The sensitive and selective monitoring of nitrogen dioxide(NO_(2))can have a significant impact on environmental monitoring and health protection.Unfortunately,commercial NO_(2)sensors largely suffer from poor detecti...The sensitive and selective monitoring of nitrogen dioxide(NO_(2))can have a significant impact on environmental monitoring and health protection.Unfortunately,commercial NO_(2)sensors largely suffer from poor detection sensitivity and high operating temperatures.In this study,we developed a sensitive roomtemperature NO_(2)sensor based on an n-n heterojunction comprised of a Cs_(2)AgInCl_(6)perovskite with chlorine vacancies(VCl)and TiO_(2)nanotube arrays(VCl-Cs_(2)AgInCl_(6)/TiO_(2)NTs).In this design,the large number of chlorine vacancies in the Cs_(2)AgInCl_(6)perovskite act as active sites for oxygen adsorption and the subsequent sensing reaction.Benefitting from the formation of the n-n type heterojunction and the onedimensional structure of the TiO_(2)nanotubes,the Fermi levels are aligned,thereby facilitating the efficient transport of charge carriers between the target gas and the sensing interface.The resulting VClCs_(2)Ag In Cl_(6)/TiO_(2)NTs demonstrate a high response of 7.26 toward 1 ppm of NO_(2)at room temperature,possess a detection limit as low as 20 ppb,and have outstanding performance stability.This work widens the application of perovskite materials and indicates their potential application in medical diagnostics,environmental monitoring,and smart sensing systems.展开更多
Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticle...Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.展开更多
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of novel coronavirus disease 2019,can cause acute respiratory symptoms and even death globally.However,the immune escape mechanism and vi...Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of novel coronavirus disease 2019,can cause acute respiratory symptoms and even death globally.However,the immune escape mechanism and viral pathogenesis remain poorly understood.Here,we report that the SARS-CoV-23C-like(3CL)protease specifically cleaves gasdermin D(GSDMD)at Q29 and Q193,producing two N-terminal fragments,GSDMD1-29 and GSDMD1-193.We also found that SARS-CoV-2 infection induced the cleavage of GSDMD.Then,we demonstrated that the ability to cleave GSDMD was dependent on the protease activity of the 3CL protease.Interestingly,unlike the GSDMD1-275 fragment cleaved by caspase-1,GSDMD1-29 and GSDMD1-193 did not trigger pyroptosis or inhibit SARS-CoV-2 replication.Additionally,various RNA viral proteases display different preferences for cleaving GSDMD at Q29 and Q193.Our findings reveal a mechanism by which SARS-CoV-2 and other RNA viruses inhibit pyroptosis,highlighting the critical role of the 3CL protease in immune evasion and viral replication.展开更多
Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost n...Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost not been reported.In this work,Bi_(2)YbO_(4)Cl was synthesized using the solid-state method and the solvothermal method.Yb3+ions show a strong characteristic absorption peak at 980 nm,which was measured by ultraviolet-visible-near-infrared absorption spectra.The transient photoconductivity of Bi_(2)YbO_(4)Cl was obtained by time-resolved terahertz spectroscopy system under 400 and 800 nm laser excitations,respectively.The frequency-dependent transient photoconductivity analysis reveals the Drude-Smith behavior in Bi_(2)YbO_(4)Cl.Under photoexcitation,the hot charge carriers with a long relaxation lifetime and a carrier mobility of 48 cm^(2)/(V·s) are obtained.The synthesis of Bi_(2)YbO_(4)Cl is of great significance for the development of novel photocatalytic and photo harvesting materials with broad spectral response.展开更多
基金supported by the National Natural Science Foundation of China(No.22374015)the Fundamental Research Funds for the Central Universities(N2424020)+1 种基金Liaoning Province Foundation for Distinguished Young Scholars(No.1727146584490,to Y.-Y.Song)Liaoning Binhai laboratory(No.LBLG-2024-02)。
文摘The sensitive and selective monitoring of nitrogen dioxide(NO_(2))can have a significant impact on environmental monitoring and health protection.Unfortunately,commercial NO_(2)sensors largely suffer from poor detection sensitivity and high operating temperatures.In this study,we developed a sensitive roomtemperature NO_(2)sensor based on an n-n heterojunction comprised of a Cs_(2)AgInCl_(6)perovskite with chlorine vacancies(VCl)and TiO_(2)nanotube arrays(VCl-Cs_(2)AgInCl_(6)/TiO_(2)NTs).In this design,the large number of chlorine vacancies in the Cs_(2)AgInCl_(6)perovskite act as active sites for oxygen adsorption and the subsequent sensing reaction.Benefitting from the formation of the n-n type heterojunction and the onedimensional structure of the TiO_(2)nanotubes,the Fermi levels are aligned,thereby facilitating the efficient transport of charge carriers between the target gas and the sensing interface.The resulting VClCs_(2)Ag In Cl_(6)/TiO_(2)NTs demonstrate a high response of 7.26 toward 1 ppm of NO_(2)at room temperature,possess a detection limit as low as 20 ppb,and have outstanding performance stability.This work widens the application of perovskite materials and indicates their potential application in medical diagnostics,environmental monitoring,and smart sensing systems.
文摘Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.
基金supported by the National Natural Science Foundation of China(82370015).
文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of novel coronavirus disease 2019,can cause acute respiratory symptoms and even death globally.However,the immune escape mechanism and viral pathogenesis remain poorly understood.Here,we report that the SARS-CoV-23C-like(3CL)protease specifically cleaves gasdermin D(GSDMD)at Q29 and Q193,producing two N-terminal fragments,GSDMD1-29 and GSDMD1-193.We also found that SARS-CoV-2 infection induced the cleavage of GSDMD.Then,we demonstrated that the ability to cleave GSDMD was dependent on the protease activity of the 3CL protease.Interestingly,unlike the GSDMD1-275 fragment cleaved by caspase-1,GSDMD1-29 and GSDMD1-193 did not trigger pyroptosis or inhibit SARS-CoV-2 replication.Additionally,various RNA viral proteases display different preferences for cleaving GSDMD at Q29 and Q193.Our findings reveal a mechanism by which SARS-CoV-2 and other RNA viruses inhibit pyroptosis,highlighting the critical role of the 3CL protease in immune evasion and viral replication.
基金Project supported by the National Natural Science Foundation of China (61988102)the Key-Area Research and Development Program of Guangdong Province(2019B090917007)the Science and Technology Planning Project of Guangdong Province (2019B090909011)。
文摘Bi_(2)YbO_(4)Cl with a fluorite layer structure belongs to the family of the bismuth rare-earth oxyhalides Bi_(2)REO_(4)X(X=Cl,B r,I).However,the synthesis and photoelectric properties of Bi_(2)YbO_(4)Cl have almost not been reported.In this work,Bi_(2)YbO_(4)Cl was synthesized using the solid-state method and the solvothermal method.Yb3+ions show a strong characteristic absorption peak at 980 nm,which was measured by ultraviolet-visible-near-infrared absorption spectra.The transient photoconductivity of Bi_(2)YbO_(4)Cl was obtained by time-resolved terahertz spectroscopy system under 400 and 800 nm laser excitations,respectively.The frequency-dependent transient photoconductivity analysis reveals the Drude-Smith behavior in Bi_(2)YbO_(4)Cl.Under photoexcitation,the hot charge carriers with a long relaxation lifetime and a carrier mobility of 48 cm^(2)/(V·s) are obtained.The synthesis of Bi_(2)YbO_(4)Cl is of great significance for the development of novel photocatalytic and photo harvesting materials with broad spectral response.
