Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnanc...Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, the other 20 patients had normal umbilical and uterine artery doppler waveforms. After the delivery, blood samples were taken from umbilical artery of double clemped umbilical cord for blood gas parameters, EPO and CD33 levels. Sociodemographic findings, antepartum, intrapartum test results, labor and delivery characteristics and newborn examination results were recorded. Blood gas parameters, EPO and CD33 levels between groups were analyzed. Mann-Whitney U test and t-test were used as statistical methods. Results: There were no differences between parity, gestational ages and newborn weights of the groups. Cord blood CD33 and EPO levels of group with abnormal umbilical and uterine artery doppler waveforms were significantly higher than group with normal umbilical and uterine artery doppler waveforms (p < 0.01). Conclusion: Pathology on doppler screen shows to us a connection between chronic hypoxemia and abnormal on doppler screen. Preference of high blood CD33 levels for cord blood transplantation especially during last years can also be used with preference of cord blood with abnormal doppler findings.展开更多
To editor:We write to draw attention to a matter of profound significance in maternal healthcare,specifically centering on the perils entailed by the escalating prevalence of unconventional birth practices in rural Af...To editor:We write to draw attention to a matter of profound significance in maternal healthcare,specifically centering on the perils entailed by the escalating prevalence of unconventional birth practices in rural Africa.This phenomenon encapsulates a spectrum of practices,ranging from unhygienic delivery procedures and unorthodox improvised episiotomy to inadequate cord care,collectively posing a formidable threat to the well-being of both mothers and newborns.Unconventional birth practices are culturally or personally preferred methods of childbirth that differ from those of routine hospital births.In rural Africa,a significant number of women still deliver at home,carrying various risks due to the lack of immediate access to medical help in case of complications.展开更多
Introduction Coronavirus disease 2019(COVID-19),caused by the SARS-CoV-2 virus,poses significant risks to pregnant women.The physiological and immunological alterations during pregnancy render them more vulnerable to ...Introduction Coronavirus disease 2019(COVID-19),caused by the SARS-CoV-2 virus,poses significant risks to pregnant women.The physiological and immunological alterations during pregnancy render them more vulnerable to severe complications,and fetal health is also a concern due to the presence of SARS-CoV-2.1 The maternal and neonatal outcomes associated with coronavirus infections,including SARS,MERS,and SARS-CoV-2,remain unclear.Although numerous studies have investigated the impact of COVID-19,there is a lack of data on the effects of gestational age at the time of diagnosis.This information is crucial for implementing trimester-specific interventions.Our clinical observation compared maternal,perinatal,and neonatal outcomes among COVID-19-infected patients across dif-ferent pregnancy trimesters.展开更多
Objective To investigate the relationship between c jun mRNA and apoptosis of neurons following perinatal ischemic hypoxia. Methods We set up a fetal rat model of perinatal ischemic hypoxia by ligating unilatera...Objective To investigate the relationship between c jun mRNA and apoptosis of neurons following perinatal ischemic hypoxia. Methods We set up a fetal rat model of perinatal ischemic hypoxia by ligating unilateral uterine horn vessel of pregnant Wistar rats (21 day gestation). The contralateral horn vessel was not ligated and the fetuses in these uteri served as controls. Rat pups were delivered by cesarean section at the end of ischemic hypoxic insult and then the rats' brain tissues were collected in different points of time. In situ hybridization and TUNEL methods were used to detect the c jun mRNA expression and neural cells apoptosis separately. Results The expression of c jun mRNA in brain tissues began at 15 minutes, reached the first peak at 1-2 hours after ischemic hypoxic insult and reduced gradually after 4 hours and the second peak at 24th hour after insult, gradually disappeared till 72nd hour. There were very low c jun mRNA expression of hippocampus in the control group 24 h after birth. Meanwhile, we observed that the apoptosis of neuronal cells in cerebral cortex was much more than that in the control group. Conclusion The increases of immediate early gene c jun expression and the cell apoptosis could be induced by perinatal ischemic hypoxia. The higher expression of c jun mRNA might induce the transcription of its target gene, especially, so called “death related genes”, which would be a promoter for cell apoptosis.展开更多
文摘Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, the other 20 patients had normal umbilical and uterine artery doppler waveforms. After the delivery, blood samples were taken from umbilical artery of double clemped umbilical cord for blood gas parameters, EPO and CD33 levels. Sociodemographic findings, antepartum, intrapartum test results, labor and delivery characteristics and newborn examination results were recorded. Blood gas parameters, EPO and CD33 levels between groups were analyzed. Mann-Whitney U test and t-test were used as statistical methods. Results: There were no differences between parity, gestational ages and newborn weights of the groups. Cord blood CD33 and EPO levels of group with abnormal umbilical and uterine artery doppler waveforms were significantly higher than group with normal umbilical and uterine artery doppler waveforms (p < 0.01). Conclusion: Pathology on doppler screen shows to us a connection between chronic hypoxemia and abnormal on doppler screen. Preference of high blood CD33 levels for cord blood transplantation especially during last years can also be used with preference of cord blood with abnormal doppler findings.
文摘To editor:We write to draw attention to a matter of profound significance in maternal healthcare,specifically centering on the perils entailed by the escalating prevalence of unconventional birth practices in rural Africa.This phenomenon encapsulates a spectrum of practices,ranging from unhygienic delivery procedures and unorthodox improvised episiotomy to inadequate cord care,collectively posing a formidable threat to the well-being of both mothers and newborns.Unconventional birth practices are culturally or personally preferred methods of childbirth that differ from those of routine hospital births.In rural Africa,a significant number of women still deliver at home,carrying various risks due to the lack of immediate access to medical help in case of complications.
文摘Introduction Coronavirus disease 2019(COVID-19),caused by the SARS-CoV-2 virus,poses significant risks to pregnant women.The physiological and immunological alterations during pregnancy render them more vulnerable to severe complications,and fetal health is also a concern due to the presence of SARS-CoV-2.1 The maternal and neonatal outcomes associated with coronavirus infections,including SARS,MERS,and SARS-CoV-2,remain unclear.Although numerous studies have investigated the impact of COVID-19,there is a lack of data on the effects of gestational age at the time of diagnosis.This information is crucial for implementing trimester-specific interventions.Our clinical observation compared maternal,perinatal,and neonatal outcomes among COVID-19-infected patients across dif-ferent pregnancy trimesters.
文摘Objective To investigate the relationship between c jun mRNA and apoptosis of neurons following perinatal ischemic hypoxia. Methods We set up a fetal rat model of perinatal ischemic hypoxia by ligating unilateral uterine horn vessel of pregnant Wistar rats (21 day gestation). The contralateral horn vessel was not ligated and the fetuses in these uteri served as controls. Rat pups were delivered by cesarean section at the end of ischemic hypoxic insult and then the rats' brain tissues were collected in different points of time. In situ hybridization and TUNEL methods were used to detect the c jun mRNA expression and neural cells apoptosis separately. Results The expression of c jun mRNA in brain tissues began at 15 minutes, reached the first peak at 1-2 hours after ischemic hypoxic insult and reduced gradually after 4 hours and the second peak at 24th hour after insult, gradually disappeared till 72nd hour. There were very low c jun mRNA expression of hippocampus in the control group 24 h after birth. Meanwhile, we observed that the apoptosis of neuronal cells in cerebral cortex was much more than that in the control group. Conclusion The increases of immediate early gene c jun expression and the cell apoptosis could be induced by perinatal ischemic hypoxia. The higher expression of c jun mRNA might induce the transcription of its target gene, especially, so called “death related genes”, which would be a promoter for cell apoptosis.
