The storage space and cost for Smart Grid datasets has been growing exponentially due to its high data-rate of various sensor readings from Automated Metering Infrastructure (AMI), and Phasor Measurement Units (PMUs)....The storage space and cost for Smart Grid datasets has been growing exponentially due to its high data-rate of various sensor readings from Automated Metering Infrastructure (AMI), and Phasor Measurement Units (PMUs). The paper focuses on Phasor Data Concentrators (PDCs) that aggregate data from PMUs. PMUs measure real-time voltage, current and frequency parameters across the electrical grid. A typical PDC can process data from anywhere ten to forty PMUs. The paper exploits the need for appropriate security and data compression challenges simultaneously. As a result, an optimal compression method ER1c is investigated for efficient storage of IREG and C37.118 timestamped PDC data sets. We expect that our approach can greatly reduce the storage cost requirements of commercial available PDCs (SEL 3373, GE Multilin P30) by 80%. For example, 2 years of PDC data storage space can be easily replaced with only 10 days of storage space. In addition, our approach in combination with AES 256 encryption can protect PDC data to larger degree as per National Institute of Standards and Technology (NIST) standards.展开更多
Background: It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this. Observations: We observ...Background: It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this. Observations: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod. The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy. Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin. We identified high numbers of PDCs in psoriatic skin lesions (up to 16%of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123. By contrast, PDCs were present at very low levels in atopic dermatitis and not detected in normal human skin. Conclusions: This study shows that psoriasis can be driven by the innate immune system through TLR ligation. Furthermore, our finding that large numbers of PDCs infiltrate psoriatic skin suggests a role of lesional PDCs as type I interferon-producing targets for the TLR7 agonist imiquimod.展开更多
Laser-assisted drilling combined with full-size polycrystalline diamond compact(PDC)bit is considered a feasible solution to enhance the drilling performance of engineering machinery.In this method,determining the opt...Laser-assisted drilling combined with full-size polycrystalline diamond compact(PDC)bit is considered a feasible solution to enhance the drilling performance of engineering machinery.In this method,determining the optimal collaborative control parameters that support rapid drilling is crucial for improving the combined performance.This study used average drilling speed,average torque,and total specificenergy for quantitative analysis to characterize the efficiencyand economy of combined rock breaking.Given the advantage of the response surface methodology in providing high-precision predictions with limited experimental data,regression models of the average drilling speed,average torque,and total specificenergy were established.The results showed that as the laser power and irradiation time increased,the average drilling speed firstincreased rapidly and then leveled off,while the average torque decreased sharply before decelerating.The total specificenergy initially decreased and then increased,with the combined drilling outperforming conventional mechanical drilling within specific parameter ranges.As the weight on bit increased,both the average torque and total specificenergy first decreased and then increased.With rising rotating speed,the average torque exhibited a trend of initial increase,then decrease,and finalincrease,whereas the total specificenergy increased slowly at firstand then sharply.Both parameters exhibited optimal values at which the average torque and total specific energy remained at minimal levels.For granite combined drilling,the optimal performance was achieved at a laser power of 3000 W,irradiation time of 31 s,the weight on bit of 2.4 kN,and the rotating speed of 97 r/min.展开更多
文摘The storage space and cost for Smart Grid datasets has been growing exponentially due to its high data-rate of various sensor readings from Automated Metering Infrastructure (AMI), and Phasor Measurement Units (PMUs). The paper focuses on Phasor Data Concentrators (PDCs) that aggregate data from PMUs. PMUs measure real-time voltage, current and frequency parameters across the electrical grid. A typical PDC can process data from anywhere ten to forty PMUs. The paper exploits the need for appropriate security and data compression challenges simultaneously. As a result, an optimal compression method ER1c is investigated for efficient storage of IREG and C37.118 timestamped PDC data sets. We expect that our approach can greatly reduce the storage cost requirements of commercial available PDCs (SEL 3373, GE Multilin P30) by 80%. For example, 2 years of PDC data storage space can be easily replaced with only 10 days of storage space. In addition, our approach in combination with AES 256 encryption can protect PDC data to larger degree as per National Institute of Standards and Technology (NIST) standards.
文摘Background: It has been proposed that the innate immune system plays a central role in driving the autoimmune T-cell cascade leading to psoriasis; however, there is no direct evidence for this. Observations: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod. The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy. Since imiquimod induces large amounts of type I interferon production from TLR7-expressing plasmacytoid dendritic cell precursors (PDCs), the natural interferon-producing cells of the peripheral blood, we asked whether PDCs are present in psoriatic skin. We identified high numbers of PDCs in psoriatic skin lesions (up to 16%of the total dermal infiltrate) based on their coexpression of BDCA2 and CD123. By contrast, PDCs were present at very low levels in atopic dermatitis and not detected in normal human skin. Conclusions: This study shows that psoriasis can be driven by the innate immune system through TLR ligation. Furthermore, our finding that large numbers of PDCs infiltrate psoriatic skin suggests a role of lesional PDCs as type I interferon-producing targets for the TLR7 agonist imiquimod.
基金funded by the National Natural Science Foundation of China(Grand No.52325904)National Key Research and Development Program of China(Grant No.2023YFB2390200)the National Natural Science Foundation of China(Grant No.52309134).
文摘Laser-assisted drilling combined with full-size polycrystalline diamond compact(PDC)bit is considered a feasible solution to enhance the drilling performance of engineering machinery.In this method,determining the optimal collaborative control parameters that support rapid drilling is crucial for improving the combined performance.This study used average drilling speed,average torque,and total specificenergy for quantitative analysis to characterize the efficiencyand economy of combined rock breaking.Given the advantage of the response surface methodology in providing high-precision predictions with limited experimental data,regression models of the average drilling speed,average torque,and total specificenergy were established.The results showed that as the laser power and irradiation time increased,the average drilling speed firstincreased rapidly and then leveled off,while the average torque decreased sharply before decelerating.The total specificenergy initially decreased and then increased,with the combined drilling outperforming conventional mechanical drilling within specific parameter ranges.As the weight on bit increased,both the average torque and total specificenergy first decreased and then increased.With rising rotating speed,the average torque exhibited a trend of initial increase,then decrease,and finalincrease,whereas the total specificenergy increased slowly at firstand then sharply.Both parameters exhibited optimal values at which the average torque and total specific energy remained at minimal levels.For granite combined drilling,the optimal performance was achieved at a laser power of 3000 W,irradiation time of 31 s,the weight on bit of 2.4 kN,and the rotating speed of 97 r/min.
