Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently so...Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently solving linear systems Aα=b.The objective of this paper is to provide one new iterative algorithm based on BCR method to find the symmetric periodic solutions of linear periodic matrix equations.This kind of periodic matrix equations has not been dealt with yet.This iterative method is guaranteed to converge in a finite number of steps in the absence of round-off errors.Some numerical results are performed to illustrate the efficiency and feasibility of new method.展开更多
The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitte...The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.展开更多
Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the...Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.展开更多
Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift w...Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift work-related circadian disruption functions in periodontitis remains unknown.Herein,we employed a simulated shift work model constructed by controlling the environmental light-dark cycles and revealed that shift work-related circadian disruption exacerbated the progression of experimental periodontitis.RNA sequencing and in vitro experiments indicated that downregulation of the core circadian protein brain and muscle ARNT-like protein 1(BMAL1)and activation of the Gasdermin D(GSDMD)-mediated pyroptosis were involved in the pathogenesis of that.Mechanically,BMAL1 regulated GSDMD-mediated pyroptosis by suppressing NOD-like receptor protein 3(NLRP3)inflammasome signaling through modulating nuclear receptor subfamily 1 group D member 1(NR1D1),and inhibiting Gsdmd transcription via directly binding to the E-box elements in its promoter.GSDMD-mediated pyroptosis accelerated periodontitis progression,whereas downregulated BMAL1 under circadian disruption further aggravated periodontal destruction by increasing GSDMD activity.And restoring the level of BMAL1 by circadian recovery and SR8278 injection alleviated simulated shift work-exacerbated periodontitis via lessening GSDMD-mediated pyroptosis.These findings provide new evidence and potential interventional targets for circadian disruption-accelerated periodontitis.展开更多
BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue...BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.展开更多
The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding sto...The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.展开更多
With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation wind...With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation window period is crucial for navigating in the Arctic route,which is of great significance to the selection of the route and the optimization of navigation.This paper introduces the establishment of a risk index system,determination of risk index weight,establishment of a risk evaluation model,and prediction algorithm for the window period.In addition,data sources of both environmental factors and ship factors are introducted,and their shortcomings are analyzed,followed by introduction of various methods involved in window prediction and analysis of their advantages and disadvantages.The quantitative risk evaluation and window period algorithm can provide a reference for the research of polar navigation window period prediction.展开更多
In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave so...In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.展开更多
Executive functions emerge throughout childhood and shape multiple cognitive and behavioral outcomes across the lifespan.Given the importance of these functions,there is considerable interest in understanding the role...Executive functions emerge throughout childhood and shape multiple cognitive and behavioral outcomes across the lifespan.Given the importance of these functions,there is considerable interest in understanding the role of environmental enrichment to support their development.The past 20 years have seen the emergence of a body of evidence around the beneficial effects of engaging in physical activity for executive functioning in children.Despite this,there are still unanswered questions,particularly about the confounding effects of the timing and dose of exercise-based interventions.During development,sensitive periods with heightened neural plasticity and sensitivity to environmental influences can offer an optimal time to introduce enrichment interventions.As such,sensitive periods for executive function could indicate an ideal time to introduce physical activity or be a potential confounder to study results if not considered.This narrative review discusses the potential presence of sensitive periods in preadolescent development where physical activity has greater benefits for executive function.Initially,we briefly review the largely parallel fields investigating the presence of sensitive periods for executive function and the effects of physical activity on executive function outcomes.We then bring together these 2 concepts to discuss the theoretical basis for developmentally sensitive periods during which children may be particularly amenable to physical activity-based interventions and offer potential ways forward to investigate this phenomenon.We hope this review will attract researchers to collaborate in the area and extend our current understanding of the development of executive functions as well as interventions like physical activity.展开更多
Repeated wet swelling and dry shrinkage of soil leads to the gradual occurrence of cracks and the formation of a complex fracture network.In order to study the development characteristics and quantitative analysis of ...Repeated wet swelling and dry shrinkage of soil leads to the gradual occurrence of cracks and the formation of a complex fracture network.In order to study the development characteristics and quantitative analysis of cracks in root-soil complex in different growth periods under dry-wet cycles,the alfalfa root-loess complex was in-vestigated during different growth periods under different dry-wet cycles,and a dry-wet cycle experiment was conducted.The crack rate,relative area,average width,total length,and the cracks fractal dimension in the root-soil complex were extracted;the crack development characteristics of plain soil were analyzed under the PG-DwC(dry-wet cycle caused by plant water management during plant growth period),as well as the crack development characteristics of root-soil complex under PG-DWC and EC-DWC(the dry-wet cycles caused by extreme natural conditions such as continuous rain);the effects of plant roots and dry-wet cycles on soil cracks were discussed.The results showed that the average crack width,crack rate,relative crack area,and total crack length of the alfalfa root-loess complex were higher than those of the plain soil during PG-DWC.The result indicated that compared with plain soil during PG-DWC,the presence of plant roots in alfalfa root-soil complex in the same growth period promoted the cracks development to some extent.The alfalfa root-soil complex crack parameters during different growth periods were relatively stable during PG-DWC(O dry-wet cycle).During EC-DWC(1,3,and 5 dry-wet cycles),the alfalfa root-loess complex crack parameters increased with the number of dry-wet cycles during different growth periods.Unlike PG-DWC,the EC-DWC accelerated crack development,and the degree of crack development increased with the number of dry-wet cycles.The existence of plant roots promoted crack development and expansion in the root-soil complex to a certain extent,and the dry-wet cycle certainly promoted crack development and expansion in the root-soil complex.This result contradicts the im-provement in the root-soil complex's macro-mechanical properties during plant growth,due to differences in the mechanical properties of roots and soil.The research results will provide reference for the root soil complex crack development law and the design of slope protection by vegetation.展开更多
The kidney is essential for maintaining fluid,electrolyte,and metabolite homeostasis,and for regulating blood pressure.The pig serves as a valuable biomedical model for human renal physiology,offering insights across ...The kidney is essential for maintaining fluid,electrolyte,and metabolite homeostasis,and for regulating blood pressure.The pig serves as a valuable biomedical model for human renal physiology,offering insights across different physiological states.In this study,single-cell RNA sequencing was used to profile 138469 cells from 12 pig kidney samples collected during the embryonic(E),fattening(F),and pregnancy(P)periods,identifying 29 cell types.Proximal tubule(PT)cells exhibited elevated expression of metabolism-related transcription factors(TFs),including GPD1,ACAA1,and AGMAT,with validation across multiple individuals,periods,and species.Fluorescence homologous double-labeling of paraffin sections further confirmed the expression of ACAA1 and AGMAT in PT cells.Comparative analysis of pig and human kidneys revealed a high degree of similarity among corresponding cell types.Analysis of cell-type heterogeneity highlighted the diversity of thick ascending limb(TAL)cells,identifying a TAL subpopulation related to immune function.Additionally,the functional heterogeneity of kidney-resident macrophages(KRM)was explored across different anatomical sites.In the renal medulla,KRM were implicated in phagocytosis and leukocyte activation,whereas in the renal pelvis,they functioned as ligands,recruiting neutrophils with bactericidal activity to the renal pelvis to combat urinary tract infections.展开更多
With the acceleration of urbanization,environmental vibration and noise pollution have become increasingly severe,and traditional vibration and noise reduction technologies are insufficient to meet current vibration c...With the acceleration of urbanization,environmental vibration and noise pollution have become increasingly severe,and traditional vibration and noise reduction technologies are insufficient to meet current vibration control requirements.This study,based on locally resonant theory,designed a novel local resonance periodic block(LRPB).Using the plane wave expansion method(PWEM)and the finite element method(FEM),this study investigated the bandgap characteristics,formation mechanisms,and vibration and acoustic performance of an LRPB under different periodic structures and material selection.The vibration reduction and noise reduction performance of LRPB has been validated through the Qingdao metro project.The research results show that the LRPB is superior to other periodic structures in terms of wide bandgap.Furthermore,configuring soft scatterer material,increasing the unit size,enhancing the material filling rate,and adopting a honeycomb arrangement can effectively reduce bandgap frequency.In structural design,non-high symmetry demonstrates greater advantages.In a study of a subway tunnel,the LRPB demonstrated superior vibration and noise mitigation performance compared to wave impeding block(WIB),thereby demonstrating potential for use in the field of vibration and noise reduction with regard to structures.展开更多
The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zen...The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zener model with periodic modulation.We obtain adiabatic phase diagrams in the(ω,δ)parameter space,where the adiabatic region is bounded by the modulating frequencyωgreater than a critical valueω_(c) and the non-reciprocal parameterδless than one.The results show that the adiabaticity of the system is not sensitive to the modulating amplitude.We find that the critical modulating frequency can be expressed as a power function of the modulating period number or the sweeping rate.Our findings suggest that one can change the adiabatic region or improve the adiabaticity by adjusting the parameters of both the modulating and the sweeping fields,which provides an effective means to flexibly control the adiabatic dynamics of non-reciprocal systems.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall hea...The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall health.Studies have demonstrated a significant association between aging and the dysfunction of neutrophils,critical cells in the early stages of periodontitis,and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion.Neutrophils differentiate and mature in the bone marrow before entering the circulation;during an infection,they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens.Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues.The impacts of aging on neutrophils'chemotaxis,anti-microbial function,cell activation,and lifespan result in impaired neutrophil functions and excessive neutrophil activation,which could influence periodontitis course.We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses.We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging.This review could help us better understand the pathogenesis of periodontitis,which could offer novel therapeutic targets for periodontitis.展开更多
Edo-period historical records and documents preserved a substantial number of images,many of which are related to epidemic outbreaks.Through systematic collation and categorical analysis,this study uses the chronologi...Edo-period historical records and documents preserved a substantial number of images,many of which are related to epidemic outbreaks.Through systematic collation and categorical analysis,this study uses the chronological and thematic characteristics of these images as a framework to examine the response mechanisms of the Japanese government and public during infectious disease pandemics in the Edo period,as well as the multidimensional impacts of epidemics on social economy,culture,and customs.Illustrations of smallpox in medical texts reveal the developmental trajectory of Japan’s traditional medical knowledge system,while drawings in essays and diaries reflect public fear and non-medical cognitive patterns during cholera outbreaks.Epidemic-themed paintings not only document cholera treatment protocols by the government and medical professionals,as well as grassroots prevention and treatment practices for measles,but also vividly depict social dynamics during crises.Images related to epidemics in advertising reflect the prosperity of the pharmaceutical industry in the Edo period,while depictions in folding screens,ukiyozoushi and the occupational illustrations demonstrate societal customs for epidemic response.Collectively,the Edo-period epidemic crises profoundly shaped Japan’s medical system,economic structure,cultural forms,folk traditions,and public psychology,prompting the government,medical professionals,and civilians to develop distinct era-specific social coping mechanisms.展开更多
The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits ...The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.展开更多
As primary load-bearing components extensively utilized in engineering applications,beam structures necessitate the design of their microstructural configurations to achieve lightweight objectives while satisfying div...As primary load-bearing components extensively utilized in engineering applications,beam structures necessitate the design of their microstructural configurations to achieve lightweight objectives while satisfying diverse mechanical performance requirements.Combining topology optimization with fully coupled homogenization beam theory,we provide a highly efficient design tool to access desirable periodic microstructures for beams.The present optimization framework comprehensively takes into account for key deformation modes,including tension,bending,torsion,and shear deformation,all within a unified formulation.Several numerical results prove that our method can be used to handle kinds of microstructure design for beam-like structures,e.g.,extreme tension(compression)-torsion stiffness,maximization of minimum critical buckling load,and minimization of structural compliance.When optimizing microstructures for macroscopic performance,we emphasize investigating the influence of shear stiffness on the optimized results.The novel chiral beam-like structures are fabricated and tested.The experimental results indicate that the optimized tension(compression)-torsion structure has excellent buffer characteristics,as compared with the traditional square tube.This proposed optimization framework can be further extended to other physical problems of Timoshenko beams.展开更多
By applying the convolution-based Hilbert transform in the zonal direction on six-hourly streamfunction fields at200 h Pa, we present the climatology and trends of the local wave period, and zonal and meridional phase...By applying the convolution-based Hilbert transform in the zonal direction on six-hourly streamfunction fields at200 h Pa, we present the climatology and trends of the local wave period, and zonal and meridional phase speeds, of Rossby waves over the globe during the solstice seasons of 1979–2023. While partly similar to and inspired by Fragkoulidis and Wirth(2020), our method differs in its ability to cover both planetary-scale and synoptic-scale waves over not only the extratropics, but also the tropics and subtropics. Based on a physically reasonable global distribution of wave periods, our key new finding is a robust prolonging of wave periods over most regions of the tropics and subtropics during both solstice seasons of 1979–2023, except for the tropical Atlantic, which experiences a shortened wave period during June–July–August of 1979–2022. Both the prolonging and shortening of wave periods are mainly associated with the changes in planetary-scale waves. Regionally varying trends of the zonal phase speed(Cpx) of synoptic waves are consistent in sign with, but smaller in magnitude than, the trends of local zonal wind, confirming the conclusion of Wu and Lu(2023)on the opposite effects of zonal wind and the meridional gradient of potential vorticity on Cpx. Meanwhile, the Cpx trends of planetary-scale waves are relatively weak, and do not exhibit a robust relation with the trend of zonal wind. These new results are helpful toward better understanding the changes in atmospheric waves and extreme events under global warming.展开更多
基金Supported by NSFC (No.12371378)NSF of Fujian Province (Nos.2024J01980,2023J01955)。
文摘Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently solving linear systems Aα=b.The objective of this paper is to provide one new iterative algorithm based on BCR method to find the symmetric periodic solutions of linear periodic matrix equations.This kind of periodic matrix equations has not been dealt with yet.This iterative method is guaranteed to converge in a finite number of steps in the absence of round-off errors.Some numerical results are performed to illustrate the efficiency and feasibility of new method.
基金supported by the Center for Cognition and Sociality,Institute for Basic Science(IBS)(IBS-R001-D2)(to WK).
文摘The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.
基金The National Natural Science Foundation of China under contract No.41821004the Basic Scientific Fund for National Public Research Institutes of China under contract No.2020Q08the Fund of Laoshan Laboratory under contract No.LSKJ202201600.
文摘Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.
基金supported by the National Natural Science Foundation of China(Nos.82170955,82101064)the Xinfei Program funded by Fourth Military Medical University。
文摘Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift work-related circadian disruption functions in periodontitis remains unknown.Herein,we employed a simulated shift work model constructed by controlling the environmental light-dark cycles and revealed that shift work-related circadian disruption exacerbated the progression of experimental periodontitis.RNA sequencing and in vitro experiments indicated that downregulation of the core circadian protein brain and muscle ARNT-like protein 1(BMAL1)and activation of the Gasdermin D(GSDMD)-mediated pyroptosis were involved in the pathogenesis of that.Mechanically,BMAL1 regulated GSDMD-mediated pyroptosis by suppressing NOD-like receptor protein 3(NLRP3)inflammasome signaling through modulating nuclear receptor subfamily 1 group D member 1(NR1D1),and inhibiting Gsdmd transcription via directly binding to the E-box elements in its promoter.GSDMD-mediated pyroptosis accelerated periodontitis progression,whereas downregulated BMAL1 under circadian disruption further aggravated periodontal destruction by increasing GSDMD activity.And restoring the level of BMAL1 by circadian recovery and SR8278 injection alleviated simulated shift work-exacerbated periodontitis via lessening GSDMD-mediated pyroptosis.These findings provide new evidence and potential interventional targets for circadian disruption-accelerated periodontitis.
文摘BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.
基金Supported by the National Natural Science Foundation of China(10671182)。
文摘The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.
文摘With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation window period is crucial for navigating in the Arctic route,which is of great significance to the selection of the route and the optimization of navigation.This paper introduces the establishment of a risk index system,determination of risk index weight,establishment of a risk evaluation model,and prediction algorithm for the window period.In addition,data sources of both environmental factors and ship factors are introducted,and their shortcomings are analyzed,followed by introduction of various methods involved in window prediction and analysis of their advantages and disadvantages.The quantitative risk evaluation and window period algorithm can provide a reference for the research of polar navigation window period prediction.
基金Supported by the National Natural Science Foundation of China(12261050)Science and Technology Project of Department of Education of Jiangxi Province(GJJ2201612 and GJJ211027)Natural Science Foundation of Jiangxi Province of China(20212BAB202021)。
文摘In this paper,we investigate the periodic traveling wave solutions problem for a single population model with advection and distributed delay.By the bifurcation analysis method,we can obtain periodic traveling wave solutions for this model under the influence of advection term and distributed delay.The obtained results indicate that weak kernel and strong kernel can both deduce the existence of periodic traveling wave solutions.Finally,we apply the main results in this paper to Logistic model and Nicholson’s blowflies model.
文摘Executive functions emerge throughout childhood and shape multiple cognitive and behavioral outcomes across the lifespan.Given the importance of these functions,there is considerable interest in understanding the role of environmental enrichment to support their development.The past 20 years have seen the emergence of a body of evidence around the beneficial effects of engaging in physical activity for executive functioning in children.Despite this,there are still unanswered questions,particularly about the confounding effects of the timing and dose of exercise-based interventions.During development,sensitive periods with heightened neural plasticity and sensitivity to environmental influences can offer an optimal time to introduce enrichment interventions.As such,sensitive periods for executive function could indicate an ideal time to introduce physical activity or be a potential confounder to study results if not considered.This narrative review discusses the potential presence of sensitive periods in preadolescent development where physical activity has greater benefits for executive function.Initially,we briefly review the largely parallel fields investigating the presence of sensitive periods for executive function and the effects of physical activity on executive function outcomes.We then bring together these 2 concepts to discuss the theoretical basis for developmentally sensitive periods during which children may be particularly amenable to physical activity-based interventions and offer potential ways forward to investigate this phenomenon.We hope this review will attract researchers to collaborate in the area and extend our current understanding of the development of executive functions as well as interventions like physical activity.
基金the Key Research and Development Project of Ningxia Hui Autonomous Region(No.2023BEG02072)for their financial support.
文摘Repeated wet swelling and dry shrinkage of soil leads to the gradual occurrence of cracks and the formation of a complex fracture network.In order to study the development characteristics and quantitative analysis of cracks in root-soil complex in different growth periods under dry-wet cycles,the alfalfa root-loess complex was in-vestigated during different growth periods under different dry-wet cycles,and a dry-wet cycle experiment was conducted.The crack rate,relative area,average width,total length,and the cracks fractal dimension in the root-soil complex were extracted;the crack development characteristics of plain soil were analyzed under the PG-DwC(dry-wet cycle caused by plant water management during plant growth period),as well as the crack development characteristics of root-soil complex under PG-DWC and EC-DWC(the dry-wet cycles caused by extreme natural conditions such as continuous rain);the effects of plant roots and dry-wet cycles on soil cracks were discussed.The results showed that the average crack width,crack rate,relative crack area,and total crack length of the alfalfa root-loess complex were higher than those of the plain soil during PG-DWC.The result indicated that compared with plain soil during PG-DWC,the presence of plant roots in alfalfa root-soil complex in the same growth period promoted the cracks development to some extent.The alfalfa root-soil complex crack parameters during different growth periods were relatively stable during PG-DWC(O dry-wet cycle).During EC-DWC(1,3,and 5 dry-wet cycles),the alfalfa root-loess complex crack parameters increased with the number of dry-wet cycles during different growth periods.Unlike PG-DWC,the EC-DWC accelerated crack development,and the degree of crack development increased with the number of dry-wet cycles.The existence of plant roots promoted crack development and expansion in the root-soil complex to a certain extent,and the dry-wet cycle certainly promoted crack development and expansion in the root-soil complex.This result contradicts the im-provement in the root-soil complex's macro-mechanical properties during plant growth,due to differences in the mechanical properties of roots and soil.The research results will provide reference for the root soil complex crack development law and the design of slope protection by vegetation.
基金supported by the International Cooperation and Exchange Program of the National Natural Science Foundation of China(32261133531)。
文摘The kidney is essential for maintaining fluid,electrolyte,and metabolite homeostasis,and for regulating blood pressure.The pig serves as a valuable biomedical model for human renal physiology,offering insights across different physiological states.In this study,single-cell RNA sequencing was used to profile 138469 cells from 12 pig kidney samples collected during the embryonic(E),fattening(F),and pregnancy(P)periods,identifying 29 cell types.Proximal tubule(PT)cells exhibited elevated expression of metabolism-related transcription factors(TFs),including GPD1,ACAA1,and AGMAT,with validation across multiple individuals,periods,and species.Fluorescence homologous double-labeling of paraffin sections further confirmed the expression of ACAA1 and AGMAT in PT cells.Comparative analysis of pig and human kidneys revealed a high degree of similarity among corresponding cell types.Analysis of cell-type heterogeneity highlighted the diversity of thick ascending limb(TAL)cells,identifying a TAL subpopulation related to immune function.Additionally,the functional heterogeneity of kidney-resident macrophages(KRM)was explored across different anatomical sites.In the renal medulla,KRM were implicated in phagocytosis and leukocyte activation,whereas in the renal pelvis,they functioned as ligands,recruiting neutrophils with bactericidal activity to the renal pelvis to combat urinary tract infections.
基金Natural Science Foundation of China under Grant No.42277130Natural Science Foundation of Shandong Province under Grant No.ZR2021ME144。
文摘With the acceleration of urbanization,environmental vibration and noise pollution have become increasingly severe,and traditional vibration and noise reduction technologies are insufficient to meet current vibration control requirements.This study,based on locally resonant theory,designed a novel local resonance periodic block(LRPB).Using the plane wave expansion method(PWEM)and the finite element method(FEM),this study investigated the bandgap characteristics,formation mechanisms,and vibration and acoustic performance of an LRPB under different periodic structures and material selection.The vibration reduction and noise reduction performance of LRPB has been validated through the Qingdao metro project.The research results show that the LRPB is superior to other periodic structures in terms of wide bandgap.Furthermore,configuring soft scatterer material,increasing the unit size,enhancing the material filling rate,and adopting a honeycomb arrangement can effectively reduce bandgap frequency.In structural design,non-high symmetry demonstrates greater advantages.In a study of a subway tunnel,the LRPB demonstrated superior vibration and noise mitigation performance compared to wave impeding block(WIB),thereby demonstrating potential for use in the field of vibration and noise reduction with regard to structures.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12375019 and 11974273)。
文摘The control of adiabatic dynamics is essential for quantum manipulation.We investigate the effects of both periodic modulating field and linear sweeping field on adiabatic dynamics based on a non-reciprocal Landau-Zener model with periodic modulation.We obtain adiabatic phase diagrams in the(ω,δ)parameter space,where the adiabatic region is bounded by the modulating frequencyωgreater than a critical valueω_(c) and the non-reciprocal parameterδless than one.The results show that the adiabaticity of the system is not sensitive to the modulating amplitude.We find that the critical modulating frequency can be expressed as a power function of the modulating period number or the sweeping rate.Our findings suggest that one can change the adiabatic region or improve the adiabaticity by adjusting the parameters of both the modulating and the sweeping fields,which provides an effective means to flexibly control the adiabatic dynamics of non-reciprocal systems.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
文摘The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall health.Studies have demonstrated a significant association between aging and the dysfunction of neutrophils,critical cells in the early stages of periodontitis,and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion.Neutrophils differentiate and mature in the bone marrow before entering the circulation;during an infection,they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens.Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues.The impacts of aging on neutrophils'chemotaxis,anti-microbial function,cell activation,and lifespan result in impaired neutrophil functions and excessive neutrophil activation,which could influence periodontitis course.We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses.We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging.This review could help us better understand the pathogenesis of periodontitis,which could offer novel therapeutic targets for periodontitis.
基金financed by the grant from the Major Project of the National Social Science Fund of China(No.20&ZD222).
文摘Edo-period historical records and documents preserved a substantial number of images,many of which are related to epidemic outbreaks.Through systematic collation and categorical analysis,this study uses the chronological and thematic characteristics of these images as a framework to examine the response mechanisms of the Japanese government and public during infectious disease pandemics in the Edo period,as well as the multidimensional impacts of epidemics on social economy,culture,and customs.Illustrations of smallpox in medical texts reveal the developmental trajectory of Japan’s traditional medical knowledge system,while drawings in essays and diaries reflect public fear and non-medical cognitive patterns during cholera outbreaks.Epidemic-themed paintings not only document cholera treatment protocols by the government and medical professionals,as well as grassroots prevention and treatment practices for measles,but also vividly depict social dynamics during crises.Images related to epidemics in advertising reflect the prosperity of the pharmaceutical industry in the Edo period,while depictions in folding screens,ukiyozoushi and the occupational illustrations demonstrate societal customs for epidemic response.Collectively,the Edo-period epidemic crises profoundly shaped Japan’s medical system,economic structure,cultural forms,folk traditions,and public psychology,prompting the government,medical professionals,and civilians to develop distinct era-specific social coping mechanisms.
基金supported bythe National Natural Science Foundation of China(Nos.U23A20523,82272504,and 82072456)the Department of Science and Technology of Jilin Province,China(Nos.20210101439JC,20210101321JC,20220204119YY,202201ZYTS131,202201ZYTS129,20230204114YY,YDZJ202201ZYTS505,and YDZJ202301ZYTS076)+4 种基金the Special Program for Science and Technology Personnel of Changchun(No.ZKICKJJ2023015)the Key Training Plan for Outstanding Youth of Jilin University(No.419070623036)the Research Fund of the First Hospital of Jilin University(No.2021-zl-01)the Graduate Innovation Fund of Jilin University(No.2024CX125)the Foun-dation of National Center for Translational Medicine(Shanghai)SHU Branch,China(No.SUITM-202405).
文摘The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.
基金supported by the National Natural Science Foundation of China(grant number 11902015)the Open Fund of Deceleration and Landing Laboratory of the Fifth Academy of Aerospace Science and Technology Group(grant number EDL19092138)the Ministry of Education Chunhui Plan(HZKY20220014).
文摘As primary load-bearing components extensively utilized in engineering applications,beam structures necessitate the design of their microstructural configurations to achieve lightweight objectives while satisfying diverse mechanical performance requirements.Combining topology optimization with fully coupled homogenization beam theory,we provide a highly efficient design tool to access desirable periodic microstructures for beams.The present optimization framework comprehensively takes into account for key deformation modes,including tension,bending,torsion,and shear deformation,all within a unified formulation.Several numerical results prove that our method can be used to handle kinds of microstructure design for beam-like structures,e.g.,extreme tension(compression)-torsion stiffness,maximization of minimum critical buckling load,and minimization of structural compliance.When optimizing microstructures for macroscopic performance,we emphasize investigating the influence of shear stiffness on the optimized results.The novel chiral beam-like structures are fabricated and tested.The experimental results indicate that the optimized tension(compression)-torsion structure has excellent buffer characteristics,as compared with the traditional square tube.This proposed optimization framework can be further extended to other physical problems of Timoshenko beams.
基金the support from the National Natural Science Foundation of China (Grant No. 42175070)supported by the National Natural Science Foundation of China (Grant No. 42288101)supported by the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (Earth Lab)。
文摘By applying the convolution-based Hilbert transform in the zonal direction on six-hourly streamfunction fields at200 h Pa, we present the climatology and trends of the local wave period, and zonal and meridional phase speeds, of Rossby waves over the globe during the solstice seasons of 1979–2023. While partly similar to and inspired by Fragkoulidis and Wirth(2020), our method differs in its ability to cover both planetary-scale and synoptic-scale waves over not only the extratropics, but also the tropics and subtropics. Based on a physically reasonable global distribution of wave periods, our key new finding is a robust prolonging of wave periods over most regions of the tropics and subtropics during both solstice seasons of 1979–2023, except for the tropical Atlantic, which experiences a shortened wave period during June–July–August of 1979–2022. Both the prolonging and shortening of wave periods are mainly associated with the changes in planetary-scale waves. Regionally varying trends of the zonal phase speed(Cpx) of synoptic waves are consistent in sign with, but smaller in magnitude than, the trends of local zonal wind, confirming the conclusion of Wu and Lu(2023)on the opposite effects of zonal wind and the meridional gradient of potential vorticity on Cpx. Meanwhile, the Cpx trends of planetary-scale waves are relatively weak, and do not exhibit a robust relation with the trend of zonal wind. These new results are helpful toward better understanding the changes in atmospheric waves and extreme events under global warming.
