A synoptic snapshot in this study is made for the East Cape Eddy (ECE) basedon the World Ocean Circulation Experiment (WOCE) P14C Hydrographic Section and Shipboard ADCPvelocity vector data collected in September 1992...A synoptic snapshot in this study is made for the East Cape Eddy (ECE) basedon the World Ocean Circulation Experiment (WOCE) P14C Hydrographic Section and Shipboard ADCPvelocity vector data collected in September 1992. The ECE is an anticyclonic eddy, barotropicallystructured and centered at 33.64°S and 176.21°E, with warm and salinous-cored subsurface water.The radius of the eddy is of the order O (110 km) and the maximum circumferential velocity is O (40cm s^(-1)); as a result, the relative vorticity is estimated to be O (7 x 10^(-6)s^(-1)). Due to theexistence of the ECE, the mixed layer north of New Zealand becomes deeper, reaching a depth of 300m in the austral winter. The ECE plays an important role in the formation and distribution of theSubtropical Mode Water (STMW) over a considerable area in the South Pacific.展开更多
AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 pol...AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal cancer.METHODS:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by immunohistochemistry.RESULTS:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and gender.Compared with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal cancer.The patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer tissues.CONCLUSION:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.展开更多
文摘A synoptic snapshot in this study is made for the East Cape Eddy (ECE) basedon the World Ocean Circulation Experiment (WOCE) P14C Hydrographic Section and Shipboard ADCPvelocity vector data collected in September 1992. The ECE is an anticyclonic eddy, barotropicallystructured and centered at 33.64°S and 176.21°E, with warm and salinous-cored subsurface water.The radius of the eddy is of the order O (110 km) and the maximum circumferential velocity is O (40cm s^(-1)); as a result, the relative vorticity is estimated to be O (7 x 10^(-6)s^(-1)). Due to theexistence of the ECE, the mixed layer north of New Zealand becomes deeper, reaching a depth of 300m in the austral winter. The ECE plays an important role in the formation and distribution of theSubtropical Mode Water (STMW) over a considerable area in the South Pacific.
基金Supported by The Korea Science and Engineering Foundation through the MRCCMT at Dong-A University
文摘AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal cancer.METHODS:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by immunohistochemistry.RESULTS:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and gender.Compared with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal cancer.The patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer tissues.CONCLUSION:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.
