Federated learning is a machine learning framework designed to protect privacy by keeping training data on clients’devices without sharing private data.It trains a global model through collaboration between clients a...Federated learning is a machine learning framework designed to protect privacy by keeping training data on clients’devices without sharing private data.It trains a global model through collaboration between clients and the server.However,the presence of data heterogeneity can lead to inefficient model training and even reduce the final model’s accuracy and generalization capability.Meanwhile,data scarcity can result in suboptimal cluster distributions for few-shot clients in centralized clustering tasks,and standalone personalization tasks may cause severe overfitting issues.To address these limitations,we introduce a federated learning dual optimization model based on clustering and personalization strategy(FedCPS).FedCPS adopts a decentralized approach,where clients identify their cluster membership locally without relying on a centralized clustering algorithm.Building on this,FedCPS introduces personalized training tasks locally,adding a regularization term to control deviations between local and cluster models.This improves the generalization ability of the final model while mitigating overfitting.The use of weight-sharing techniques also reduces the computational cost of central machines.Experimental results on MNIST,FMNIST,CIFAR10,and CIFAR100 datasets demonstrate that our method achieves better personalization effects compared to other personalized federated learning methods,with an average test accuracy improvement of 0.81%–2.96%.Meanwhile,we adjusted the proportion of few-shot clients to evaluate the impact on accuracy across different methods.The experiments show that FedCPS reduces accuracy by only 0.2%–3.7%,compared to 2.1%–10%for existing methods.Our method demonstrates its advantages across diverse data environments.展开更多
This comprehensive study investigates the multifaceted impact of AI-powered personalization on strategic communications, delving deeply into its opportunities, challenges, and future directions. Employing a rigorous m...This comprehensive study investigates the multifaceted impact of AI-powered personalization on strategic communications, delving deeply into its opportunities, challenges, and future directions. Employing a rigorous mixed-methods approach, we conduct an in-depth analysis of the effects of AI-driven personalization on audience engagement, brand perception, and conversion rates across various industries and communication channels. Our findings reveal that while AI-powered personalization significantly enhances communication effectiveness and offers unprecedented opportunities for audience connection, it also raises critical ethical considerations and implementation challenges. The study contributes substantially to the growing body of literature on AI in communications, offering both theoretical insights and practical guidelines for professionals navigating this rapidly evolving landscape. Furthermore, we propose a novel framework for ethical AI implementation in strategic communications and outline a robust agenda for future research in this dynamic field.展开更多
Product innovation is creation of new concepts to plan and realize technological and functional details in the product to satisfy market and customer needs. One of the key drivers to product innovation is reactions of...Product innovation is creation of new concepts to plan and realize technological and functional details in the product to satisfy market and customer needs. One of the key drivers to product innovation is reactions of the product to users’ needs. Product innovation needs a cognitive design method based on needs of variant users for the product personalization. In this paper, an open concept is introduced to provide ways to meet user’s individual need in product lifespan. It is for industries to propose product concepts based on open sources, develop and support the product on the public capability. Using the open concept in the product architecture, called open?architecture product(OAP), can improve the product personalization leading to massive product innovation. To promote this promise of the OAP, effective methods are discussed for the OAP development. This paper introduces research on OAPs using adaptable design methods to meet product personalization. Adaptable design is based on the modular structure for product adaptability using function modules and adaptable interfaces. The proposed method provides solutions for planning modules and implementation of OAPs. Methods of OAP module planning, detail and interface design are described for transformation of product concepts into physical structures. A multiple?purpose electrical car is developed in a case study to show effectiveness of the proposed method.展开更多
With the rapid development of molecular biology and related disciplines, animal breeding has moved from conventional breeding to molecular breeding. Marker-assisted selection and genomic selection have become mainstre...With the rapid development of molecular biology and related disciplines, animal breeding has moved from conventional breeding to molecular breeding. Marker-assisted selection and genomic selection have become mainstream practices in molecular breeding of livestock. However, these techniques only use information from genomic variation but not multi-omics information, thus do not fully explain the molecular basis of phenotypic variations in complex traits. In addition, the accuracy of breeding value estimation based on these techniques is occasionally controversial in different populations or varieties. Given the rapid development of high-throughput sequencing techniques and functional genome and dramatic reductions in the overall cost of sequencing, it is possible to clarify the interactions between genes and formation of phenotypes using massive sets of omic-level data from studies of the transcriptome, proteome, epigenome, and metabolome. During livestock breeding, multi-omics information regarding breeding populations and individuals should be taken into account. The interactive regulatory networks governing gene regulation and phenotype formation in diverse livestock population, varieties and species should be analyzed. In addition, a multi-omics regulatory breeding model should be constructed. Precision, population-personalized breeding is expected to become a crucial practice in future livestock breeding. Precision breeding of individuals can be achieved by combining population genomic information at multi-omics levels together with genomic selection and genome editing techniques.展开更多
Personalized products and services in e-commerce bring consumers many new experiences, but also trigger a series of information security issues. Considering the bounded rationality of the game participants, in this pa...Personalized products and services in e-commerce bring consumers many new experiences, but also trigger a series of information security issues. Considering the bounded rationality of the game participants, in this paper, we propose an evolutionary game model of privacy protection between firms and consumers based on e-commerce personalization. Evolutionary stable strategies（ESSs） are obtained from the equilibrium points according to the model analysis, and then simulation experiments are launched to validate the decision-making results and the influencing mechanism of various factors. The results show that the model can eventually evolve toward a win-win situation by wisely varying its various factors, such as ratios of initial strategies, cost of privacy protection, commodity prices, and other related factors. Further, we find that reducing the possibility of the privacy breach under the premise of privacy protection can help promote the e-commerce personalization.展开更多
The digital technologies that run based on users’content provide a platform for users to help air their opinions on various aspects of a particular subject or product.The recommendation agents play a crucial role in ...The digital technologies that run based on users’content provide a platform for users to help air their opinions on various aspects of a particular subject or product.The recommendation agents play a crucial role in personalizing the needs of individual users.Therefore,it is essential to improve the user experience.The recommender system focuses on recommending a set of items to a user to help the decision-making process and is prevalent across e-commerce and media websites.In Context-Aware Recommender Systems(CARS),several influential and contextual variables are identified to provide an effective recommendation.A substantial trade-off is applied in context to achieve the proper accuracy and coverage required for a collaborative recommendation.The CARS will generate more recommendations utilizing adapting them to a certain contextual situation of users.However,the key issue is how contextual information is used to create good and intelligent recommender systems.This paper proposes an Artificial Neural Network(ANN)to achieve contextual recommendations based on usergenerated reviews.The ability of ANNs to learn events and make decisions based on similar events makes it effective for personalized recommendations in CARS.Thus,the most appropriate contexts in which a user should choose an item or service are achieved.This work converts every label set into a Multi-Label Classification(MLC)problem to enhance recommendations.Experimental results show that the proposed ANN performs better in the Binary Relevance(BR)Instance-Based Classifier,the BR Decision Tree,and the Multi-label SVM for Trip Advisor and LDOS-CoMoDa Dataset.Furthermore,the accuracy of the proposed ANN achieves better results by 1.1%to 6.1%compared to other existing methods.展开更多
The user interesting degree evaluation index is designed to fulfill the users＇ real needs, which includes the user＇ attention degree of commodity, hot commodity and preferential commodity. User interesting degree mo...The user interesting degree evaluation index is designed to fulfill the users＇ real needs, which includes the user＇ attention degree of commodity, hot commodity and preferential commodity. User interesting degree model （UIDM） is constructed to justify the value of user interesting degree; the personalization approach is presented; operations of add and delete nodes （branches） are covered in this paper. The improved e-catalog is more satisfied to users＇ needs and wants than the former e-catalog which stands for enterprises, and the improved one can complete the recommendation of related products of enterDriscs.展开更多
This paper introduces a new approach dedicated to the Ontology Personalization. Inspired by works in Cognitive Psychology, our work is based on a process which aims at capturing the user-sensitive relevance of the cat...This paper introduces a new approach dedicated to the Ontology Personalization. Inspired by works in Cognitive Psychology, our work is based on a process which aims at capturing the user-sensitive relevance of the categorization process, that is the one which is really perceived by the end-user. Practically, this process consists in decorating the Specialization/Generalization links (i.e. the is-a links) of the hierarchy of concepts with 2 gradients. The goal of the first gradient, called Conceptual Prototypicality Gradient, is to capture the user-sensitive relevance of the categorization process, that is the one which is perceived by the end-user. As this gradient is defined according to the three aspects of the semiotic triangle (i.e. intentional, extensional and expressional dimension), we call it Semiotic based Prototypicality Gradient. The objective of the second gradient, called Lexical Prototypicality Gradient, is to capture the user-sensitive relevance of the lexicalization process, i.e. the definition of a set of terms used to denote a concept. These gradients enrich the initial formal semantics of an ontology by adding a pragmatics defined according to a context of use which depends on parameters like culture, educational background and/or emotional context of the end-user. This paper also introduces a new similarity measure also defined in the context of a semiotic-based approach. The first originality of this measure, called SEMIOSEM, is to consider the three semiotic dimensions of the conceptualization underlying an ontology. Thus, SEMIOSEM aims at aggregating and improving existing extensional-based and intentional-based measures. The second originality of this measure is to be context-sensitive, and in particular user-sensitive. This makes SEMIOSEM more flexible, more robust and more close to the end-user’s judgment than the other similarity measures which are usually only based on one aspect of a conceptualization and never take the end-user’s perceptions and purposes into account.展开更多
Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the ...Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial functions.In vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal architecture.An important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific structures.Organoids may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic profile.These models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic strategies.The aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.展开更多
Cross-silo federated learning(FL),which benefits from relatively abundant data and rich computing power,is drawing increasing focus due to the significant transformations that foundation models(FMs)are instigating in ...Cross-silo federated learning(FL),which benefits from relatively abundant data and rich computing power,is drawing increasing focus due to the significant transformations that foundation models(FMs)are instigating in the artificial intelligence field.The intensified data heterogeneity issue of this area,unlike that in cross-device FL,is caused mainly by substantial data volumes and distribution shifts across clients,which requires algorithms to comprehensively consider the personalization and generalization balance.In this paper,we aim to address the objective of generalized and personalized federated learning(GPFL)by enhancing the global model’s cross-domain generalization capabilities and simultaneously improving the personalization performance of local training clients.By investigating the fairness of performance distribution within the federation system,we explore a new connection between generalization gap and aggregation weights established in previous studies,culminating in the fairness-guided federated training for generalization and personalization(FFT-GP)approach.FFT-GP integrates a fairness-aware aggregation(FAA)approach to minimize the generalization gap variance among training clients and a meta-learning strategy that aligns local training with the global model’s feature distribution,thereby balancing generalization and personalization.Our extensive experimental results demonstrate FFT-GP’s superior efficacy compared to existing models,showcasing its potential to enhance FL systems across a variety of practical scenarios.展开更多
Blood-brain barrier disruption and the neuroinflammatory response are significant pathological features that critically influence disease progression and treatment outcomes.This review systematically analyzes the curr...Blood-brain barrier disruption and the neuroinflammatory response are significant pathological features that critically influence disease progression and treatment outcomes.This review systematically analyzes the current understanding of the bidirectional relationship between blood-brain barrier disruption and neuroinflammation in traumatic brain injury,along with emerging combination therapeutic strategies.Literature review indicates that blood-brain barrier disruption and neuroinflammatory responses are key pathological features following traumatic brain injury.In the acute phase after traumatic brain injury,the pathological characteristics include primary blood-brain barrier disruption and the activation of inflammatory cascades.In the subacute phase,the pathological features are characterized by repair mechanisms and inflammatory modulation.In the chronic phase,the pathological features show persistent low-grade inflammation and incomplete recovery of the blood-brain barrier.Various physiological changes,such as structural alterations of the blood-brain barrier,inflammatory cascades,and extracellular matrix remodeling,interact with each other and are influenced by genetic,age,sex,and environmental factors.The dynamic balance between blood-brain barrier permeability and neuroinflammation is regulated by hormones,particularly sex hormones and stress-related hormones.Additionally,the role of gastrointestinal hormones is receiving increasing attention.Current treatment strategies for traumatic brain injury include various methods such as conventional drug combinations,multimodality neuromonitoring,hyperbaric oxygen therapy,and non-invasive brain stimulation.Artificial intelligence also shows potential in treatment decision-making and personalized therapy.Emerging sequential combination strategies and precision medicine approaches can help improve treatment outcomes;however,challenges remain,such as inadequate research on the mechanisms of the chronic phase traumatic brain injury and difficulties with technology integration.Future research on traumatic brain injury should focus on personalized treatment strategies,the standardization of techniques,costeffectiveness evaluations,and addressing the needs of patients with comorbidities.A multidisciplinary approach should be used to enhance treatment and improve patient outcomes.展开更多
BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking rec...BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.展开更多
Personalized pricing is on the rise in the retail industry,and it’s been used in many service platforms.Personalized pricing assumes that the platform has an idea of who the customer is,and allows the platform to inc...Personalized pricing is on the rise in the retail industry,and it’s been used in many service platforms.Personalized pricing assumes that the platform has an idea of who the customer is,and allows the platform to incentivize the customers based on their characteristics and actions.In this work,we consider a personalized pricing problem with revisiting customers.We assume a customer’s utility depends on some feature information and some unobserved personal shock.For the case where customer utilities are unknown,we propose a heuristic that combines the idea of binary search and feature-based pricing,and show that it outperforms common benchmarks.We also demonstrate that if we have some information about either the customer utility or the dependence on the feature information,then we can learn the other much faster,and this is what we mean by the synergy between customer segmentation and personalization.This observation can help managers make better personalized decisions for customers that repeatedly interact with the platform.展开更多
Nanotechnology has revolutionized drug delivery,particularly through nanoformulations of phytoconstituents,enhancing their therapeutic potential.Despite their broad bioactivities,plant-based compounds often suffer fro...Nanotechnology has revolutionized drug delivery,particularly through nanoformulations of phytoconstituents,enhancing their therapeutic potential.Despite their broad bioactivities,plant-based compounds often suffer from poor bioavailability and stability.Nanoformulations address these limitations by improving solubility,targeted delivery,and controlled release.This approach opens new possibilities for treating chronic diseases like cancer,diabetes,and neurodegenerative disorders.This review aims to examine recent advancements in nanotechnology-based formulation strategies designed to enhance the delivery,stability,and therapeutic efficacy of phytochemicals and also discusses regulatory issues,safety concerns,scalability,and cost-effectiveness.Emphasis was placed on nanoformulation techniques employed for key phytoconstituents such as curcumin,resveratrol,epigallocatechin gallate,and quercetin.The most commonly employed nanocarriers included polymeric nanoparticles,solid lipid nanoparticles,and liposomes.These formulations significantly improved the solubility,stability,and controlled release profiles of phytochemicals.In vitro and in vivo studies demonstrated enhanced anti-inflammatory,anticancer,and antioxidant activities.Moreover,surface-modified and targeted nanoparticles showed promise in increasing site-specific targeting and enhancing bioavailability of the encapsulated compounds.Nanoformulations present a promising strategy for overcoming the pharmacokinetic limitations of phytochemicals.Despite encouraging preclinical results,further studies are needed to address issues related to long-term safety,clinical efficacy,and regulatory approval for successful clinical translation.展开更多
Your comments are welcome!Please feel free to contact us with your personal stories or vivid pictures!Address:24 Baiwanzhuang St.,Xicheng Dist.,Beijing,100037 E-mail:chinatodaynews@aliyun.com.
Your comments are welcome!Please feel free to contact us with your personal stories or vivid pictures!Address:24 Baiwanzhuang St.,Xicheng Dist.,Beijing,100037 E-mail:chinatodaynews@aliyun.com,I am the director of the ...Your comments are welcome!Please feel free to contact us with your personal stories or vivid pictures!Address:24 Baiwanzhuang St.,Xicheng Dist.,Beijing,100037 E-mail:chinatodaynews@aliyun.com,I am the director of the Singapore Chinese Opera Museum.The museum,nestled in a serene neighborhood distinguished by its Southeast Asian architectural charm,chronicles Chinese opera’s centuries-long journey.展开更多
Objective:To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes(GDM),and explore its impact on the incidence of maternal complications and pregnancy outcomes.Met...Objective:To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes(GDM),and explore its impact on the incidence of maternal complications and pregnancy outcomes.Methods:A total of 90 elderly pregnant women with gestational diabetes who were delivered in our hospital from January 2023 to January 2024 were selected as the research objects.They were randomly divided into an observation group and a control group,with 45 cases in each group.The control group only received routine pregnancy care and basic nutrition guidance,while the observation group received personalized nutrition support on this basis.Compare the blood glucose control,incidence of pregnancy complications,pregnancy outcomes,and neonatal outcomes between two groups of parturient.Result:After intervention,the fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)of the observation group were significantly lower than those of the control group,and the differences were statistically significant(p<0.05);The incidence of complications such as gestational hypertension syndrome,polyhydramnios,premature rupture of membranes,and postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the difference was statistically significant(p<0.05);The cesarean section rate in the observation group was significantly lower than that in the control group,and the incidence of adverse neonatal outcomes such as fetal distress,macrosomia,neonatal asphyxia,and neonatal hypoglycemia in the observation group was significantly lower than that in the control group,with statistical significance(p<0.05).Conclusion:Individualized nutritional support for elderly women with gestational diabetes can effectively improve the level of maternal blood sugar control,reduce the incidence of complications during pregnancy,and improve the outcome of pregnancy and neonatal outcomes,which is of high clinical value.展开更多
This study focuses on the "Yuyue Brewing" brand and employs grounded theory in conjunction with NVivo 11 software analysis to identify the key factors and dimensions influencing the cultivation of customer m...This study focuses on the "Yuyue Brewing" brand and employs grounded theory in conjunction with NVivo 11 software analysis to identify the key factors and dimensions influencing the cultivation of customer mindset, thereby constructing a theoretical model. The findings suggest that the three fundamental components of an entrepreneur s personal mindset—energy, ability, and wisdom—collectively constitute the foundation of entrepreneurial leadership. Establishing a clear brand positioning and developing its core values accordingly are essential aspects of the brand mindset. Furthermore, articulating the customer mindset involves comprehending the emotions and perspectives of target customers within specific contexts. The success of a brand depends not only on the product itself but also on the synergistic interaction among the entrepreneur s personal mindset, the brand mindset, and the customer mindset.展开更多
Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the...Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the publication by Meštrovićet al,emphasizing the complex balance between risks of relapse,antidrug antibody formation,and potential complications of long-term immunosuppression.Recent evidence underscores high relapse rates following withdrawal-especially of anti-tumor necrosis factor agents-and highlights the lack of robust data for newer biologics.Updated guidelines from European Crohn’s and Colitis Organization,British Society of Gastroenterology,and American College of Gastroenterology all support cautious and individualized approaches,with strict criteria and close follow-up,particularly in Crohn’s disease.For ulcerative colitis,therapeutic cycling remains insufficiently addressed.We proposed a flowchart to support clinical decision-making and stress the importance of shared decisionmaking in the era of personalized medicine since,despite new drug classes and evolving strategies,the therapeutic ceiling in inflammatory bowel disease has yet to be fully overcome.展开更多
基金supported by the Foundation of President of Hebei University(XZJJ202303).
文摘Federated learning is a machine learning framework designed to protect privacy by keeping training data on clients’devices without sharing private data.It trains a global model through collaboration between clients and the server.However,the presence of data heterogeneity can lead to inefficient model training and even reduce the final model’s accuracy and generalization capability.Meanwhile,data scarcity can result in suboptimal cluster distributions for few-shot clients in centralized clustering tasks,and standalone personalization tasks may cause severe overfitting issues.To address these limitations,we introduce a federated learning dual optimization model based on clustering and personalization strategy(FedCPS).FedCPS adopts a decentralized approach,where clients identify their cluster membership locally without relying on a centralized clustering algorithm.Building on this,FedCPS introduces personalized training tasks locally,adding a regularization term to control deviations between local and cluster models.This improves the generalization ability of the final model while mitigating overfitting.The use of weight-sharing techniques also reduces the computational cost of central machines.Experimental results on MNIST,FMNIST,CIFAR10,and CIFAR100 datasets demonstrate that our method achieves better personalization effects compared to other personalized federated learning methods,with an average test accuracy improvement of 0.81%–2.96%.Meanwhile,we adjusted the proportion of few-shot clients to evaluate the impact on accuracy across different methods.The experiments show that FedCPS reduces accuracy by only 0.2%–3.7%,compared to 2.1%–10%for existing methods.Our method demonstrates its advantages across diverse data environments.
文摘This comprehensive study investigates the multifaceted impact of AI-powered personalization on strategic communications, delving deeply into its opportunities, challenges, and future directions. Employing a rigorous mixed-methods approach, we conduct an in-depth analysis of the effects of AI-driven personalization on audience engagement, brand perception, and conversion rates across various industries and communication channels. Our findings reveal that while AI-powered personalization significantly enhances communication effectiveness and offers unprecedented opportunities for audience connection, it also raises critical ethical considerations and implementation challenges. The study contributes substantially to the growing body of literature on AI in communications, offering both theoretical insights and practical guidelines for professionals navigating this rapidly evolving landscape. Furthermore, we propose a novel framework for ethical AI implementation in strategic communications and outline a robust agenda for future research in this dynamic field.
基金Supported by Discovery Grants(Grant No.RGPIN-2015-04173)of the Natural Sciences and Engineering Research Council(NSERC)of CanadaNational Natural Science Foundation of China(Grant Nos.51375287,51505269)
文摘Product innovation is creation of new concepts to plan and realize technological and functional details in the product to satisfy market and customer needs. One of the key drivers to product innovation is reactions of the product to users’ needs. Product innovation needs a cognitive design method based on needs of variant users for the product personalization. In this paper, an open concept is introduced to provide ways to meet user’s individual need in product lifespan. It is for industries to propose product concepts based on open sources, develop and support the product on the public capability. Using the open concept in the product architecture, called open?architecture product(OAP), can improve the product personalization leading to massive product innovation. To promote this promise of the OAP, effective methods are discussed for the OAP development. This paper introduces research on OAPs using adaptable design methods to meet product personalization. Adaptable design is based on the modular structure for product adaptability using function modules and adaptable interfaces. The proposed method provides solutions for planning modules and implementation of OAPs. Methods of OAP module planning, detail and interface design are described for transformation of product concepts into physical structures. A multiple?purpose electrical car is developed in a case study to show effectiveness of the proposed method.
基金supported by National High Technology Plan of China (2013 AA102502)the National Natural Science Foundation of China (313300453)the National Key Basic Research Program of China (2015CB943101)
文摘With the rapid development of molecular biology and related disciplines, animal breeding has moved from conventional breeding to molecular breeding. Marker-assisted selection and genomic selection have become mainstream practices in molecular breeding of livestock. However, these techniques only use information from genomic variation but not multi-omics information, thus do not fully explain the molecular basis of phenotypic variations in complex traits. In addition, the accuracy of breeding value estimation based on these techniques is occasionally controversial in different populations or varieties. Given the rapid development of high-throughput sequencing techniques and functional genome and dramatic reductions in the overall cost of sequencing, it is possible to clarify the interactions between genes and formation of phenotypes using massive sets of omic-level data from studies of the transcriptome, proteome, epigenome, and metabolome. During livestock breeding, multi-omics information regarding breeding populations and individuals should be taken into account. The interactive regulatory networks governing gene regulation and phenotype formation in diverse livestock population, varieties and species should be analyzed. In addition, a multi-omics regulatory breeding model should be constructed. Precision, population-personalized breeding is expected to become a crucial practice in future livestock breeding. Precision breeding of individuals can be achieved by combining population genomic information at multi-omics levels together with genomic selection and genome editing techniques.
基金Supported by the National Natural Science Foundation of China(71571082,71471073)the Fundamental Research Funds for the Central Universities(CCNU14Z02016,CCNU15A02046)
文摘Personalized products and services in e-commerce bring consumers many new experiences, but also trigger a series of information security issues. Considering the bounded rationality of the game participants, in this paper, we propose an evolutionary game model of privacy protection between firms and consumers based on e-commerce personalization. Evolutionary stable strategies（ESSs） are obtained from the equilibrium points according to the model analysis, and then simulation experiments are launched to validate the decision-making results and the influencing mechanism of various factors. The results show that the model can eventually evolve toward a win-win situation by wisely varying its various factors, such as ratios of initial strategies, cost of privacy protection, commodity prices, and other related factors. Further, we find that reducing the possibility of the privacy breach under the premise of privacy protection can help promote the e-commerce personalization.
文摘The digital technologies that run based on users’content provide a platform for users to help air their opinions on various aspects of a particular subject or product.The recommendation agents play a crucial role in personalizing the needs of individual users.Therefore,it is essential to improve the user experience.The recommender system focuses on recommending a set of items to a user to help the decision-making process and is prevalent across e-commerce and media websites.In Context-Aware Recommender Systems(CARS),several influential and contextual variables are identified to provide an effective recommendation.A substantial trade-off is applied in context to achieve the proper accuracy and coverage required for a collaborative recommendation.The CARS will generate more recommendations utilizing adapting them to a certain contextual situation of users.However,the key issue is how contextual information is used to create good and intelligent recommender systems.This paper proposes an Artificial Neural Network(ANN)to achieve contextual recommendations based on usergenerated reviews.The ability of ANNs to learn events and make decisions based on similar events makes it effective for personalized recommendations in CARS.Thus,the most appropriate contexts in which a user should choose an item or service are achieved.This work converts every label set into a Multi-Label Classification(MLC)problem to enhance recommendations.Experimental results show that the proposed ANN performs better in the Binary Relevance(BR)Instance-Based Classifier,the BR Decision Tree,and the Multi-label SVM for Trip Advisor and LDOS-CoMoDa Dataset.Furthermore,the accuracy of the proposed ANN achieves better results by 1.1%to 6.1%compared to other existing methods.
基金the National Natural Science Foundation of China(Nos.70972094,71072077 and 71172043)the National Key Technology Research and Development Program of China(No.2011BAH16B02)the Fundamental Research Funds for the Central Universities of China(No.2010-II-11)
文摘The user interesting degree evaluation index is designed to fulfill the users＇ real needs, which includes the user＇ attention degree of commodity, hot commodity and preferential commodity. User interesting degree model （UIDM） is constructed to justify the value of user interesting degree; the personalization approach is presented; operations of add and delete nodes （branches） are covered in this paper. The improved e-catalog is more satisfied to users＇ needs and wants than the former e-catalog which stands for enterprises, and the improved one can complete the recommendation of related products of enterDriscs.
文摘This paper introduces a new approach dedicated to the Ontology Personalization. Inspired by works in Cognitive Psychology, our work is based on a process which aims at capturing the user-sensitive relevance of the categorization process, that is the one which is really perceived by the end-user. Practically, this process consists in decorating the Specialization/Generalization links (i.e. the is-a links) of the hierarchy of concepts with 2 gradients. The goal of the first gradient, called Conceptual Prototypicality Gradient, is to capture the user-sensitive relevance of the categorization process, that is the one which is perceived by the end-user. As this gradient is defined according to the three aspects of the semiotic triangle (i.e. intentional, extensional and expressional dimension), we call it Semiotic based Prototypicality Gradient. The objective of the second gradient, called Lexical Prototypicality Gradient, is to capture the user-sensitive relevance of the lexicalization process, i.e. the definition of a set of terms used to denote a concept. These gradients enrich the initial formal semantics of an ontology by adding a pragmatics defined according to a context of use which depends on parameters like culture, educational background and/or emotional context of the end-user. This paper also introduces a new similarity measure also defined in the context of a semiotic-based approach. The first originality of this measure, called SEMIOSEM, is to consider the three semiotic dimensions of the conceptualization underlying an ontology. Thus, SEMIOSEM aims at aggregating and improving existing extensional-based and intentional-based measures. The second originality of this measure is to be context-sensitive, and in particular user-sensitive. This makes SEMIOSEM more flexible, more robust and more close to the end-user’s judgment than the other similarity measures which are usually only based on one aspect of a conceptualization and never take the end-user’s perceptions and purposes into account.
文摘Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial functions.In vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal architecture.An important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific structures.Organoids may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic profile.These models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic strategies.The aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.
基金Project supported by the National Key R&D Program of China(No.2022ZD0160702)the STCSM(Nos.22511106101,18DZ2270700,and 21DZ1100-100)+1 种基金the 111 Plan(No.BP0719010)the State Key Laboratory of UHD Video and Audio Production and Presentation。
文摘Cross-silo federated learning(FL),which benefits from relatively abundant data and rich computing power,is drawing increasing focus due to the significant transformations that foundation models(FMs)are instigating in the artificial intelligence field.The intensified data heterogeneity issue of this area,unlike that in cross-device FL,is caused mainly by substantial data volumes and distribution shifts across clients,which requires algorithms to comprehensively consider the personalization and generalization balance.In this paper,we aim to address the objective of generalized and personalized federated learning(GPFL)by enhancing the global model’s cross-domain generalization capabilities and simultaneously improving the personalization performance of local training clients.By investigating the fairness of performance distribution within the federation system,we explore a new connection between generalization gap and aggregation weights established in previous studies,culminating in the fairness-guided federated training for generalization and personalization(FFT-GP)approach.FFT-GP integrates a fairness-aware aggregation(FAA)approach to minimize the generalization gap variance among training clients and a meta-learning strategy that aligns local training with the global model’s feature distribution,thereby balancing generalization and personalization.Our extensive experimental results demonstrate FFT-GP’s superior efficacy compared to existing models,showcasing its potential to enhance FL systems across a variety of practical scenarios.
基金supported by Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZhao).
文摘Blood-brain barrier disruption and the neuroinflammatory response are significant pathological features that critically influence disease progression and treatment outcomes.This review systematically analyzes the current understanding of the bidirectional relationship between blood-brain barrier disruption and neuroinflammation in traumatic brain injury,along with emerging combination therapeutic strategies.Literature review indicates that blood-brain barrier disruption and neuroinflammatory responses are key pathological features following traumatic brain injury.In the acute phase after traumatic brain injury,the pathological characteristics include primary blood-brain barrier disruption and the activation of inflammatory cascades.In the subacute phase,the pathological features are characterized by repair mechanisms and inflammatory modulation.In the chronic phase,the pathological features show persistent low-grade inflammation and incomplete recovery of the blood-brain barrier.Various physiological changes,such as structural alterations of the blood-brain barrier,inflammatory cascades,and extracellular matrix remodeling,interact with each other and are influenced by genetic,age,sex,and environmental factors.The dynamic balance between blood-brain barrier permeability and neuroinflammation is regulated by hormones,particularly sex hormones and stress-related hormones.Additionally,the role of gastrointestinal hormones is receiving increasing attention.Current treatment strategies for traumatic brain injury include various methods such as conventional drug combinations,multimodality neuromonitoring,hyperbaric oxygen therapy,and non-invasive brain stimulation.Artificial intelligence also shows potential in treatment decision-making and personalized therapy.Emerging sequential combination strategies and precision medicine approaches can help improve treatment outcomes;however,challenges remain,such as inadequate research on the mechanisms of the chronic phase traumatic brain injury and difficulties with technology integration.Future research on traumatic brain injury should focus on personalized treatment strategies,the standardization of techniques,costeffectiveness evaluations,and addressing the needs of patients with comorbidities.A multidisciplinary approach should be used to enhance treatment and improve patient outcomes.
文摘BACKGROUND:Hemiplegia,a prevalent stroke-related condition,is often studied for motor dysfunction;however,spasticity remains under-researched.Abnormal muscle tone significantly hinders hemiplegic patients’walking recovery.OBJECTIVE:To determine whether early suspension-protected training with a personal assistant machine for stroke patients enhances walking ability and prevents muscle spasms.METHODS:Thirty-two early-stage stroke patients from Shenzhen University General Hospital and the China Rehabilitation Research Center were randomly assigned to the experimental group(n=16)and the control group(n=16).Both groups underwent 4 weeks of gait training under the suspension protection system for 30 minutes daily,5 days a week.The experimental group used the personal assistant machine during training.Three-dimensional gait analysis(using the Cortex motion capture system),Brunnstrom staging,Fugl-Meyer Assessment for lower limb motor function,Fugl-Meyer balance function,and the modified Ashworth Scale were evaluated within 1 week before the intervention and after 4 weeks of intervention.RESULTS AND CONCLUSION:After the 4-week intervention,all outcome measures showed significant changes in each group.The experimental group had a small but significant increase in the modified Ashworth Scale score(P<0.05,d=|0.15|),while the control group had a large significant increase(P<0.05,d=|1.48|).The experimental group demonstrated greater improvements in walking speed(16.5 to 38.44 cm/s,P<0.05,d=|4.01|),step frequency(46.44 to 64.94 steps/min,P<0.05,d=|2.32|),stride length(15.50 to 29.81 cm,P<0.05,d=|3.44|),and peak hip and knee flexion(d=|1.82|to|2.17|).After treatment,the experimental group showed significantly greater improvements than the control group in walking speed(38.44 vs.26.63 cm/s,P<0.05,d=|2.75|),stride length,peak hip and knee flexion(d=|1.31|to|1.45|),step frequency(64.94 vs.59.38 steps/min,P<0.05,d=|0.85|),and a reduced support phase(bilateral:24.31%vs.28.38%,P<0.05,d=|0.88|;non-paretic:66.19%vs.70.13%,P<0.05,d=|0.94|).For early hemiplegia,personal assistant machine-assisted gait training under the suspension protection system helps establish a correct gait pattern,prevents muscle spasms,and improves motor function.
文摘Personalized pricing is on the rise in the retail industry,and it’s been used in many service platforms.Personalized pricing assumes that the platform has an idea of who the customer is,and allows the platform to incentivize the customers based on their characteristics and actions.In this work,we consider a personalized pricing problem with revisiting customers.We assume a customer’s utility depends on some feature information and some unobserved personal shock.For the case where customer utilities are unknown,we propose a heuristic that combines the idea of binary search and feature-based pricing,and show that it outperforms common benchmarks.We also demonstrate that if we have some information about either the customer utility or the dependence on the feature information,then we can learn the other much faster,and this is what we mean by the synergy between customer segmentation and personalization.This observation can help managers make better personalized decisions for customers that repeatedly interact with the platform.
文摘Nanotechnology has revolutionized drug delivery,particularly through nanoformulations of phytoconstituents,enhancing their therapeutic potential.Despite their broad bioactivities,plant-based compounds often suffer from poor bioavailability and stability.Nanoformulations address these limitations by improving solubility,targeted delivery,and controlled release.This approach opens new possibilities for treating chronic diseases like cancer,diabetes,and neurodegenerative disorders.This review aims to examine recent advancements in nanotechnology-based formulation strategies designed to enhance the delivery,stability,and therapeutic efficacy of phytochemicals and also discusses regulatory issues,safety concerns,scalability,and cost-effectiveness.Emphasis was placed on nanoformulation techniques employed for key phytoconstituents such as curcumin,resveratrol,epigallocatechin gallate,and quercetin.The most commonly employed nanocarriers included polymeric nanoparticles,solid lipid nanoparticles,and liposomes.These formulations significantly improved the solubility,stability,and controlled release profiles of phytochemicals.In vitro and in vivo studies demonstrated enhanced anti-inflammatory,anticancer,and antioxidant activities.Moreover,surface-modified and targeted nanoparticles showed promise in increasing site-specific targeting and enhancing bioavailability of the encapsulated compounds.Nanoformulations present a promising strategy for overcoming the pharmacokinetic limitations of phytochemicals.Despite encouraging preclinical results,further studies are needed to address issues related to long-term safety,clinical efficacy,and regulatory approval for successful clinical translation.
文摘Your comments are welcome!Please feel free to contact us with your personal stories or vivid pictures!Address:24 Baiwanzhuang St.,Xicheng Dist.,Beijing,100037 E-mail:chinatodaynews@aliyun.com.
文摘Your comments are welcome!Please feel free to contact us with your personal stories or vivid pictures!Address:24 Baiwanzhuang St.,Xicheng Dist.,Beijing,100037 E-mail:chinatodaynews@aliyun.com,I am the director of the Singapore Chinese Opera Museum.The museum,nestled in a serene neighborhood distinguished by its Southeast Asian architectural charm,chronicles Chinese opera’s centuries-long journey.
文摘Objective:To explore the clinical effect of personalized nutritional support in elderly women with gestational diabetes(GDM),and explore its impact on the incidence of maternal complications and pregnancy outcomes.Methods:A total of 90 elderly pregnant women with gestational diabetes who were delivered in our hospital from January 2023 to January 2024 were selected as the research objects.They were randomly divided into an observation group and a control group,with 45 cases in each group.The control group only received routine pregnancy care and basic nutrition guidance,while the observation group received personalized nutrition support on this basis.Compare the blood glucose control,incidence of pregnancy complications,pregnancy outcomes,and neonatal outcomes between two groups of parturient.Result:After intervention,the fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)of the observation group were significantly lower than those of the control group,and the differences were statistically significant(p<0.05);The incidence of complications such as gestational hypertension syndrome,polyhydramnios,premature rupture of membranes,and postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the difference was statistically significant(p<0.05);The cesarean section rate in the observation group was significantly lower than that in the control group,and the incidence of adverse neonatal outcomes such as fetal distress,macrosomia,neonatal asphyxia,and neonatal hypoglycemia in the observation group was significantly lower than that in the control group,with statistical significance(p<0.05).Conclusion:Individualized nutritional support for elderly women with gestational diabetes can effectively improve the level of maternal blood sugar control,reduce the incidence of complications during pregnancy,and improve the outcome of pregnancy and neonatal outcomes,which is of high clinical value.
基金Supported by The 23 rd Batch of Undergraduate Innovation Training Program Projects of Shanxi Provincial Department of Education"Research on the Path for Enhancing Customer Loyalty of Time-honored Chinese Brands from the Perspective of New Quality Productive Forces:A Case Study of Yuyue Brewing"(S202510108074).
文摘This study focuses on the "Yuyue Brewing" brand and employs grounded theory in conjunction with NVivo 11 software analysis to identify the key factors and dimensions influencing the cultivation of customer mindset, thereby constructing a theoretical model. The findings suggest that the three fundamental components of an entrepreneur s personal mindset—energy, ability, and wisdom—collectively constitute the foundation of entrepreneurial leadership. Establishing a clear brand positioning and developing its core values accordingly are essential aspects of the brand mindset. Furthermore, articulating the customer mindset involves comprehending the emotions and perspectives of target customers within specific contexts. The success of a brand depends not only on the product itself but also on the synergistic interaction among the entrepreneur s personal mindset, the brand mindset, and the customer mindset.
文摘Therapy discontinuation in inflammatory bowel disease,particularly involving immunomodulators,biologics,and small molecules,remains a controversial and evolving topic.This letter reflects on developments following the publication by Meštrovićet al,emphasizing the complex balance between risks of relapse,antidrug antibody formation,and potential complications of long-term immunosuppression.Recent evidence underscores high relapse rates following withdrawal-especially of anti-tumor necrosis factor agents-and highlights the lack of robust data for newer biologics.Updated guidelines from European Crohn’s and Colitis Organization,British Society of Gastroenterology,and American College of Gastroenterology all support cautious and individualized approaches,with strict criteria and close follow-up,particularly in Crohn’s disease.For ulcerative colitis,therapeutic cycling remains insufficiently addressed.We proposed a flowchart to support clinical decision-making and stress the importance of shared decisionmaking in the era of personalized medicine since,despite new drug classes and evolving strategies,the therapeutic ceiling in inflammatory bowel disease has yet to be fully overcome.
