在面向卫星物联网的免授权随机接入(Grant-free Random Access,GFRA)系统中,受大规模连接和设备随机激活的影响,前导碰撞成为用户接入性能提升的主要制约因素。鉴于此,借助正交与非正交序列在前导检测和冲突抑制方面的各自优势,提出一...在面向卫星物联网的免授权随机接入(Grant-free Random Access,GFRA)系统中,受大规模连接和设备随机激活的影响,前导碰撞成为用户接入性能提升的主要制约因素。鉴于此,借助正交与非正交序列在前导检测和冲突抑制方面的各自优势,提出一种基于混合ZC(Zadoff-Chu)序列的大容量前导设计和检测方法。该方法利用正交ZC序列与其循环移位映射的不同根ZC序列级联来构建前导序列,并采用一种基于假设检验的两阶段干扰消除活跃用户检测算法,以确保大规模接入场景下的高精度用户识别。此外,对所提前导结构进行扩展,将相位旋转因子与多段非正交序列相结合,在不增加峰均比的前提下进一步扩大前导集容量。所提方法较现有复合和正交前导方法具有显著改善的多用户识别性能,在相同活跃用户下,成功检测概率最大提升约30.3%。展开更多
随着精准医疗和个性化治疗的发展,肿瘤研究领域不断探索新的分子靶点和治疗策略。含锌指CCCH型13 (Zinc finger CCCH-type containing 13, ZC3H13)作为一种重要的N6-甲基腺苷(N6-methyladenosine, m6A)甲基转移酶,近年来受到广泛关注,...随着精准医疗和个性化治疗的发展,肿瘤研究领域不断探索新的分子靶点和治疗策略。含锌指CCCH型13 (Zinc finger CCCH-type containing 13, ZC3H13)作为一种重要的N6-甲基腺苷(N6-methyladenosine, m6A)甲基转移酶,近年来受到广泛关注,其在肿瘤发生、发展及转移过程中的作用逐渐被揭示。本文综述ZC3H13在肿瘤中的作用机制及其研究进展。本文的研究重点在于揭示ZC3H13如何通过调控甲基化影响RNA代谢及特定信号通路影响肿瘤细胞的增殖、凋亡和侵袭能力,以及其在肿瘤微环境中的作用。此外,本文还探讨了ZC3H13作为潜在生物标志物和治疗靶点的可能性。以期为理解肿瘤的分子机制、开发新型抗肿瘤药物以及提高肿瘤治疗效果提供新的策略。With the development of precision medicine and personalized therapy, the field of cancer research continues to explore new molecular targets and treatment strategies. Zinc finger CCCH-type containing 13 (ZC3H13), as an important N6-methyladenosine (m6A) methyltransferase, has attracted extensive attention in recent years, and its role in tumorigenesis, development and metastasis has been gradually revealed. This article reviews the mechanism of action of ZC3H13 in tumors and its research progress. This study focuses on revealing how ZC3H13 affects RNA metabolism and specific signaling pathways by regulating methylation, as well as its role in the tumor microenvironment. In addition, the potential of ZC3H13 as a potential biomarker and therapeutic target is also explored, in order to provide new strategies for understanding the molecular mechanism of tumors, developing new anti-tumor drugs, and improving the therapeutic effect of tumors.展开更多
文摘在面向卫星物联网的免授权随机接入(Grant-free Random Access,GFRA)系统中,受大规模连接和设备随机激活的影响,前导碰撞成为用户接入性能提升的主要制约因素。鉴于此,借助正交与非正交序列在前导检测和冲突抑制方面的各自优势,提出一种基于混合ZC(Zadoff-Chu)序列的大容量前导设计和检测方法。该方法利用正交ZC序列与其循环移位映射的不同根ZC序列级联来构建前导序列,并采用一种基于假设检验的两阶段干扰消除活跃用户检测算法,以确保大规模接入场景下的高精度用户识别。此外,对所提前导结构进行扩展,将相位旋转因子与多段非正交序列相结合,在不增加峰均比的前提下进一步扩大前导集容量。所提方法较现有复合和正交前导方法具有显著改善的多用户识别性能,在相同活跃用户下,成功检测概率最大提升约30.3%。
文摘随着精准医疗和个性化治疗的发展,肿瘤研究领域不断探索新的分子靶点和治疗策略。含锌指CCCH型13 (Zinc finger CCCH-type containing 13, ZC3H13)作为一种重要的N6-甲基腺苷(N6-methyladenosine, m6A)甲基转移酶,近年来受到广泛关注,其在肿瘤发生、发展及转移过程中的作用逐渐被揭示。本文综述ZC3H13在肿瘤中的作用机制及其研究进展。本文的研究重点在于揭示ZC3H13如何通过调控甲基化影响RNA代谢及特定信号通路影响肿瘤细胞的增殖、凋亡和侵袭能力,以及其在肿瘤微环境中的作用。此外,本文还探讨了ZC3H13作为潜在生物标志物和治疗靶点的可能性。以期为理解肿瘤的分子机制、开发新型抗肿瘤药物以及提高肿瘤治疗效果提供新的策略。With the development of precision medicine and personalized therapy, the field of cancer research continues to explore new molecular targets and treatment strategies. Zinc finger CCCH-type containing 13 (ZC3H13), as an important N6-methyladenosine (m6A) methyltransferase, has attracted extensive attention in recent years, and its role in tumorigenesis, development and metastasis has been gradually revealed. This article reviews the mechanism of action of ZC3H13 in tumors and its research progress. This study focuses on revealing how ZC3H13 affects RNA metabolism and specific signaling pathways by regulating methylation, as well as its role in the tumor microenvironment. In addition, the potential of ZC3H13 as a potential biomarker and therapeutic target is also explored, in order to provide new strategies for understanding the molecular mechanism of tumors, developing new anti-tumor drugs, and improving the therapeutic effect of tumors.
