目的检测单核细胞趋化蛋白(Monocyte chemotactic protein 1,MCP-1)和内脂素/前B细胞克隆因子(Visfantin ormer B cel cloning,Visfantin/PBEF)在妊娠高血压综合征产妇和正常产妇胎盘组织中的表达,探讨二者在妊娠高血压综合征发生发展...目的检测单核细胞趋化蛋白(Monocyte chemotactic protein 1,MCP-1)和内脂素/前B细胞克隆因子(Visfantin ormer B cel cloning,Visfantin/PBEF)在妊娠高血压综合征产妇和正常产妇胎盘组织中的表达,探讨二者在妊娠高血压综合征发生发展过程中的意义。方法收集经临床诊断证实为妊娠高血压综合征产妇及正常产妇的胎盘组织各30例,分娩方式顺产、剖宫产均可,采用免疫组化学法检测标本组织中MCP-1和Visfantin/PBEF俩因子的表达水平。结果在妊娠高血压综合征产妇胎盘组织中MCP-1、Visfantin/PBEF的表达较正常产妇的胎盘组织中MCP-1、Visfantin/PBEF高(<0.05);MCP-1、Visfantin/PBEF在妊娠高血压综合征产妇胎盘组织中的表达呈明显正相关(r=0.436,<0.01)。结论 MCP-1、Visfantin/PBEF在妊娠高血压综合征产妇胎盘组织中高表达,且二者的表达水平呈明显正相关;MCP-1、Visfantin/PBEF表达异常可能与妊娠高血压综合征发生发展有关。展开更多
Focal ischemic stroke（FIS）results from the lack of blood flow in a particular region of the brain and accounts for about 80%of all human strokes.Although tremendous efforts have been made in translational research,t...Focal ischemic stroke（FIS）results from the lack of blood flow in a particular region of the brain and accounts for about 80%of all human strokes.Although tremendous efforts have been made in translational research,the treatment strategies are still limited.Tissue plasminogen activator is the only FDA-approved drug currently available for acute stroke treatment,展开更多
Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression h...Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression has been implicated in several human diseases. In recent years, an increasing attention has been drawn to NAMPT’s role in the pathogenesis of cancer and its value as a therapeutic target in cancer therapy. A molecular nutrition link between NAMPT and cancer looms large among the scientific findings. This review article will be centered on this theme. We will summarize the genomic discoveries of NAMPT in cancer and the current understanding of molecular mechanisms underlying NAMPT in the pathogenesis of cancer, especially on a molecular nutrition link. We will also synopsize several small molecule inhibitors of NAMPT and their potential therapeutic utilities in cancer and usher in some terra incognita of future researches on NAMPT in cancer.展开更多
文摘目的检测单核细胞趋化蛋白(Monocyte chemotactic protein 1,MCP-1)和内脂素/前B细胞克隆因子(Visfantin ormer B cel cloning,Visfantin/PBEF)在妊娠高血压综合征产妇和正常产妇胎盘组织中的表达,探讨二者在妊娠高血压综合征发生发展过程中的意义。方法收集经临床诊断证实为妊娠高血压综合征产妇及正常产妇的胎盘组织各30例,分娩方式顺产、剖宫产均可,采用免疫组化学法检测标本组织中MCP-1和Visfantin/PBEF俩因子的表达水平。结果在妊娠高血压综合征产妇胎盘组织中MCP-1、Visfantin/PBEF的表达较正常产妇的胎盘组织中MCP-1、Visfantin/PBEF高(<0.05);MCP-1、Visfantin/PBEF在妊娠高血压综合征产妇胎盘组织中的表达呈明显正相关(r=0.436,<0.01)。结论 MCP-1、Visfantin/PBEF在妊娠高血压综合征产妇胎盘组织中高表达,且二者的表达水平呈明显正相关;MCP-1、Visfantin/PBEF表达异常可能与妊娠高血压综合征发生发展有关。
基金supported by NIH NS069726 and NS094539America Heart Association 13GRANT17020004(to SD)
文摘Focal ischemic stroke（FIS）results from the lack of blood flow in a particular region of the brain and accounts for about 80%of all human strokes.Although tremendous efforts have been made in translational research,the treatment strategies are still limited.Tissue plasminogen activator is the only FDA-approved drug currently available for acute stroke treatment,
文摘Nicotinamide phosphoribosyl transferase (NAMPT, EC 2.4.2.12), a pleiotropic protein, is a key enzyme for cellular NAD synthesis and may function as a growth factor or cytokine. Dysregulation of NAMPT gene expression has been implicated in several human diseases. In recent years, an increasing attention has been drawn to NAMPT’s role in the pathogenesis of cancer and its value as a therapeutic target in cancer therapy. A molecular nutrition link between NAMPT and cancer looms large among the scientific findings. This review article will be centered on this theme. We will summarize the genomic discoveries of NAMPT in cancer and the current understanding of molecular mechanisms underlying NAMPT in the pathogenesis of cancer, especially on a molecular nutrition link. We will also synopsize several small molecule inhibitors of NAMPT and their potential therapeutic utilities in cancer and usher in some terra incognita of future researches on NAMPT in cancer.
