With the severe challenges brought by global climate change,exploring and developing clean and renewable energy systems to upgrade the energy structure has become an inevitable trend in related research.The comprehens...With the severe challenges brought by global climate change,exploring and developing clean and renewable energy systems to upgrade the energy structure has become an inevitable trend in related research.The comprehensive park systems integrated with photovoltaic,energy storage,direct current,and flexible loads(PEDF)is able to play an important role in promoting energy transformation and achieving sustainable development.In order to fully understand the advantages of PEDF parks in energy conservation and carbon reduction,this paper summarizes existing studies and prospects future research directions on the low-carbon operation of the PEDF park.This paper first introduces carbon emission monitoring and evaluation methods,and then analyzes bi-level optimal dispatch strategies for flexible loads.Meanwhile,the paper provides a prospective analysis of the innovations that can be brought by advanced technologies to the PEDF park.Finally,this paper puts forward the challenges faced by current research and provides prospects for future research directions.This paper emphasizes that related research should focus on collaborating key technologies of PEDF systems and integrating advanced innovations to address challenges and fully leverage the advantages of PEDF technology in energy saving and carbon reduction.This paper aims to provide systematic theoretical guidance and supplements for the research and practice of the PEDF technology.展开更多
【目的】研究色素上皮衍生因子PEDF表达水平与脂代谢的关系,探讨PEDF参与血脂代谢的可能调控机制,为揭示PEDF参与多种代谢疾病提供重要依据。【方法】应用Crispr/Cas9基因修饰技术构建PEDF-/-小鼠,高脂饮食(HFD)诱导肥胖小鼠模型,检测...【目的】研究色素上皮衍生因子PEDF表达水平与脂代谢的关系,探讨PEDF参与血脂代谢的可能调控机制,为揭示PEDF参与多种代谢疾病提供重要依据。【方法】应用Crispr/Cas9基因修饰技术构建PEDF-/-小鼠,高脂饮食(HFD)诱导肥胖小鼠模型,检测小鼠血脂水平(甘油三脂TG、总胆固醇TC、游离脂肪酸FFAs)的变化,实时定量RT-PCR检测脂肪组织中脂肪代谢关键基因(ATGL、PPAR-γ、FAS、HSL)的表达量。【结果】基因组水平鉴定和蛋白水平检测表明PEDF-/-小鼠构建成功;HFD诱导肥胖后,野生型(WT)小鼠体重增加百分比、内脏脂肪及血脂水平均比正常饮食组(CD)的高(P<0.05),差异均具有统计学意义,说明肥胖模型构建成功,而PEDF-/-组小鼠HFD后体重增加百比、内脏脂肪和血脂水平高于CD组(P<0.05),高于WT小鼠的HFD组(P<0.05);实时定量RT-PCR结果显示,WT小鼠HFD后ATGL、PPAR-γ和FAS转录水平都比CD组低(P<0.05),HSL m RNA水平无明显差别;而PEDF敲除后,ATGL、PPAR-γ和HSL转录水平较WT组的显著下调(P<0.01),而FAS水平CD组明显升高,HFD组显著下调;PEDF敲除后,HFD组ATGL m RNA水平高于CD组,PPAR-γ和HSL m RNA水平低于CD组。【结论】成功构建PEDF基因敲除小鼠;PEDF可能通过ATGL、PPAR-γ和HSL促进了脂肪分解,通过FAS抑制脂肪酸合成,从而参与了肥胖小鼠的血脂代谢及内脏脂肪沉积。展开更多
基金This work was supported by National Key R&D Program of China for International S&T Cooperation Projects(Grant No.2019YFE0118700)which was provided by the Ministry of Science and Technology of the People’s Republic of China(https://www.most.gov.cn/(accessed on 1 January 2025))+2 种基金the grant was received by Yun Zhao.This work was supported by Science and Technology Project of CSG Electric Power Research Institute(Grant No.SEPRIK23B052)which was provided by CSG Electric Power Research Institute(http://www.sepri.csg.cn/(accessed on 1 January 2025))the grant was received by Ziwen Cai.
文摘With the severe challenges brought by global climate change,exploring and developing clean and renewable energy systems to upgrade the energy structure has become an inevitable trend in related research.The comprehensive park systems integrated with photovoltaic,energy storage,direct current,and flexible loads(PEDF)is able to play an important role in promoting energy transformation and achieving sustainable development.In order to fully understand the advantages of PEDF parks in energy conservation and carbon reduction,this paper summarizes existing studies and prospects future research directions on the low-carbon operation of the PEDF park.This paper first introduces carbon emission monitoring and evaluation methods,and then analyzes bi-level optimal dispatch strategies for flexible loads.Meanwhile,the paper provides a prospective analysis of the innovations that can be brought by advanced technologies to the PEDF park.Finally,this paper puts forward the challenges faced by current research and provides prospects for future research directions.This paper emphasizes that related research should focus on collaborating key technologies of PEDF systems and integrating advanced innovations to address challenges and fully leverage the advantages of PEDF technology in energy saving and carbon reduction.This paper aims to provide systematic theoretical guidance and supplements for the research and practice of the PEDF technology.
文摘【目的】研究色素上皮衍生因子PEDF表达水平与脂代谢的关系,探讨PEDF参与血脂代谢的可能调控机制,为揭示PEDF参与多种代谢疾病提供重要依据。【方法】应用Crispr/Cas9基因修饰技术构建PEDF-/-小鼠,高脂饮食(HFD)诱导肥胖小鼠模型,检测小鼠血脂水平(甘油三脂TG、总胆固醇TC、游离脂肪酸FFAs)的变化,实时定量RT-PCR检测脂肪组织中脂肪代谢关键基因(ATGL、PPAR-γ、FAS、HSL)的表达量。【结果】基因组水平鉴定和蛋白水平检测表明PEDF-/-小鼠构建成功;HFD诱导肥胖后,野生型(WT)小鼠体重增加百分比、内脏脂肪及血脂水平均比正常饮食组(CD)的高(P<0.05),差异均具有统计学意义,说明肥胖模型构建成功,而PEDF-/-组小鼠HFD后体重增加百比、内脏脂肪和血脂水平高于CD组(P<0.05),高于WT小鼠的HFD组(P<0.05);实时定量RT-PCR结果显示,WT小鼠HFD后ATGL、PPAR-γ和FAS转录水平都比CD组低(P<0.05),HSL m RNA水平无明显差别;而PEDF敲除后,ATGL、PPAR-γ和HSL转录水平较WT组的显著下调(P<0.01),而FAS水平CD组明显升高,HFD组显著下调;PEDF敲除后,HFD组ATGL m RNA水平高于CD组,PPAR-γ和HSL m RNA水平低于CD组。【结论】成功构建PEDF基因敲除小鼠;PEDF可能通过ATGL、PPAR-γ和HSL促进了脂肪分解,通过FAS抑制脂肪酸合成,从而参与了肥胖小鼠的血脂代谢及内脏脂肪沉积。
