The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial...The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial lactate accumulation.2 Recent research indicates that the accumulation of lactic acid during the metabolic process can serve as a substrate.3 The high concentration of lactate accumulated by metabolites can promote the malignant progression of tumor cells by modifying key proteins through lactylation.展开更多
基金supported by the National Natural Science Foundation of China(No.82203469)the Liaoning Province Joint Fund General Project(China)(No.2023-MSLH-166).
文摘The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial lactate accumulation.2 Recent research indicates that the accumulation of lactic acid during the metabolic process can serve as a substrate.3 The high concentration of lactate accumulated by metabolites can promote the malignant progression of tumor cells by modifying key proteins through lactylation.
