical preparations play a pivotal role in determining their critical quality attributes(CQAs),such as drug release,content uniformity,and stability,which greatly impact the safety and efficacy of drugs.Unlike the inherent molecular structures of active pharmaceutical ingredients(APIs)and excipients,the microstructures of pharmaceutical preparations are developed during the formulation process,presenting unique analytical challenges.In this review,we primarily focus on presenting the research methods used to elucidate the microstructures of pharmaceutical preparations,including X-ray imaging(XRI),scanning electron microscopy(SEM),atomic force microscopy(AFM),Raman spectroscopy,infrared(IR)spectroscopy,and rheometer technology.Subsequently,we highlight the applications,advantages,and limitations of these methods.Finally,we discuss the current challenges and future perspectives in this field.This review aims to provide a comprehensive reference for understanding the microstructures of pharmaceutical preparations,offering new insights and potential advancements in their development.
基金supported by National Natural Science Foundation of China(Grant No.:32301161)the Natural Scientific Foundation of Hunan Province,China(Grant No.:2023JJ60052)+3 种基金the Scientific Research Project of Hunan Provincial Health Commission,China(Grant No.:202112062218,20190161)the Scientific Research Project of Hunan Provincial Department of Education,China(Grant No.:22B0455)the Clinical“4310”Project of the University of South China,China(Grant No.:20224310NHYCG02)the Doctoral Scientific Research Foundation of University of South China,China(Grant No.:200XQD042).
文摘Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challenge emerges from the misalignment between the mid-IR light wavelength range and molecular dimensions,culminating in a constrained absorption cross-section and diminished vibrational absorption coefficients(Supplementary data).
基金supported by the National Natural Science Foundation of China(Nos.21976046 and 42177412)the Ministry of Education of China(No.B17025).
文摘Pharmaceuticals and personal care products(PPCPs)have been considered as potential contributors to thyroid nodule(TN)and abnormal thyroid homeostasis,but epidemiological evidence is scarce.A total of 1261 individuals comprised of 367 TN patients and 895 controls were recruited from Sichuan,China.The urinary concentrations of fourteen PPCPs were measured.Five thyroid hormones(THs)in serum were determined as indicators of thyroid homeostasis,including thyroid-stimulating hormone,triiodothyronine(T3),thyroxine(T4),free-T3 and free-T4.Serum levels of thyroglobulin antibody(TGAb)and thyroperoxidase antibody(TPOAb)were quantified to identify individual thyroid antibody(TA)statuses.TN patients exhibited higher propyl-paraben(PrP)(median:1.30μg/g Cr)level than controls(0.64μg/g Cr).PrP were significantly associated with TN risk with ORs of 1.060(95%CI:1.002,1.122).The relationship of methyl-paraben with TN risk was nonlinear(p=0.049).PPCP exposurewas significantwith TN risk only in females and TA positive(TPOAb or TGAb)groups,indicating that PPCP susceptibility to TN differs by sex and TA status.Linear regression models showed ethyl-paraben was significantly negatively associated with T4(β:-0.005,95%CI:-0.011,-0.002)and T3(β:-0.007,95%CI:-0.015,-0.002),and positively associated with TPOAb(β:0.059,95%CI:0.000,0.119),suggesting that certain PPCP exposure could affect thyroid homeostasis and autoimmunity.The effects of PPCP exposure on TH and TA levels presented sex-specific.Our findings suggest that PPCP exposure increases TN risk and affects thyroid homeostasis,exhibiting sex and antibody status dependence.
基金Guangdong Provincial Graduate Education Innovation Program Project in 2024(Project No.:2024XSLT-039)。
文摘With the rapid growth of the cosmetics industry,the demand for diversified and interdisciplinary talent is increasing.However,a structural mismatch persists between current educational approaches and industry needs,particularly in aligning with the holistic education model,which emphasizes moral,intellectual,physical,aesthetic,and labor development.To bridge this gap,Guangdong Pharmaceutical University has implemented a comprehensive reform of its holistic education system,aiming to cultivate well-rounded cosmetics professionals.Key initiatives include integrating professional ethics into moral education,strengthening the integration of theory and practice in intellectual training,emphasizing skin health management in physical education,enhancing aesthetic appreciation and creative thinking,and promoting labor spirit and practical skills through hands-on experiences.These reform efforts have yielded significant results,contributing high-quality talent to the cosmetics industry and offering a valuable model for other institutions seeking to align education with industry demands.
文摘Objective To empirically analyze the relationship between Government R&D funding and R&D investment of the enterprises in different sub industries of pharmaceutical industry,and to provide reference for the development of policies related to R&D funding input.Methods Granger causality test was performed using the data of relevant indicators in different sub industries of China’s pharmaceutical industry from 1995 to 2019 based on the theory of covariance.Results and Conclusion The funding of R&D from the government had a significant positive effect on their R&D funding inputs to enterprises with chemo products,Chinese patent products,and biological products.It means the improvement of government funding was beneficial in promoting the R&D investment from various sub industries of pharmaceutical industry.The order of this influence was biological products,chemo products,and Chinese patent drugs.As to chemical drugs and biological products,the government’s R&D funding and enterprises R&D funding input showed a good trend of mutual promotion in a certain lag period.The government can fully leverage its funding to promote the investment of all sub industries of pharmaceutical industry.Meanwhile,regulatory mechanisms should be refined for government funding.For the inheritance,innovation,and development of traditional Chinese medicine,the government should give more policy support than financial support.
文摘AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.
文摘Introduction: In recent times, satisfaction studies have gained importance in the health sector as a way to monitor services and products. The main aim of this study was to explore patient satisfaction with pharmaceutical care provided in Nampula healthcare centers. Material and Methods: The study was conducted at the 25 de Setembro, 1˚ de Maio, and Muhala-Expansão healthcare centers in Nampula. The sample consisted of 381 patients, with 127 from each center, selected for accessibility. Data were collected through a questionnaire with an internal consistency of 0.816, calculated using McDonald’s total Omega (ωt). The analysis included frequencies, descriptive statistics (mean and standard deviation), and inferential statistics like Binary Logistic Regression. Results: Overall satisfaction was 3.62 ± 0.627 on a scale of 1 to 5, or 69.8%. The binary regression associated a higher education level with dissatisfaction (COR 0.204, 95% CI: −2.752 to −0.427) and living in Marrere (COR 0.083, 95% CI: -5.098 to 0.120) and Muahivir-Expansão (COR 0.589, 95% CI: −1.824 to 0.767) with dissatisfaction as well. Conclusion: Satisfaction was generally high, mainly influenced by the availability of medicines and medical supplies, and less by other factors such as healthcare center accessibility, facility quality, and relationships with pharmacy professionals. Although variables like sex, religion, age, marital status, profession, occupation, and the number of pharmacy visits in the last five years were not statistically significant for general satisfaction in this study, they should be considered in future studies as they are often linked to pharmaceutical satisfaction.
基金supported by the National Natural Science Foundation of China(Nos.52293442,52300249,and 52388101)the Scientific Research Project of China Three Gorges Corporation(No.201903139).
文摘Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.
文摘Objective To provide effective decision making for the subsidy policies given by the government to pharmaceutical enterprises and the coordination model adopted by pharmaceutical stakeholders under the carbon emission trading policy.Methods The Stackelberg model was used to discuss the optimal profits of each member and the whole supply chain under different decision-making models while considering the technical capacity of emission reduction and cost sharing contract.Based on this,the impact of the combined contract decisionmaking model on the technical efforts of drug manufacturers to reduce carbon emission,the profits of supply chain members and the overall profits of supply chain was investigated.Results and Conclusion Research has found that improving the research and development efforts of emission reduction technologies by pharmaceutical enterprises can increase drug sales and enhance the expected profits of pharmaceutical supply chain members.The members of the secondary pharmaceutical supply chain can achieve the optimal expected profit when reaching cooperation.Besides,when the cost sharing contract and quantity discount contract meet the constraint conditions,the combined contract decision model can perfectly coordinate the pharmaceutical supply chain,enabling supply chain members to achieve Pareto improvement and gradually reach Pareto optimum.
文摘Universities serve as pivotal platforms for cultivating postdoctoral talent,particularly in pharmaceutical sciences.This study provided an empirical assessment of the key determinants influencing research productivity among postdoctoral fellows in this field.We analyzed a cohort of postdoctoral researchers who entered the School of Pharmaceutical Sciences at Peking University between October 2016 and December 2024,gathering comprehensive data on their demographic characteristics and scholarly accomplishments throughout their fellowship.Indicators of postdoctoral success encompassed securing research funding,publishing scholarly articles,and filing patent applications.To identify the principal factors shaping these outcomes,we employed logistic regression analysis.The findings demonstrated that postdoctoral fellows enrolled in incentive programs exhibited markedly higher success rates in acquiring research grants,especially high-tier funding,as well as in publishing both general and high-impact research articles.Conversely,fellows engaged in interdisciplinary research showed significantly reduced success rates in obtaining both general and high-level grants.Additionally,extended fellowship durations were positively correlated with greater likelihoods of publishing high-impact papers and achieving patents.Notably,postdoctoral fellows specializing in Pharmaceutical Analysis had a significantly higher probability of securing prestigious research grants,while those focusing on Pharmaceutics demonstrated a superior capacity for research publication.Regarding intellectual property,fellows mentored by supervisors with overseas experience were substantially more likely to obtain patents,whereas those guided by tenure-track supervisors exhibited lower patent acquisition rates.In light of these insights,we proposed several recommendations for postdoctoral management bodies within pharmaceutical academic institutions.These included refining selection criteria for postdoctoral candidates,amplifying support through incentive mechanisms,enhancing interdisciplinary fellows’integration into pharmaceutical research paradigms,and optimizing postdoctoral training frameworks to nurture academic excellence and research innovation.
