In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, wh...In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, which have caused her failure in the fulfillment of her view of freedom.展开更多
I wish to explore the idea that thought experiments are best accounted for as a special case of a narrative that features an interplay between puzzles and paradoxes. Furthermore, I believe the more successfully though...I wish to explore the idea that thought experiments are best accounted for as a special case of a narrative that features an interplay between puzzles and paradoxes. Furthermore, I believe the more successfully thought experiments manage to combine puzzles and paradoxes the more insightful and instructive they become. I suggest the latter kind of thought experiments also use the technique of mental variation.展开更多
Based on an analytical solution for the current point source in an anisotropic half-space,we study the apparent resistivity and apparent chargeability of a transversely isotropic medium with vertical and horizontal ax...Based on an analytical solution for the current point source in an anisotropic half-space,we study the apparent resistivity and apparent chargeability of a transversely isotropic medium with vertical and horizontal axes symmetry,respectively.We then provide a simple derivation of the anisotropy paradoxes in direct current resistivity and time-domain induced polarization methods.Analogous to the mean resistivity,we propose a formulation for deriving the mean polarizability.We also present a three-dimensional finite element algorithm for modeling the direct current resistivity and time-domain induced polarization using an unstructured tetrahedral grid.Finally,we provide the apparent resistivity and apparent chargeability curves of a tilted,transversely isotropic medium with diff erent angles,respectively.The subsequent results illustrate the anisotropy paradoxes of direct current resistivity and time-domain induced polarization.展开更多
It is generally believed a variation of 3He/4He isotopic ratios in the mantle is due to only the decay of U and Th,which produces4 He as well as heat.Here we show that not only3He/4He isotopic ratios but also helium c...It is generally believed a variation of 3He/4He isotopic ratios in the mantle is due to only the decay of U and Th,which produces4 He as well as heat.Here we show that not only3He/4He isotopic ratios but also helium contents can be fractionated by thermal diffusion in the lower mantle.The driving force for that fractionation is the adiabatic or convective temperature gradient,which always produces elemental and isotopic fractionation along temperature gradient by thermal diffusion with higher light/heavy isotopic ratio in the hot end.Our theoretical model and calculations indicate that the lower mantle is helium stratified,caused by thermal diffusion due to*400℃temperature contrast across the lower mantle.The highest3He/4He isotopic ratios and lowest He contents are in the lowermost mantle,which is a consequence of thermaldiffusion fractionation rather than the lower mantle is a primordial and undegassed reservoir.Therefore,oceanicisland basalts derived from the deepest lower mantle with high3He/4He isotopic ratios and less He contents—the long-standing helium paradox,is solved by our model.Because vigorous convection in the upper mantle had resulted in disordered or disorganized thermal-diffusion effects in He,Mid-ocean ridge basalts unaffected by mantle plume have a relatively homogenous and lower!3He/4He isotopic compositions.Our model also predicts that 3He/4He isotopic ratios in the deepest lower mantle of early Earth could be even higher than that of Jupiter,the initial He isotopic ratio in our solar system,because the temperature contrast across the lower mantle in the early Earth is the largest and less4 He had been produced by the decay of U and Th.Moreover,the early helium-stratified lower mantle owned the lowest He contents due to over-degassing caused by the largest temperature contrast.Consequently,succeeding evolution of the lower mantle is a He ingassed process due to secular cooling of the deepest mantle.This explains why significant amount of He produced by the decay of U and Th in the lower mantle were not released,another long-standing heat–helium paradox.展开更多
A new mathematical expectation formula with some hypotheses, notions and propositions was given to get rid of the challenge of St. Petersburg paradox and Pascal's wager. Relevant results show that it is very effec...A new mathematical expectation formula with some hypotheses, notions and propositions was given to get rid of the challenge of St. Petersburg paradox and Pascal's wager. Relevant results show that it is very effective to apply the model to solve the expected revenue problems containing random events with low proba-bility but high revenue. This work also provides the probability theory with a more widely applied perspective in group decision-making.展开更多
This paper provides a clear analysis of how hypothetical concepts not allowed in Special Relativity should be treated and exposes hidden assumptions in space-time diagrams used on YouTube, where some prominent physici...This paper provides a clear analysis of how hypothetical concepts not allowed in Special Relativity should be treated and exposes hidden assumptions in space-time diagrams used on YouTube, where some prominent physicists have taken to publishing on popular topics that may not survive peer review. Such casual graphical treatment conceals the fact that space-time diagrams provide only for the Einstein synchronization convention for all observers, not the many other valid synchronization protocols, and also obscure that relativity’s equality of reference frames is rebutted if concepts outside relativity, such as instant communication, are introduced. These omissions of unconscious assumptions have been used to “prove” the existence of block time and time travel or time paradoxes. We will show the contradictory assumptions amount to assuming time travel, rather than the more mundane need to adjust synchronization conventions. We further show a new result that the use of the space-time diagrams as proposed by these “explainers” leads to discontinuities in which a differential change in communication speed leads to a sudden jump from present to long-past arrival time, strongly suggesting invalidity of the method.展开更多
In light of the recently published Western Han period bamboo-slip Laozi, now in the collection of Peking University, this paper explores several paradoxes in the textual development of the Laozi. Specifically, it pres...In light of the recently published Western Han period bamboo-slip Laozi, now in the collection of Peking University, this paper explores several paradoxes in the textual development of the Laozi. Specifically, it presents two examples suggesting that since the wording in the Laozi was originally intended to be ambiguous and paradoxical, during the transmission of the text, the compilers or commentators modified some of the paradoxes to make better sense. Eventually those modifications came to replace the original text. In the first part of this article examines certain contrasting differences in Chapter Eight from the Beida Laozi, the Mawangdui Laozi, and the received Laozi. The second part, I examine certain other contrasting differences from these same versions from Chapter Twenty-Four are discussed. This paper argues that these differences among the various versions are not the product of transcribal error; rather, they are the result of compilers or commentators who revised these passages against their earliest versions in order to make the meaning clearer and more explicit.展开更多
The supreme triumph of reason is to cast doubt upon ixs own validity.--Miguel de Unamuno理智的最大胜利在于对其自身的正确性提出了怀疑。米格尔·德·乌纳穆诺(1864-1936,西班牙教育家,哲学家及作家)Boredom-the desire...The supreme triumph of reason is to cast doubt upon ixs own validity.--Miguel de Unamuno理智的最大胜利在于对其自身的正确性提出了怀疑。米格尔·德·乌纳穆诺(1864-1936,西班牙教育家,哲学家及作家)Boredom-the desire for desires. --Leo Tolstoy厌烦--寻求欲望的欲望。列·托尔斯泰(1828-1910,俄国作家,思想家)The only way to get rid of a temptation is to yield to it.--Oscar展开更多
This article is concerned with paradoxes in 2×2×n contingency tables, suchas Simpson’s paradox, in which the association in the 2 × 2 marginal table is quite different from the associations in the 2 &#...This article is concerned with paradoxes in 2×2×n contingency tables, suchas Simpson’s paradox, in which the association in the 2 × 2 marginal table is quite different from the associations in the 2 × 2 partial tables. We prove that if the relative number of observations in each row of each partial table or in each column of each partial table is constant, then Simpson’s paradox cannot occur. We also prove that under a certain condition, the paradox cannot occur if the odds ratios in the partial tables are uniformly greater than a lower bound (e.g. ＞ 1.125) or uniformly less than some upper bound.Finally, we show that Simpson’s paradox and an amalgamation paradox cannot occur if certain ratios of cell counts are constant in the partial tables.展开更多
There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al...There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.展开更多
Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understand...Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understanding of friendship paradox is very limited.Only few works provide theoretical evidence of single-step and multi-step friendship paradoxes,given that the neighbors of interest are onehop and multi-hop away from the target node.However,they consider non-evolving networks,as opposed to the topology of real social networks that are constantly growing over time.We are thus motivated to present a first look into friendship paradox in evolving networks,where newly added nodes preferentially attach themselves to those with higher degrees.Our analytical verification of both single-step and multistep friendship paradoxes in evolving networks,along with comparison to the non-evolving counterparts,discloses that“friendship paradox is even more paradoxical in evolving networks”,primarily from three aspects:1)we demonstrate a strengthened effect of single-step friendship paradox in evolving networks,with a larger probability(more than 0.8)of a random node’s neighbors having higher average degree than the random node itself;2)we unravel higher effectiveness of multi-step friendship paradox in seeking for influential nodes in evolving networks,as the rate of reaching the max degree node can be improved by a factor of at least Θ(t^(2/3))with t being the network size;3)we empirically verify our findings through both synthetic and real datasets,which suggest high agreements of results and consolidate the reasonability of evolving model for real social networks.展开更多
Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of ...Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.展开更多
The“obesity paradox”in hepatocellular carcinoma(HCC)suggests patients with obesity may experience better treatment outcomes compared to patients without obesity.Wang et al highlighted this paradox in HCC immunothera...The“obesity paradox”in hepatocellular carcinoma(HCC)suggests patients with obesity may experience better treatment outcomes compared to patients without obesity.Wang et al highlighted this paradox in HCC immunotherapy,demonstrating superior progression-free survival and overall survival in patients with overweight and obesity treated with lenvatinib and camrelizumab,focusing on hepatitis B virus-related HCC.Mechanisms such as better nutritional reserves,leptin-mediated immune modulation,and reduced protein breakdown may explain these outcomes.Obesity’s role in anti-programmed cell death protein-1 therapy appears could have a benefit,while its effects on other treatments,such as anti-vascular endothelial growth factor therapy,may reduce efficacy.Further research is needed to explore how obesity influences the effectiveness of other most common immunotherapies like nivolumab,pembrolizumab,and bevacizumab,and whether weight loss as well as weight-loss related sarcopenia impacts these benefits.展开更多
For the first time in human history,hundreds of millions of people all over the world have been subjected to compulsory vaccination with a new type of nucleic acid based vaccines in order to keep their jobs or be able...For the first time in human history,hundreds of millions of people all over the world have been subjected to compulsory vaccination with a new type of nucleic acid based vaccines in order to keep their jobs or be able to travel due to some notorious coronavirus disease 2019(COVID-19)mandates.The vast majority of African countries were either initially deprived of these vaccines,or later,a majority of the population was too skeptical to receive them and preferred a safe early treatment pharmacological approach.Yet,Africa had the lowest COVID-19 mortality rate compared to those countries that adopted mass vaccination.This letter to the editor adds African insights that should be helpful in future pandemics to save millions of precious lives.展开更多
Hydrogenation catalysts frequently impose a compromise between activity and selectivity,where maximizing one property inevitably diminishes the other.Researchers from the Dalian Institute of Chemical Physics(DICP)of t...Hydrogenation catalysts frequently impose a compromise between activity and selectivity,where maximizing one property inevitably diminishes the other.Researchers from the Dalian Institute of Chemical Physics(DICP)of the Chinese Academy of Sciences,in collaboration with scholars from University of Science and Technology of China and the Karlsruhe Institute of Technology in Germany,cracked this dilemma by engineering bimetallic catalysts with atomic precision-a breakthrough that boosts hydrogenation efficiency by 35-fold while maintaining pinpoint accuracy,resolving the stubborn activity-selectivity paradox.展开更多
What laws do the universe naturally operate according to?What should be the logical foundation of the human real world?This is a foundational and fundamental issue that humans have always wanted to clarify.From Thales...What laws do the universe naturally operate according to?What should be the logical foundation of the human real world?This is a foundational and fundamental issue that humans have always wanted to clarify.From Thales to philosophers such as Socrates,Plato,and Aristotle,ancient Greece achieved the origin and development of philosophy;Later,Descartes,Hume,Kant,Hegel,Nietzsche,and others explored new fields and concepts;Philosophers such as Husserl,Sartre,Russell,Wittgenstein,and Derrida left a profound mark in the 20th century.The emergence of a worldview emerged in the ancient Indian Vedas,and later in the religious and philosophical work The Upanishads,there was a discourse on the entities of"Brahma"and"I",which gave rise to the idea of"Advaita"in later generations.The Book of Changes was born in ancient China,along with major academic schools such as Taoism,Confucianism,Legalism,and Mohism.Later,Buddhist thought was integrated;With the Eastern ideas of yin and yang,the Doctrine of the Mean,harmony,and the ultimate goodness,I have integrated Eastern and Western historical philosophies,modern physics,and classical logic theories in my thinking on the principle of cosmic paradox,proposing a new perspective of understanding the essence of the universe and its natural logical relationship structure using the principle of paradox as the law of cosmic operation.The theoretical exploration and discussion of the dual nature relationship of"non-contradiction"and"contradiction"in the"first contradiction"relationship of things in the universe,that is,the identity of the universe is a self-contradictory overall transformation process;Attempting to reveal the paradoxical relationship of the universe from a new perspective in modern science,philosophy,and logic,striving to have a beneficial impact on the exploration and practical application of sustainable human survival and development models in the future.展开更多
Transportation problem has many real world applications, it can be solved by linear programming model, but in most time the model exists more for less paradox, this paper considers the reasons for the paradox and s...Transportation problem has many real world applications, it can be solved by linear programming model, but in most time the model exists more for less paradox, this paper considers the reasons for the paradox and search the way to eliminate the phenomenon. First this paper formulates a loose constrained linear programming model for the transportation problem, and gives the definition of the paradox which exists in it, some preliminary notions and one example is also given. Then it gives a table based algorithm for the loose constrained model, the steps of the algorithm and example will follow. The examples show that: (1) It is not a contradictory that transportation problem exists more for less paradox. (2) The loose constrained model is better used in practice for its less total cost. (3) The algorithm is easy to calculate, to study and highly speed to convergence. Finally, comparied with other ways it shows that the loose constrained model can thoroughly eliminate the paradox.展开更多
文摘In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, which have caused her failure in the fulfillment of her view of freedom.
文摘I wish to explore the idea that thought experiments are best accounted for as a special case of a narrative that features an interplay between puzzles and paradoxes. Furthermore, I believe the more successfully thought experiments manage to combine puzzles and paradoxes the more insightful and instructive they become. I suggest the latter kind of thought experiments also use the technique of mental variation.
基金the special funding of Guiyang science and technology bureau and Guiyang University[GYUKY-[2021]]the National Key Research and Development Program of China-Geophysical Comprehensive Exploration and Information Extraction of Deep Mineral Resources(2016YFC0600505)the National K&D Program(2018YFC1504901,2018YFC1504904).
文摘Based on an analytical solution for the current point source in an anisotropic half-space,we study the apparent resistivity and apparent chargeability of a transversely isotropic medium with vertical and horizontal axes symmetry,respectively.We then provide a simple derivation of the anisotropy paradoxes in direct current resistivity and time-domain induced polarization methods.Analogous to the mean resistivity,we propose a formulation for deriving the mean polarizability.We also present a three-dimensional finite element algorithm for modeling the direct current resistivity and time-domain induced polarization using an unstructured tetrahedral grid.Finally,we provide the apparent resistivity and apparent chargeability curves of a tilted,transversely isotropic medium with diff erent angles,respectively.The subsequent results illustrate the anisotropy paradoxes of direct current resistivity and time-domain induced polarization.
基金Funding for this study comes from the Strategic Priority Research Program (B) of CAS (XDB18010100)the Chinese NSF projects (41490635, 41530210, 41225012, 41573040)
文摘It is generally believed a variation of 3He/4He isotopic ratios in the mantle is due to only the decay of U and Th,which produces4 He as well as heat.Here we show that not only3He/4He isotopic ratios but also helium contents can be fractionated by thermal diffusion in the lower mantle.The driving force for that fractionation is the adiabatic or convective temperature gradient,which always produces elemental and isotopic fractionation along temperature gradient by thermal diffusion with higher light/heavy isotopic ratio in the hot end.Our theoretical model and calculations indicate that the lower mantle is helium stratified,caused by thermal diffusion due to*400℃temperature contrast across the lower mantle.The highest3He/4He isotopic ratios and lowest He contents are in the lowermost mantle,which is a consequence of thermaldiffusion fractionation rather than the lower mantle is a primordial and undegassed reservoir.Therefore,oceanicisland basalts derived from the deepest lower mantle with high3He/4He isotopic ratios and less He contents—the long-standing helium paradox,is solved by our model.Because vigorous convection in the upper mantle had resulted in disordered or disorganized thermal-diffusion effects in He,Mid-ocean ridge basalts unaffected by mantle plume have a relatively homogenous and lower!3He/4He isotopic compositions.Our model also predicts that 3He/4He isotopic ratios in the deepest lower mantle of early Earth could be even higher than that of Jupiter,the initial He isotopic ratio in our solar system,because the temperature contrast across the lower mantle in the early Earth is the largest and less4 He had been produced by the decay of U and Th.Moreover,the early helium-stratified lower mantle owned the lowest He contents due to over-degassing caused by the largest temperature contrast.Consequently,succeeding evolution of the lower mantle is a He ingassed process due to secular cooling of the deepest mantle.This explains why significant amount of He produced by the decay of U and Th in the lower mantle were not released,another long-standing heat–helium paradox.
基金the Scientific Research Foundation of Hunan Education Department (No. 05C185)
文摘A new mathematical expectation formula with some hypotheses, notions and propositions was given to get rid of the challenge of St. Petersburg paradox and Pascal's wager. Relevant results show that it is very effective to apply the model to solve the expected revenue problems containing random events with low proba-bility but high revenue. This work also provides the probability theory with a more widely applied perspective in group decision-making.
文摘This paper provides a clear analysis of how hypothetical concepts not allowed in Special Relativity should be treated and exposes hidden assumptions in space-time diagrams used on YouTube, where some prominent physicists have taken to publishing on popular topics that may not survive peer review. Such casual graphical treatment conceals the fact that space-time diagrams provide only for the Einstein synchronization convention for all observers, not the many other valid synchronization protocols, and also obscure that relativity’s equality of reference frames is rebutted if concepts outside relativity, such as instant communication, are introduced. These omissions of unconscious assumptions have been used to “prove” the existence of block time and time travel or time paradoxes. We will show the contradictory assumptions amount to assuming time travel, rather than the more mundane need to adjust synchronization conventions. We further show a new result that the use of the space-time diagrams as proposed by these “explainers” leads to discontinuities in which a differential change in communication speed leads to a sudden jump from present to long-past arrival time, strongly suggesting invalidity of the method.
文摘In light of the recently published Western Han period bamboo-slip Laozi, now in the collection of Peking University, this paper explores several paradoxes in the textual development of the Laozi. Specifically, it presents two examples suggesting that since the wording in the Laozi was originally intended to be ambiguous and paradoxical, during the transmission of the text, the compilers or commentators modified some of the paradoxes to make better sense. Eventually those modifications came to replace the original text. In the first part of this article examines certain contrasting differences in Chapter Eight from the Beida Laozi, the Mawangdui Laozi, and the received Laozi. The second part, I examine certain other contrasting differences from these same versions from Chapter Twenty-Four are discussed. This paper argues that these differences among the various versions are not the product of transcribal error; rather, they are the result of compilers or commentators who revised these passages against their earliest versions in order to make the meaning clearer and more explicit.
文摘The supreme triumph of reason is to cast doubt upon ixs own validity.--Miguel de Unamuno理智的最大胜利在于对其自身的正确性提出了怀疑。米格尔·德·乌纳穆诺(1864-1936,西班牙教育家,哲学家及作家)Boredom-the desire for desires. --Leo Tolstoy厌烦--寻求欲望的欲望。列·托尔斯泰(1828-1910,俄国作家,思想家)The only way to get rid of a temptation is to yield to it.--Oscar
文摘This article is concerned with paradoxes in 2×2×n contingency tables, suchas Simpson’s paradox, in which the association in the 2 × 2 marginal table is quite different from the associations in the 2 × 2 partial tables. We prove that if the relative number of observations in each row of each partial table or in each column of each partial table is constant, then Simpson’s paradox cannot occur. We also prove that under a certain condition, the paradox cannot occur if the odds ratios in the partial tables are uniformly greater than a lower bound (e.g. ＞ 1.125) or uniformly less than some upper bound.Finally, we show that Simpson’s paradox and an amalgamation paradox cannot occur if certain ratios of cell counts are constant in the partial tables.
文摘There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.
基金supported by NSF China(No.61960206002,62020106005,42050105,62061146002)Shanghai Pilot Program for Basic Research–Shanghai Jiao Tong University.
文摘Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understanding of friendship paradox is very limited.Only few works provide theoretical evidence of single-step and multi-step friendship paradoxes,given that the neighbors of interest are onehop and multi-hop away from the target node.However,they consider non-evolving networks,as opposed to the topology of real social networks that are constantly growing over time.We are thus motivated to present a first look into friendship paradox in evolving networks,where newly added nodes preferentially attach themselves to those with higher degrees.Our analytical verification of both single-step and multistep friendship paradoxes in evolving networks,along with comparison to the non-evolving counterparts,discloses that“friendship paradox is even more paradoxical in evolving networks”,primarily from three aspects:1)we demonstrate a strengthened effect of single-step friendship paradox in evolving networks,with a larger probability(more than 0.8)of a random node’s neighbors having higher average degree than the random node itself;2)we unravel higher effectiveness of multi-step friendship paradox in seeking for influential nodes in evolving networks,as the rate of reaching the max degree node can be improved by a factor of at least Θ(t^(2/3))with t being the network size;3)we empirically verify our findings through both synthetic and real datasets,which suggest high agreements of results and consolidate the reasonability of evolving model for real social networks.
基金The Trùndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trùndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public HealthThe coordination of European Prospective Investigation into Cancer and Nutrition - Spain study (EPIC) is financially supported by the International Agency for Research on Cancer (IARC)+7 种基金by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC)supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc 1a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)funded by The Netherlands Organisation for Health Research and DevelopmentZon Mw (Grant No.: 531-00141-3)Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBFidentification codes 01 ZZ96030, 01 ZZ0103, and 01 ZZ0701)support from the Swedish Research Council (2018-02527 and 2019-00193)financed by the Helmholtz Zentrum München - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.
文摘Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.
文摘The“obesity paradox”in hepatocellular carcinoma(HCC)suggests patients with obesity may experience better treatment outcomes compared to patients without obesity.Wang et al highlighted this paradox in HCC immunotherapy,demonstrating superior progression-free survival and overall survival in patients with overweight and obesity treated with lenvatinib and camrelizumab,focusing on hepatitis B virus-related HCC.Mechanisms such as better nutritional reserves,leptin-mediated immune modulation,and reduced protein breakdown may explain these outcomes.Obesity’s role in anti-programmed cell death protein-1 therapy appears could have a benefit,while its effects on other treatments,such as anti-vascular endothelial growth factor therapy,may reduce efficacy.Further research is needed to explore how obesity influences the effectiveness of other most common immunotherapies like nivolumab,pembrolizumab,and bevacizumab,and whether weight loss as well as weight-loss related sarcopenia impacts these benefits.
文摘For the first time in human history,hundreds of millions of people all over the world have been subjected to compulsory vaccination with a new type of nucleic acid based vaccines in order to keep their jobs or be able to travel due to some notorious coronavirus disease 2019(COVID-19)mandates.The vast majority of African countries were either initially deprived of these vaccines,or later,a majority of the population was too skeptical to receive them and preferred a safe early treatment pharmacological approach.Yet,Africa had the lowest COVID-19 mortality rate compared to those countries that adopted mass vaccination.This letter to the editor adds African insights that should be helpful in future pandemics to save millions of precious lives.
文摘Hydrogenation catalysts frequently impose a compromise between activity and selectivity,where maximizing one property inevitably diminishes the other.Researchers from the Dalian Institute of Chemical Physics(DICP)of the Chinese Academy of Sciences,in collaboration with scholars from University of Science and Technology of China and the Karlsruhe Institute of Technology in Germany,cracked this dilemma by engineering bimetallic catalysts with atomic precision-a breakthrough that boosts hydrogenation efficiency by 35-fold while maintaining pinpoint accuracy,resolving the stubborn activity-selectivity paradox.
文摘What laws do the universe naturally operate according to?What should be the logical foundation of the human real world?This is a foundational and fundamental issue that humans have always wanted to clarify.From Thales to philosophers such as Socrates,Plato,and Aristotle,ancient Greece achieved the origin and development of philosophy;Later,Descartes,Hume,Kant,Hegel,Nietzsche,and others explored new fields and concepts;Philosophers such as Husserl,Sartre,Russell,Wittgenstein,and Derrida left a profound mark in the 20th century.The emergence of a worldview emerged in the ancient Indian Vedas,and later in the religious and philosophical work The Upanishads,there was a discourse on the entities of"Brahma"and"I",which gave rise to the idea of"Advaita"in later generations.The Book of Changes was born in ancient China,along with major academic schools such as Taoism,Confucianism,Legalism,and Mohism.Later,Buddhist thought was integrated;With the Eastern ideas of yin and yang,the Doctrine of the Mean,harmony,and the ultimate goodness,I have integrated Eastern and Western historical philosophies,modern physics,and classical logic theories in my thinking on the principle of cosmic paradox,proposing a new perspective of understanding the essence of the universe and its natural logical relationship structure using the principle of paradox as the law of cosmic operation.The theoretical exploration and discussion of the dual nature relationship of"non-contradiction"and"contradiction"in the"first contradiction"relationship of things in the universe,that is,the identity of the universe is a self-contradictory overall transformation process;Attempting to reveal the paradoxical relationship of the universe from a new perspective in modern science,philosophy,and logic,striving to have a beneficial impact on the exploration and practical application of sustainable human survival and development models in the future.
文摘Transportation problem has many real world applications, it can be solved by linear programming model, but in most time the model exists more for less paradox, this paper considers the reasons for the paradox and search the way to eliminate the phenomenon. First this paper formulates a loose constrained linear programming model for the transportation problem, and gives the definition of the paradox which exists in it, some preliminary notions and one example is also given. Then it gives a table based algorithm for the loose constrained model, the steps of the algorithm and example will follow. The examples show that: (1) It is not a contradictory that transportation problem exists more for less paradox. (2) The loose constrained model is better used in practice for its less total cost. (3) The algorithm is easy to calculate, to study and highly speed to convergence. Finally, comparied with other ways it shows that the loose constrained model can thoroughly eliminate the paradox.
