Cadaverine. a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various appli...Cadaverine. a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various applications, especially as an important monomer for bio-based polyamides. Cadaverine-based polyamide PA 5X has broad application prospects owing to its environmentally friendly characteristics and exceptional performance in water absorption and dimensional stability. In this review, we summarize recent findings on the biosynthesis, metabolism, and physiological function of cadaverine in bacteria, with a focus on the regu- latory mechanism of cadaverine synthesis in Escherichia coil （E. coli）. We also describe recent developments in bacterial production of cadaverine by direct fermentation and whole-cell bioconversion, and recent approaches for the separation and purification of cadaverine. In addition, we present an overview of the ap- plication of cadaverine in the synthesis of completely bio-based polyamides. Finally. we provide an outlook and suggest future developments to advance the production of cadaverine from renewable resources.展开更多
基金This work was supported by the National Key Research and Development Program （2016YFA0204300） the National Natural Science Foundation of China （21390200, 31440024） and the Tech- nology Support Program of Gansu Provincial S＆T Department, China （1304FKCE106）.
文摘Cadaverine. a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various applications, especially as an important monomer for bio-based polyamides. Cadaverine-based polyamide PA 5X has broad application prospects owing to its environmentally friendly characteristics and exceptional performance in water absorption and dimensional stability. In this review, we summarize recent findings on the biosynthesis, metabolism, and physiological function of cadaverine in bacteria, with a focus on the regu- latory mechanism of cadaverine synthesis in Escherichia coil （E. coli）. We also describe recent developments in bacterial production of cadaverine by direct fermentation and whole-cell bioconversion, and recent approaches for the separation and purification of cadaverine. In addition, we present an overview of the ap- plication of cadaverine in the synthesis of completely bio-based polyamides. Finally. we provide an outlook and suggest future developments to advance the production of cadaverine from renewable resources.
