Translational medicine is a comprehensive discipline that aims to convert laboratory research results into products and technology for clinical application using modern molecular biological techniques, to improve our ...Translational medicine is a comprehensive discipline that aims to convert laboratory research results into products and technology for clinical application using modern molecular biological techniques, to improve our understanding of the human body and disease and to optimize laboratory design for clinical observation and analysis for basic research. Its ultimate goal is improving holistic medicine and helping patients solve their health problems. Translational medicine includes two processes： bench to bedside and bedside to bench, known as B-to-B processes. The first B-to-B （bench to bedside） refers to the application of results of the laboratory to clinical use as a medical product or a diagnosis and treatment technology. The second B-to-B （bedside to bench） describes the process by which clinical observation and analysis provides ideas and guidance for experiment design for basic medical research. The two processes complement each other and constitute the two-way cycle of translational medicine. Translational medicine can be applied to clinical disease detection in the form of new biomarkers and can accelerate drug discovery. In recent years, with the biotechnology, increasing rapid development of outcomes of research on molecular pathogenesis can be directly applied to clinical theraDv.展开更多
In the context of internationalization,China-UK Joint Education Programs are receiving increasing attention from universities.Based on the difficulties faced in China-UK Joint Education Program,this paper adopts a que...In the context of internationalization,China-UK Joint Education Programs are receiving increasing attention from universities.Based on the difficulties faced in China-UK Joint Education Program,this paper adopts a questionnaire survey method to study the learning effectiveness of students majoring in digital media technology in the China-UK Joint Education Program at Guangxi University of Finance and Economics,focusing on four aspects:learning materials,learning content,teacher conditions,and student learning outcomes.The research analysis in this paper not only provides strong support for the construction of China-UK Joint Education Program but also offers references for other China-UK Joint Education Programs.展开更多
In this paper,we investigate the reconfigurable intelligent surface(RIS)-enabled multiple-input-single-output orthogonal frequency division multiplexing(MISO-OFDM)system under frequency-selective channels,and propose ...In this paper,we investigate the reconfigurable intelligent surface(RIS)-enabled multiple-input-single-output orthogonal frequency division multiplexing(MISO-OFDM)system under frequency-selective channels,and propose a low-complexity alternating optimization(AO)based joint beamforming and RIS phase shifts optimization algorithm to maximize the achievable rate.First,with fixed RIS phase shifts,we devise the optimal closedform transmit beamforming vectors corresponding to different subcarriers.Then,with given active beamforming vectors,near-optimal RIS reflection coefficients can be determined efficiently leveraging fractional programming(FP)combined with manifold optimization(MO)or majorization-minimization(MM)framework.Additionally,we also propose a heuristic RIS phase shifts design approach based on the sum of subcarrier gain maximization(SSGM)criterion requiring lower complexity.Numerical results indicate that the proposed MO/MM algorithm can achieve almost the same rate as the upper bound achieved by the semidefinite relaxation(SDR)algorithm,and the proposed SSGM based scheme is only slightly inferior to the upper bound while has much lower complexity.These results demonstrate the effectiveness of the proposed algorithms.展开更多
Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink...Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink ISAC system that simultaneously serves multiple single-antenna communication users and senses multiple targets. Hybrid RIS differs from fully passive RIS in that it is composed of both active and passive elements, with the active elements having the effect of amplifying the signal in addition to phase-shifting. We maximize the achievable sum rate of communication users by collaboratively improving the beamforming matrix at the dual function base station(DFBS) and the phase-shifting matrix of the hybrid RIS, subject to the transmit power constraint at the DFBS, the signal-to-interference-plus-noise-ratio(SINR) constraint of the radar echo signal and the RIS constraint are satisfied at the same time. The builtin RIS-assisted ISAC design problem model is significantly non-convex due to the fractional objective function of this optimization problem and the coupling of the optimization variables in the objective function and constraints. As a result, we provide an effective alternating optimization approach based on fractional programming(FP) with block coordinate descent(BCD)to solve the optimization variables. Results from simulations show that the hybrid RIS-assisted ISAC system outperforms the other benchmark solutions.展开更多
Large-scale genetic population used for genetic breeding researches covers a large area in the field experiment,and the effect of local control would be gradually weakened.The block in replication(BIR)design is suitab...Large-scale genetic population used for genetic breeding researches covers a large area in the field experiment,and the effect of local control would be gradually weakened.The block in replication(BIR)design is suitable for large population,which is applied to the field experiment of genetic population.The statistical methods of analysis of variance(ANOVA)and heritability estimation in single and multiple environments were derived and implemented using the statistical analysis system(SAS)program for the analysis of BIR.As a work example,a comparison of statistical analysis between BIR design and the completely random block(CRB)design were conducted for the protein content from a panel containing 455 soybean germplasms.The results indicated the different estimates of average heritability in multiple environments.The research results provided technical support for the application of BIR design in genetics and breeding studies.展开更多
The American Association of State Highway and Transportation Officials Mechanistic-Empirical Pavement DesignGuide (AASHTO M-E) offers an opportunity to design more economical and sustainable high-volume rigid pavement...The American Association of State Highway and Transportation Officials Mechanistic-Empirical Pavement DesignGuide (AASHTO M-E) offers an opportunity to design more economical and sustainable high-volume rigid pavementscompared to conventional design guidelines. It is achieved through optimizing pavement structural andthickness design under specified climate and traffic conditions using advanced M-E principles, thereby minimizingeconomic costs and environmental impact. However, the implementation of AASHTO M-E design for low-volumeconcrete pavements using AASHTOWare Pavement ME Design (Pavement ME) software is often overly conservative.This is because Pavement ME specifies the minimum design thickness of concrete slab as 152.4 mm (6 in.). Thispaper introduces a novel extension of the AASHTO M-E framework for the design of low-volume joint plain concretepavements (JPCPs) without modification of Pavement ME. It utilizes multi-gene genetic programming (MGGP)-based computational models to obtain rapid solutions for JPCP damage accumulation and long-term performanceanalyses. The developed MGGP models simulate the fatigue damage and differential energy accumulations. Thispermits the prediction of transverse cracking and joint faulting for a wide range of design input parameters and axlespectrum. The developed MGGP-based models match Pavement ME-predicted cracking and faulting for rigidpavements with conventional concrete slab thicknesses and enable rational extrapolation of performance predictionfor thinner JPCPs. This paper demonstrates how the developed computational model enables sustainable lowvolumepavement design using optimized ME solutions for Pittsburgh, PA, conditions.展开更多
In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the I...In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to Earth.Additionally,it monitors various disturbances generated within the Earth system that impact geospace.Over the past two years,significant progress has been made on the IMCP.In particular,the second phase of construction for the China-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active construction.The 2024 IMCP joint observation campaign was successfully conducted.To facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by Chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil.展开更多
The joint beamforming design challenge for dual-functional radar-communication systems is addressed in this paper.The base station in these systems is tasked with simultaneously sending shared signals for both multi-u...The joint beamforming design challenge for dual-functional radar-communication systems is addressed in this paper.The base station in these systems is tasked with simultaneously sending shared signals for both multi-user communication and target sensing.The primary objective is to maximize the sum rate of multi-user communication,while also ensuring sufficient beampattern gain at particular angles that are of interest for sensing,all within the constraints of the transmit power budget.To tackle this complex non-convex problem,an effective algorithm that iteratively optimizes the joint beamformers is developed.This algorithm leverages the techniques of fractional programming and semidefinite relaxation to achieve its goals.The numerical results confirm the effectiveness of the proposed algorithm.展开更多
抽取滤波器是数字下变频(Digital Down Converter,DDC)系统中的核心组成部分,一直是工程实践中研究的重点。CIC滤波器(Cascade Integrator Comb,CIC)以及半带滤波器是广泛用于实现抽取功能的两种滤波器。通过分析研究CIC滤波器与半带滤...抽取滤波器是数字下变频(Digital Down Converter,DDC)系统中的核心组成部分,一直是工程实践中研究的重点。CIC滤波器(Cascade Integrator Comb,CIC)以及半带滤波器是广泛用于实现抽取功能的两种滤波器。通过分析研究CIC滤波器与半带滤波器的工作原理,基于Python与Matlab联合编程的方式,设计了可交互的自动化平台。该平台可根据输入的CIC滤波器或半带滤波器的特性参数,自动设计多级CIC滤波器以及多级级联的半带滤波器RTL代码,增强了代码的可复用性,提升了设计效率。可自动设计2倍~128倍抽取的CIC滤波器以及2倍~16倍抽取的半带滤波器。该平台还特别添加了生成CIC滤波器与半带滤波器的多种幅频响应曲线的功能,可以更直观地体现所设计的滤波器的各项参数指标。展开更多
“双碳”目标的提出促进了绿色生产与低碳发展相结合的需求。围绕着商业园区的能量共享与低碳运行这一问题,提出了一种充电站、商业楼宇、光储电站的电-碳交易模型,研究了园区主体与电力交易中心、微网运营商、碳交易中心之间能量和信...“双碳”目标的提出促进了绿色生产与低碳发展相结合的需求。围绕着商业园区的能量共享与低碳运行这一问题,提出了一种充电站、商业楼宇、光储电站的电-碳交易模型,研究了园区主体与电力交易中心、微网运营商、碳交易中心之间能量和信息流动关系。在模型求解上,运用分布式鲁棒优化将商业园区电-碳分布式调度模型的非凸的机会约束问题转化为半正定规划问题。通过设定的3种方案从运营成本、碳排放量2个方面验证了所提方法在降成本、降碳排方面的有效性。最后,将所提方法与基于条件风险价值(conditional value at risk,CVaR)模型的线性规划方法对比,结果表明分布式鲁棒在决策结果方面更符合实际调度情况。展开更多
文摘Translational medicine is a comprehensive discipline that aims to convert laboratory research results into products and technology for clinical application using modern molecular biological techniques, to improve our understanding of the human body and disease and to optimize laboratory design for clinical observation and analysis for basic research. Its ultimate goal is improving holistic medicine and helping patients solve their health problems. Translational medicine includes two processes： bench to bedside and bedside to bench, known as B-to-B processes. The first B-to-B （bench to bedside） refers to the application of results of the laboratory to clinical use as a medical product or a diagnosis and treatment technology. The second B-to-B （bedside to bench） describes the process by which clinical observation and analysis provides ideas and guidance for experiment design for basic medical research. The two processes complement each other and constitute the two-way cycle of translational medicine. Translational medicine can be applied to clinical disease detection in the form of new biomarkers and can accelerate drug discovery. In recent years, with the biotechnology, increasing rapid development of outcomes of research on molecular pathogenesis can be directly applied to clinical theraDv.
基金Guangxi Key Laboratory of Financial Big Data Fund Project(Guikejizi[2021]No.5)Research on the Innovation of Teaching Models for Foreign Professional Courses in China-UK Joint Education Under the Background of Internationalization-Taking Guangxi University of Finance and Economics as an Example(2023XJJG26)Exploration and Practice of Digital Media Technology Talent Training Models in the Context of New Productive Forces(XGK202423)。
文摘In the context of internationalization,China-UK Joint Education Programs are receiving increasing attention from universities.Based on the difficulties faced in China-UK Joint Education Program,this paper adopts a questionnaire survey method to study the learning effectiveness of students majoring in digital media technology in the China-UK Joint Education Program at Guangxi University of Finance and Economics,focusing on four aspects:learning materials,learning content,teacher conditions,and student learning outcomes.The research analysis in this paper not only provides strong support for the construction of China-UK Joint Education Program but also offers references for other China-UK Joint Education Programs.
基金supported in part by the National Natural Science Foundation of China under Grants 61971126 and 61921004ZTE CorporationState Key Laboratory of Mobile Network and Mobile Multimedia Technology.
文摘In this paper,we investigate the reconfigurable intelligent surface(RIS)-enabled multiple-input-single-output orthogonal frequency division multiplexing(MISO-OFDM)system under frequency-selective channels,and propose a low-complexity alternating optimization(AO)based joint beamforming and RIS phase shifts optimization algorithm to maximize the achievable rate.First,with fixed RIS phase shifts,we devise the optimal closedform transmit beamforming vectors corresponding to different subcarriers.Then,with given active beamforming vectors,near-optimal RIS reflection coefficients can be determined efficiently leveraging fractional programming(FP)combined with manifold optimization(MO)or majorization-minimization(MM)framework.Additionally,we also propose a heuristic RIS phase shifts design approach based on the sum of subcarrier gain maximization(SSGM)criterion requiring lower complexity.Numerical results indicate that the proposed MO/MM algorithm can achieve almost the same rate as the upper bound achieved by the semidefinite relaxation(SDR)algorithm,and the proposed SSGM based scheme is only slightly inferior to the upper bound while has much lower complexity.These results demonstrate the effectiveness of the proposed algorithms.
文摘Integrated sensing and communication(ISAC) is considered an effective technique to solve spectrum congestion in the future. In this paper, we consider a hybrid reconfigurable intelligent surface(RIS)-assisted downlink ISAC system that simultaneously serves multiple single-antenna communication users and senses multiple targets. Hybrid RIS differs from fully passive RIS in that it is composed of both active and passive elements, with the active elements having the effect of amplifying the signal in addition to phase-shifting. We maximize the achievable sum rate of communication users by collaboratively improving the beamforming matrix at the dual function base station(DFBS) and the phase-shifting matrix of the hybrid RIS, subject to the transmit power constraint at the DFBS, the signal-to-interference-plus-noise-ratio(SINR) constraint of the radar echo signal and the RIS constraint are satisfied at the same time. The builtin RIS-assisted ISAC design problem model is significantly non-convex due to the fractional objective function of this optimization problem and the coupling of the optimization variables in the objective function and constraints. As a result, we provide an effective alternating optimization approach based on fractional programming(FP) with block coordinate descent(BCD)to solve the optimization variables. Results from simulations show that the hybrid RIS-assisted ISAC system outperforms the other benchmark solutions.
基金Supported by Key Research and Development Project of Heilongjiang Province(GA21B009-6)Heilongjiang Province Natural Science Foundation(C2015009)。
文摘Large-scale genetic population used for genetic breeding researches covers a large area in the field experiment,and the effect of local control would be gradually weakened.The block in replication(BIR)design is suitable for large population,which is applied to the field experiment of genetic population.The statistical methods of analysis of variance(ANOVA)and heritability estimation in single and multiple environments were derived and implemented using the statistical analysis system(SAS)program for the analysis of BIR.As a work example,a comparison of statistical analysis between BIR design and the completely random block(CRB)design were conducted for the protein content from a panel containing 455 soybean germplasms.The results indicated the different estimates of average heritability in multiple environments.The research results provided technical support for the application of BIR design in genetics and breeding studies.
基金the financial support from the University of Pittsburgh Anthony Gill Chair and the Impactful Resilient Infrastructure Science and Engineering Consortium(IRISE)at University of Pittsburgh.
文摘The American Association of State Highway and Transportation Officials Mechanistic-Empirical Pavement DesignGuide (AASHTO M-E) offers an opportunity to design more economical and sustainable high-volume rigid pavementscompared to conventional design guidelines. It is achieved through optimizing pavement structural andthickness design under specified climate and traffic conditions using advanced M-E principles, thereby minimizingeconomic costs and environmental impact. However, the implementation of AASHTO M-E design for low-volumeconcrete pavements using AASHTOWare Pavement ME Design (Pavement ME) software is often overly conservative.This is because Pavement ME specifies the minimum design thickness of concrete slab as 152.4 mm (6 in.). Thispaper introduces a novel extension of the AASHTO M-E framework for the design of low-volume joint plain concretepavements (JPCPs) without modification of Pavement ME. It utilizes multi-gene genetic programming (MGGP)-based computational models to obtain rapid solutions for JPCP damage accumulation and long-term performanceanalyses. The developed MGGP models simulate the fatigue damage and differential energy accumulations. Thispermits the prediction of transverse cracking and joint faulting for a wide range of design input parameters and axlespectrum. The developed MGGP-based models match Pavement ME-predicted cracking and faulting for rigidpavements with conventional concrete slab thicknesses and enable rational extrapolation of performance predictionfor thinner JPCPs. This paper demonstrates how the developed computational model enables sustainable lowvolumepavement design using optimized ME solutions for Pittsburgh, PA, conditions.
基金Supported by International Meridian Circle Program Headquarters,China-Brazil Joint Laboratory for Space Weather(Y42347A99S)。
文摘In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 stations.This achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to Earth.Additionally,it monitors various disturbances generated within the Earth system that impact geospace.Over the past two years,significant progress has been made on the IMCP.In particular,the second phase of construction for the China-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active construction.The 2024 IMCP joint observation campaign was successfully conducted.To facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by Chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil.
基金supported in part by the National Natural Science Foundation of China under Grant No.62201266in part by the Natural Science Foundation of Jiangsu Province under Grant No.BK20210335.
文摘The joint beamforming design challenge for dual-functional radar-communication systems is addressed in this paper.The base station in these systems is tasked with simultaneously sending shared signals for both multi-user communication and target sensing.The primary objective is to maximize the sum rate of multi-user communication,while also ensuring sufficient beampattern gain at particular angles that are of interest for sensing,all within the constraints of the transmit power budget.To tackle this complex non-convex problem,an effective algorithm that iteratively optimizes the joint beamformers is developed.This algorithm leverages the techniques of fractional programming and semidefinite relaxation to achieve its goals.The numerical results confirm the effectiveness of the proposed algorithm.
文摘抽取滤波器是数字下变频(Digital Down Converter,DDC)系统中的核心组成部分,一直是工程实践中研究的重点。CIC滤波器(Cascade Integrator Comb,CIC)以及半带滤波器是广泛用于实现抽取功能的两种滤波器。通过分析研究CIC滤波器与半带滤波器的工作原理,基于Python与Matlab联合编程的方式,设计了可交互的自动化平台。该平台可根据输入的CIC滤波器或半带滤波器的特性参数,自动设计多级CIC滤波器以及多级级联的半带滤波器RTL代码,增强了代码的可复用性,提升了设计效率。可自动设计2倍~128倍抽取的CIC滤波器以及2倍~16倍抽取的半带滤波器。该平台还特别添加了生成CIC滤波器与半带滤波器的多种幅频响应曲线的功能,可以更直观地体现所设计的滤波器的各项参数指标。
文摘“双碳”目标的提出促进了绿色生产与低碳发展相结合的需求。围绕着商业园区的能量共享与低碳运行这一问题,提出了一种充电站、商业楼宇、光储电站的电-碳交易模型,研究了园区主体与电力交易中心、微网运营商、碳交易中心之间能量和信息流动关系。在模型求解上,运用分布式鲁棒优化将商业园区电-碳分布式调度模型的非凸的机会约束问题转化为半正定规划问题。通过设定的3种方案从运营成本、碳排放量2个方面验证了所提方法在降成本、降碳排方面的有效性。最后,将所提方法与基于条件风险价值(conditional value at risk,CVaR)模型的线性规划方法对比,结果表明分布式鲁棒在决策结果方面更符合实际调度情况。
