OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided int...OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.展开更多
Objective:Pestle needle therapy is a unique external treatment method of traditional Chinese medicine(TCM)that has been secretly passed down through 14 generations of the LI family.It was ultimately developed through ...Objective:Pestle needle therapy is a unique external treatment method of traditional Chinese medicine(TCM)that has been secretly passed down through 14 generations of the LI family.It was ultimately developed through over 6 decades of profound research and clinical practice by professor LI Zhongyu.This study aims to explore the application and efficacy of pestle needle therapy in the prevention and treatment of cervical spondylosis,a prevalent public health concern in China.Methods:Guided by TCM theory,pestle needle therapy expands upon traditional acupuncture theory and techniques while maintaining its own distinct characteristics.The study review recent academic theories,clinical applications,mechanisms of action,and notable advantages of pestle needle therapy based on search results in 8 databases,including PubMed,Cochrane Library,Embase,Medline,China National Knowledge Infrastructure(CNKI),VIP,Wanfang,and Chinese Biomedical Literature Database(CBM).Results:Pestle needle therapy has demonstrated significant efficacy in the management of cervical spondylosis,through targeting specific acupoints or areas and employing unique manipulation techniques with specialized needles,characterized by simple operation,safety without side effects,and high patient compliance.Its unique approach aligns with the development trend of modern medicine,offering functional,preventive,therapeutic,health-promoting,wellness-enhancing,and strengthening effects.Conclusions:This study reviews and summarizes the notable advantages of pestle needle therapy in treating cervical spondylosis and analyzes current research limitations,with the aim of expanding the clinical application of pestle needle therapy and providing a reference for the use of external treatment methods in TCM for the prevention and treatment of cervical spondylosis.Further research is needed to address existing limitations and enhance the understanding and utilization of this unique therapy.展开更多
Background:Hemorrhoids are one of the most common conditions that lead to surgery,and until now surgical hemorrhoidectomy has been the major effective treatment.Post-operative pain from hemorrhoidectomy has been exper...Background:Hemorrhoids are one of the most common conditions that lead to surgery,and until now surgical hemorrhoidectomy has been the major effective treatment.Post-operative pain from hemorrhoidectomy has been experienced by thousands of patients and remains a major inconvenience of the operation.Objective:This study evaluates the clinical efficacy of the pestle needle therapy,an acupoint stimulation method,for relief of post-hemorrhoidectomy pain.Design,setting,participants and interventions:This was a single-center,patient-assessor-blinded and randomized controlled trial with 154 patients receiving Milligan hemorrhoidectomy surgery.Eligible patients were randomly assigned to either a treatment group or a control group at a ratio of 1:1.The treatment group received the pestle needle therapy,with manual stimulation at Yaoshu(DU2),Mingmen(DU4),Changqiang(DU1),Chengshan(BL57),Erbai(EX-UE2)and the perianal points(1,3,5,7,9,and 11 o’clock around the lesion);while the control group received a sham treatment with very light pressure.Three sessions of treatment were performed at 30 min,4 h and 12 h after the surgery,and each lasted for 15 min.Main outcome measures:The primary outcome was post-operative pain measured with the visual analogue scale(VAS)at 12 h after surgery.The secondary outcomes included the VAS scores measured at0.5,2,4,6,8,24 and 48 h after surgery,the analgesic dose,the time and the VAS score of the patients’first defecation after surgery,as well as the Hamilton Rating Scale for Anxiety(HAMA)evaluated before discharge.Results:The mean pain score of the treatment group was significantly lower than that of the control group(3.10±1.27 vs 4.82±1.29;P<0.001)at 12 h after surgery.Compared with the control group,patients in the treatment group needed a smaller dose of analgesic within the first 24 hours after surgery(P=0.002);and their HAMA scores before discharge were lower(4.07±2.40 vs 5.10±2.45,P=0.009).Compared to the treatment group,patients in the control group had a greater time to the first defecation after surgery([52.34±15.72]h vs[27.08±13.68]h;P<0.001),but there was no difference in their VAS scores at the first defecation(P=0.092).Conclusion:The pestle needle therapy was effective for relieving pain,reducing anxiety and improving bowel function after hemorrhoidectomy,and it is worthy of clinical application.展开更多
Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and west...Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and western medication.Methods:A total of 210 patients with intractable lumbodynia after lumbar disc herniation were randomly divided into pestle needle group,electroacupuncture group and western medication group,with 70 cases in each group.The pestle needle group was treated with pestle needle poking Yāoyángguān-Bāzhèn(GV3-Bāzhèn)points.The electroacupuncture group was treated with conventional electroacupuncture,and the western medication group was treated with oral diclofenac sodium dual release enteric-coated capsules(Difene).The pestle needle group and the electroacupuncture group were treated once a day,and there was 1 day of rest after 6 days of treatment,and a course of treatment included 7 days,and a total of 3 courses of treatment were performed.The western medication group took 1 Difene capsule(75 mg)at a time,with once a day continuing for 21 days.Visual Analog Scale(VAS),Pain Rating Index(PRI)and Present Pain Intensity(PPI)were used to observe the improvement of pain before and after treatment,and the waist muscle tone was examined and the clinical efficacy was observed.Results:The post-treatment VAS,PRI,and PPI scores of the three groups were all lower than pretreatment,and the differences were statistically significant(all P<0.05).There were no statistically significant differences in VAS,PRI and PPI scores between pestle needle group and western medication group(all P>0.05).Meanwhile,they were all lower than the electroacupuncture group,and the differences were statistically significant(both P<0.05).After treatment,the waist muscle tone of the three groups was higher than that pre-treatment,and the differences were statistically significant(all P<0.05).After treatment,the waist muscle tone of the pestle needle group was higher than the electroacupuncture group,and the electroacupuncture group was higher than the western medication group,and the differences were statistically significant(both P<0.05).The total effective rate was 88.57%in the pestle needle group,80%in the electroacupuncture group,and 77.14%in the western medication group,and there were no statistically significant differences among the groups(P>0.05).Conclusions:Pestle needle poking GV3-Bāzhèn points can effectively relieve intractable lumbodynia after lumbar disc herniation surgery,decrease VAS,PRI,PPI scores and relieve waist muscle tone,and the effect was remarkable.展开更多
Background:Diabetic peripheral neuropathy(DPN)is one of the most common complications of diabetes mellitus.Impaired neurological function is one of the main characteristics of DPN and is strongly associated with the i...Background:Diabetic peripheral neuropathy(DPN)is one of the most common complications of diabetes mellitus.Impaired neurological function is one of the main characteristics of DPN and is strongly associated with the inflammatory response.Our previous studies have confirmed that pestle needle can improve the nerve function of patients with DPN.But the mechanism of pestle needle treatment of DPN is still unclear.Methods:A total of 70 DPN patients who met the inclusion criteria were randomly divided into two groups.Control group(CG)(n=35)received DPN conventional treatment and the pestle needle group(PNG)(n=35)received pestle needle therapy at Zhiyang(DU09)eight array,Mingmen(DU04)eight array and Heche Road(from Mingmen(DU04)to Changqiang(DU01)),Zusanli(ST36),Sanyinjiao(SP06),Taixi(KI03)and Yongquan(KI01).Patients in the PNG group were required to take this treatment for 4 weeks,5 times a week.Examination indexes were collected before and after treatment,respectively.Nerve function was examined using the Toronto clinical scoring system and nerve conduction velocity detection.Serum inflammatory factors were measured by enzyme linked immunosorbent assay.Results:The Toronto clinical scoring system was significantly reduced in the PNG compared with the CG after treatment.The sensory nerve conduction velocity and motor nerve conduction velocity of the right peroneal and median nerves were significantly faster in the PNG than those in the CG(P<0.05).After treatment,serum interleukin-1 beta,interleukin-6 and tumor necrosis factor-alpha levels decreased in both groups,and the improvement of PNG was better than CG(P<0.05).Conclusion:The pestle needle can significantly improve the symptoms and nerve conduction velocity of DPN,and its mechanism may be related to the reduction of inflammatory factors.展开更多
Objective:To investigate the effect of pestle needle treatment on Nrf2 pathway and the relationship with oxidative stress in diabetic peripheral neuropathy.Methods:Patients with DPN who met the inclusion criteria were...Objective:To investigate the effect of pestle needle treatment on Nrf2 pathway and the relationship with oxidative stress in diabetic peripheral neuropathy.Methods:Patients with DPN who met the inclusion criteria were randomly divided into control and test groups with 30 patients in each group in a 1:1 allocation ratio.Both groups were given basic treatment,and the pestle group was treated with needle pestle therapy 5 times a week for a total of 4 weeks of intervention.Serum SOD and GSH PX levels were examined by colorimetry before and after intervention;Serum Keap1/Nrf2/ARE signaling pathway related factors expression levels were measured by ELISA;Keap1 and Nrf2 mRNA expression was determined by RT-PCR.Results:Compared with the control group,SOD and GSH-Px in the test group were significantly increased,Keap1 expression was decreased,Nrf2 expression was increased,Keap1 mRNA expression was significantly decreased,and Nrf2 mRNA expression was significantly increased.Conclusions:the pestle needle may enhance the body's antioxidant capacity by modulating the Keap1/Nrf2/ARE signaling pathway to enhance the production of its downstream antioxidant enzymes SOD and GSH Px,thereby protecting and repairing the damaged peripheral nerves in DPN patients.展开更多
The disappearance of resources with high genetic potential and great utility for people and the challenge of the conservation and sustainable management of these resources are two opposing facts of which the world is ...The disappearance of resources with high genetic potential and great utility for people and the challenge of the conservation and sustainable management of these resources are two opposing facts of which the world is now concerned. In Benin, forests and agroforestry systems complement each other in wood supply for mortar and pestle manufacture. Thus, this study aimed to investigate the diversity of woody species used for mortar and pestle manufacture and to analyze the preferences of manufacturers through an ethnobotanical approach. Based on the snowball sampling method, and interviews with 112 manufacturers from different ethnic groups, we identified 31 tree species. These species belong to 30 genera and 13 plant families. The Fabaceae are more represented with 14 species (i.e. 45% of the total). Ten are frequently used. But there are four species, such as Vitellaria paradoxa C. F. Gaertn., Prosopis africana (Guill. & Perr.) Taub., Terminalia glaucescens Planch. ex Benth. and Pericopsis laxiflora (Benth.) Meeuwen, which are highly preferred by manufacturers respectively. The calculation of the Indexes of Possession of Global Knowledge (IPSG) revealed that the ethnic group Nagot (0.204) possessed more knowledge and is followed by Mahi (0.201) and Fon (0.18) respectively. Forests and agroforestry systems are both supply sites for manufacturers. The non-parametric Wilcoxon test proved that there are no significant differences between the species’ preference for mortars or pestles manufacture (v = 181, p-value = 0.38). Since the trees cutting in agroforestry systems can be destructive to them, provisions such as the promotion of agroforestry in rural areas and the integration of the used species in the reforestations programs must be taken to curb the pressure and contribute to the conservation of the biodiversity.展开更多
Objective：To observe the clinical effect of pestle needle combined with Chinese herbal fumigation on cervical spondylosis and provide a safe effective therapy for this condition.Methods：A total of 54 cases were rand...Objective：To observe the clinical effect of pestle needle combined with Chinese herbal fumigation on cervical spondylosis and provide a safe effective therapy for this condition.Methods：A total of 54 cases were randomly allocated into two groups（27 cases in each group） according to their sequence of consultation.Patients in both groups were treated with the same Chinese herbal fumigation.Patients in the treatment group were additionally treated with pestle needle therapy on a unique set of Ba Zhen points around Dazhui（GV 14）,Fengfu（GV 16） and the distance between Naohu（GV 17） and Dazhui（GV 14） along the He Che pathway,whereas patients in the control group were additionally treated with routine acupuncture therapy.Then the short-term and long-term efficacies were observed and compared after treatment using the visual analog scale（VAS） and pain rating index（PRI）.Results：At the end of treatment,VAS scores were significantly decreased in both groups,and the VAS score in the treatment group was lower than that in the control group（P〈0.05）.The intra-group differences were statistically significant in VAS scores 1 month,3 and 6 months after treatment（all P〈0.05）.At the end of treatment,the sensory and total PRI scores in the treatment group were significantly lower than those in the control group,showing statistically significant differences（both P〈0.01）;and there was no significant between-group difference（P〈0.05） in the affective PRI score.At the end of treatment,the total effective rate was 85.2% in the treatment group,versus 65.4% in the control group,showing a statistical significance（P〈0.05）.The follow-up six months later showed that the total effective rate was 92.6% in the treatment group,versus 76.9% in the control group,showing a statistical significance（P〈0.05）.Conclusion：Pestle needle therapy is a stable and positive therapy for cervical spondylosis.展开更多
The bamboo industry in Central Luzon holds significant promise for economic development and environmental sustainability. This study aims to analyze the internal and external factors influencing the bamboo industry in...The bamboo industry in Central Luzon holds significant promise for economic development and environmental sustainability. This study aims to analyze the internal and external factors influencing the bamboo industry in the region through SWOT and PESTLE analyses. Based on a focus group discussion involving key industry players, the study explores the industry’s strengths, weaknesses, opportunities, and threats, as well as political, economic, social, technological, legal, and environmental factors. Findings reveal the importance of comprehensive strategies that address political stability, economic growth, consumer awareness, technological advancement, legal compliance, and environmental sustainability. Recommendations include capacity-building for production and marketing, the establishment of bamboo treatment facilities, and advocacy for supportive policies. By addressing these factors, the bamboo industry in Central Luzon can realize its potential for socio-economic development and environmental stewardship.展开更多
Tibial pilon fractures are rare injuries most often associated with soft tissue injuries, occurring during high-energy trauma. Surgical treatment represents the therapy of choice and must ensure anatomical reconstruct...Tibial pilon fractures are rare injuries most often associated with soft tissue injuries, occurring during high-energy trauma. Surgical treatment represents the therapy of choice and must ensure anatomical reconstruction of the joint surface while respecting the surrounding tissues. The evolution of our results showed a majority of good functional clinical radio results by the open treatment which showed its superiority compared to the closed treatment and the combined treatment.展开更多
The merger of Sainsbury’s and Asda caused huge impacts on Britain retail industry.Since the announcement that J Sainsbury plc would acquire Asda for £7.5 billion was published in April,2018,the changes in the UK...The merger of Sainsbury’s and Asda caused huge impacts on Britain retail industry.Since the announcement that J Sainsbury plc would acquire Asda for £7.5 billion was published in April,2018,the changes in the UK grocery market have been discussed and questioned.And the grocery market in UK will be reordered without doubt.This essay firstly introduces Sainsbury by using Pestle model,then aims to figure out the type and the benefits of this M&A,analyze the market response and how investors react to this event in the first two parts.In the third and the last part,we aim to explain why the CMA blocked the merge.展开更多
基金Suppoorted by Sichuan Provincial Administration of Traditional Chinese Medicine Key Project of Scientific Research in Traditional Chinese Medicine:Deep Learning-based Three-dimensional Finite Element Analysis of Pestle Needle Therapy for the Treatment of Cervical Spine Physiologic Curvature Abnormalities(2023zd025)Scientific Research Project of Sichuan Provincial Science and Technology Department:Improvement of cartilage Degeneration in Knee Osteoarthritis by Regulating Zn^(2+)Homeostasis via Autophagy in Duhuo Jisheng Decoction(23NFSC2298)。
文摘OBJECTIVE:To investigate the effect of pestle needle therapy(PNT)on the posterior cervical muscle(PCM)in a rabbit model of cervical spondylosis(CS)and explore the underlying mechanisms.METHODS:Rabbits were divided into control,CS modelsⅠandⅡ(CS1 and CS2),electroacupuncture(EA),PNTⅠandⅡ(PN1 and PN2),activator(AVT),and PNT combined with activator(C-AVT)groups.A long-term neck immobilization technique was used to establish a rabbit model of CS.Following completion of modeling,the EA group received electroacupuncture intervention,whereas the CS1,CS2,and C-AVT groups received PNT intervention.The AVT and C-AVT groups received local 740 Y-P injections into the PCM daily.The inflammatory injury to PCM was evaluated based on pain threshold,morphological changes,and interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αlevels.PCM fibrosis was evaluated by measuring the positive area(PA)of collagen fibrils(CFs)and collagen type 1 alpha 1(Col1α1)using Masson's and immunohistochemical staining.Terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay and transmission electron microscopy were used to identify apoptotic cells and assess autophagy,respectively.Western blotting was used to determine B-cell lymphoma-2(Bcl-2),Bcl-2 associated X protein(Bax),cysteine aspartate-specific protease(caspase)-3,sequestosome-1(P62),microtubuleassociated protein light chain 3(LC3-Ⅰ/Ⅱ),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR)levels.Real-time quantitative polymerase chain reaction was used to determine mRNA expression levels of PI3K,AKT,mTOR,autophagy protein(ATG),and ATG7.RESULTS:PNT alleviated PCM cell degeneration and necrosis,inhibited inflammatory cell infiltration,decreased IL-1β,IL-6,and TNF-αlevels,and decreased the PA of CFs and Col1α1.In the PN1 group,cell apoptosis in the PCM decreased,autophagy increased,Bcl-2 and LC3-Ⅱ/Ⅰlevels increased,Bax,Caspase-3,and P62 levels decreased,and the mRNA expression of ATG5 and ATG7 increased.PNT inhibits protein and mRNA expression of PI3K,AKT,and mTOR.Finally,the trend in the results of the rescue experiment was consistent with previous results.CONCLUSION:PNT inhibited apoptosis and promoted autophagy of PCM cells in CS rabbits and alleviated inflammation and fibrosis injury of PCM by inhibiting the PI3K/AKT/mTOR pathway.
基金supported by the Beijing Union University Education and Teaching Research and Reform Project“Chinese Medicine Massage Biomechanics Curriculum System Construction”(No.JY2023Y009)the Study on the Effect of Pestle and Needle Therapy Intervention on Patients with Cervical Spondylosis and Anxiety at Dongzhimen Hospital of Beijing University of Chinese Medicine(No.DZMG-HLZX-24020).
文摘Objective:Pestle needle therapy is a unique external treatment method of traditional Chinese medicine(TCM)that has been secretly passed down through 14 generations of the LI family.It was ultimately developed through over 6 decades of profound research and clinical practice by professor LI Zhongyu.This study aims to explore the application and efficacy of pestle needle therapy in the prevention and treatment of cervical spondylosis,a prevalent public health concern in China.Methods:Guided by TCM theory,pestle needle therapy expands upon traditional acupuncture theory and techniques while maintaining its own distinct characteristics.The study review recent academic theories,clinical applications,mechanisms of action,and notable advantages of pestle needle therapy based on search results in 8 databases,including PubMed,Cochrane Library,Embase,Medline,China National Knowledge Infrastructure(CNKI),VIP,Wanfang,and Chinese Biomedical Literature Database(CBM).Results:Pestle needle therapy has demonstrated significant efficacy in the management of cervical spondylosis,through targeting specific acupoints or areas and employing unique manipulation techniques with specialized needles,characterized by simple operation,safety without side effects,and high patient compliance.Its unique approach aligns with the development trend of modern medicine,offering functional,preventive,therapeutic,health-promoting,wellness-enhancing,and strengthening effects.Conclusions:This study reviews and summarizes the notable advantages of pestle needle therapy in treating cervical spondylosis and analyzes current research limitations,with the aim of expanding the clinical application of pestle needle therapy and providing a reference for the use of external treatment methods in TCM for the prevention and treatment of cervical spondylosis.Further research is needed to address existing limitations and enhance the understanding and utilization of this unique therapy.
基金supported by grant from Shanghai Municipal Health Commission,China (No. 2018MSB-12). The sponsor provided financial support in the case observation,the collection,analysis of data,and the decision to submit the article for publication。
文摘Background:Hemorrhoids are one of the most common conditions that lead to surgery,and until now surgical hemorrhoidectomy has been the major effective treatment.Post-operative pain from hemorrhoidectomy has been experienced by thousands of patients and remains a major inconvenience of the operation.Objective:This study evaluates the clinical efficacy of the pestle needle therapy,an acupoint stimulation method,for relief of post-hemorrhoidectomy pain.Design,setting,participants and interventions:This was a single-center,patient-assessor-blinded and randomized controlled trial with 154 patients receiving Milligan hemorrhoidectomy surgery.Eligible patients were randomly assigned to either a treatment group or a control group at a ratio of 1:1.The treatment group received the pestle needle therapy,with manual stimulation at Yaoshu(DU2),Mingmen(DU4),Changqiang(DU1),Chengshan(BL57),Erbai(EX-UE2)and the perianal points(1,3,5,7,9,and 11 o’clock around the lesion);while the control group received a sham treatment with very light pressure.Three sessions of treatment were performed at 30 min,4 h and 12 h after the surgery,and each lasted for 15 min.Main outcome measures:The primary outcome was post-operative pain measured with the visual analogue scale(VAS)at 12 h after surgery.The secondary outcomes included the VAS scores measured at0.5,2,4,6,8,24 and 48 h after surgery,the analgesic dose,the time and the VAS score of the patients’first defecation after surgery,as well as the Hamilton Rating Scale for Anxiety(HAMA)evaluated before discharge.Results:The mean pain score of the treatment group was significantly lower than that of the control group(3.10±1.27 vs 4.82±1.29;P<0.001)at 12 h after surgery.Compared with the control group,patients in the treatment group needed a smaller dose of analgesic within the first 24 hours after surgery(P=0.002);and their HAMA scores before discharge were lower(4.07±2.40 vs 5.10±2.45,P=0.009).Compared to the treatment group,patients in the control group had a greater time to the first defecation after surgery([52.34±15.72]h vs[27.08±13.68]h;P<0.001),but there was no difference in their VAS scores at the first defecation(P=0.092).Conclusion:The pestle needle therapy was effective for relieving pain,reducing anxiety and improving bowel function after hemorrhoidectomy,and it is worthy of clinical application.
基金Supported by Plan of Shanghai Commission of Science and Technology: No. 18401902400)Special Disease Construction Project of Shanghai Traditional Chinese Medicine: No. ZY(20182020)- FWTX-4020Characteristic Diagnosis and Treatment Technology Upgrade Project of TCM:No. ZY(2018-2020)-ZYJS-01
文摘Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and western medication.Methods:A total of 210 patients with intractable lumbodynia after lumbar disc herniation were randomly divided into pestle needle group,electroacupuncture group and western medication group,with 70 cases in each group.The pestle needle group was treated with pestle needle poking Yāoyángguān-Bāzhèn(GV3-Bāzhèn)points.The electroacupuncture group was treated with conventional electroacupuncture,and the western medication group was treated with oral diclofenac sodium dual release enteric-coated capsules(Difene).The pestle needle group and the electroacupuncture group were treated once a day,and there was 1 day of rest after 6 days of treatment,and a course of treatment included 7 days,and a total of 3 courses of treatment were performed.The western medication group took 1 Difene capsule(75 mg)at a time,with once a day continuing for 21 days.Visual Analog Scale(VAS),Pain Rating Index(PRI)and Present Pain Intensity(PPI)were used to observe the improvement of pain before and after treatment,and the waist muscle tone was examined and the clinical efficacy was observed.Results:The post-treatment VAS,PRI,and PPI scores of the three groups were all lower than pretreatment,and the differences were statistically significant(all P<0.05).There were no statistically significant differences in VAS,PRI and PPI scores between pestle needle group and western medication group(all P>0.05).Meanwhile,they were all lower than the electroacupuncture group,and the differences were statistically significant(both P<0.05).After treatment,the waist muscle tone of the three groups was higher than that pre-treatment,and the differences were statistically significant(all P<0.05).After treatment,the waist muscle tone of the pestle needle group was higher than the electroacupuncture group,and the electroacupuncture group was higher than the western medication group,and the differences were statistically significant(both P<0.05).The total effective rate was 88.57%in the pestle needle group,80%in the electroacupuncture group,and 77.14%in the western medication group,and there were no statistically significant differences among the groups(P>0.05).Conclusions:Pestle needle poking GV3-Bāzhèn points can effectively relieve intractable lumbodynia after lumbar disc herniation surgery,decrease VAS,PRI,PPI scores and relieve waist muscle tone,and the effect was remarkable.
基金the Science and Technology Development Project of Hospital of Chengdu University of Traditional Chinese Medicine(No.21HL26).
文摘Background:Diabetic peripheral neuropathy(DPN)is one of the most common complications of diabetes mellitus.Impaired neurological function is one of the main characteristics of DPN and is strongly associated with the inflammatory response.Our previous studies have confirmed that pestle needle can improve the nerve function of patients with DPN.But the mechanism of pestle needle treatment of DPN is still unclear.Methods:A total of 70 DPN patients who met the inclusion criteria were randomly divided into two groups.Control group(CG)(n=35)received DPN conventional treatment and the pestle needle group(PNG)(n=35)received pestle needle therapy at Zhiyang(DU09)eight array,Mingmen(DU04)eight array and Heche Road(from Mingmen(DU04)to Changqiang(DU01)),Zusanli(ST36),Sanyinjiao(SP06),Taixi(KI03)and Yongquan(KI01).Patients in the PNG group were required to take this treatment for 4 weeks,5 times a week.Examination indexes were collected before and after treatment,respectively.Nerve function was examined using the Toronto clinical scoring system and nerve conduction velocity detection.Serum inflammatory factors were measured by enzyme linked immunosorbent assay.Results:The Toronto clinical scoring system was significantly reduced in the PNG compared with the CG after treatment.The sensory nerve conduction velocity and motor nerve conduction velocity of the right peroneal and median nerves were significantly faster in the PNG than those in the CG(P<0.05).After treatment,serum interleukin-1 beta,interleukin-6 and tumor necrosis factor-alpha levels decreased in both groups,and the improvement of PNG was better than CG(P<0.05).Conclusion:The pestle needle can significantly improve the symptoms and nerve conduction velocity of DPN,and its mechanism may be related to the reduction of inflammatory factors.
基金Sichuan Provincial Administration of Traditional Chinese Medicine Science and Technology Research Special Project(No.2021MS544)。
文摘Objective:To investigate the effect of pestle needle treatment on Nrf2 pathway and the relationship with oxidative stress in diabetic peripheral neuropathy.Methods:Patients with DPN who met the inclusion criteria were randomly divided into control and test groups with 30 patients in each group in a 1:1 allocation ratio.Both groups were given basic treatment,and the pestle group was treated with needle pestle therapy 5 times a week for a total of 4 weeks of intervention.Serum SOD and GSH PX levels were examined by colorimetry before and after intervention;Serum Keap1/Nrf2/ARE signaling pathway related factors expression levels were measured by ELISA;Keap1 and Nrf2 mRNA expression was determined by RT-PCR.Results:Compared with the control group,SOD and GSH-Px in the test group were significantly increased,Keap1 expression was decreased,Nrf2 expression was increased,Keap1 mRNA expression was significantly decreased,and Nrf2 mRNA expression was significantly increased.Conclusions:the pestle needle may enhance the body's antioxidant capacity by modulating the Keap1/Nrf2/ARE signaling pathway to enhance the production of its downstream antioxidant enzymes SOD and GSH Px,thereby protecting and repairing the damaged peripheral nerves in DPN patients.
文摘The disappearance of resources with high genetic potential and great utility for people and the challenge of the conservation and sustainable management of these resources are two opposing facts of which the world is now concerned. In Benin, forests and agroforestry systems complement each other in wood supply for mortar and pestle manufacture. Thus, this study aimed to investigate the diversity of woody species used for mortar and pestle manufacture and to analyze the preferences of manufacturers through an ethnobotanical approach. Based on the snowball sampling method, and interviews with 112 manufacturers from different ethnic groups, we identified 31 tree species. These species belong to 30 genera and 13 plant families. The Fabaceae are more represented with 14 species (i.e. 45% of the total). Ten are frequently used. But there are four species, such as Vitellaria paradoxa C. F. Gaertn., Prosopis africana (Guill. & Perr.) Taub., Terminalia glaucescens Planch. ex Benth. and Pericopsis laxiflora (Benth.) Meeuwen, which are highly preferred by manufacturers respectively. The calculation of the Indexes of Possession of Global Knowledge (IPSG) revealed that the ethnic group Nagot (0.204) possessed more knowledge and is followed by Mahi (0.201) and Fon (0.18) respectively. Forests and agroforestry systems are both supply sites for manufacturers. The non-parametric Wilcoxon test proved that there are no significant differences between the species’ preference for mortars or pestles manufacture (v = 181, p-value = 0.38). Since the trees cutting in agroforestry systems can be destructive to them, provisions such as the promotion of agroforestry in rural areas and the integration of the used species in the reforestations programs must be taken to curb the pressure and contribute to the conservation of the biodiversity.
基金supported by Key Project of Sichuan Provincial Education Department(Nature Science)[No.15ZA0398]~~
文摘Objective：To observe the clinical effect of pestle needle combined with Chinese herbal fumigation on cervical spondylosis and provide a safe effective therapy for this condition.Methods：A total of 54 cases were randomly allocated into two groups（27 cases in each group） according to their sequence of consultation.Patients in both groups were treated with the same Chinese herbal fumigation.Patients in the treatment group were additionally treated with pestle needle therapy on a unique set of Ba Zhen points around Dazhui（GV 14）,Fengfu（GV 16） and the distance between Naohu（GV 17） and Dazhui（GV 14） along the He Che pathway,whereas patients in the control group were additionally treated with routine acupuncture therapy.Then the short-term and long-term efficacies were observed and compared after treatment using the visual analog scale（VAS） and pain rating index（PRI）.Results：At the end of treatment,VAS scores were significantly decreased in both groups,and the VAS score in the treatment group was lower than that in the control group（P〈0.05）.The intra-group differences were statistically significant in VAS scores 1 month,3 and 6 months after treatment（all P〈0.05）.At the end of treatment,the sensory and total PRI scores in the treatment group were significantly lower than those in the control group,showing statistically significant differences（both P〈0.01）;and there was no significant between-group difference（P〈0.05） in the affective PRI score.At the end of treatment,the total effective rate was 85.2% in the treatment group,versus 65.4% in the control group,showing a statistical significance（P〈0.05）.The follow-up six months later showed that the total effective rate was 92.6% in the treatment group,versus 76.9% in the control group,showing a statistical significance（P〈0.05）.Conclusion：Pestle needle therapy is a stable and positive therapy for cervical spondylosis.
文摘The bamboo industry in Central Luzon holds significant promise for economic development and environmental sustainability. This study aims to analyze the internal and external factors influencing the bamboo industry in the region through SWOT and PESTLE analyses. Based on a focus group discussion involving key industry players, the study explores the industry’s strengths, weaknesses, opportunities, and threats, as well as political, economic, social, technological, legal, and environmental factors. Findings reveal the importance of comprehensive strategies that address political stability, economic growth, consumer awareness, technological advancement, legal compliance, and environmental sustainability. Recommendations include capacity-building for production and marketing, the establishment of bamboo treatment facilities, and advocacy for supportive policies. By addressing these factors, the bamboo industry in Central Luzon can realize its potential for socio-economic development and environmental stewardship.
文摘Tibial pilon fractures are rare injuries most often associated with soft tissue injuries, occurring during high-energy trauma. Surgical treatment represents the therapy of choice and must ensure anatomical reconstruction of the joint surface while respecting the surrounding tissues. The evolution of our results showed a majority of good functional clinical radio results by the open treatment which showed its superiority compared to the closed treatment and the combined treatment.
文摘The merger of Sainsbury’s and Asda caused huge impacts on Britain retail industry.Since the announcement that J Sainsbury plc would acquire Asda for £7.5 billion was published in April,2018,the changes in the UK grocery market have been discussed and questioned.And the grocery market in UK will be reordered without doubt.This essay firstly introduces Sainsbury by using Pestle model,then aims to figure out the type and the benefits of this M&A,analyze the market response and how investors react to this event in the first two parts.In the third and the last part,we aim to explain why the CMA blocked the merge.
