Biomedical scaffold fabrication has seen advancements in mimicking the native extracellular matrix through intricate three-dimensional(3D)structures conducive to tissue regeneration.Coiled fibrous scaffolds have emerg...Biomedical scaffold fabrication has seen advancements in mimicking the native extracellular matrix through intricate three-dimensional(3D)structures conducive to tissue regeneration.Coiled fibrous scaffolds have emerged as promising substrates owing to their ability to provide unique topographical cues.In this study,coiled poly(ε-caprolactone)(PCL)fibrous bundles were fabricated using an alginate-based composite system,and processed with 3D printing.The unique structure was obtained through the die-swell phenomenon related to the release of residual stresses from the printed strut,thereby transforming aligned PCL fibers into coiled structures.The effects of printing parameters,such as pneumatic pressure and nozzle moving speed,on fiber morphology were investigated to ensure a consistent formation of coiled PCL fibers.The resulting coiled PCL fibrous scaffold demonstrated higher activation of mechanotransduction signaling as well as upregulation of osteogenic-related genes in human adipose stem cells(hASCs),supporting its potential in bone tissue engineering.展开更多
为了制备具有远程可控变形且性能优越的形状记忆聚合物,采用巯基-烯点击化学法制备了PCL/CB复合材料,并用FTIR、DSC、1 H NMR和DMA对复合材料的结构、热性能以及形状记忆特性等进行表征。结果表明:交联复合材料薄膜的热转变温度为50℃,...为了制备具有远程可控变形且性能优越的形状记忆聚合物,采用巯基-烯点击化学法制备了PCL/CB复合材料,并用FTIR、DSC、1 H NMR和DMA对复合材料的结构、热性能以及形状记忆特性等进行表征。结果表明:交联复合材料薄膜的热转变温度为50℃,且当预拉伸的复合材料薄膜受到100 mW/cm^(2)强度的激光照射时,CB颗粒吸收激光光子而产生光热转换且由于各向异性链松弛和应变能释放,致使上层薄膜在受到激光照射时,结晶熔融发生形状记忆效应而收缩,与此同时下层薄膜仍然处于玻璃态,上层薄膜的收缩力使PCL/CB复合材料薄膜朝着激光照射方向发生弯曲变形。同时,弯曲角度可以通过薄膜预拉伸应变量、激光照射时间以及薄膜厚度3个参数进行调控;当预拉伸应变为300%、薄膜厚度为0.4 mm时,最大弯曲角为164°。这种具备局部可编程行为的PCL/CB复合薄膜可为光响应SMP的变形模式提供新思路。展开更多
基金supported by the‘Korea National Institute of Health’research project(2022ER130502)a grant from by SMC-SKKU Future Convergence Academic Research Program,2024supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2024-00336758)。
文摘Biomedical scaffold fabrication has seen advancements in mimicking the native extracellular matrix through intricate three-dimensional(3D)structures conducive to tissue regeneration.Coiled fibrous scaffolds have emerged as promising substrates owing to their ability to provide unique topographical cues.In this study,coiled poly(ε-caprolactone)(PCL)fibrous bundles were fabricated using an alginate-based composite system,and processed with 3D printing.The unique structure was obtained through the die-swell phenomenon related to the release of residual stresses from the printed strut,thereby transforming aligned PCL fibers into coiled structures.The effects of printing parameters,such as pneumatic pressure and nozzle moving speed,on fiber morphology were investigated to ensure a consistent formation of coiled PCL fibers.The resulting coiled PCL fibrous scaffold demonstrated higher activation of mechanotransduction signaling as well as upregulation of osteogenic-related genes in human adipose stem cells(hASCs),supporting its potential in bone tissue engineering.
文摘为了制备具有远程可控变形且性能优越的形状记忆聚合物,采用巯基-烯点击化学法制备了PCL/CB复合材料,并用FTIR、DSC、1 H NMR和DMA对复合材料的结构、热性能以及形状记忆特性等进行表征。结果表明:交联复合材料薄膜的热转变温度为50℃,且当预拉伸的复合材料薄膜受到100 mW/cm^(2)强度的激光照射时,CB颗粒吸收激光光子而产生光热转换且由于各向异性链松弛和应变能释放,致使上层薄膜在受到激光照射时,结晶熔融发生形状记忆效应而收缩,与此同时下层薄膜仍然处于玻璃态,上层薄膜的收缩力使PCL/CB复合材料薄膜朝着激光照射方向发生弯曲变形。同时,弯曲角度可以通过薄膜预拉伸应变量、激光照射时间以及薄膜厚度3个参数进行调控;当预拉伸应变为300%、薄膜厚度为0.4 mm时,最大弯曲角为164°。这种具备局部可编程行为的PCL/CB复合薄膜可为光响应SMP的变形模式提供新思路。
