Electrospinning has gained significant importance across various fields,including biomedicine,filtration,and packaging due to the control it provides over the properties of the resulting materials,such as fiber diamet...Electrospinning has gained significant importance across various fields,including biomedicine,filtration,and packaging due to the control it provides over the properties of the resulting materials,such as fiber diameter and membrane thickness.Chitosan is a biopolymer that can be utilized with both natural and synthetic copolymers,owing to its therapeutic potential,biocompatibility,and biodegradability.However,producing electrospun chitosan is challenging due to its high solution viscosity,which often results in the formation of beads instead of uniform fibers.To address this issue,the spinnability of chitosan is significantly enhanced,and the production of continuous nanofibers is facilitated by combining it with polymers such as polyethylene oxide(PEO)in suitable ratios.These chitosan–PEO nanofibers are primarily used in biomedical applications,including wound healing,drug delivery systems,and tissue engineering scaffolds.Additionally,they have shown promise in water treatment,filtration membranes,and packaging.Among all the nanofiber mats,chitosan/PEO-AC had the smallest fiber diameter(83±12.5 nm),chitosan/PEO_45S5 had the highest tensile strength(1611±678 MPa).This comprehensive review highlights recent advancements,ongoing challenges,and future directions in the electrospinning of chitosan-based fibers assisted by PEO.展开更多
The considerable hazard posed by periprosthetic joint infections underlines the urgent need for the rapid advancement of in-situ drug delivery systems within joint materials.However,the pursuit of sustained antibacter...The considerable hazard posed by periprosthetic joint infections underlines the urgent need for the rapid advancement of in-situ drug delivery systems within joint materials.However,the pursuit of sustained antibacterial efficacy remains a formidable challenge.In this context,we proposed a novel strategy that leverages swelling and erosion mechanisms to facilitate drug release of drug-loaded ultrahigh molecular weight polyethylene(UHMWPE),thereby ensuring its long-lasting antibacterial performance.Polyethylene oxide(PEO),a hydrophilic polymer with fast hydrating ability and high swelling capacity,was incorporated in UHMWPE alongside the antibacterial tea polyphenol(epigallocatechin gallate,EGCG as representative).The swelling of PEO enhanced water infiltration into the matrix,while the erosion of PEO balanced the release of the encapsulated EGCG,resulting in a steady release.The behavior was supported by the EGCG release profiles and the corresponding fitted release kinetic models.As demonstrated by segmented antibacterial assessments,the antibacterial efficiency was enhanced 2to 3 times in the PEO/EGCG/UHMWPE composite compared to that of EGCG/UHMWPE.Additionally,the PEO/EGCG/UHMWPE composite exhibited favorable biocompatibility and mechanical performance,making it a potential candidate for the development of drug-releasing joint implants to combat prosthetic bacterial infections.展开更多
Magnesium alloys have illustrated great promise for building biodegradable implantable devices due to their unique combination of biocompatibility,mechanical properties,and degradable absorption characteristics.Howeve...Magnesium alloys have illustrated great promise for building biodegradable implantable devices due to their unique combination of biocompatibility,mechanical properties,and degradable absorption characteristics.However,the uncontrollably fast degradation in physiological environments remains a humongous challenge restraining their clinical application,requiring engineering strategies such as surface modification for biocorrosion and biofunctionality optimization.Herein,CeO_(2) nanoparticle-doped plasma electrolytic oxidation(PEO)coatings were applied to surface modify a novel Mg-Zn-Y-Nd alloy.During the PEO process,nanocrystal CeO_(2) nanoparticles,alongside the newly formed secondary corrosion-resistant(CePO_(4))phase,sealed the micropores of the PEO coatings under discharge,affording enhanced barrier effects against biocorrosion.Electrochemical tests in Hank’s solution showed a remarkable increase in corrosion potential and charge transfer resistance and a decrease in corrosion current density.Further characterization showed that a dense anti-corrosion coating of Mg(OH)_(2)/CeO_(2)/Ce(OH)_(3) was formed,effectively limiting the attacks of corrosive mediums and ensuring controlled degradation.The coatingfunctionalized implants,as reveled in vitro and in ovo,were compatible with NIH3T3 fibroblasts,HUVECs,red blood cells,and chick chorioallantoic membranes,with even enhanced pro-healing effects in scratch-based wound models.Overall,this work highlights the potential of CeO_(2)-doped PEO coatings to fine-tune the corrosion resistance and biocompatibility of Mg-Zn-Y-Nd alloys for biomaterial implants.展开更多
This article discusses potential solutions to overcome current limitations for clinical implementation of Mg implants by forming the biocompatible hybrid PEO-based inhibitor-and polymer-containing coatings for a contr...This article discusses potential solutions to overcome current limitations for clinical implementation of Mg implants by forming the biocompatible hybrid PEO-based inhibitor-and polymer-containing coatings for a controlled corrosion degradation of the bioresorbable material.Multifunctional hybrid coatings were obtained on MA8 magnesium alloy.The porous ceramic-like coating synthesized by plasma electrolytic oxidation served as a base for further modification with bioresorbable polymer(polycaprolactone,PCL)contained halloysite nanotubes(HNTs)with corrosion inhibitor(benzotriazole,BTA).The method for HNT impregnating with BTA and introducing them into the matrix of PCL was proposed.The chemical composition of the protective layers was studied using SEM-EDX,XRD,XPS,and Raman microspectroscopy.Anticorrosion protection level of the coated specimens was determined by means of electrochemical techniques,weight loss,and hydrogen evolution tests.The samples with hybrid layers showed the best corrosion protection during 23 h exposure to Hanks’Balanced Salt Solution(|Z|_(f=0.1 Hz)=1.02 MΩ·cm^(2),I_(C)=11 nA·cm^(-2),R_(p)=2.4 MΩ·cm^(2))and the lowest degradation rate(0.021 mm/year)after 7 day of exposure to HBSS among all the tested samples.The electrochemical activity on microscale of samples with the studied coatings was estimated by localized electrochemical techniques.The degradation mechanism of specimens with hybrid layers was proposed.The prospects of hybrid layer application in regulating the resorption process of Mg alloys were shown.展开更多
The corrosion resistance of magnesium alloys is a significant concern in industries seeking to use these materials for lightweight structures.Plasma electrolytic oxidation(PEO)is a process that forms a ceramic oxide f...The corrosion resistance of magnesium alloys is a significant concern in industries seeking to use these materials for lightweight structures.Plasma electrolytic oxidation(PEO)is a process that forms a ceramic oxide film on Mg alloy surfaces,effectively enhancing their corrosion performance in the short term.In this regard,optimizing PEO process parameters is crucial for creating a stable oxide layer.An improved level of corrosion resistance is ensured by applying superhydrophobic coating(SHC)on top of the PEO layer to prevent moisture infiltration,creating air pockets on the surface.Various methods are employed to fabricate SHC on Mg alloys,including techniques like electrophoretic deposition(EPD),Hydrothermal(HT),dip,and spray coating.The synergistic combination of PEO and SHC coatings has demonstrated encouraging outcomes in enhancing the corrosion performance of Mg alloys.This study offers an extensive overview of recent progress in the preparation,characterization,and corrosion behavior of Mg alloys by employing PEO coatings and SHC treatment processes.展开更多
Plasma electrolytic oxidation is a well-known technique for surface modification of biomedical magnesium alloys,with good corrosion protection and the ability to produce biocompatible and bioactive coatings.In this st...Plasma electrolytic oxidation is a well-known technique for surface modification of biomedical magnesium alloys,with good corrosion protection and the ability to produce biocompatible and bioactive coatings.In this study,calcium-phosphate coatings were produced on WE43 magnesium alloy for use,as orthopedic implants.Coating formation was prepared using different oxidation parameters with various duty ratios(DR)of 15,25 and 50%and current ratios(R)-2 or 1.6.Application of R with excess cathodic current(R>1)in processes with DR≥25%allowed attaining the soft-sparking regime(SSR)that resulted in thicker oxide coatings with higher degree of crystallinity compared to the films obtained without SSR.The results of the corrosion tests contributed to a noticeable improvement in the corrosion resistance of the magnesium alloy.Optimization of the oxidation parameters allowed the selection of the variants with the most favorable degradation behavior over the tested immersion period,indicating a successful modification of the magnesium alloy surface to obtain an implant biomaterial capable of providing controlled degradation.Furthermore,biological evaluation of the produced coatings showed that the proposed surface modifications significantly reduced the cytotoxic effects observed in direct contact with the material while still maintaining the cell proliferation-promoting effects of the material eluents.展开更多
文摘Electrospinning has gained significant importance across various fields,including biomedicine,filtration,and packaging due to the control it provides over the properties of the resulting materials,such as fiber diameter and membrane thickness.Chitosan is a biopolymer that can be utilized with both natural and synthetic copolymers,owing to its therapeutic potential,biocompatibility,and biodegradability.However,producing electrospun chitosan is challenging due to its high solution viscosity,which often results in the formation of beads instead of uniform fibers.To address this issue,the spinnability of chitosan is significantly enhanced,and the production of continuous nanofibers is facilitated by combining it with polymers such as polyethylene oxide(PEO)in suitable ratios.These chitosan–PEO nanofibers are primarily used in biomedical applications,including wound healing,drug delivery systems,and tissue engineering scaffolds.Additionally,they have shown promise in water treatment,filtration membranes,and packaging.Among all the nanofiber mats,chitosan/PEO-AC had the smallest fiber diameter(83±12.5 nm),chitosan/PEO_45S5 had the highest tensile strength(1611±678 MPa).This comprehensive review highlights recent advancements,ongoing challenges,and future directions in the electrospinning of chitosan-based fibers assisted by PEO.
基金the National Natural Science Foundation of China(No.5220031085)the Postdoctoral Research Project in Henan Province(No.HN2022054)+2 种基金the Key Scientific Research Projects of Colleges and Universities in Henan Province(No.23A430009)the State Key Laboratory of Polymer Materials Engineering(No.sklpme2022-4-03)the Key Technologies R&D Program of Henan Province(No.242102230131)。
文摘The considerable hazard posed by periprosthetic joint infections underlines the urgent need for the rapid advancement of in-situ drug delivery systems within joint materials.However,the pursuit of sustained antibacterial efficacy remains a formidable challenge.In this context,we proposed a novel strategy that leverages swelling and erosion mechanisms to facilitate drug release of drug-loaded ultrahigh molecular weight polyethylene(UHMWPE),thereby ensuring its long-lasting antibacterial performance.Polyethylene oxide(PEO),a hydrophilic polymer with fast hydrating ability and high swelling capacity,was incorporated in UHMWPE alongside the antibacterial tea polyphenol(epigallocatechin gallate,EGCG as representative).The swelling of PEO enhanced water infiltration into the matrix,while the erosion of PEO balanced the release of the encapsulated EGCG,resulting in a steady release.The behavior was supported by the EGCG release profiles and the corresponding fitted release kinetic models.As demonstrated by segmented antibacterial assessments,the antibacterial efficiency was enhanced 2to 3 times in the PEO/EGCG/UHMWPE composite compared to that of EGCG/UHMWPE.Additionally,the PEO/EGCG/UHMWPE composite exhibited favorable biocompatibility and mechanical performance,making it a potential candidate for the development of drug-releasing joint implants to combat prosthetic bacterial infections.
基金financially supported by the National Natural Science Foundation of China(Nos.52127801 and 22205012)the Shenzhen Basic Research Projects(Nos.JCYJ20210324120001003,JCYJ20220531091802006,and JCYJ20220531091801003)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515012951)IER Foundation(Nos.IERF202201,IERF202202,and IERF202102).
文摘Magnesium alloys have illustrated great promise for building biodegradable implantable devices due to their unique combination of biocompatibility,mechanical properties,and degradable absorption characteristics.However,the uncontrollably fast degradation in physiological environments remains a humongous challenge restraining their clinical application,requiring engineering strategies such as surface modification for biocorrosion and biofunctionality optimization.Herein,CeO_(2) nanoparticle-doped plasma electrolytic oxidation(PEO)coatings were applied to surface modify a novel Mg-Zn-Y-Nd alloy.During the PEO process,nanocrystal CeO_(2) nanoparticles,alongside the newly formed secondary corrosion-resistant(CePO_(4))phase,sealed the micropores of the PEO coatings under discharge,affording enhanced barrier effects against biocorrosion.Electrochemical tests in Hank’s solution showed a remarkable increase in corrosion potential and charge transfer resistance and a decrease in corrosion current density.Further characterization showed that a dense anti-corrosion coating of Mg(OH)_(2)/CeO_(2)/Ce(OH)_(3) was formed,effectively limiting the attacks of corrosive mediums and ensuring controlled degradation.The coatingfunctionalized implants,as reveled in vitro and in ovo,were compatible with NIH3T3 fibroblasts,HUVECs,red blood cells,and chick chorioallantoic membranes,with even enhanced pro-healing effects in scratch-based wound models.Overall,this work highlights the potential of CeO_(2)-doped PEO coatings to fine-tune the corrosion resistance and biocompatibility of Mg-Zn-Y-Nd alloys for biomaterial implants.
基金supported by Russian Science Foundation,Russia(project no.24-73-10008,https://rscf.ru/en/project/24-73-10008/)the government assignments from the Ministry of Science and Higher Education of the RF,Russia(project no.FWFN-2024-0001).
文摘This article discusses potential solutions to overcome current limitations for clinical implementation of Mg implants by forming the biocompatible hybrid PEO-based inhibitor-and polymer-containing coatings for a controlled corrosion degradation of the bioresorbable material.Multifunctional hybrid coatings were obtained on MA8 magnesium alloy.The porous ceramic-like coating synthesized by plasma electrolytic oxidation served as a base for further modification with bioresorbable polymer(polycaprolactone,PCL)contained halloysite nanotubes(HNTs)with corrosion inhibitor(benzotriazole,BTA).The method for HNT impregnating with BTA and introducing them into the matrix of PCL was proposed.The chemical composition of the protective layers was studied using SEM-EDX,XRD,XPS,and Raman microspectroscopy.Anticorrosion protection level of the coated specimens was determined by means of electrochemical techniques,weight loss,and hydrogen evolution tests.The samples with hybrid layers showed the best corrosion protection during 23 h exposure to Hanks’Balanced Salt Solution(|Z|_(f=0.1 Hz)=1.02 MΩ·cm^(2),I_(C)=11 nA·cm^(-2),R_(p)=2.4 MΩ·cm^(2))and the lowest degradation rate(0.021 mm/year)after 7 day of exposure to HBSS among all the tested samples.The electrochemical activity on microscale of samples with the studied coatings was estimated by localized electrochemical techniques.The degradation mechanism of specimens with hybrid layers was proposed.The prospects of hybrid layer application in regulating the resorption process of Mg alloys were shown.
文摘The corrosion resistance of magnesium alloys is a significant concern in industries seeking to use these materials for lightweight structures.Plasma electrolytic oxidation(PEO)is a process that forms a ceramic oxide film on Mg alloy surfaces,effectively enhancing their corrosion performance in the short term.In this regard,optimizing PEO process parameters is crucial for creating a stable oxide layer.An improved level of corrosion resistance is ensured by applying superhydrophobic coating(SHC)on top of the PEO layer to prevent moisture infiltration,creating air pockets on the surface.Various methods are employed to fabricate SHC on Mg alloys,including techniques like electrophoretic deposition(EPD),Hydrothermal(HT),dip,and spray coating.The synergistic combination of PEO and SHC coatings has demonstrated encouraging outcomes in enhancing the corrosion performance of Mg alloys.This study offers an extensive overview of recent progress in the preparation,characterization,and corrosion behavior of Mg alloys by employing PEO coatings and SHC treatment processes.
基金funded by Silesian University of Technology,no.07/020/BKM24/0104.
文摘Plasma electrolytic oxidation is a well-known technique for surface modification of biomedical magnesium alloys,with good corrosion protection and the ability to produce biocompatible and bioactive coatings.In this study,calcium-phosphate coatings were produced on WE43 magnesium alloy for use,as orthopedic implants.Coating formation was prepared using different oxidation parameters with various duty ratios(DR)of 15,25 and 50%and current ratios(R)-2 or 1.6.Application of R with excess cathodic current(R>1)in processes with DR≥25%allowed attaining the soft-sparking regime(SSR)that resulted in thicker oxide coatings with higher degree of crystallinity compared to the films obtained without SSR.The results of the corrosion tests contributed to a noticeable improvement in the corrosion resistance of the magnesium alloy.Optimization of the oxidation parameters allowed the selection of the variants with the most favorable degradation behavior over the tested immersion period,indicating a successful modification of the magnesium alloy surface to obtain an implant biomaterial capable of providing controlled degradation.Furthermore,biological evaluation of the produced coatings showed that the proposed surface modifications significantly reduced the cytotoxic effects observed in direct contact with the material while still maintaining the cell proliferation-promoting effects of the material eluents.
