Objective: To compare the intraoperative signal-to-noise ratio (SNR), reproducibility and rapidity of popliteal fossa (PF), optimized P37, standard P37 and P31 potentials. Methods: Raw sweeps and 11 averages doubling ...Objective: To compare the intraoperative signal-to-noise ratio (SNR), reproducibility and rapidity of popliteal fossa (PF), optimized P37, standard P37 and P31 potentials. Methods: Raw sweeps and 11 averages doubling sweep number from 2 to 2048 were compared in 37 patients undergoing scoliosis surgery. Optimized (highest amplitude or SNR) P37 derivations were Cz-CPc (22), CPz-CPc (27), Pz-CPc (7), iCPi-CPc (8), CPi-CPc (1), Cz-Pz (2)orPz-FPz (3), and in two patients with non-decussation, Cz-CPi (1) or CPz-CPi (3). Standard P37 and P31 derivations were CPz-FPz and FPz-C5S. Signal amplitude was measured in 2048 sweep averages; peak noise was measured in raw sweeps and ±averages; SNR was amplitude/noise. Visual superimposability and < 20-30%amplitude variation determined reproducibility. Sweeps to reproducibility determined rapidity. Results: The SNR order was PFoptimized P37 > standard P37 > P31. Mean optimized P37 SNR advantages over the standard P37 and P31 were 2.1:1 and 4.9:1. SNR had powerful non-linear correlations to reproducibility and rapidity. Median sweeps to reproducibility were PF: 2, optimized P37: 128, standard P37: 512 and P31: 1024. EEG noise was greatest in FPz derivations. Burst-suppression increased scalp potential SNR and rapidity. Conclusions: Optimized P37 and PF recordings are most rapidly reproducible due to superior SNRs and are recommended. FPz should be avoided. Burst-suppression may be desirable. Significance: CPz-FPz and FPz-C5S should no longer be standard.展开更多
目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将...目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将患者分为轻型组(n=64)、中型组(n=54)、重型组(n=51)。另选同期东南大学附属徐州市中心医院体检的健康者100例为对照组。比较所有受试者血清miR-31-5p、miR-129-5p水平、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分。采用Pearson相关分析血清miR-31-5p、miR-129-5p水平与NIHSS评分的相关性,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-31-5p、miR-129-5p水平对创伤性颅脑损伤患者发生神经功能缺损的诊断价值。结果 重型组、中型组、轻型组血清miR-31-5p水平、NIHSS评分均高于对照组,血清miR-129-5p水平均低于对照组,重型组、中型组血清miR-31-5p水平、NIHSS评分均高于轻型组,血清miR-129-5p水平均低于轻型组,重型组血清miR-31-5p水平、NIHSS评分均高于中型组,血清miR-129-5p水平低于中型组(P<0.05)。血清miR-31-5p水平与NIHSS评分呈正相关(r=0.666,P<0.05),血清miR-129-5p水平与NIHSS评分呈负相关(r=-0.715,P<0.05)。ROC结果显示,血清miR-31-5p、miR-129-5p水平联合诊断创伤性颅脑损伤患者神经功能缺损的敏感度为99.3%,特异度为92.9%,AUC为0.951,预测价值较高。结论 血清miR-31-5p水平升高、miR-129-5p水平降低与创伤性颅脑损伤患者神经功能缺损程度密切相关,二者联合检测对评估神经功能缺损具有较高预测价值。展开更多
文摘Objective: To compare the intraoperative signal-to-noise ratio (SNR), reproducibility and rapidity of popliteal fossa (PF), optimized P37, standard P37 and P31 potentials. Methods: Raw sweeps and 11 averages doubling sweep number from 2 to 2048 were compared in 37 patients undergoing scoliosis surgery. Optimized (highest amplitude or SNR) P37 derivations were Cz-CPc (22), CPz-CPc (27), Pz-CPc (7), iCPi-CPc (8), CPi-CPc (1), Cz-Pz (2)orPz-FPz (3), and in two patients with non-decussation, Cz-CPi (1) or CPz-CPi (3). Standard P37 and P31 derivations were CPz-FPz and FPz-C5S. Signal amplitude was measured in 2048 sweep averages; peak noise was measured in raw sweeps and ±averages; SNR was amplitude/noise. Visual superimposability and < 20-30%amplitude variation determined reproducibility. Sweeps to reproducibility determined rapidity. Results: The SNR order was PFoptimized P37 > standard P37 > P31. Mean optimized P37 SNR advantages over the standard P37 and P31 were 2.1:1 and 4.9:1. SNR had powerful non-linear correlations to reproducibility and rapidity. Median sweeps to reproducibility were PF: 2, optimized P37: 128, standard P37: 512 and P31: 1024. EEG noise was greatest in FPz derivations. Burst-suppression increased scalp potential SNR and rapidity. Conclusions: Optimized P37 and PF recordings are most rapidly reproducible due to superior SNRs and are recommended. FPz should be avoided. Burst-suppression may be desirable. Significance: CPz-FPz and FPz-C5S should no longer be standard.
文摘目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将患者分为轻型组(n=64)、中型组(n=54)、重型组(n=51)。另选同期东南大学附属徐州市中心医院体检的健康者100例为对照组。比较所有受试者血清miR-31-5p、miR-129-5p水平、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分。采用Pearson相关分析血清miR-31-5p、miR-129-5p水平与NIHSS评分的相关性,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-31-5p、miR-129-5p水平对创伤性颅脑损伤患者发生神经功能缺损的诊断价值。结果 重型组、中型组、轻型组血清miR-31-5p水平、NIHSS评分均高于对照组,血清miR-129-5p水平均低于对照组,重型组、中型组血清miR-31-5p水平、NIHSS评分均高于轻型组,血清miR-129-5p水平均低于轻型组,重型组血清miR-31-5p水平、NIHSS评分均高于中型组,血清miR-129-5p水平低于中型组(P<0.05)。血清miR-31-5p水平与NIHSS评分呈正相关(r=0.666,P<0.05),血清miR-129-5p水平与NIHSS评分呈负相关(r=-0.715,P<0.05)。ROC结果显示,血清miR-31-5p、miR-129-5p水平联合诊断创伤性颅脑损伤患者神经功能缺损的敏感度为99.3%,特异度为92.9%,AUC为0.951,预测价值较高。结论 血清miR-31-5p水平升高、miR-129-5p水平降低与创伤性颅脑损伤患者神经功能缺损程度密切相关,二者联合检测对评估神经功能缺损具有较高预测价值。
