BACKGROUND Helicobacter pylori(H.pylori),a globally prevalent pathogen,is exhibiting increasing rates of antimicrobial resistance.However,clinical implementation of pre-treatment susceptibility testing remains limited...BACKGROUND Helicobacter pylori(H.pylori),a globally prevalent pathogen,is exhibiting increasing rates of antimicrobial resistance.However,clinical implementation of pre-treatment susceptibility testing remains limited due to the organism’s fastidious growth requirements and prolonged culture time.AIM To propose a novel detection method utilizing antibiotic-supplemented media to inhibit susceptible strains,while resistant isolates were identified through urease-mediated hydrolysis of urea,inducing a phenol red color change for visual confirmation.METHODS Colombia agar was supplemented with urea,phenol red,and nickel chloride,and the final pH was adjusted to 7.35.Antibiotic-selective media were prepared by incorporating amoxicillin(0.5μg/mL),clarithromycin(2μg/mL),metronidazole(8μg/mL),or levofloxacin(2μg/mL)into separate batches.Gastric antral biopsies were homogenized and inoculated at 1.0×105 CFU onto the media,and then incubated under microaerobic conditions at 37°C for 28-36 hours.Resistance was determined based on a color change from yellow to pink,and the results were validated via broth microdilution according to Clinical and Laboratory Standards Institute guidelines.RESULTS After 28-36 hours of incubation,the drug-resistant H.pylori isolates induced a light red color change in the medium.Conversely,susceptible strains(H.pylori 26695 and G27)produced no visible color change.Compared with the conventional 11-day protocol,the novel method significantly reduced detection time.Among 201 clinical isolates,182 were successfully evaluated using the new method,resulting in a 90.5%detection rate.This was consistent with the 95.5%agreement rate observed when compared with microdilution-based susceptibility testing.The success rate of the novel approach was significantly higher than that of the comparative method(P<0.01).The accuracy of the new method was comparable to that of the dilution method.CONCLUSION The novel detection method can rapidly detect H.pylori drug resistance within 28-36 hours.With its operational simplicity and high diagnostic performance,it holds strong potential for clinical application in the management of H.pylori antimicrobial resistance.展开更多
Reservoirs with a group of vertical fractures in a vertical transversely isotropic(VTI)background are considered as orthorhombic(ORT)medium.However,fracture detection in ORT medium using seismic inversion methods rema...Reservoirs with a group of vertical fractures in a vertical transversely isotropic(VTI)background are considered as orthorhombic(ORT)medium.However,fracture detection in ORT medium using seismic inversion methods remains challenging,as it requires the estimation of more than eight parameters.Assuming the reservoir to be a weakly anisotropic ORT medium with small contrasts in the background elastic parameters,a new azimuthal elastic impedance equation was first derived using parameter combinations and mathematical approximations.This equation exhibited almost the same accuracy as the original equation and contained only six model parameters:the compression modulus,anisotropic shear modulus,anisotropic compression modulus,density,normal fracture weakness,and tangential fracture weakness.Subsequently,a stepwise inversion method using second-order derivatives of the elastic impedance was developed to estimate these parameters.Moreover,the Thomsen anisotropy parameter,epsilon,was estimated from the inversion results using the ratio of the anisotropic compression modulus to the compression modulus.Synthetic examples with moderate noise and field data examples confirm the feasibility and effectiveness of the inversion method.The proposed method exhibited accuracy similar to that of previous inversion strategies and could predict richer vertical fracture information.Ultimately,the method was applied to a three-dimensional work area,and the predictions were consistent with logging and geological a priori information,confirming the effectiveness of this method.Summarily,the proposed stepwise inversion method can alleviate the uncertainty of multi-parameter inversion in ORT medium,thereby improving the reliability of fracture detection.展开更多
Permeability is a key parameter to describe fluid transport properties of porous medium; however, the permeability measurement is extremely difficult for tight porous medium, e.g. fine-grained rock or dense soil. In t...Permeability is a key parameter to describe fluid transport properties of porous medium; however, the permeability measurement is extremely difficult for tight porous medium, e.g. fine-grained rock or dense soil. In this paper, three methods for gas permeability measurement, i.e. steady state method, pulse decay method(PDM) and pressure oscillation method(POM), are first reviewed and then their advantages and drawbacks are discussed. Both analytical and numerical solutions of gas permeability are presented for the tight porous medium. The results show that the analytical method is relatively simple but only valid under certain conditions, whilst the numerical method is more robust and generic, which can take into account several factors such as porosity, saturation, gas leakage, and unconventional boundary conditions. The influence of the effective porosity on the permeability determination is further analyzed using the proposed numerical method. In this study, new pressure data interpretation procedures for PDM and POM are proposed, and the obtained results can serve as a guidance to define a proper method for permeability measurement of the tight porous medium.展开更多
It is an important subject to probe the structure in the medium by various kinds of detection methods in the geotechnical engineering. Based on the propagation theory of elastic wave in half-space layered medium, the ...It is an important subject to probe the structure in the medium by various kinds of detection methods in the geotechnical engineering. Based on the propagation theory of elastic wave in half-space layered medium, the propagation characteristics of elastic wave in layered medium with different elastic parameters are discussed using dynamic analysis of finite element method. It is known that the S-wave velocity, density and thickness of layer are related to the properties of the elastic wave including waveform characteristics, spectral characteristics and time-frequency characteristics. We pay special attention to the structure with low velocity interlayer. The impact imaging method is applied to the grouting construction of the immersed tube tunnel. Data acquisition and analytical method are introduced in detail. The grouting effects can be qualitatively evaluated by comparing the characteristics of elastic wave before grouting with those after grouting. Finally, a quantitative evaluation is obtained according to the relationship between energy response of elastic wave and impedance ratio.展开更多
A new membrane finite element method for modeling fluid flow in a porous medium is presented in order to quickly and accurately simulate the geo-membrane fabric used in civil engineering. It is based on discontinuous ...A new membrane finite element method for modeling fluid flow in a porous medium is presented in order to quickly and accurately simulate the geo-membrane fabric used in civil engineering. It is based on discontinuous finite element theory, and can be easily coupled with the normal Galerkin finite element method. Based on the saturated seepage equation, the element coefficient matrix of the membrane element method is derived, and a geometric transform relation for the membrane element between a global coordinate system and a local coordinate system is obtained. A method for the determination of the fluid flux conductivity of the membrane element is presented. This method provides a basis for determining discontinuous parameters in discontinuous finite element theory. An anti-seepage problem regarding the foundation of a building is analyzed by coupling the membrane finite element method with the normal Galerkin finite element method. The analysis results demonstrate the utility and superiority of the membrane finite element method in fluid flow analysis of a porous medium.展开更多
In the current work, transient heat conduction in a semi-infinite medium is considered for its many applications in various heat fields. Here, the homotopy analysis method （HAM） is applied to solve this problem and ...In the current work, transient heat conduction in a semi-infinite medium is considered for its many applications in various heat fields. Here, the homotopy analysis method （HAM） is applied to solve this problem and analytical results are compared with those of the exact and integral methods results. The results show that the HAM can give much better approximations than the other approximate methods： Changes in heat fluxes and profiles of temperature are obtained at different times and positions for copper, iron and aluminum.展开更多
Electromagnetic scattering from a rough surface of layered medium is investigated, and the formulae of the scattering coefficients for different polarizations are derived using the small perturbation method. A rough s...Electromagnetic scattering from a rough surface of layered medium is investigated, and the formulae of the scattering coefficients for different polarizations are derived using the small perturbation method. A rough surface with exponential correlation function is presented for describing a rough soil surface of layered medium, the formula of its scattering coefficient is derived by considering the spectrum of the rough surface with exponential correlation function; the curves of the bistatic scattering coefficient of HH polarization with variation of the scattering angle are obtained by numerical calculation. The influence of the permittivity of layered medium, the mean layer thickness of intermediate medium, the roughness surface parameters and the frequency of the incident wave on the blstatic scattering coefficient is discussed. Numerical results show that the influence of the permittivity of layered medium, the mean layer thickness of intermediate medium, the rms and the correlation length of the rough surface, and the frequency of the incident wave on the bistatic scattering coefficient is very complex.展开更多
In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on ...In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on the bounda-ries among fluid saturated porous medium, elastic single-phase medium and ideal fluid medium. This method is a very effective one with the characteristic of high calculating speed and small memory needed because the formulae for this explicit finite element method have the characteristic of decoupling, and which does not need to solve sys-tem of linear equations. The method is applied to analyze the dynamic response of a reservoir with considering the dynamic interactions among water, dam, sediment and basement rock. The vertical displacement at the top point of the dam is calculated and some conclusions are given.展开更多
This paper presents a technique for Medium Term Load Forecasting (MTLF) using Particle Swarm Optimization (PSO) algorithm based on Least Squares Regression Methods to forecast the electric loads of the Jordanian grid ...This paper presents a technique for Medium Term Load Forecasting (MTLF) using Particle Swarm Optimization (PSO) algorithm based on Least Squares Regression Methods to forecast the electric loads of the Jordanian grid for year of 2015. Linear, quadratic and exponential forecast models have been examined to perform this study and compared with the Auto Regressive (AR) model. MTLF models were influenced by the weather which should be considered when predicting the future peak load demand in terms of months and weeks. The main contribution for this paper is the conduction of MTLF study for Jordan on weekly and monthly basis using real data obtained from National Electric Power Company NEPCO. This study is aimed to develop practical models and algorithm techniques for MTLF to be used by the operators of Jordan power grid. The results are compared with the actual peak load data to attain minimum percentage error. The value of the forecasted weekly and monthly peak loads obtained from these models is examined using Least Square Error (LSE). Actual reported data from NEPCO are used to analyze the performance of the proposed approach and the results are reported and compared with the results obtained from PSO algorithm and AR model.展开更多
In this paper, the analytical solution of a viscous and incompressible fluid towards an exponentially stretching porous sheet with surface heat flux in porous medium, for the boundary layer and heat transfer flow, is ...In this paper, the analytical solution of a viscous and incompressible fluid towards an exponentially stretching porous sheet with surface heat flux in porous medium, for the boundary layer and heat transfer flow, is presented. The equations of continuity, momentum and the energy are transformed into non-linear ordinary differential by using similarity transformation. The solutions of these highly non-linear ordinary differential equations are found analytically by means of Homotopy Analysis Method (HAM). The result obtained by HAM is compared with numerical results presented in the literature. The accuracy of the HAM is indicated by close agreement of the two sets of results. By this method, an expression is obtained which is admissible for all values of effective parameters. This method has the ability to control the convergence of the solution.展开更多
In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutr...In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, neutral and oxidative conditions. Mild degradation was observed in basic conditions. The drug is relatively stable in the solid-state. Successful separation of drug from degradation products formed under stress conditions was achieved on a Kromasil C18 column (250 mm × 4.6 mm, 5.0 μ particle size) using methanol: THF: acetate buffer (68:12:20 v/v) pH adjusted to 6.0 with acetic acid as mobile phase, flow rate was 1.0 mL●min–1 and column was maintained at 45°C. Quantification and linearity was achieved at 307 nm over the concentration range of 0.5 - 160 μg●mL–1 for tenatoprazole. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness.展开更多
Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress te...Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress tensor by measuring strain using an HI strain cell.However,existing analytical solutions for stress calculation based on an HI strain cell in a double-layer medium are not applicable when an HI strain cell is used in a three-layer medium,leading to erroneous stress calculations.To address this issue,this paper presents a method for calculating stress tensors in a three-layer medium using numerical simulations,specifically by obtaining a constitutive matrix that relates strain measurements to stress tensors in a three-layer medium.Furthermore,using Latin hypercube sampling (LHS) and orthogonal experimental design strategies,764 groups of numerical models encompassing various stress measurement scenarios have been established and calculated using FLAC^(3D)software.Finally,a surrogate model based on artificial neural network (ANN) was developed to predict constitutive matrices,achieving a goodness of fit (R^(2)) of 0.999 and a mean squared error (MSE) of 1.254.A software program has been developed from this surrogate model for ease of use in practical engineering applications.The method’s accuracy was verified through numerical simulations,analytical solution and laboratory experiment,demonstrating its effectiveness in calculating stress in a three-layer medium.The surrogate model was applied to calculate mining-induced stress in the roadway roof rock of a coal mine,a typical case for stress measurement in a three-layer medium.Errors in stress calculations arising from the use of existing analytical solutions were corrected.The study also highlights the significant errors associated with using double-layer analytical solutions in a three-layer medium,which could lead to inappropriate engineering design.展开更多
Seismic attenuation has been inherent media characteristics in which an interesting topic of research, for it reflects the seismic waves propagate. There are many factors that cause seismic wave attenuation, such as g...Seismic attenuation has been inherent media characteristics in which an interesting topic of research, for it reflects the seismic waves propagate. There are many factors that cause seismic wave attenuation, such as geometry attenuation caused by energy dissipating during propagation, friction attenuation by relative sliding among rock grains, and scattering attenuation by rock heterogeneity. In this paper we study P-wave scattering attenuation in a random elastic medium by numerical simulations from a statistical point of view. A random elastic medium model is built based on general stochastic process theory. Then a staggered-grid pseudo-spectral method is used to simulate wave propagation. Scattering attenuation is estimated by the spectral ratio method based on virtual detector records. Random elastic media numerical scatter results with various heterogeneity levels show that the higher heterogeneous levels cause greater scattering attenuation. When the scatter sizes are smaller than a wave length, the larger scatters give a greater attenuation. Finally, we propose a method to evaluate fluid-flow attenuation in porous media. The fluid- flow attenuation is derived from total attenuation and scattering attenuation in random porous media and the attenuation is estimated quantitatively. Results show that in the real seismic frequency range when the heterogeneous scale is about 10^1 meters （less than one wave length）, scattering attenuation is larger than fluid-tlow attenuation in random porous media and scattering attenuation is the main factor of seismic attenuation in real heterogeneous porous media.展开更多
基金Supported by the Guangxi Science and Technology Major Projects,No.AA23073012the National Natural Science Foundation of China,No.32360035 and No.32060018。
文摘BACKGROUND Helicobacter pylori(H.pylori),a globally prevalent pathogen,is exhibiting increasing rates of antimicrobial resistance.However,clinical implementation of pre-treatment susceptibility testing remains limited due to the organism’s fastidious growth requirements and prolonged culture time.AIM To propose a novel detection method utilizing antibiotic-supplemented media to inhibit susceptible strains,while resistant isolates were identified through urease-mediated hydrolysis of urea,inducing a phenol red color change for visual confirmation.METHODS Colombia agar was supplemented with urea,phenol red,and nickel chloride,and the final pH was adjusted to 7.35.Antibiotic-selective media were prepared by incorporating amoxicillin(0.5μg/mL),clarithromycin(2μg/mL),metronidazole(8μg/mL),or levofloxacin(2μg/mL)into separate batches.Gastric antral biopsies were homogenized and inoculated at 1.0×105 CFU onto the media,and then incubated under microaerobic conditions at 37°C for 28-36 hours.Resistance was determined based on a color change from yellow to pink,and the results were validated via broth microdilution according to Clinical and Laboratory Standards Institute guidelines.RESULTS After 28-36 hours of incubation,the drug-resistant H.pylori isolates induced a light red color change in the medium.Conversely,susceptible strains(H.pylori 26695 and G27)produced no visible color change.Compared with the conventional 11-day protocol,the novel method significantly reduced detection time.Among 201 clinical isolates,182 were successfully evaluated using the new method,resulting in a 90.5%detection rate.This was consistent with the 95.5%agreement rate observed when compared with microdilution-based susceptibility testing.The success rate of the novel approach was significantly higher than that of the comparative method(P<0.01).The accuracy of the new method was comparable to that of the dilution method.CONCLUSION The novel detection method can rapidly detect H.pylori drug resistance within 28-36 hours.With its operational simplicity and high diagnostic performance,it holds strong potential for clinical application in the management of H.pylori antimicrobial resistance.
基金sponsorship of the National Natural Science Foundation of China(42430809,42274157,42030103,42404132)the Fund of State Key Laboratory of Deep Oil and Gas,China University of Petroleum(East China)(SKLDOG2024-ZYTS-02)+5 种基金the Postdoctoral Fellowship Program of CPSF(GZB20240850)the Postdoctoral Project of Qingdao(QDBSH20240102082)the Fundamental Research Funds for the Central Universities(24CX07004A,24CX06036A)the CNPC Innovation Fund(2024DQ02-0505,2024DQ02-0136)the Innovation fund project for graduate student of China University of Petroleum(East China)the Fundamental Research Funds for the Central Universities(24CX04002A).
文摘Reservoirs with a group of vertical fractures in a vertical transversely isotropic(VTI)background are considered as orthorhombic(ORT)medium.However,fracture detection in ORT medium using seismic inversion methods remains challenging,as it requires the estimation of more than eight parameters.Assuming the reservoir to be a weakly anisotropic ORT medium with small contrasts in the background elastic parameters,a new azimuthal elastic impedance equation was first derived using parameter combinations and mathematical approximations.This equation exhibited almost the same accuracy as the original equation and contained only six model parameters:the compression modulus,anisotropic shear modulus,anisotropic compression modulus,density,normal fracture weakness,and tangential fracture weakness.Subsequently,a stepwise inversion method using second-order derivatives of the elastic impedance was developed to estimate these parameters.Moreover,the Thomsen anisotropy parameter,epsilon,was estimated from the inversion results using the ratio of the anisotropic compression modulus to the compression modulus.Synthetic examples with moderate noise and field data examples confirm the feasibility and effectiveness of the inversion method.The proposed method exhibited accuracy similar to that of previous inversion strategies and could predict richer vertical fracture information.Ultimately,the method was applied to a three-dimensional work area,and the predictions were consistent with logging and geological a priori information,confirming the effectiveness of this method.Summarily,the proposed stepwise inversion method can alleviate the uncertainty of multi-parameter inversion in ORT medium,thereby improving the reliability of fracture detection.
基金financially supported by the National Natural Science Foundation of China (Grant Nos. 41572290, 51479190 and 51879260)the Chinese Fundamental Research (973) Program (Grant No. 2015CB057906)Hubei Provincial Natural Science Foundation of China (Grant No. 2018CFA012)
文摘Permeability is a key parameter to describe fluid transport properties of porous medium; however, the permeability measurement is extremely difficult for tight porous medium, e.g. fine-grained rock or dense soil. In this paper, three methods for gas permeability measurement, i.e. steady state method, pulse decay method(PDM) and pressure oscillation method(POM), are first reviewed and then their advantages and drawbacks are discussed. Both analytical and numerical solutions of gas permeability are presented for the tight porous medium. The results show that the analytical method is relatively simple but only valid under certain conditions, whilst the numerical method is more robust and generic, which can take into account several factors such as porosity, saturation, gas leakage, and unconventional boundary conditions. The influence of the effective porosity on the permeability determination is further analyzed using the proposed numerical method. In this study, new pressure data interpretation procedures for PDM and POM are proposed, and the obtained results can serve as a guidance to define a proper method for permeability measurement of the tight porous medium.
基金the National Basic Research Program (973) of China(No.2011CB013505)
文摘It is an important subject to probe the structure in the medium by various kinds of detection methods in the geotechnical engineering. Based on the propagation theory of elastic wave in half-space layered medium, the propagation characteristics of elastic wave in layered medium with different elastic parameters are discussed using dynamic analysis of finite element method. It is known that the S-wave velocity, density and thickness of layer are related to the properties of the elastic wave including waveform characteristics, spectral characteristics and time-frequency characteristics. We pay special attention to the structure with low velocity interlayer. The impact imaging method is applied to the grouting construction of the immersed tube tunnel. Data acquisition and analytical method are introduced in detail. The grouting effects can be qualitatively evaluated by comparing the characteristics of elastic wave before grouting with those after grouting. Finally, a quantitative evaluation is obtained according to the relationship between energy response of elastic wave and impedance ratio.
基金supported by the National Natural Science Foundation of China (Grant No. 50779012)
文摘A new membrane finite element method for modeling fluid flow in a porous medium is presented in order to quickly and accurately simulate the geo-membrane fabric used in civil engineering. It is based on discontinuous finite element theory, and can be easily coupled with the normal Galerkin finite element method. Based on the saturated seepage equation, the element coefficient matrix of the membrane element method is derived, and a geometric transform relation for the membrane element between a global coordinate system and a local coordinate system is obtained. A method for the determination of the fluid flux conductivity of the membrane element is presented. This method provides a basis for determining discontinuous parameters in discontinuous finite element theory. An anti-seepage problem regarding the foundation of a building is analyzed by coupling the membrane finite element method with the normal Galerkin finite element method. The analysis results demonstrate the utility and superiority of the membrane finite element method in fluid flow analysis of a porous medium.
文摘In the current work, transient heat conduction in a semi-infinite medium is considered for its many applications in various heat fields. Here, the homotopy analysis method （HAM） is applied to solve this problem and analytical results are compared with those of the exact and integral methods results. The results show that the HAM can give much better approximations than the other approximate methods： Changes in heat fluxes and profiles of temperature are obtained at different times and positions for copper, iron and aluminum.
基金supported by the National Natural Science Foundation of China (Grant No 60571058)the Specialized Research Fund for the Doctoral Program of Higher Education Institutions of China (Grant No 20070701010)
文摘Electromagnetic scattering from a rough surface of layered medium is investigated, and the formulae of the scattering coefficients for different polarizations are derived using the small perturbation method. A rough surface with exponential correlation function is presented for describing a rough soil surface of layered medium, the formula of its scattering coefficient is derived by considering the spectrum of the rough surface with exponential correlation function; the curves of the bistatic scattering coefficient of HH polarization with variation of the scattering angle are obtained by numerical calculation. The influence of the permittivity of layered medium, the mean layer thickness of intermediate medium, the roughness surface parameters and the frequency of the incident wave on the blstatic scattering coefficient is discussed. Numerical results show that the influence of the permittivity of layered medium, the mean layer thickness of intermediate medium, the rms and the correlation length of the rough surface, and the frequency of the incident wave on the bistatic scattering coefficient is very complex.
基金National Natural Scienccs Foundation of China (50178005).
文摘In this paper, an explicit finite element method to analyze the dynamic responses of three-medium coupled systems with any terrain is developed on the basis of the numerical simulation of the continuous conditions on the bounda-ries among fluid saturated porous medium, elastic single-phase medium and ideal fluid medium. This method is a very effective one with the characteristic of high calculating speed and small memory needed because the formulae for this explicit finite element method have the characteristic of decoupling, and which does not need to solve sys-tem of linear equations. The method is applied to analyze the dynamic response of a reservoir with considering the dynamic interactions among water, dam, sediment and basement rock. The vertical displacement at the top point of the dam is calculated and some conclusions are given.
文摘This paper presents a technique for Medium Term Load Forecasting (MTLF) using Particle Swarm Optimization (PSO) algorithm based on Least Squares Regression Methods to forecast the electric loads of the Jordanian grid for year of 2015. Linear, quadratic and exponential forecast models have been examined to perform this study and compared with the Auto Regressive (AR) model. MTLF models were influenced by the weather which should be considered when predicting the future peak load demand in terms of months and weeks. The main contribution for this paper is the conduction of MTLF study for Jordan on weekly and monthly basis using real data obtained from National Electric Power Company NEPCO. This study is aimed to develop practical models and algorithm techniques for MTLF to be used by the operators of Jordan power grid. The results are compared with the actual peak load data to attain minimum percentage error. The value of the forecasted weekly and monthly peak loads obtained from these models is examined using Least Square Error (LSE). Actual reported data from NEPCO are used to analyze the performance of the proposed approach and the results are reported and compared with the results obtained from PSO algorithm and AR model.
文摘In this paper, the analytical solution of a viscous and incompressible fluid towards an exponentially stretching porous sheet with surface heat flux in porous medium, for the boundary layer and heat transfer flow, is presented. The equations of continuity, momentum and the energy are transformed into non-linear ordinary differential by using similarity transformation. The solutions of these highly non-linear ordinary differential equations are found analytically by means of Homotopy Analysis Method (HAM). The result obtained by HAM is compared with numerical results presented in the literature. The accuracy of the HAM is indicated by close agreement of the two sets of results. By this method, an expression is obtained which is admissible for all values of effective parameters. This method has the ability to control the convergence of the solution.
文摘In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, neutral and oxidative conditions. Mild degradation was observed in basic conditions. The drug is relatively stable in the solid-state. Successful separation of drug from degradation products formed under stress conditions was achieved on a Kromasil C18 column (250 mm × 4.6 mm, 5.0 μ particle size) using methanol: THF: acetate buffer (68:12:20 v/v) pH adjusted to 6.0 with acetic acid as mobile phase, flow rate was 1.0 mL●min–1 and column was maintained at 45°C. Quantification and linearity was achieved at 307 nm over the concentration range of 0.5 - 160 μg●mL–1 for tenatoprazole. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness.
基金funding support from the National Natural Science Foundation of China (Nos. 42477208 and 52079134)the Natural Science Foundation of Hubei Province, China (No. 2024AFA072)+2 种基金the Youth Innovation Promotion Association CAS (No. 2022332)the National Key R&D Program of China (No. 2024YFF0508203)the Open Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering Safety (Nos. SKLGME-JBGS2402 and SKLGME022022)。
文摘Accurate acquisition of the rock stress is crucial for various rock engineering applications.The hollow inclusion (HI) technique is widely used for measuring in-situ rock stress.This technique calculates the stress tensor by measuring strain using an HI strain cell.However,existing analytical solutions for stress calculation based on an HI strain cell in a double-layer medium are not applicable when an HI strain cell is used in a three-layer medium,leading to erroneous stress calculations.To address this issue,this paper presents a method for calculating stress tensors in a three-layer medium using numerical simulations,specifically by obtaining a constitutive matrix that relates strain measurements to stress tensors in a three-layer medium.Furthermore,using Latin hypercube sampling (LHS) and orthogonal experimental design strategies,764 groups of numerical models encompassing various stress measurement scenarios have been established and calculated using FLAC^(3D)software.Finally,a surrogate model based on artificial neural network (ANN) was developed to predict constitutive matrices,achieving a goodness of fit (R^(2)) of 0.999 and a mean squared error (MSE) of 1.254.A software program has been developed from this surrogate model for ease of use in practical engineering applications.The method’s accuracy was verified through numerical simulations,analytical solution and laboratory experiment,demonstrating its effectiveness in calculating stress in a three-layer medium.The surrogate model was applied to calculate mining-induced stress in the roadway roof rock of a coal mine,a typical case for stress measurement in a three-layer medium.Errors in stress calculations arising from the use of existing analytical solutions were corrected.The study also highlights the significant errors associated with using double-layer analytical solutions in a three-layer medium,which could lead to inappropriate engineering design.
基金supported by the State Key Program of National Natural Science of China (Grant No. 40839901)
文摘Seismic attenuation has been inherent media characteristics in which an interesting topic of research, for it reflects the seismic waves propagate. There are many factors that cause seismic wave attenuation, such as geometry attenuation caused by energy dissipating during propagation, friction attenuation by relative sliding among rock grains, and scattering attenuation by rock heterogeneity. In this paper we study P-wave scattering attenuation in a random elastic medium by numerical simulations from a statistical point of view. A random elastic medium model is built based on general stochastic process theory. Then a staggered-grid pseudo-spectral method is used to simulate wave propagation. Scattering attenuation is estimated by the spectral ratio method based on virtual detector records. Random elastic media numerical scatter results with various heterogeneity levels show that the higher heterogeneous levels cause greater scattering attenuation. When the scatter sizes are smaller than a wave length, the larger scatters give a greater attenuation. Finally, we propose a method to evaluate fluid-flow attenuation in porous media. The fluid- flow attenuation is derived from total attenuation and scattering attenuation in random porous media and the attenuation is estimated quantitatively. Results show that in the real seismic frequency range when the heterogeneous scale is about 10^1 meters （less than one wave length）, scattering attenuation is larger than fluid-tlow attenuation in random porous media and scattering attenuation is the main factor of seismic attenuation in real heterogeneous porous media.
