目的:分析人脑胶质瘤术后复发的诱导因素。方法:通过SEER*Stat(8.3.8版本)软件搜集SEER数据库2019—2023年均接受显微手术治疗的人脑胶质瘤病例731例,依据术后复发情况,将患者分为复发组(182例)与未复发组(549例),采用一般资料调查表收...目的:分析人脑胶质瘤术后复发的诱导因素。方法:通过SEER*Stat(8.3.8版本)软件搜集SEER数据库2019—2023年均接受显微手术治疗的人脑胶质瘤病例731例,依据术后复发情况,将患者分为复发组(182例)与未复发组(549例),采用一般资料调查表收集并整理两组患者临床资料,采用单因素及多因素分析人脑胶质瘤术后复发的诱导因素。结果:单因素分析发现,两组年龄、病理分级、肿瘤直径、是否放化疗、细胞质多聚腺苷酸化元件结合蛋白4(cytoplasmic polyadenylation element binding protein 4,CPEB4)表达水平、miR-542-3p表达水平比较,差异有统计学意义(P<0.05)。Logistic回归分析发现,年龄≥50岁、病理分级Ⅲ~Ⅳ级、肿瘤直径≥4cm、CPEB4高表达、miR-542-3p低表达为人脑胶质瘤患者术后复发的诱导因素(P<0.05)。结论:存在年龄≥50岁、病理分级Ⅲ~Ⅳ级、肿瘤直径≥4cm、CPEB4高表达、miR-542-3p低表达的人脑胶质瘤患者术后复发的风险较高,医务人员应予以重视,及时采取有效预防措施,以降低术后复发率。展开更多
Tectonic movements and climate changes are two main controllers on the development of landform. In order to reconstruct the history of the evolution of the landform in the Fenhe drainage basin d...Tectonic movements and climate changes are two main controllers on the development of landform. In order to reconstruct the history of the evolution of the landform in the Fenhe drainage basin during middle-late Quaternary comprehensively, this paper has provided a variety of geomorphological and geologic evidences to discuss how tectonic movements and climate changes worked together to influence the landform processes. According to the features of the lacustrine and alluvial terraces in this drainage basin, it is deduced that it was the three tectonic uplifts that resulted in the three great lake-regressions with an extent of about 40-60 m and the formation of the three lacustrine terraces. The times when the tectonic uplifts took place are 0.76 MaBP, 0.55 MaBP and 0.13 MaBP respectively, synchronous with the formation of paleosol units S 8 , S 5 and S 1 respectively. During the intervals between two tectonic uplifts when tectonic movement was very weak, climate changes played a major role in the evolution of the paleolakes and caused frequent fluctuations of lake levels. The changes of the features of lacustrine sediment in the grabens show the extent of such fluctuations of lake level is about 2-3 m.展开更多
文摘目的:分析人脑胶质瘤术后复发的诱导因素。方法:通过SEER*Stat(8.3.8版本)软件搜集SEER数据库2019—2023年均接受显微手术治疗的人脑胶质瘤病例731例,依据术后复发情况,将患者分为复发组(182例)与未复发组(549例),采用一般资料调查表收集并整理两组患者临床资料,采用单因素及多因素分析人脑胶质瘤术后复发的诱导因素。结果:单因素分析发现,两组年龄、病理分级、肿瘤直径、是否放化疗、细胞质多聚腺苷酸化元件结合蛋白4(cytoplasmic polyadenylation element binding protein 4,CPEB4)表达水平、miR-542-3p表达水平比较,差异有统计学意义(P<0.05)。Logistic回归分析发现,年龄≥50岁、病理分级Ⅲ~Ⅳ级、肿瘤直径≥4cm、CPEB4高表达、miR-542-3p低表达为人脑胶质瘤患者术后复发的诱导因素(P<0.05)。结论:存在年龄≥50岁、病理分级Ⅲ~Ⅳ级、肿瘤直径≥4cm、CPEB4高表达、miR-542-3p低表达的人脑胶质瘤患者术后复发的风险较高,医务人员应予以重视,及时采取有效预防措施,以降低术后复发率。
基金National Natural Science Foundation of China No.40071016
文摘Tectonic movements and climate changes are two main controllers on the development of landform. In order to reconstruct the history of the evolution of the landform in the Fenhe drainage basin during middle-late Quaternary comprehensively, this paper has provided a variety of geomorphological and geologic evidences to discuss how tectonic movements and climate changes worked together to influence the landform processes. According to the features of the lacustrine and alluvial terraces in this drainage basin, it is deduced that it was the three tectonic uplifts that resulted in the three great lake-regressions with an extent of about 40-60 m and the formation of the three lacustrine terraces. The times when the tectonic uplifts took place are 0.76 MaBP, 0.55 MaBP and 0.13 MaBP respectively, synchronous with the formation of paleosol units S 8 , S 5 and S 1 respectively. During the intervals between two tectonic uplifts when tectonic movement was very weak, climate changes played a major role in the evolution of the paleolakes and caused frequent fluctuations of lake levels. The changes of the features of lacustrine sediment in the grabens show the extent of such fluctuations of lake level is about 2-3 m.
